The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011] See more...

Aliases for GULP1 Gene

Aliases for GULP1 Gene

  • GULP PTB Domain Containing Engulfment Adaptor 1 2 3 5
  • CED6 2 3 4
  • GULP 2 3 4
  • PTB Domain-Containing Engulfment Adapter Protein 1 3 4
  • PTB Domain Adapter Protein CED-6 3 4
  • Cell Death Protein 6 Homolog 3 4
  • CED-6 2 3
  • GULP, Engulfment Adaptor PTB Domain Containing 1 3
  • GULP Engulfment Adaptor PTB Domain Containing 1 2
  • PTB Domain Adaptor Protein CED-6 3
  • Engulfment Adapter Protein 3
  • Protein GULP 4
  • GULP1 5

External Ids for GULP1 Gene

Previous GeneCards Identifiers for GULP1 Gene

  • GC02P189358
  • GC02P189360
  • GC02P188981
  • GC02P188864
  • GC02P189156
  • GC02P181017

Summaries for GULP1 Gene

Entrez Gene Summary for GULP1 Gene

  • The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for GULP1 Gene

GULP1 (GULP PTB Domain Containing Engulfment Adaptor 1) is a Protein Coding gene. Diseases associated with GULP1 include Lingual Goiter and Lipid Pneumonia. Among its related pathways are Arf6 signaling events. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is LDLRAP1.

UniProtKB/Swiss-Prot Summary for GULP1 Gene

  • May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GULP1 Gene

Genomics for GULP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GULP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J188289 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 612 +2.1 2065 8.1 CTCF PRDM10 ZNF629 LEF1 IKZF1 ZNF692 TARDBP FOXA1 PRDM1 MTA2 GULP1 DIRC1 MIR561 lnc-COL3A1-3 LINC01090 COL3A1
GH02J188314 Enhancer 1 Ensembl ENCODE dbSUPER 23.7 +28.1 28090 11.3 CTCF ZNF629 CEBPB SP1 TCF7L2 HMBOX1 OSR2 ATF2 FOSL1 POLR2A GULP1 MIR561 LINC01090 DIRC1 HSALNG0021008 COL3A1
GH02J188326 Enhancer 1 Ensembl ENCODE 22.7 +35.6 35618 1.8 ZNF629 IKZF1 JUND FOXA1 PKNOX1 ZNF24 DPF2 HDAC1 SOX6 EP300 GULP1 MIR561 LINC01090 HSALNG0021008 COL3A1
GH02J188334 Enhancer 0.8 Ensembl ENCODE 22.9 +42.2 42232 3.4 ZNF600 OSR2 ZNF580 MYNN ZBTB17 ZNF189 ZNF366 ZNF843 FEZF1 PRDM6 GULP1 MIR561 LINC01090 DIRC1 HSALNG0021008 COL3A1
GH02J188302 Enhancer 1 Ensembl ENCODE dbSUPER 11.8 +13.9 13931 6.4 TEAD4 PRDM10 KDM1A PRDM1 PKNOX1 POLR2A HMBOX1 CEBPB NFE2 MAFG GULP1 MIR561 HSALNG0021008 LINC01090 COL3A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GULP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GULP1

Top Transcription factor binding sites by QIAGEN in the GULP1 gene promoter:
  • ARP-1
  • FAC1
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-3

Genomic Locations for GULP1 Gene

Genomic Locations for GULP1 Gene
chr2:188,291,669-188,595,931
(GRCh38/hg38)
Size:
304,263 bases
Orientation:
Plus strand
chr2:189,156,396-189,460,653
(GRCh37/hg19)
Size:
304,258 bases
Orientation:
Plus strand

Genomic View for GULP1 Gene

Genes around GULP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GULP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GULP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GULP1 Gene

Proteins for GULP1 Gene

  • Protein details for GULP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBP9-GULP1_HUMAN
    Recommended name:
    PTB domain-containing engulfment adapter protein 1
    Protein Accession:
    Q9UBP9
    Secondary Accessions:
    • B2RB51
    • B4DQ40
    • B8ZZ72
    • D3DPH1
    • E9PB86
    • Q53PC1
    • Q53RF3
    • Q9BVL3

    Protein attributes for GULP1 Gene

    Size:
    304 amino acids
    Molecular mass:
    34490 Da
    Quaternary structure:
    • Homodimer. Interacts with clathrin. Interacts with GDP-bound ARF6, but not with GTP-bound ARF6. Part of a complex composed of GULP1, ACAP1 and ARF6. Interacts with ACAP1, LRP1, MEGF10 and STAB2.

    Three dimensional structures from OCA and Proteopedia for GULP1 Gene

    Alternative splice isoforms for GULP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GULP1 Gene

Post-translational modifications for GULP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GULP1 Gene

Domains & Families for GULP1 Gene

Gene Families for GULP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GULP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GULP1 Gene

GenScript: Design optimal peptide antigens:
  • Protein GULP (GULP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBP9

UniProtKB/Swiss-Prot:

GULP1_HUMAN :
  • Belongs to the ced-6 family.
Family:
  • Belongs to the ced-6 family.
genes like me logo Genes that share domains with GULP1: view

Function for GULP1 Gene

Molecular function for GULP1 Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.

Phenotypes From GWAS Catalog for GULP1 Gene

Gene Ontology (GO) - Molecular Function for GULP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with GULP1: view
genes like me logo Genes that share phenotypes with GULP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GULP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GULP1 Gene

Localization for GULP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GULP1 Gene

Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GULP1 gene
Compartment Confidence
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
endosome 2
lysosome 2
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GULP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GULP1: view

Pathways & Interactions for GULP1 Gene

PathCards logo

SuperPathways for GULP1 Gene

SuperPathway Contained pathways
1 Arf6 signaling events
genes like me logo Genes that share pathways with GULP1: view

Pathways by source for GULP1 Gene

1 BioSystems pathway for GULP1 Gene

Gene Ontology (GO) - Biological Process for GULP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0006909 phagocytosis IEA --
GO:0006911 phagocytosis, engulfment IDA 11729193
GO:0006915 apoptotic process TAS,IEA --
genes like me logo Genes that share ontologies with GULP1: view

No data available for SIGNOR curated interactions for GULP1 Gene

Drugs & Compounds for GULP1 Gene

(1) Drugs for GULP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GULP1: view

Transcripts for GULP1 Gene

mRNA/cDNA for GULP1 Gene

32 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GULP1

Alternative Splicing Database (ASD) splice patterns (SP) for GULP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5:
SP6:
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - -
SP14: - - - -
SP15: - -
SP16:
SP17: - - - - - - -

ExUns: 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d · 22e
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for GULP1 Gene

GeneLoc Exon Structure for
GULP1

Expression for GULP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GULP1 Gene

Protein differential expression in normal tissues from HIPED for GULP1 Gene

This gene is overexpressed in Plasma (25.9) and Placenta (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GULP1 Gene



Protein tissue co-expression partners for GULP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GULP1

SOURCE GeneReport for Unigene cluster for GULP1 Gene:

Hs.470887

mRNA Expression by UniProt/SwissProt for GULP1 Gene:

Q9UBP9-GULP1_HUMAN
Tissue specificity: Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.

Evidence on tissue expression from TISSUES for GULP1 Gene

  • Nervous system(3.2)
  • Muscle(2.3)
  • Skin(2.2)
  • Blood(2.2)
  • Kidney(2.2)
  • Stomach(2.2)
  • Heart(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with GULP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GULP1 Gene

Orthologs for GULP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GULP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GULP1 30 31
  • 99.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GULP1 31
  • 96 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gulp1 30
  • 89.69 (n)
Mouse
(Mus musculus)
Mammalia Gulp1 30 17 31
  • 89.69 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GULP1 31
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GULP1 31
  • 85 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia GULP1 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GULP1 31
  • 95 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GULP1 31
  • 88 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii gulp1a 30 31
  • 74.78 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta ced-6 31
  • 21 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea ced-6 30 31
  • 51.87 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToOne
Species where no ortholog for GULP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for GULP1 Gene

ENSEMBL:
Gene Tree for GULP1 (if available)
TreeFam:
Gene Tree for GULP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GULP1: view image

Paralogs for GULP1 Gene

genes like me logo Genes that share paralogs with GULP1: view

Variants for GULP1 Gene

Additional dbSNP identifiers (rs#s) for GULP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GULP1 Gene

Variant ID Type Subtype PubMed ID
dgv4135n100 CNV gain 25217958
dgv7232n54 CNV gain 21841781
dgv750e199 CNV deletion 23128226
esv2721252 CNV deletion 23290073
esv274925 CNV gain+loss 21479260
esv275130 CNV gain+loss 21479260
esv27753 CNV loss 19812545
esv3305036 CNV mobile element insertion 20981092
esv3308832 CNV mobile element insertion 20981092
esv3348168 CNV insertion 20981092
esv3376956 CNV insertion 20981092
esv3419237 CNV insertion 20981092
esv3584243 CNV loss 25503493
esv3584244 CNV loss 25503493
esv3593715 CNV loss 21293372
esv3593716 CNV loss 21293372
esv3593718 CNV loss 21293372
esv8987 CNV gain 19470904
nsv1003974 CNV loss 25217958
nsv1125389 OTHER inversion 24896259
nsv524228 CNV gain 19592680
nsv584055 CNV loss 21841781
nsv834489 CNV gain 17160897
nsv954447 CNV deletion 24416366

Variation tolerance for GULP1 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GULP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GULP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GULP1 Gene

Disorders for GULP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GULP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lingual goiter
lipid pneumonia
  • exogenous lipoid pneumonia
hemophagocytic lymphohistiocytosis, familial, 1
  • fhl1
- elite association - COSMIC cancer census association via MalaCards
Search GULP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GULP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GULP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GULP1 Gene

Publications for GULP1 Gene

  1. Apoptotic engulfment pathway and schizophrenia. (PMID: 19721717) Chen X … Kendler KS (PloS one 2009) 3 41
  2. Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment. (PMID: 18230608) Park SY … Kim IS (The Journal of biological chemistry 2008) 3 4
  3. Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP. (PMID: 17398097) Ma Z … Ravichandran KS (Current biology : CB 2007) 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). (PMID: 11729193) Su HP … Ravichandran KS (The Journal of biological chemistry 2002) 2 3

Products for GULP1 Gene

Sources for GULP1 Gene