Free for academic non-profit institutions. Other users need a Commercial license
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
H1-0 (H1.0 Linker Histone) is a Protein Coding gene. Diseases associated with H1-0 include Hyperoxaluria, Primary, Type I and Spherocytosis, Type 1. Among its related pathways are Activation of cAMP-Dependent PKA and Granzyme-A Pathway. An important paralog of this gene is H1-4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003680 | AT DNA binding | IEA | -- |
GO:0003690 | double-stranded DNA binding | IEA,IBA | 21873635 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 9499053 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000786 | nucleosome | IEA | -- |
GO:0000790 | nuclear chromatin | IDA | 19882353 |
GO:0005634 | nucleus | IBA,IDA | 21383955 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic execution phase |
.31
|
|
2 | Apoptosis induced DNA fragmentation | ||
3 | Cellular Senescence (REACTOME) | ||
4 | DNA Damage/Telomere Stress Induced Senescence | ||
5 | Granzyme-A Pathway |
Granzyme-A Pathway
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IGI | 19158276 |
GO:0006309 | apoptotic DNA fragmentation | TAS | -- |
GO:0006334 | nucleosome assembly | IEA | -- |
GO:0006342 | chromatin silencing | IGI | 19158276 |
GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | H1F0 31 |
|
OneToOne | |
LOC743278 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | H1F0 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | H1f0 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | H1F0 31 31 |
|
OneToMany | |
African clawed frog (Xenopus laevis) |
Amphibia | LOC398662 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.4764 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | h1f0 31 |
|
OneToOne | |
wufb23b02 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10060 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758838 | CNV | loss | 17122850 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hyperoxaluria, primary, type i |
|
|
spherocytosis, type 1 |
|
|
lung cancer |
|
|
primary hyperoxaluria |
|
|
carbohydrate metabolic disorder |
|
|