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GUCY1B2 (Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)) is a Pseudogene. Diseases associated with GUCY1B2 include Lung Cancer. Among its related pathways are Endothelin Pathways and Development Angiotensin activation of ERK.
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. There are two main groups of guanylyl cyclase.
SuperPathway | Contained pathways | ||
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1 | Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 |
Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
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2 | Development Angiotensin activation of ERK |
Development EDNRB signaling
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3 | Endothelin Pathways |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Riociguat | Approved | Pharma | Soluble guanylate cyclase (sGC) stimulator | 51 | ||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Manganese | Approved | Nutra | 56 | |||
Cyclic GMP | Experimental | Pharma | 0 | |||
Guanosine triphosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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pyrophosphate |
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14000-31-8 |
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CFM 1571 hydrochloride |
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1215548-30-3 |
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Compound | Action | Cas Number |
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A 350619 hydrochloride | Soluble guanylyl cyclase (sGC) activator | 1217201-17-6 |
BAY 41-2272 | Soluble guanylyl cyclase (sGC) activator | 256376-24-6 |
BPIPP | Non-competitive GC inhibitor. Also AC inhibitor | 325746-94-9 |
CFM 1571 hydrochloride | Soluble guanylyl cyclase (sGC) activator | 1215548-30-3 |
YC 1 | Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest | 170632-47-0 |
Compound | Action | Cas Number |
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A 350619 hydrochloride | Activator of soluble guanylyl cyclase (sGC) | 1217201-17-6 |
BAY 41-2272 | Activator of soluble guanylyl cyclase (sGC) | 256376-24-6 |
BPIPP | 325746-94-9 | |
Cinaciguat | Soluble guanylate cyclase (sGC) activators | 329773-35-5 |
Guanylin (human) | 183200-12-6 | |
NS 2028 | 204326-43-2 | |
Riociguat | Soluble guanylate cyclase (sGC) stimulator | 625115-55-1 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
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SP1: | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Fruit Fly (Drosophila melanogaster) |
Insecta | CG14886 32 |
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CG4154 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | gcy-35 32 |
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gcy-31 32 |
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gcy-32 32 |
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gcy-34 32 |
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gcy-37 32 |
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SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
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rs11841997 | - | p.Met128Ile | |||
rs1328361 | - | p.Asn316His | |||
rs9568497 | - | p.Tyr55Cys |
Disorder | Aliases | PubMed IDs |
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lung cancer |
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