GUCY1B2 Gene (Pseudogene)

Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)

GC13M050994
GIFtS:
30

Aliases for GUCY1B2 Gene

Aliases for GUCY1B2 Gene

  • Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene) 2 3 5
  • Guanylate Cyclase 1 Solube Subunit Beta 2 (Pseudogene) 2 3
  • EC 4.6.1.2 4 52
  • Guanylate Cyclase 1, Soluble, Beta 2 (Pseudogene) 3
  • Guanylate Cyclase Soluble Subunit Beta-2 4
  • Guanylate Cyclase 1, Soluble, Beta 2 2
  • GCS-Beta-2 4
  • GC-SB2 3

External Ids for GUCY1B2 Gene

Previous GeneCards Identifiers for GUCY1B2 Gene

  • GC13M049568
  • GC13M045556
  • GC13M050505
  • GC13M049366
  • GC13M050466
  • GC13M051568
  • GC13M032357

Summaries for GUCY1B2 Gene

GeneCards Summary for GUCY1B2 Gene

GUCY1B2 (Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)) is a Pseudogene. Diseases associated with GUCY1B2 include Lung Cancer. Among its related pathways are Development Angiotensin activation of ERK and Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2.

Tocris Summary for GUCY1B2 Gene

  • Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. There are two main groups of guanylyl cyclase.

Additional gene information for GUCY1B2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GUCY1B2 Gene

Genomics for GUCY1B2 Gene

GeneHancer (GH) Regulatory Elements for GUCY1B2 Gene

Promoters and enhancers for GUCY1B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH13J051080 Promoter 0.7 Ensembl 525 +0.4 361 1 ZNF341 NFRKB GLIS1 ATF4 GABPB1 L3MBTL2 ZBTB8A ATF2 GUCY1B2 lnc-C13orf42-7 piR-45012-139 piR-46002-154 piR-56759-142 piR-54764-148 piR-55361-147 piR-58156-027
GH13J051070 Enhancer 0.9 Ensembl ENCODE 49.9 +10.5 10461 2 CTCF ZSCAN5C TEAD4 REST RAD21 TRIM22 TEAD1 SMC3 ZBTB17 SMARCA5 GUCY1B2 piR-36393-136 lnc-C13orf42-7 RNA5SP29
GH13J051071 Promoter 0.3 Ensembl 48.7 +13.7 13661 0.4 GUCY1B2 lnc-C13orf42-7 piR-36393-136 RNA5SP29
GH13J051096 Enhancer 0.6 Ensembl ENCODE 11.8 -17.0 -17030 1.8 MAFK JUND CHD7 RBBP5 GUCY1B2 FAM124A NONHSAG013539.2 piR-55596 lnc-C13orf42-1 C13orf42
GH13J051123 Enhancer 1.1 Ensembl ENCODE 5 -43.5 -43539 3.6 CTCF ZSCAN5C KDM6A TCF7 REST CUX1 RAD21 ZBTB7A TRIM22 TEAD1 FAM124A GUCY1B2 RNASEH2B-AS1 piR-55596 lnc-INTS6-7 lnc-C13orf42-1 C13orf42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GUCY1B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GUCY1B2 gene promoter:
  • FOXC1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RORalpha2
  • TBP

Genomic Locations for GUCY1B2 Gene

Genomic Locations for GUCY1B2 Gene
chr13:50,994,511-51,080,862
(GRCh38/hg38)
Size:
86,352 bases
Orientation:
Minus strand
chr13:51,568,647-51,654,998
(GRCh37/hg19)
Size:
86,352 bases
Orientation:
Minus strand

Genomic View for GUCY1B2 Gene

Genes around GUCY1B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY1B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY1B2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GUCY1B2 Gene

Proteins for GUCY1B2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GUCY1B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75343-GCYB2_HUMAN
    Recommended name:
    Guanylate cyclase soluble subunit beta-2
    Protein Accession:
    O75343
    Secondary Accessions:
    • Q9NZ64

    Protein attributes for GUCY1B2 Gene

    Size:
    617 amino acids
    Molecular mass:
    70368 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • Heterodimer of an alpha and a beta chain.
    Miscellaneous:
    • There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

neXtProt entry for GUCY1B2 Gene

Protein Expression for GUCY1B2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GUCY1B2 Gene

O75343:
  • TRDLILLNQQRL
  • YKVETIGDAY
  • PRYCLFGDTVNTASRMES
  • MPRYCLFG

Post-translational modifications for GUCY1B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GUCY1B2 Gene

Gene Families for GUCY1B2 Gene

HGNC:
IUPHAR :

Protein Domains for GUCY1B2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GUCY1B2 Gene

GenScript: Design optimal peptide antigens:
  • Guanylate cyclase soluble subunit beta-2 (GCYB2_HUMAN)
  • Guanylate cyclase 1, soluble, beta 2 (Q5T8J7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75343

UniProtKB/Swiss-Prot:

GCYB2_HUMAN :
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY1B2: view

Function for GUCY1B2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GUCY1B2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by nitric oxide in the presence of magnesium or manganese ions.
GENATLAS Biochemistry:
guanylate cyclase,soluble,beta 2 subunit,expressed in liver and kidney (renal tubules and collecting ducts),inhibiting the nitric oxide (No) stimulated activity of the alpha 1/beta 1 form of guanylate cyclase,maybe involved in the regulation of blood pressure

Enzyme Numbers (IUBMB) for GUCY1B2 Gene

Phenotypes From GWAS Catalog for GUCY1B2 Gene

genes like me logo Genes that share phenotypes with GUCY1B2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GUCY1B2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GUCY1B2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GUCY1B2 Gene

Localization for GUCY1B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY1B2 Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GUCY1B2 Gene

Pathways & Interactions for GUCY1B2 Gene

PathCards logo

SuperPathways for GUCY1B2 Gene

SuperPathway Contained pathways
1 Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
-
2 Development Angiotensin activation of ERK
Development EDNRB signaling
.54
3 Endothelin Pathways
Endothelin Pathways
-
genes like me logo Genes that share pathways with GUCY1B2: view

Pathways by source for GUCY1B2 Gene

1 BioSystems pathway for GUCY1B2 Gene
2 GeneGo (Thomson Reuters) pathways for GUCY1B2 Gene
  • Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
  • Development EDNRB signaling
;

Gene Ontology (GO) - Biological Process for GUCY1B2 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for GUCY1B2 Gene

Drugs & Compounds for GUCY1B2 Gene

Products:

  1. Drug

(14) Drugs for GUCY1B2 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riociguat Approved Pharma Soluble guanylate cyclase (sGC) stimulator 48
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 51
Cyclic GMP Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GUCY1B2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
 14000-31-8

(5) Tocris Compounds for GUCY1B2 Gene

Compound Action Cas Number
A 350619 hydrochloride Soluble guanylyl cyclase (sGC) activator 1217201-17-6
BAY 41-2272 Soluble guanylyl cyclase (sGC) activator 256376-24-6
BPIPP Non-competitive GC inhibitor. Also AC inhibitor 325746-94-9
CFM 1571 hydrochloride Soluble guanylyl cyclase (sGC) activator 1215548-30-3
YC 1 Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest 170632-47-0

(8) ApexBio Compounds for GUCY1B2 Gene

Compound Action Cas Number
A 350619 hydrochloride Activator of soluble guanylyl cyclase (sGC) 1217201-17-6
BAY 41-2272 Activator of soluble guanylyl cyclase (sGC) 256376-24-6
BPIPP 325746-94-9
CFM 1571 hydrochloride sGC activator 1215548-30-3
Cinaciguat Soluble guanylate cyclase (sGC) activators 329773-35-5
Guanylin (human) 183200-12-6
NS 2028 204326-43-2
Riociguat Soluble guanylate cyclase (sGC) stimulator 625115-55-1
genes like me logo Genes that share compounds with GUCY1B2: view

Drug Products

Transcripts for GUCY1B2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GUCY1B2 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GUCY1B2

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: -

Relevant External Links for GUCY1B2 Gene

GeneLoc Exon Structure for
GUCY1B2

Expression for GUCY1B2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GUCY1B2 Gene

mRNA expression in normal human tissues for GUCY1B2 Gene
mRNA expression by BioGPS for GUCY1B2 GenemRNA expression by GTEx for GUCY1B2 Gene

mRNA differential expression in normal tissues according to GTEx for GUCY1B2 Gene

This gene is overexpressed in Spleen (x6.3), Skin - Sun Exposed (Lower leg) (x5.6), and Kidney - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for GUCY1B2 Gene

This gene is overexpressed in Breast (53.8) and Kidney (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GUCY1B2 Gene



Protein tissue co-expression partners for GUCY1B2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GUCY1B2

SOURCE GeneReport for Unigene cluster for GUCY1B2 Gene:

Hs.411573

mRNA Expression by UniProt/SwissProt for GUCY1B2 Gene:

O75343-GCYB2_HUMAN
Tissue specificity: Expressed in gastric signet ring cell carcinoma, but not in the normal stomach.
genes like me logo Genes that share expression patterns with GUCY1B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY1B2 Gene

Orthologs for GUCY1B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY1B2 Gene

Organism Taxonomy Gene Similarity Type Details
fruit fly
(Drosophila melanogaster)
 Insecta CG14886 32
  • 37 (a)
CG4154 32
  • 35 (a)
worm
(Caenorhabditis elegans)
 Secernentea gcy-35 32
  • 38 (a)
gcy-31 32
  • 37 (a)
gcy-32 32
  • 33 (a)
gcy-34 32
  • 32 (a)
gcy-37 32
  • 26 (a)
Species where no ortholog for GUCY1B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for GUCY1B2 Gene

ENSEMBL:
Gene Tree for GUCY1B2 (if available)
TreeFam:
Gene Tree for GUCY1B2 (if available)

Paralogs for GUCY1B2 Gene

(3) SIMAP similar genes for GUCY1B2 Gene using alignment to 1 proteins:

  • GCYB2_HUMAN
genes like me logo Genes that share paralogs with GUCY1B2: view

No data available for Paralogs for GUCY1B2 Gene

Variants for GUCY1B2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GUCY1B2 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs11841997 - p.Met128Ile
rs1328361 - p.Asn316His
rs9568497 - p.Tyr55Cys

Structural Variations from Database of Genomic Variants (DGV) for GUCY1B2 Gene

Variant ID Type Subtype PubMed ID
esv3632075 CNV loss 21293372
nsv478825 CNV novel sequence insertion 20440878
nsv561618 CNV loss 21841781
nsv832610 CNV gain 17160897

Additional Variant Information for GUCY1B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GUCY1B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) and Variation tolerance for GUCY1B2 Gene

Disorders for GUCY1B2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GUCY1B2 Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GUCY1B2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GUCY1B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCY1B2 Gene

Publications for GUCY1B2 Gene

  1. Assignment of GUCY1B2, the gene coding for the beta2 subunit of human guanylyl cyclase to chromosomal band 13q14.3 between markers D13S168 and D13S155. (PMID: 9889008) Behrends S … Eiberg H (Genomics 1999) 2 3 4 54
  2. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. (PMID: 20451256) Djurovic S … Andreassen OA (Journal of affective disorders 2010) 3 41 54
  3. The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma. (PMID: 10777682) Behrends S … Vehse K (Biochemical and biophysical research communications 2000) 3 4 54
  4. Assignment of GUCY1B2, the human homologue of a candidate gene for hypertension, to chromosome bands 13q14.2-->q14.3 by in situ hybridization. (PMID: 10449911) Malterer A … Danziger RS (Cytogenetics and cell genetics 1999) 2 3 54
  5. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. (PMID: 24532677) Bossini-Castillo L … Koeleman BP (Annals of the rheumatic diseases 2015) 3 54

ExternalLinks

View latest publications for GUCY1B2 gene in Mastermind

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