Aliases for H1-0 Gene
External Ids for H1-0 Gene
Previous HGNC Symbols for H1-0 Gene
Previous GeneCards Identifiers for H1-0 Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
GeneCards Summary for H1-0 Gene
H1-0 (H1.0 Linker Histone) is a Protein Coding gene. Diseases associated with H1-0 include Spherocytosis, Type 1 and Hyperoxaluria, Primary, Type I. Among its related pathways are Activation of DNA fragmentation factor and DNA Damage/Telomere Stress Induced Senescence. An important paralog of this gene is H1-4.
UniProtKB/Swiss-Prot Summary for H1-0 Gene
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.