Aliases for GZMB Gene
- Granzyme B 2 3 4 5
- T-Cell Serine Protease 1-3E 2 3 4
- Cathepsin G-Like 1 2 3 4
- CTSGL1 2 3 4
- CGL1 2 3 4
- SECT 2 3 4
- HLP 2 3 4
- Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1) 2 3
- Cytotoxic T-Lymphocyte Proteinase 2 3 4
- Cytotoxic Serine Protease B 2 3
- Human Lymphocyte Protein 3 4
- Fragmentin 2 2 3
- EC 184.108.40.206 4 50
- CGL-1 2 3
External Ids for GZMB Gene
Previous HGNC Symbols for GZMB Gene
Previous GeneCards Identifiers for GZMB Gene
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
GeneCards Summary for GZMB Gene
GZMB (Granzyme B) is a Protein Coding gene. Diseases associated with GZMB include Peripheral T-Cell Lymphoma and Aggressive Nk-Cell Leukemia. Among its related pathways are Granzyme Pathway and NOTCH2 Activation and Transmission of Signal to the Nucleus. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is GZMH.
UniProtKB/Swiss-Prot Summary for GZMB Gene
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3262682, PubMed:3263427, PubMed:1985927). It cleaves after Asp (PubMed:8258716, PubMed:1985927). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:32188940, PubMed:31953257). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (PubMed:9852092).
Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.