Aliases for GULP1 Gene
External Ids for GULP1 Gene
Previous GeneCards Identifiers for GULP1 Gene
The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for GULP1 Gene
GULP1 (GULP PTB Domain Containing Engulfment Adaptor 1) is a Protein Coding gene. Diseases associated with GULP1 include Lingual Goiter and Lipid Pneumonia. Among its related pathways are Arf6 signaling events. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is LDLRAP1.
UniProtKB/Swiss-Prot Summary for GULP1 Gene
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.