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Aliases for GULOP Gene

Aliases for GULOP Gene

  • Gulonolactone (L-) Oxidase, Pseudogene 2 3 5
  • SCURVY 3
  • GULO 3

External Ids for GULOP Gene

Previous GeneCards Identifiers for GULOP Gene

  • GC08U990039
  • GC08P027255
  • GC08P027457
  • GC08P027491
  • GC08P027418

Summaries for GULOP Gene

Entrez Gene Summary for GULOP Gene

  • This gene is nonfunctional in humans and other primates. In most mammalian species the corresponding gene encodes L-gulono-gamma-lactone oxidase which catalyzes the last step of ascorbic acid biosynthesis. The human gene is a remnant that lacks five of twelve exons found in functional rodent genes. The loss of enzyme activity results in hypoascorbemia or the inability to synthesize vitamin C. [provided by RefSeq, Nov 2010]

GeneCards Summary for GULOP Gene

GULOP (Gulonolactone (L-) Oxidase, Pseudogene) is a Pseudogene. Diseases associated with GULOP include Hypoascorbemia.

Gene Wiki entry for GULOP Gene

Additional gene information for GULOP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GULOP Gene

Genomics for GULOP Gene

GeneHancer (GH) Regulatory Elements for GULOP Gene

Promoters and enhancers for GULOP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J027610 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.9 +53.8 53801 8.1 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 CLU FZD3 ZNF395 SCARA3 GULOP MIR6843
GH08J027602 Enhancer 1.2 ENCODE dbSUPER 6.9 +43.1 43113 2.5 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF143 SP5 ENSG00000253875 LOC100130612 LOC100132229 EPHX2 CHRNA2 CCDC25 ESCO2 RNU6-1276P GULOP MIR6843
GH08J027592 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.5 +32.2 32215 0.8 HDGF ATF1 ARID4B SIN3A ZNF2 IRF4 ZNF48 YY1 ZNF121 CBX5 GULOP MIR6843
GH08J027600 Enhancer 1 ENCODE dbSUPER 7 +40.3 40305 0.2 HDAC1 FOXA2 PKNOX1 RAD21 YY1 TCF12 EGR1 POLR3A ATF7 CREM ELP3 EPHX2 CHRNA2 GULOP MIR6843 CLU
GH08J027583 Enhancer 1.1 ENCODE dbSUPER 5.6 +24.1 24094 2.6 PKNOX1 ARID4B FEZF1 DMAP1 ZNF48 ETS1 YY1 RXRA MXD4 MIER2 CHRNA2 GULOP MIR6843
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GULOP on UCSC Golden Path with GeneCards custom track

Genomic Locations for GULOP Gene

Genomic Locations for GULOP Gene
28,800 bases
Plus strand
28,800 bases
Plus strand

Genomic View for GULOP Gene

Genes around GULOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GULOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GULOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GULOP Gene

Function for GULOP Gene

Molecular function for GULOP Gene

GENATLAS Biochemistry:
gulono-gamma oxidase,non functional

Phenotypes From GWAS Catalog for GULOP Gene

Phenotypes for GULOP Gene

genes like me logo Genes that share phenotypes with GULOP: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GULOP Gene

Localization for GULOP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GULOP Gene

Pathways & Interactions for GULOP Gene

SuperPathways for GULOP Gene

No Data Available

Interacting Proteins for GULOP Gene

Gene Ontology (GO) - Biological Process for GULOP Gene


No data available for Pathways by source and SIGNOR curated interactions for GULOP Gene

Drugs & Compounds for GULOP Gene

No Compound Related Data Available

Transcripts for GULOP Gene

mRNA/cDNA for GULOP Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GULOP Gene

No ASD Table

Relevant External Links for GULOP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GULOP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GULOP Gene

mRNA differential expression in normal tissues according to GTEx for GULOP Gene

This gene is overexpressed in Pancreas (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of GULOP Gene:

genes like me logo Genes that share expression patterns with GULOP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GULOP Gene

Orthologs for GULOP Gene

Evolution for GULOP Gene

Gene Tree for GULOP (if available)
Gene Tree for GULOP (if available)

No data available for Orthologs for GULOP Gene

Paralogs for GULOP Gene

No data available for Paralogs for GULOP Gene

Variants for GULOP Gene

Additional Variant Information for GULOP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for GULOP Gene

Disorders for GULOP Gene

MalaCards: The human disease database

(1) MalaCards diseases for GULOP Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
  • scurvy
- elite association - COSMIC cancer census association via MalaCards
Search GULOP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GULOP

Genetic Association Database
genes like me logo Genes that share disorders with GULOP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GULOP Gene

Publications for GULOP Gene

  1. Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. (PMID: 8175804) Nishikimi M … Yagi K (The Journal of biological chemistry 1994) 2 3 58
  2. Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase. (PMID: 3214183) Nishikimi M … Yagi K (Archives of biochemistry and biophysics 1988) 2 3 58
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
  4. Conserved or lost: molecular evolution of the key gene GULO in vertebrate vitamin C biosynthesis. (PMID: 23404229) Yang H (Biochemical genetics 2013) 3 58
  5. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang ZD … Gerstein M (Genome biology 2010) 3 58

Products for GULOP Gene

Sources for GULOP Gene

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