Aliases for GZMM Gene
External Ids for GZMM Gene
Previous GeneCards Identifiers for GZMM Gene
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for GZMM Gene
GZMM (Granzyme M) is a Protein Coding gene. Diseases associated with GZMM include Larsen-Like Syndrome B3gat3 Type and Cataract 38. Among its related pathways are Granzyme Pathway and Creation of C4 and C2 activators. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity. An important paralog of this gene is PRSS57.
UniProtKB/Swiss-Prot Summary for GZMM Gene
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.