Aliases for GVINP1 Gene

Aliases for GVINP1 Gene

  • GTPase, Very Large Interferon Inducible Pseudogene 1 2 3 5
  • GTPase, Very Large Interferon Inducible 1, Pseudogene 2 3
  • Very Large Inducible GTPase 1 2 3
  • GVIN1 3 4
  • VLIG1 3 4
  • Interferon-Induced Very Large GTPase Pseudogene 1 4
  • GTPase, Very Large Interferon Inducible 1 2
  • Interferon-Induced Very Large GTPase 1 4
  • VLIG-1 3
  • GVIN1P 3

External Ids for GVINP1 Gene

Previous HGNC Symbols for GVINP1 Gene

  • GVIN1
  • GVIN1P

Previous GeneCards Identifiers for GVINP1 Gene

  • GC11M006735

Summaries for GVINP1 Gene

GeneCards Summary for GVINP1 Gene

GVINP1 (GTPase, Very Large Interferon Inducible Pseudogene 1) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include GTP binding.

Additional gene information for GVINP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GVINP1 Gene

Genomics for GVINP1 Gene

GeneHancer (GH) Regulatory Elements for GVINP1 Gene

Promoters and enhancers for GVINP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006742 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 757.2 +1.3 1307 6.7 ZNF24 SMARCE1 CC2D1A L3MBTL2 DACH1 TEAD4 RELA ZNF148 POLR2A MLLT1 GVINP1 MRPL17 lnc-OR2AG2-1 ILK CAVIN3 OR2AG2 RRP8 ENSG00000254641 TAF10 OR10A4
GH11J006728 Enhancer 1 Ensembl ENCODE dbSUPER 7.4 +18.3 18338 3 SMARCE1 L3MBTL2 MAFK BACH1 ZNF639 IKZF1 DPF2 ZNF316 NFE2 SOX6 MRPL17 ENSG00000241678 OR2AG2 GVINP1 piR-47211-071 piR-57505
GH11J006991 Enhancer 0.7 Ensembl ENCODE 6.6 -246.0 -245966 2.5 PKNOX1 ZIC2 ZNF792 ZBTB20 ZXDB ZNF335 ZNF843 PRDM6 LOC102724711 NLRP14 ZNF214 GVINP1 ZNF215 lnc-ZNF214-1 piR-61580-072
GH11J006733 Enhancer 0.4 ENCODE dbSUPER 7.6 +11.9 11871 2.9 JUN lnc-OR2AG1-2 OR2AG2 GVINP1 piR-56705 lnc-OR2AG2-1
GH11J006717 Enhancer 0.3 Ensembl dbSUPER 7.4 +28.3 28338 1.4 piR-57505 ENSG00000241678 MRPL17 OR2AG2 OR2AG1 GVINP1 piR-47211-071
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GVINP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GVINP1 Gene

Genomic Locations for GVINP1 Gene
chr11:6,713,139-6,746,439
(GRCh38/hg38)
Size:
33,301 bases
Orientation:
Minus strand
chr11:6,734,370-6,767,670
(GRCh37/hg19)
Size:
33,301 bases
Orientation:
Minus strand

Genomic View for GVINP1 Gene

Genes around GVINP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GVINP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GVINP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GVINP1 Gene

Proteins for GVINP1 Gene

  • Protein details for GVINP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2Y8-GVIN1_HUMAN
    Recommended name:
    Interferon-induced very large GTPase 1
    Protein Accession:
    Q7Z2Y8
    Secondary Accessions:
    • A6NFL2
    • Q9H8N5

    Protein attributes for GVINP1 Gene

    Size:
    2422 amino acids
    Molecular mass:
    279048 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14573.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for GVINP1 Gene

Post-translational modifications for GVINP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GVINP1 Gene

Domains & Families for GVINP1 Gene

Protein Domains for GVINP1 Gene

Suggested Antigen Peptide Sequences for GVINP1 Gene

GenScript: Design optimal peptide antigens:
  • Interferon-induced very large GTPase pseudogene 1 (GVIN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z2Y8

UniProtKB/Swiss-Prot:

GVIN1_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
genes like me logo Genes that share domains with GVINP1: view

No data available for Gene Families for GVINP1 Gene

Function for GVINP1 Gene

Phenotypes From GWAS Catalog for GVINP1 Gene

Gene Ontology (GO) - Molecular Function for GVINP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GVINP1: view

Phenotypes for GVINP1 Gene

genes like me logo Genes that share phenotypes with GVINP1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GVINP1 Gene

Localization for GVINP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GVINP1 Gene

Cytoplasm, cytosol. Nucleus.

Gene Ontology (GO) - Cellular Components for GVINP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with GVINP1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GVINP1 Gene

Pathways & Interactions for GVINP1 Gene

PathCards logo

SuperPathways for GVINP1 Gene

No Data Available

Interacting Proteins for GVINP1 Gene

Selected Interacting proteins: Q7Z2Y8-GVIN1_HUMAN for GVINP1 Gene via IID

Symbol External ID(s) Details
COPS5
CUL3

Gene Ontology (GO) - Biological Process for GVINP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GVINP1 Gene

Drugs & Compounds for GVINP1 Gene

No Compound Related Data Available

Transcripts for GVINP1 Gene

mRNA/cDNA for GVINP1 Gene

(4) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GVINP1 Gene

No ASD Table

Relevant External Links for GVINP1 Gene

GeneLoc Exon Structure for
GVINP1
ECgene alternative splicing isoforms for
GVINP1

Expression for GVINP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GVINP1 Gene

mRNA differential expression in normal tissues according to GTEx for GVINP1 Gene

This gene is overexpressed in Spleen (x6.4), Small Intestine - Terminal Ileum (x6.3), and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for GVINP1 Gene

This gene is overexpressed in Liver, secretome (30.9), Pancreatic juice (19.0), and Adipocyte (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GVINP1 Gene



Protein tissue co-expression partners for GVINP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GVINP1 Gene:

GVINP1

SOURCE GeneReport for Unigene cluster for GVINP1 Gene:

Hs.494757
genes like me logo Genes that share expression patterns with GVINP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GVINP1 Gene

Orthologs for GVINP1 Gene

Evolution for GVINP1 Gene

ENSEMBL:
Gene Tree for GVINP1 (if available)
TreeFam:
Gene Tree for GVINP1 (if available)

No data available for Orthologs for GVINP1 Gene

Paralogs for GVINP1 Gene

No data available for Paralogs for GVINP1 Gene

Variants for GVINP1 Gene

Sequence variations from dbSNP and Humsavar for GVINP1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000020713 -- 6,721,265(-) C/A non_coding_transcript_variant
rs1000884627 -- 6,716,197(-) T/C non_coding_transcript_variant
rs1001038972 -- 6,722,378(-) G/A/C upstream_transcript_variant
rs1001299998 -- 6,722,584(-) T/C upstream_transcript_variant
rs1001469488 -- 6,722,967(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GVINP1 Gene

Variant ID Type Subtype PubMed ID
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv819468 CNV loss 19587683
nsv832060 CNV gain 17160897

Additional Variant Information for GVINP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GVINP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GVINP1 Gene

Disorders for GVINP1 Gene

Additional Disease Information for GVINP1

No disorders were found for GVINP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GVINP1 Gene

Publications for GVINP1 Gene

  1. A giant GTPase, very large inducible GTPase-1, is inducible by IFNs. (PMID: 12874213) Klamp T … Howard JC (Journal of immunology (Baltimore, Md. : 1950) 2003) 2 3 23 56
  2. The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates. (PMID: 19369598) Li G … Wang Y (Molecular biology and evolution 2009) 2 3 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 56
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 56

Products for GVINP1 Gene

Sources for GVINP1 Gene