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Aliases for GYPE Gene

Aliases for GYPE Gene

  • Glycophorin E (MNS Blood Group) 2 3 5
  • GPE 3 4
  • Glycophorin-E 3
  • Glycophorin E 2
  • MiIX 3
  • MNS 3

External Ids for GYPE Gene

Previous GeneCards Identifiers for GYPE Gene

  • GC04M145588
  • GC04M145167
  • GC04M145369
  • GC04M145149
  • GC04M145011
  • GC04M144792
  • GC04M140521

Summaries for GYPE Gene

Entrez Gene Summary for GYPE Gene

  • The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GYPE Gene

GYPE (Glycophorin E (MNS Blood Group)) is a Protein Coding gene. Diseases associated with GYPE include Night Blindness, Congenital Stationary, Type 1A and Hemidystonia.

UniProtKB/Swiss-Prot for GYPE Gene

  • This protein is a minor sialoglycoprotein in human erythrocyte membranes.

Gene Wiki entry for GYPE Gene

Additional gene information for GYPE Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYPE Gene

Genomics for GYPE Gene

GeneHancer (GH) Regulatory Elements for GYPE Gene

Promoters and enhancers for GYPE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J143905 Promoter 1.2 EPDnew 650.7 0.0 -16 0.1 PKNOX1 ATF1 ARNT NCOA2 TCF12 ATF7 NCOA1 REST ZNF592 ATF4 GYPE FREM3 LOC100420464 ENSG00000251600
GH04J144104 Enhancer 0.8 FANTOM5 31.9 -199.4 -199416 0.2 NFRKB CHAMP1 TCF12 ZBTB2 CEBPB ZNF592 GMEB1 SMARCA4 ZNF24 MGA GYPA GYPE GYPB LOC105377460 ENSG00000251600
GH04J143910 Promoter/Enhancer 1.1 Ensembl ENCODE 4.7 -6.0 -6038 2 SMARCA5 ZNF687 L3MBTL2 BACH1 MEF2B ELF1 POLR2A GABPB1 IKZF1 ETV6 LOC100420464 LOC101927636 LOC100419356 FREM3 GYPE ENSG00000251600
GH04J143984 Enhancer 0.2 FANTOM5 15.4 -79.0 -78974 0.3 LOC100419356 GYPE GYPA GYPB PIR47279 ENSG00000251600
GH04J143986 Enhancer 0.2 ENCODE 5 -80.7 -80740 0.2 LOC100419356 FREM3 GYPE GYPB PIR47279 ENSG00000251600
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GYPE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GYPE gene promoter:
  • FOXL1
  • HTF
  • Nkx5-1
  • CREB
  • FOXD3
  • ATF
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for GYPE Gene

Genomic Locations for GYPE Gene
chr4:143,870,866-143,905,563
(GRCh38/hg38)
Size:
34,698 bases
Orientation:
Minus strand
chr4:144,792,019-144,826,716
(GRCh37/hg19)
Size:
34,698 bases
Orientation:
Minus strand

Genomic View for GYPE Gene

Genes around GYPE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GYPE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GYPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYPE Gene

Proteins for GYPE Gene

  • Protein details for GYPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15421-GLPE_HUMAN
    Recommended name:
    Glycophorin-E
    Protein Accession:
    P15421
    Secondary Accessions:
    • D3DNZ5

    Protein attributes for GYPE Gene

    Size:
    78 amino acids
    Molecular mass:
    8463 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GYPE Gene

Post-translational modifications for GYPE Gene

  • The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.

Other Protein References for GYPE Gene

No data available for DME Specific Peptides for GYPE Gene

Domains & Families for GYPE Gene

Gene Families for GYPE Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GYPE Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GYPE Gene

Graphical View of Domain Structure for InterPro Entry

P15421

UniProtKB/Swiss-Prot:

GLPE_HUMAN :
  • Belongs to the glycophorin-A family.
Family:
  • Belongs to the glycophorin-A family.
genes like me logo Genes that share domains with GYPE: view

Function for GYPE Gene

Molecular function for GYPE Gene

UniProtKB/Swiss-Prot Function:
This protein is a minor sialoglycoprotein in human erythrocyte membranes.
GENATLAS Biochemistry:
glycophorin E

Phenotypes From GWAS Catalog for GYPE Gene

genes like me logo Genes that share phenotypes with GYPE: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GYPE

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GYPE Gene

Localization for GYPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for GYPE Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GYPE gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GYPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 2295603
GO:0005887 integral component of plasma membrane TAS 7622054
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GYPE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GYPE Gene

Pathways & Interactions for GYPE Gene

No Data Available

Interacting Proteins for GYPE Gene

Gene Ontology (GO) - Biological Process for GYPE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GYPE Gene

Drugs & Compounds for GYPE Gene

(14) Drugs for GYPE Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(18) Additional Compounds for GYPE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GYPE: view

Transcripts for GYPE Gene

mRNA/cDNA for GYPE Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GYPE Gene

Glycophorin E (MNS blood group):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GYPE

Alternative Splicing Database (ASD) splice patterns (SP) for GYPE Gene

No ASD Table

Relevant External Links for GYPE Gene

GeneLoc Exon Structure for
GYPE
ECgene alternative splicing isoforms for
GYPE

Expression for GYPE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GYPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GYPE Gene

This gene is overexpressed in Whole Blood (x5.1) and Spleen (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of GYPE Gene:

GYPE

SOURCE GeneReport for Unigene cluster for GYPE Gene:

Hs.728753

mRNA Expression by UniProt/SwissProt for GYPE Gene:

P15421-GLPE_HUMAN
Tissue specificity: Erythrocytes.

Evidence on tissue expression from TISSUES for GYPE Gene

  • Blood(4.5)
  • Lung(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with GYPE: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GYPE Gene

Orthologs for GYPE Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GYPE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GYPE2 33
  • 99.15 (n)
GYPE 34
  • 75 (a)
OneToOne
Species where no ortholog for GYPE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GYPE Gene

ENSEMBL:
Gene Tree for GYPE (if available)
TreeFam:
Gene Tree for GYPE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GYPE: view image

Paralogs for GYPE Gene

(11) SIMAP similar genes for GYPE Gene using alignment to 7 proteins:

  • GLPE_HUMAN
  • E9PCN6_HUMAN
  • G8CXN1_HUMAN
  • G8CXT7_HUMAN
  • Q6WBE2_HUMAN
  • Q6WBE7_HUMAN
  • Q9NRB2_HUMAN
genes like me logo Genes that share paralogs with GYPE: view

No data available for Paralogs for GYPE Gene

Variants for GYPE Gene

Sequence variations from dbSNP and Humsavar for GYPE Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1132785 benign, not specified 143,880,509(-) C/G/T coding_sequence_variant, missense_variant
rs1000045332 -- 143,873,151(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000093917 -- 143,913,731(-) C/G/T upstream_transcript_variant
rs1000259137 -- 143,903,072(-) C/G intron_variant
rs1000349496 -- 143,897,751(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GYPE Gene

Variant ID Type Subtype PubMed ID
dgv127e203 CNV gain+loss 21179565
dgv189e55 CNV gain 17911159
dgv5416n100 CNV loss 25217958
dgv5417n100 CNV gain 25217958
dgv5418n100 CNV gain 25217958
dgv5419n100 CNV gain 25217958
dgv5420n100 CNV loss 25217958
dgv5421n100 CNV gain 25217958
dgv5422n100 CNV loss 25217958
dgv5423n100 CNV loss 25217958
dgv667n27 CNV gain 19166990
dgv6n29 CNV loss 16826518
dgv851e201 CNV deletion 23290073
dgv978e199 CNV deletion 23128226
dgv979e199 CNV deletion 23128226
dgv980e199 CNV deletion 23128226
esv2668125 CNV deletion 23128226
esv2728476 CNV deletion 23290073
esv2728480 CNV deletion 23290073
esv2752026 CNV gain 17911159
esv2752030 CNV gain 17911159
esv2759288 CNV gain+loss 17122850
esv3575775 CNV gain 25503493
esv3602516 CNV loss 21293372
esv3602519 CNV loss 21293372
esv3602520 CNV gain 21293372
esv3894044 CNV gain 25118596
esv3894047 CNV gain 25118596
nsv1020719 CNV gain 25217958
nsv1021396 CNV loss 25217958
nsv1023490 CNV gain+loss 25217958
nsv1028150 CNV loss 25217958
nsv1033785 CNV gain 25217958
nsv10584 CNV gain+loss 18304495
nsv1074221 CNV deletion 25765185
nsv428452 CNV loss 18775914
nsv435790 CNV deletion 17901297
nsv436078 CNV insertion 17901297
nsv436411 CNV deletion 17901297
nsv436452 CNV deletion 17901297
nsv461664 CNV gain 19166990
nsv461665 CNV loss 19166990
nsv517006 CNV gain+loss 19592680
nsv528303 CNV gain 19592680
nsv595607 CNV gain 21841781
nsv966324 CNV duplication 23825009

Variation tolerance for GYPE Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GYPE Gene

Human Gene Mutation Database (HGMD)
GYPE
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GYPE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GYPE Gene

Disorders for GYPE Gene

MalaCards: The human disease database

(2) MalaCards diseases for GYPE Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search GYPE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GYPE

genes like me logo Genes that share disorders with GYPE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GYPE Gene

Publications for GYPE Gene

  1. Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction. (PMID: 2295603) Kudo S … Fukuda M (The Journal of biological chemistry 1990) 3 4 22 58
  2. A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression. (PMID: 2390989) Vignal A … Cartron JP (European journal of biochemistry 1990) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites. (PMID: 12949139) Wang HY … Wu CI (Molecular biology and evolution 2003) 3 22 58
  5. Contribution of gene conversion to the retention of the sequence for M blood group type determinant in glycophorin E gene. (PMID: 7521873) Kudo S … Fukuda M (The Journal of biological chemistry 1994) 3 22 58

Products for GYPE Gene

Sources for GYPE Gene

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