This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008] See more...

Aliases for GUCY2EP Gene

Aliases for GUCY2EP Gene

  • Guanylate Cyclase 2E, Pseudogene 2 3 5
  • Olfactory Guanylate Cyclase 3
  • Guanylate Cyclase 2E 2
  • GUCY2E 3
  • GC-E 3
  • GCD 3

External Ids for GUCY2EP Gene

Previous HGNC Symbols for GUCY2EP Gene

  • GUCY2E

Previous GeneCards Identifiers for GUCY2EP Gene

  • GC11M076392

Summaries for GUCY2EP Gene

Entrez Gene Summary for GUCY2EP Gene

  • This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008]

GeneCards Summary for GUCY2EP Gene

GUCY2EP (Guanylate Cyclase 2E, Pseudogene) is a Pseudogene. Diseases associated with GUCY2EP include Guanylate Cyclase 2E, Pseudogene. Among its related pathways are Sweet Taste Signaling and Visual Cycle in Retinal Rods.

Additional gene information for GUCY2EP Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GUCY2EP Gene

Genomics for GUCY2EP Gene

GeneHancer (GH) Regulatory Elements for GUCY2EP Gene

Promoters and enhancers for GUCY2EP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GUCY2EP on UCSC Golden Path with GeneCards custom track

Genomic Locations for GUCY2EP Gene

Genomic Locations for GUCY2EP Gene
chr11:76,680,166-76,721,789
(GRCh38/hg38)
Size:
41,624 bases
Orientation:
Minus strand
chr11:76,391,210-76,432,833
(GRCh37/hg19)
Size:
41,624 bases
Orientation:
Minus strand

Genomic View for GUCY2EP Gene

Genes around GUCY2EP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY2EP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY2EP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY2EP Gene

Proteins for GUCY2EP Gene

Post-translational modifications for GUCY2EP Gene

No Post-translational modifications

No data available for DME Specific Peptides for GUCY2EP Gene

Domains & Families for GUCY2EP Gene

Gene Families for GUCY2EP Gene

genes like me logo Genes that share domains with GUCY2EP: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GUCY2EP Gene

Function for GUCY2EP Gene

Phenotypes From GWAS Catalog for GUCY2EP Gene

Phenotypes for GUCY2EP Gene

genes like me logo Genes that share phenotypes with GUCY2EP: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GUCY2EP Gene

Localization for GUCY2EP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GUCY2EP Gene

Pathways & Interactions for GUCY2EP Gene

PathCards logo

SuperPathways for GUCY2EP Gene

SuperPathway Contained pathways
1 G-Beta Gamma Signaling
.44
.37
.30
2 Sweet Taste Signaling
.46
.37
3 Nanog in Mammalian ESC Pluripotency
.48
4 CREB Pathway
.50
5 Sertoli-Sertoli Cell Junction Dynamics
.38
genes like me logo Genes that share pathways with GUCY2EP: view

Pathways by source for GUCY2EP Gene

9 Qiagen pathways for GUCY2EP Gene
  • Cellular Effects of Sildenafil
  • CRHR Pathway
  • eNOS Signaling
  • Intracellular Calcium Signaling
  • Relaxin Pathway
;

Gene Ontology (GO) - Biological Process for GUCY2EP Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for GUCY2EP Gene

Drugs & Compounds for GUCY2EP Gene

No Compound Related Data Available

Transcripts for GUCY2EP Gene

mRNA/cDNA for GUCY2EP Gene

1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY2EP Gene

No ASD Table

Relevant External Links for GUCY2EP Gene

GeneLoc Exon Structure for
GUCY2EP

Expression for GUCY2EP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GUCY2EP Gene

mRNA differential expression in normal tissues according to GTEx for GUCY2EP Gene

This gene is overexpressed in Kidney - Cortex (x13.2) and Liver (x10.3).

SOURCE GeneReport for Unigene cluster for GUCY2EP Gene:

Hs.440026
genes like me logo Genes that share expression patterns with GUCY2EP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY2EP Gene

Orthologs for GUCY2EP Gene

Evolution for GUCY2EP Gene

ENSEMBL:
Gene Tree for GUCY2EP (if available)
TreeFam:
Gene Tree for GUCY2EP (if available)

No data available for Orthologs for GUCY2EP Gene

Paralogs for GUCY2EP Gene

No data available for Paralogs for GUCY2EP Gene

Variants for GUCY2EP Gene

Structural Variations from Database of Genomic Variants (DGV) for GUCY2EP Gene

Variant ID Type Subtype PubMed ID
dgv1228n100 CNV loss 25217958
esv1729465 CNV deletion 17803354
esv2675807 CNV deletion 23128226
esv2744793 CNV deletion 23290073
esv2744794 CNV deletion 23290073
esv2744795 CNV deletion 23290073
esv2744797 CNV deletion 23290073
esv2744798 CNV deletion 23290073
esv3548017 CNV deletion 23714750
nsv1047069 CNV gain 25217958
nsv1127211 CNV deletion 24896259
nsv1139514 CNV deletion 24896259
nsv39437 CNV deletion 16902084
nsv509433 CNV insertion 20534489

Additional Variant Information for GUCY2EP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GUCY2EP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for GUCY2EP Gene

Disorders for GUCY2EP Gene

MalaCards: The human disease database

(1) MalaCards diseases for GUCY2EP Gene - From: GeneCards

Disorder Aliases PubMed IDs
guanylate cyclase 2e, pseudogene
  • gucy2ep
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GUCY2EP

genes like me logo Genes that share disorders with GUCY2EP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCY2EP Gene

Publications for GUCY2EP Gene

  1. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PMID: 8838319) Yang RB … Garbers DL (Genomics 1996) 2 3 23 54
  2. Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion. (PMID: 20012162) Karan S … Baehr W (Molecular and cellular biochemistry 2010) 3 54
  3. Comparative genomics search for losses of long-established genes on the human lineage. (PMID: 18085818) Zhu J … Haussler D (PLoS computational biology 2007) 3 54
  4. Degeneration of the olfactory guanylyl cyclase D gene during primate evolution. (PMID: 17849013) Young JM … Liman ER (PloS one 2007) 3 54
  5. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. (PMID: 9153227) Yang RB … Garbers DL (The Journal of biological chemistry 1997) 3 54

Products for GUCY2EP Gene

Sources for GUCY2EP Gene