Aliases for GYPC Gene
External Ids for GYPC Gene
Previous GeneCards Identifiers for GYPC Gene
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
GeneCards Summary for GYPC Gene
GYPC (Glycophorin C (Gerbich Blood Group)) is a Protein Coding gene. Diseases associated with GYPC include Blood Group, Gerbich System and Malaria. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+.
UniProtKB/Swiss-Prot Summary for GYPC Gene
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.