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Aliases for GUCY2EP Gene

Aliases for GUCY2EP Gene

  • Guanylate Cyclase 2E, Pseudogene 2 3 5
  • Olfactory Guanylate Cyclase 3
  • Guanylate Cyclase 2E 2
  • GUCY2E 3
  • GC-E 3
  • GCD 3

External Ids for GUCY2EP Gene

Previous HGNC Symbols for GUCY2EP Gene

  • GUCY2E

Previous GeneCards Identifiers for GUCY2EP Gene

  • GC11M076392

Summaries for GUCY2EP Gene

Entrez Gene Summary for GUCY2EP Gene

  • This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008]

GeneCards Summary for GUCY2EP Gene

GUCY2EP (Guanylate Cyclase 2E, Pseudogene) is a Pseudogene. Diseases associated with GUCY2EP include Guanylate Cyclase 2E, Pseudogene. Among its related pathways are CREB Pathway and Sertoli-Sertoli Cell Junction Dynamics.

Additional gene information for GUCY2EP Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY2EP Gene

Genomics for GUCY2EP Gene

GeneHancer (GH) Regulatory Elements for GUCY2EP Gene

Promoters and enhancers for GUCY2EP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J076721 Enhancer 0.7 ENCODE 600.7 -0.2 -153 0.2 CTCF RAD21 ZNF600 ZIC2 ZNF143 REST TRIM22 HDAC1 SMARCB1 MAX GUCY2EP LOC105369397
GH11J076744 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -23.4 -23425 2.8 CC2D1A CBFA2T2 BACH1 TRIM24 ZNF639 EGR1 SMARCA4 MTA1 DPF2 IKZF1 ENSG00000254632 ACER3 LOC105369397 GUCY2EP
GH11J076694 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.3 +22.7 22700 12.2 CC2D1A SP1 ZFX ZKSCAN8 CBFA2T2 ZNF148 MLLT1 GTF2F1 CTCF CDC5L ENSG00000254975 LRRC32 ENSG00000254810 ENSG00000236304 LOC101928837 TSKU ENSG00000254632 ACER3 EMSY GC11P076710
GH11J076735 Enhancer 1 Ensembl ENCODE 0.4 -15.1 -15112 4.6 CBFA2T2 MLLT1 GTF2F1 TRIM24 SMARCA4 MTA1 DPF2 ZIC2 ATF1 HDAC1 ENSG00000254632 LOC101928837 LOC105369397 GUCY2EP
GH11J076734 Enhancer 0.9 Ensembl ENCODE 0.4 -11.5 -11512 2.2 CC2D1A CTCF RAD21 ARID2 REST ZEB2 ZNF24 DEK ZBTB17 SMC3 ENSG00000254632 ENSG00000261578 GUCY2EP LOC105369397
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GUCY2EP on UCSC Golden Path with GeneCards custom track

Genomic Locations for GUCY2EP Gene

Genomic Locations for GUCY2EP Gene
chr11:76,680,166-76,721,789
(GRCh38/hg38)
Size:
41,624 bases
Orientation:
Minus strand
chr11:76,391,210-76,432,833
(GRCh37/hg19)
Size:
41,624 bases
Orientation:
Minus strand

Genomic View for GUCY2EP Gene

Genes around GUCY2EP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY2EP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY2EP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY2EP Gene

Proteins for GUCY2EP Gene

Post-translational modifications for GUCY2EP Gene

No Post-translational modifications

No data available for DME Specific Peptides for GUCY2EP Gene

Domains & Families for GUCY2EP Gene

Gene Families for GUCY2EP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GUCY2EP: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GUCY2EP Gene

Function for GUCY2EP Gene

Phenotypes From GWAS Catalog for GUCY2EP Gene

Phenotypes for GUCY2EP Gene

genes like me logo Genes that share phenotypes with GUCY2EP: view

Animal Model Products

Clone Products

  • Applied Biological Materials (abm): Clones for GUCY2EP - Now 50% OFF >
  • * GUCY2EP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GUCY2EP tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GUCY2EP Gene

Localization for GUCY2EP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GUCY2EP Gene

Pathways & Interactions for GUCY2EP Gene

genes like me logo Genes that share pathways with GUCY2EP: view

Pathways by source for GUCY2EP Gene

Interacting Proteins for GUCY2EP Gene

Gene Ontology (GO) - Biological Process for GUCY2EP Gene

None

No data available for SIGNOR curated interactions for GUCY2EP Gene

Drugs & Compounds for GUCY2EP Gene

No Compound Related Data Available

Transcripts for GUCY2EP Gene

mRNA/cDNA for GUCY2EP Gene

(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for GUCY2EP Gene

Guanylate cyclase 2E, pseudogene:
Representative Sequences:

Clone Products

  • Applied Biological Materials (abm): Clones for GUCY2EP - Now 50% OFF >
  • * GUCY2EP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GUCY2EP tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY2EP Gene

No ASD Table

Relevant External Links for GUCY2EP Gene

GeneLoc Exon Structure for
GUCY2EP
ECgene alternative splicing isoforms for
GUCY2EP

Expression for GUCY2EP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GUCY2EP Gene

mRNA differential expression in normal tissues according to GTEx for GUCY2EP Gene

This gene is overexpressed in Kidney - Cortex (x13.2) and Liver (x10.3).

NURSA nuclear receptor signaling pathways regulating expression of GUCY2EP Gene:

GUCY2EP

SOURCE GeneReport for Unigene cluster for GUCY2EP Gene:

Hs.440026
genes like me logo Genes that share expression patterns with GUCY2EP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY2EP Gene

Orthologs for GUCY2EP Gene

Evolution for GUCY2EP Gene

ENSEMBL:
Gene Tree for GUCY2EP (if available)
TreeFam:
Gene Tree for GUCY2EP (if available)

No data available for Orthologs for GUCY2EP Gene

Paralogs for GUCY2EP Gene

No data available for Paralogs for GUCY2EP Gene

Variants for GUCY2EP Gene

Sequence variations from dbSNP and Humsavar for GUCY2EP Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000104831 -- 76,681,074(-) A/G intron_variant
rs1000174680 -- 76,689,050(-) C/A non_coding_transcript_variant
rs1000221643 -- 76,714,977(-) C/T intron_variant
rs1000317183 -- 76,696,452(-) G/A/T intron_variant
rs1000328983 -- 76,719,295(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY2EP Gene

Variant ID Type Subtype PubMed ID
dgv1228n100 CNV loss 25217958
esv1729465 CNV deletion 17803354
esv2675807 CNV deletion 23128226
esv2744793 CNV deletion 23290073
esv2744794 CNV deletion 23290073
esv2744795 CNV deletion 23290073
esv2744797 CNV deletion 23290073
esv2744798 CNV deletion 23290073
esv3548017 CNV deletion 23714750
nsv1047069 CNV gain 25217958
nsv1127211 CNV deletion 24896259
nsv1139514 CNV deletion 24896259
nsv39437 CNV deletion 16902084
nsv509433 CNV insertion 20534489

Additional Variant Information for GUCY2EP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GUCY2EP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GUCY2EP Gene

Disorders for GUCY2EP Gene

MalaCards: The human disease database

(1) MalaCards diseases for GUCY2EP Gene - From: GeneCards

Disorder Aliases PubMed IDs
guanylate cyclase 2e, pseudogene
  • gucy2ep
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GUCY2EP

genes like me logo Genes that share disorders with GUCY2EP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCY2EP Gene

Publications for GUCY2EP Gene

  1. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PMID: 8838319) Yang RB … Garbers DL (Genomics 1996) 2 3 23 58
  2. Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion. (PMID: 20012162) Karan S … Baehr W (Molecular and cellular biochemistry 2010) 3 58
  3. Degeneration of the olfactory guanylyl cyclase D gene during primate evolution. (PMID: 17849013) Young JM … Liman ER (PloS one 2007) 3 58
  4. Comparative genomics search for losses of long-established genes on the human lineage. (PMID: 18085818) Zhu J … Haussler D (PLoS computational biology 2007) 3 58
  5. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. (PMID: 9153227) Yang RB … Garbers DL (The Journal of biological chemistry 1997) 3 58

Products for GUCY2EP Gene

Sources for GUCY2EP Gene

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