Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...

Aliases for H1-10 Gene

Aliases for H1-10 Gene

  • H1.10 Linker Histone 2 3 5
  • H1 Histone Family Member X 2 3
  • Histone H1.10 3 4
  • Histone H1x 3 4
  • H1FX 3 4
  • H1X 2 3
  • H1 Histone Family, Member X 2
  • MGC15959 2
  • MGC8350 2
  • H1.10 3
  • H1-10 5

External Ids for H1-10 Gene

Previous HGNC Symbols for H1-10 Gene

  • H1FX

Summaries for H1-10 Gene

Entrez Gene Summary for H1-10 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

GeneCards Summary for H1-10 Gene

H1-10 (H1.10 Linker Histone) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Granzyme-A Pathway. An important paralog of this gene is H1-4.

UniProtKB/Swiss-Prot Summary for H1-10 Gene

  • Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.

Gene Wiki entry for H1-10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H1-10 Gene

Genomics for H1-10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for H1-10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H1-10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H1-10

Genomic Locations for H1-10 Gene

Latest Assembly
chr3:129,314,771-129,316,286
(GRCh38/hg38)
Size:
1,516 bases
Orientation:
Minus strand

Previous Assembly
chr3:129,033,614-129,035,129
(GRCh37/hg19 by Entrez Gene)
Size:
1,516 bases
Orientation:
Minus strand

chr3:129,033,615-129,035,120
(GRCh37/hg19 by Ensembl)
Size:
1,506 bases
Orientation:
Minus strand

Genomic View for H1-10 Gene

Genes around H1-10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1-10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1-10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1-10 Gene

Proteins for H1-10 Gene

  • Protein details for H1-10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92522-H1X_HUMAN
    Recommended name:
    Histone H1.10
    Protein Accession:
    Q92522

    Protein attributes for H1-10 Gene

    Size:
    213 amino acids
    Molecular mass:
    22487 Da
    Quaternary structure:
    • Interacts with RRP1B.

    Three dimensional structures from OCA and Proteopedia for H1-10 Gene

neXtProt entry for H1-10 Gene

Post-translational modifications for H1-10 Gene

  • Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • Ubiquitination at Lys47 and Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for H1-10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H1-10 Gene

Domains & Families for H1-10 Gene

Gene Families for H1-10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for H1-10 Gene

InterPro:
Blocks:
  • Histone H1/H5

Suggested Antigen Peptide Sequences for H1-10 Gene

GenScript: Design optimal peptide antigens:
  • Histone H1x (H1X_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92522

UniProtKB/Swiss-Prot:

H1X_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1-10: view

Function for H1-10 Gene

Molecular function for H1-10 Gene

UniProtKB/Swiss-Prot Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.

Phenotypes From GWAS Catalog for H1-10 Gene

Gene Ontology (GO) - Molecular Function for H1-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IBA 21873635
GO:0003723 RNA binding HDA 22681889
GO:0031492 nucleosomal DNA binding IBA 21873635
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with H1-10: view
genes like me logo Genes that share phenotypes with H1-10: view

Animal Models for H1-10 Gene

MGI Knock Outs for H1-10:
  • H1f10 H1f10<tm1.1(KOMP)Vlcg>

miRNA for H1-10 Gene

miRTarBase miRNAs that target H1-10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for H1-10 Gene

Localization for H1-10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1-10 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H1-10 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoli rim (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for H1-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with H1-10: view

Pathways & Interactions for H1-10 Gene

PathCards logo

SuperPathways for H1-10 Gene

SuperPathway Contained pathways
1 Granzyme-A Pathway
-
2 Activation of cAMP-Dependent PKA
.56
3 E2F mediated regulation of DNA replication
.53
4 Cell cycle_Chromosome condensation in prometaphase
-
genes like me logo Genes that share pathways with H1-10: view

Pathways by source for H1-10 Gene

2 GeneGo (Thomson Reuters) pathways for H1-10 Gene
  • Cell cycle Start of DNA replication in early S phase
  • Cell cycle_Chromosome condensation in prometaphase
2 Qiagen pathways for H1-10 Gene
  • Granzyme-A Pathway
  • PKA Signaling

Gene Ontology (GO) - Biological Process for H1-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0016584 nucleosome positioning IBA 21873635
GO:0030261 chromosome condensation IBA 21873635
GO:0031936 negative regulation of chromatin silencing IBA 21873635
GO:0045910 negative regulation of DNA recombination IBA 21873635
genes like me logo Genes that share ontologies with H1-10: view

No data available for SIGNOR curated interactions for H1-10 Gene

Drugs & Compounds for H1-10 Gene

No Compound Related Data Available

Transcripts for H1-10 Gene

mRNA/cDNA for H1-10 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-10

Alternative Splicing Database (ASD) splice patterns (SP) for H1-10 Gene

No ASD Table

Relevant External Links for H1-10 Gene

GeneLoc Exon Structure for
H1-10

Expression for H1-10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H1-10

SOURCE GeneReport for Unigene cluster for H1-10 Gene:

Hs.75307

mRNA Expression by UniProt/SwissProt for H1-10 Gene:

Q92522-H1X_HUMAN
Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for H1-10 Gene

  • Lung(5)
  • Nervous system(4.4)
  • Liver(4.4)
  • Intestine(3.6)
  • Kidney(3.5)
  • Eye(3.4)
  • Pancreas(3)
  • Bone marrow(2.4)
  • Bone(2.1)
  • Skin(2)
  • Blood(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with H1-10: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1-10 Gene

Orthologs for H1-10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for H1-10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia H1FX 29 30
  • 99.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia H1FX 29
  • 91.55 (n)
Cow
(Bos Taurus)
Mammalia H1FX 29 30
  • 88.89 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia H1fx 29 30
  • 79.96 (n)
OneToOne
H1f10 16
Rat
(Rattus norvegicus)
Mammalia H1fx 29
  • 77.95 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia H1FX 30
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia H1FX 30
  • 67 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii h1fx 30
  • 51 (a)
OneToOne
Species where no ortholog for H1-10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for H1-10 Gene

ENSEMBL:
Gene Tree for H1-10 (if available)
TreeFam:
Gene Tree for H1-10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H1-10: view image
Alliance of Genome Resources:
Additional Orthologs for H1-10

Paralogs for H1-10 Gene

Paralogs for H1-10 Gene

genes like me logo Genes that share paralogs with H1-10: view

Variants for H1-10 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for H1-10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for H1-10 Gene

Variant ID Type Subtype PubMed ID
nsv520607 CNV gain+loss 19592680
nsv591651 CNV loss 21841781
nsv822244 CNV gain 20364138
nsv829722 CNV gain 17160897

Variation tolerance for H1-10 Gene

Gene Damage Index Score: 0.53; 11.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H1-10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H1-10
Leiden Open Variation Database (LOVD)
H1-10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H1-10 Gene

Disorders for H1-10 Gene

Additional Disease Information for H1-10

No disorders were found for H1-10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for H1-10 Gene

Publications for H1-10 Gene

  1. Cloning of the cDNA encoding a novel subtype of histone H1. (PMID: 8964515) Yamamoto T … Horikoshi M (Gene 1996) 2 3 4
  2. The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. (PMID: 19710015) Crawford NP … Hunter KW (The Journal of biological chemistry 2009) 3 4
  3. Histone H1x is highly expressed in human neuroendocrine cells and tumours. (PMID: 19108733) Warneboldt J … Happel N (BMC cancer 2008) 3 22
  4. G1 phase-dependent nucleolar accumulation of human histone H1x. (PMID: 17868027) Stoldt S … Happel N (Biology of the cell 2007) 3 22
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4

Products for H1-10 Gene

Sources for H1-10 Gene