Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with... See more...

Aliases for H1-0 Gene

Aliases for H1-0 Gene

  • H1.0 Linker Histone 2 3
  • H1 Histone Family Member 0 2 3 5
  • H1F0 3 4 5
  • H1.0, H1(0), H1-0 2 3
  • Histone H1(0) 3 4
  • Histone H1.0 3 4
  • Histone H1' 3 4
  • H1FV 3 4
  • H1 Histone Family, Member 0 2
  • H1.0 3
  • H10 3

External Ids for H1-0 Gene

Previous HGNC Symbols for H1-0 Gene

  • H1FV
  • H1F0

Previous GeneCards Identifiers for H1-0 Gene

  • GC22P037806

Summaries for H1-0 Gene

Entrez Gene Summary for H1-0 Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

GeneCards Summary for H1-0 Gene

H1-0 (H1.0 Linker Histone) is a Protein Coding gene. Diseases associated with H1-0 include Spherocytosis, Type 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and DNA Damage/Telomere Stress Induced Senescence. An important paralog of this gene is H1-4.

UniProtKB/Swiss-Prot Summary for H1-0 Gene

  • Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

Additional gene information for H1-0 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for H1-0 Gene

Genomics for H1-0 Gene

GeneHancer (GH) Regulatory Elements for H1-0 Gene

Promoters and enhancers for H1-0 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around H1-0 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for H1-0

Genomic Locations for H1-0 Gene

Genomic Locations for H1-0 Gene
chr22:37,805,093-37,807,436
(GRCh38/hg38)
Size:
2,344 bases
Orientation:
Plus strand
chr22:38,201,114-38,203,443
(GRCh37/hg19)
Size:
2,330 bases
Orientation:
Plus strand

Genomic View for H1-0 Gene

Genes around H1-0 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
H1-0 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for H1-0 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for H1-0 Gene

Proteins for H1-0 Gene

  • Protein details for H1-0 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07305-H10_HUMAN
    Recommended name:
    Histone H1.0
    Protein Accession:
    P07305
    Secondary Accessions:
    • B2R6I0
    • B4DRD6
    • Q6FG88
    • Q8N6R3

    Protein attributes for H1-0 Gene

    Size:
    194 amino acids
    Molecular mass:
    20863 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for H1-0 Gene

    Alternative splice isoforms for H1-0 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for H1-0 Gene

Post-translational modifications for H1-0 Gene

Other Protein References for H1-0 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for H1-0 Gene

Domains & Families for H1-0 Gene

Gene Families for H1-0 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for H1-0 Gene

Blocks:
  • Histone H1/H5
  • Linker histone, N-terminal
  • Histone H5 signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for H1-0 Gene

GenScript: Design optimal peptide antigens:
  • Histone H1(0) (H10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07305

UniProtKB/Swiss-Prot:

H10_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with H1-0: view

Function for H1-0 Gene

Molecular function for H1-0 Gene

UniProtKB/Swiss-Prot Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
UniProtKB/Swiss-Prot Induction:
Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level).

Phenotypes From GWAS Catalog for H1-0 Gene

Gene Ontology (GO) - Molecular Function for H1-0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003680 AT DNA binding IEA --
GO:0003690 double-stranded DNA binding IBA,IEA 21873635
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9499053
genes like me logo Genes that share ontologies with H1-0: view
genes like me logo Genes that share phenotypes with H1-0: view

Animal Models for H1-0 Gene

MGI Knock Outs for H1-0:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for H1-0 Gene

Localization for H1-0 Gene

Subcellular locations from UniProtKB/Swiss-Prot for H1-0 Gene

Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for H1-0 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
golgi apparatus 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
  • Actin filaments (1)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for H1-0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IDA 19882353
GO:0005634 nucleus IBA,IDA 21383955
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with H1-0: view

Pathways & Interactions for H1-0 Gene

genes like me logo Genes that share pathways with H1-0: view

Pathways by source for H1-0 Gene

2 GeneGo (Thomson Reuters) pathways for H1-0 Gene
  • Cell cycle Start of DNA replication in early S phase
  • Cell cycle_Chromosome condensation in prometaphase
2 Qiagen pathways for H1-0 Gene
  • Granzyme-A Pathway
  • PKA Signaling
1 GeneTex pathway for H1-0 Gene

Gene Ontology (GO) - Biological Process for H1-0 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IGI 19158276
GO:0006309 apoptotic DNA fragmentation TAS --
GO:0006334 nucleosome assembly IEA --
GO:0006342 chromatin silencing IGI 19158276
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with H1-0: view

No data available for SIGNOR curated interactions for H1-0 Gene

Drugs & Compounds for H1-0 Gene

(1) Drugs for H1-0 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with H1-0: view

Transcripts for H1-0 Gene

mRNA/cDNA for H1-0 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for H1-0 Gene

No ASD Table

Relevant External Links for H1-0 Gene

GeneLoc Exon Structure for
H1-0

Expression for H1-0 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for H1-0

SOURCE GeneReport for Unigene cluster for H1-0 Gene:

Hs.745024

Evidence on tissue expression from TISSUES for H1-0 Gene

  • Nervous system(5)
  • Intestine(4.6)
  • Liver(3.9)
  • Muscle(2.8)
  • Kidney(2.7)
  • Blood(2.5)
  • Lung(2.5)
  • Skin(2.4)
  • Bone marrow(2.3)
  • Heart(2.3)
  • Spleen(2.2)
  • Thyroid gland(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for H1-0 Gene

Orthologs for H1-0 Gene

This gene was present in the common ancestor of chordates.

Orthologs for H1-0 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia H1F0 31
  • 100 (a)
OneToOne
LOC743278 30
  • 98.46 (n)
cow
(Bos Taurus)
Mammalia H1F0 31
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H1f0 17 31 30
  • 91.73 (n)
chicken
(Gallus gallus)
Aves H1F0 31 31
  • 67 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398662 30
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4764 30
zebrafish
(Danio rerio)
Actinopterygii h1f0 31
  • 58 (a)
OneToOne
wufb23b02 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10060 30
Species where no ortholog for H1-0 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for H1-0 Gene

ENSEMBL:
Gene Tree for H1-0 (if available)
TreeFam:
Gene Tree for H1-0 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for H1-0: view image

Paralogs for H1-0 Gene

Paralogs for H1-0 Gene

genes like me logo Genes that share paralogs with H1-0: view

Variants for H1-0 Gene

Additional dbSNP identifiers (rs#s) for H1-0 Gene

Structural Variations from Database of Genomic Variants (DGV) for H1-0 Gene

Variant ID Type Subtype PubMed ID
esv2758838 CNV loss 17122850

Variation tolerance for H1-0 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for H1-0 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
H1-0

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for H1-0 Gene

Disorders for H1-0 Gene

MalaCards: The human disease database

(1) MalaCards diseases for H1-0 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spherocytosis, type 1
  • sph1
- elite association - COSMIC cancer census association via MalaCards
Search H1-0 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for H1-0

genes like me logo Genes that share disorders with H1-0: view

No data available for UniProtKB/Swiss-Prot and Genatlas for H1-0 Gene

Publications for H1-0 Gene

  1. Differential distribution of lysine and arginine residues in the closely related histones H1 and H5. Analysis of a human H1 gene. (PMID: 3084796) Doenecke D … Tönjes R (Journal of molecular biology 1986) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 54
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 54

Products for H1-0 Gene

Sources for H1-0 Gene