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This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008] See more...
Aliases for GUCY2EP Gene
Aliases for GUCY2EP Gene
External Ids for GUCY2EP Gene
- HGNC: 4690
- NCBI Entrez Gene: 390226
- Ensembl: ENSG00000204529
Previous HGNC Symbols for GUCY2EP Gene
- GUCY2E
Previous GeneCards Identifiers for GUCY2EP Gene
- GC11M076392
Summaries for GUCY2EP Gene
-
This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008]
GeneCards Summary for GUCY2EP Gene
GUCY2EP (Guanylate Cyclase 2E, Pseudogene) is a Pseudogene. Diseases associated with GUCY2EP include Guanylate Cyclase 2E, Pseudogene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and G-Beta Gamma Signaling.
Additional gene information for GUCY2EP Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GUCY2EP Gene
Genomics for GUCY2EP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GUCY2EP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GUCY2EP on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for GUCY2EP Gene
Latest Assembly
- chr11:76,680,166-76,721,789
- (GRCh38/hg38)
- Size:
- 41,624 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:76,391,210-76,432,833
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 41,624 bases
- Orientation:
- Minus strand
- chr11:76,405,087-76,418,685
- (GRCh37/hg19 by Ensembl)
- Size:
- 13,599 bases
- Orientation:
- Minus strand
Genomic View for GUCY2EP Gene
Genes around GUCY2EP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.5 by HGNC
- 11q13.5 by Entrez Gene
- 11q13.5 by Ensembl
GUCY2EP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GUCY2EP Gene
Proteins for GUCY2EP Gene
Post-translational modifications for GUCY2EP Gene
No Post-translational modifications
Antibodies for research
Protein products for research
-
OriGene Purified Proteins for GUCY2EP
- Search Origene for MassSpec and Protein Over-expression Lysates for GUCY2EP
- Origene Custom Protein Services for GUCY2EP
Assay products for research
No data available for DME Specific Peptides for GUCY2EP Gene
Domains & Families for GUCY2EP Gene
Gene Families for GUCY2EP Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GUCY2EP Gene
Function for GUCY2EP Gene
Phenotypes From GWAS Catalog for GUCY2EP Gene
Phenotypes for GUCY2EP Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GUCY2EP - Starting at $85 >
- * GUCY2EP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GUCY2EP
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GUCY2EP
- Browse OriGene Inhibitory RNA Products For GUCY2EP
Clone products for research
- Applied Biological Materials (abm): Clones for GUCY2EP - Starting at $45 >
- * GUCY2EP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GUCY2EP Gene
Localization for GUCY2EP Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GUCY2EP Gene
Pathways & Interactions for GUCY2EP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | G-Beta Gamma Signaling |
CRHR Pathway
.44
Relaxin Pathway
.37
|
Signaling in Gap Junctions
.30
|
| 2 | Sweet Taste Signaling |
Cellular Effects of Sildenafil
.46
|
Sperm Motility
.37
|
| 3 | Nanog in Mammalian ESC Pluripotency |
eNOS Signaling
.48
|
|
| 4 | CREB Pathway |
Intracellular Calcium Signaling
.50
|
|
| 5 | Sertoli-Sertoli Cell Junction Dynamics |
Sertoli-Sertoli Cell Junction Dynamics
.38
|
|
Pathways by source for GUCY2EP Gene
9 Qiagen pathways for GUCY2EP Gene
- Cellular Effects of Sildenafil
- CRHR Pathway
- eNOS Signaling
- Intracellular Calcium Signaling
- Relaxin Pathway
No data available for Interacting Proteins and SIGNOR curated interactions for GUCY2EP Gene
Transcripts for GUCY2EP Gene
mRNA/cDNA for GUCY2EP Gene
- 1 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000525328 832 nts (view in UCSC)
- ENST00000526984 573 nts (view in UCSC)
- ENST00000531117 1918 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GUCY2EP - Starting at $85 >
- * GUCY2EP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GUCY2EP
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GUCY2EP
- Browse OriGene Inhibitory RNA Products For GUCY2EP
Clone products for research
- Applied Biological Materials (abm): Clones for GUCY2EP - Starting at $45 >
- * GUCY2EP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for GUCY2EP Gene
- GeneLoc Exon Structure for
- GUCY2EP
Expression for GUCY2EP Gene
mRNA differential expression in normal tissues according to GTEx for GUCY2EP Gene
This gene is overexpressed in Kidney - Cortex (x13.2) and Liver (x10.3).
SOURCE GeneReport for Unigene cluster for GUCY2EP Gene:
Hs.440026Primer products for research
-
OriGene qPCR primer pairs for GUCY2EP
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY2EP Gene
Orthologs for GUCY2EP Gene
No data available for Orthologs for GUCY2EP Gene
Paralogs for GUCY2EP Gene
No data available for Paralogs for GUCY2EP Gene
Variants for GUCY2EP Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1228n100 | CNV | loss | 25217958 |
| esv1729465 | CNV | deletion | 17803354 |
| esv2675807 | CNV | deletion | 23128226 |
| esv2744793 | CNV | deletion | 23290073 |
| esv2744794 | CNV | deletion | 23290073 |
| esv2744795 | CNV | deletion | 23290073 |
| esv2744797 | CNV | deletion | 23290073 |
| esv2744798 | CNV | deletion | 23290073 |
| esv3548017 | CNV | deletion | 23714750 |
| nsv1047069 | CNV | gain | 25217958 |
| nsv1127211 | CNV | deletion | 24896259 |
| nsv1139514 | CNV | deletion | 24896259 |
| nsv39437 | CNV | deletion | 16902084 |
| nsv509433 | CNV | insertion | 20534489 |
Additional Variant Information for GUCY2EP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GUCY2EP
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for GUCY2EP Gene
Disorders for GUCY2EP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| guanylate cyclase 2e, pseudogene |
|
|
Search GUCY2EP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GUCY2EP
No data available for UniProtKB/Swiss-Prot and Genatlas for GUCY2EP Gene
Publications for GUCY2EP Gene
- Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PMID: 8838319) Yang RB … Garbers DL (Genomics 1996) 2 3 23
- Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion. (PMID: 20012162) Karan S … Baehr W (Molecular and cellular biochemistry 2010) 3
- Comparative genomics search for losses of long-established genes on the human lineage. (PMID: 18085818) Zhu J … Haussler D (PLoS computational biology 2007) 3
- Degeneration of the olfactory guanylyl cyclase D gene during primate evolution. (PMID: 17849013) Young JM … Liman ER (PloS one 2007) 3
- Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. (PMID: 9153227) Yang RB … Garbers DL (The Journal of biological chemistry 1997) 3
ExternalLinks
Products for GUCY2EP Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GUCY2EP
- Search Origene for MassSpec and Protein Over-expression Lysates for GUCY2EP
- Origene Custom Protein Services for GUCY2EP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GUCY2EP
- Browse OriGene Inhibitory RNA Products For GUCY2EP
- OriGene qPCR primer pairs for GUCY2EP
- OriGene CRISPR knockouts for GUCY2EP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GUCY2EP
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- antibodies-online: Search results for available GUCY2E related products ranked by validation data
- antibodies-online: Search results for available GUCY2E related products ranked by validation data
- antibodies-online: Search results for available GUCY2E related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for GUCY2EP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for GUCY2EP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GUCY2EP
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for GUCY2EP
Sources for GUCY2EP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB