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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in ... See more...
Aliases for H1-1 Gene
Aliases for H1-1 Gene
External Ids for H1-1 Gene
- HGNC: 4715
- Entrez Gene: 3024
- Ensembl: ENSG00000124610
- OMIM: 142709
- UniProtKB: Q02539
Previous HGNC Symbols for H1-1 Gene
- H1F1
- HIST1H1A
Summaries for H1-1 Gene
-
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for H1-1 Gene
H1-1 (H1.1 Linker Histone, Cluster Member) is a Protein Coding gene. Diseases associated with H1-1 include Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 3 and Tonsil Squamous Cell Carcinoma. Among its related pathways are Activation of cAMP-Dependent PKA and Granzyme-A Pathway. An important paralog of this gene is H1-4.
UniProtKB/Swiss-Prot Summary for H1-1 Gene
-
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Additional gene information for H1-1 Gene
- HGNC(4715)
- Entrez Gene(3024)
- Ensembl(ENSG00000124610)
- OMIM(142709)
- UniProtKB(Q02539)
- Open Targets Platform(ENSG00000124610)
- Search for H1-1 at DataMed
- Search for H1-1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H1-1 Gene
Genomics for H1-1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for H1-1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around H1-1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H1-1
Genomic Locations for H1-1 Gene
Genomic Locations for H1-1 Gene
- chr6:26,017,032-26,017,787
- (GRCh38/hg38)
- Size:
- 756 bases
- Orientation:
- Minus strand
- chr6:26,017,260-26,018,040
- (GRCh37/hg19)
- Size:
- 781 bases
- Orientation:
- Minus strand
Genomic View for H1-1 Gene
Genes around H1-1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by HGNC
- 6p22.2 by Entrez Gene
- 6p22.2 by Ensembl
H1-1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for H1-1 Gene
Proteins for H1-1 Gene
-
Protein details for H1-1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q02539-H11_HUMAN
- Recommended name:
- Histone H1.1
- Protein Accession:
- Q02539
- Q3MJ34
Protein attributes for H1-1 Gene
- Size:
- 215 amino acids
- Molecular mass:
- 21842 Da
- Quaternary structure:
-
- Interacts with DFFB.
Post-translational modifications for H1-1 Gene
- H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
- Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for H1-1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for H1-1
- Novus Biologicals Antibodies for H1-1
- Invitrogen Antibodies for H1-1 (AFLGC-H1-1)
- antibodies-online: Show 63 available Histone H1.1 Antibodies ranked by validation data
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for H1-1
- Origene Custom Protein Services for H1-1
-
Abcam proteins for H1-1
No data available for DME Specific Peptides for H1-1 Gene
Domains & Families for H1-1 Gene
Gene Families for H1-1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for H1-1 Gene
- InterPro:
- Blocks:
-
- Histone H1/H5
- ProtoNet:
Suggested Antigen Peptide Sequences for H1-1 Gene
- GenScript: Design optimal peptide antigens:
-
- Histone H1.1 (H11_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q02539UniProtKB/Swiss-Prot:
H11_HUMAN :- The C-terminal domain is required for high-affinity binding to chromatin.
- Belongs to the histone H1/H5 family.
- Domain:
-
- The C-terminal domain is required for high-affinity binding to chromatin.
- Family:
-
- Belongs to the histone H1/H5 family.
Function for H1-1 Gene
Molecular function for H1-1 Gene
- UniProtKB/Swiss-Prot Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Phenotypes From GWAS Catalog for H1-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003690 | double-stranded DNA binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 19895577 |
| GO:0008201 | heparin binding | IEA | -- |
| GO:0031490 | chromatin DNA binding | IMP | 15911621 |
Phenotypes for H1-1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H1-1 - Select products 50% OFF >
- * H1-1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H1-1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H1-1
miRNA for H1-1 Gene
- miRTarBase miRNAs that target H1-1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H1-1
- Browse OriGene Inhibitory RNA Products For H1-1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-1
Clone Products
- Applied Biological Materials (abm): Clones for H1-1 - Select products 50% OFF >
- * H1-1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H1-1
- Addgene plasmids for H1-1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H1-1
Cell Line Products
-
Horizon Cell Lines for H1-1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for H1-1 Gene
Localization for H1-1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for H1-1 Gene
- Nucleus. Chromosome. Note=Mainly localizes in euchromatin.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000790 | nuclear chromatin | IBA,IDA | 19882353 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005719 | nuclear euchromatin | IBA,IDA | 15911621 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for H1-1 Gene
Pathways & Interactions for H1-1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic execution phase |
.31
|
|
| 2 | Apoptosis induced DNA fragmentation | ||
| 3 | Cellular Senescence (REACTOME) | ||
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | Granzyme-A Pathway |
Granzyme-A Pathway
-
|
|
Pathways by source for H1-1 Gene
9 Reactome pathways for H1-1 Gene
2 GeneGo (Thomson Reuters) pathways for H1-1 Gene
- Cell cycle Start of DNA replication in early S phase
- Cell cycle_Chromosome condensation in prometaphase
2 Qiagen pathways for H1-1 Gene
- Granzyme-A Pathway
- PKA Signaling
1 GeneTex pathway for H1-1 Gene
Interacting Proteins for H1-1 Gene
Selected Interacting proteins:
Q02539-H11_HUMAN
ENSP00000244573
for H1-1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for H1-1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
| GO:0007283 | spermatogenesis | IEA,IBA | 21873635 |
| GO:0016584 | nucleosome positioning | IBA | 21873635 |
| GO:0030261 | chromosome condensation | IBA | 21873635 |
Transcripts for H1-1 Gene
mRNA/cDNA for H1-1 Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000244573 756 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for H1-1 - Select products 50% OFF >
- * H1-1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for H1-1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H1-1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H1-1
- Browse OriGene Inhibitory RNA Products For H1-1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-1
Clone Products
- Applied Biological Materials (abm): Clones for H1-1 - Select products 50% OFF >
- * H1-1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for H1-1
- Addgene plasmids for H1-1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H1-1
Relevant External Links for H1-1 Gene
- GeneLoc Exon Structure for
- H1-1
Expression for H1-1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H1-1
SOURCE GeneReport for Unigene cluster for H1-1 Gene:
Hs.150206Evidence on tissue expression from TISSUES for H1-1 Gene
- Skin(2.9)
- Nervous system(2.6)
- Blood(2.5)
- Kidney(2.5)
- Liver(2.4)
- Heart(2.3)
- Muscle(2.3)
- Intestine(2.2)
No Expression Related Data Available
Primer Products
-
OriGene qPCR primer pairs for H1-1
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1-1 Gene
Orthologs for H1-1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HIST1H1A 31 |
|
OneToOne | |
| LOC471874 30 |
|
||||
| Dog (Canis familiaris) |
Mammalia | HIST1H1A 31 |
|
OneToOne | |
| LOC488258 30 |
|
||||
| Mouse (Mus musculus) |
Mammalia | Hist1h1a 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HIST1H1A 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | HIST1H111L 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:163061 31 31 |
|
ManyToMany | |
| CU457819.3 31 |
|
ManyToMany | |||
| zgc:110425 31 |
|
ManyToMany | |||
| CABZ01086354.1 31 |
|
ManyToMany | |||
| FP325123.1 31 |
|
ManyToMany | |||
| si:ch211-113a14.24 31 |
|
ManyToMany | |||
| zgc:153405 31 |
|
ManyToMany | |||
| si:ch211-113a14.18 31 |
|
ManyToMany | |||
| si:ch211-113a14.12 31 |
|
ManyToMany | |||
| si:dkey-108k21.14 31 |
|
ManyToMany | |||
| si:dkey-108k21.10 31 |
|
ManyToMany | |||
| histh1l 31 |
|
ManyToMany | |||
| si:dkey-261m9.12 31 |
|
ManyToMany | |||
| si:dkey-108k21.21 31 |
|
ManyToMany |
- Species where no ortholog for H1-1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for H1-1 Gene
- ENSEMBL:
- Gene Tree for H1-1 (if available)
- TreeFam:
- Gene Tree for H1-1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for H1-1: view image
Paralogs for H1-1 Gene
Variants for H1-1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H1-1 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs16891235 | - | p.Lys140Arg | |||
| rs34541321 | - | p.Ser115Phe | |||
| rs417751 | - | p.Thr99Ile |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv509122 | CNV | insertion | 20534489 |
Residual Variation Intolerance Score:
64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.10;
61.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for H1-1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- H1-1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for H1-1 Gene
Disorders for H1-1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 3 |
|
|
| tonsil squamous cell carcinoma |
|
|
| retinitis pigmentosa 18 |
|
|
| retinitis pigmentosa |
|
|
Search H1-1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for H1-1
No data available for UniProtKB/Swiss-Prot and Genatlas for H1-1 Gene
Publications for H1-1 Gene
- The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. (PMID: 14985337) Hendzel MJ … Th'ng JP (The Journal of biological chemistry 2004) 3 4 23
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4
- Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PMID: 2759094) Eick S … Doenecke D (European journal of cell biology 1989) 2 3 4
- Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. (PMID: 19882353) Ninios YP … Sourlingas TG (Apoptosis : an international journal on programmed cell death 2010) 3 4
- Binding of barrier to autointegration factor (BAF) to histone H3 and selected linker histones including H1.1. (PMID: 16203725) Montes de Oca R … Wilson KL (The Journal of biological chemistry 2005) 3 23
ExternalLinks
Products for H1-1 Gene
- Custom Antibody ServicesOriGene Antibodies for H1-1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for H1-1
- Origene Custom Protein Services for H1-1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for H1-1
- Browse OriGene Inhibitory RNA Products For H1-1
- OriGene qPCR primer pairs for H1-1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For H1-1
- Sino Biological Human cDNA Clone for H1-1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for H1-1
- Novus Biologicals proteins and lysates for H1-1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for H1-1
- Find your target
- Browse Primary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for H1-1 (AFLGC-H1-1)
- VectorBuilder Custom and pre-made DNA vectors for H1-1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for H1-1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for H1-1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for H1-1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for H1-1
- Addgene plasmids for H1-1
- antibodies-online: Show 63 available Histone H1.1 Antibodies ranked by validation data
- antibodies-online: Search results for available Histone H1.1 related products ranked by validation data
- antibodies-online: Search results for available Histone H1.1 related products ranked by validation data
- Horizon Cell Lines for H1-1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for H1-1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for H1-1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for H1-1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for H1-1
Sources for H1-1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB