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Aliases for GUCY1B1 Gene

Aliases for GUCY1B1 Gene

  • Guanylate Cyclase 1 Soluble Subunit Beta 1 2 3 5
  • Guanylate Cyclase Soluble Subunit Beta-3 3 4
  • Soluble Guanylate Cyclase Small Subunit 3 4
  • Guanylate Cyclase 1, Soluble, Beta 3 2 3
  • GCS-Beta-1 3 4
  • GCS-Beta-3 3 4
  • GUCY1B3 3 4
  • GUC1B3 3 4
  • GUCSB3 3 4
  • Guanylate Cyclase Soluble Subunit Beta-1 3
  • Guanylate Cyclase 1 Soluble Subunit Beta 2
  • GC-S-Beta-1 3
  • EC 4
  • GC-SB3 3
  • GUCB3 3

External Ids for GUCY1B1 Gene

Previous HGNC Symbols for GUCY1B1 Gene

  • GUC1B3
  • GUCY1B3

Summaries for GUCY1B1 Gene

Entrez Gene Summary for GUCY1B1 Gene

  • This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for GUCY1B1 Gene

GUCY1B1 (Guanylate Cyclase 1 Soluble Subunit Beta 1) is a Protein Coding gene. Among its related pathways are G-Beta Gamma Signaling and NO-dependent CFTR activation (normal and CF). An important paralog of this gene is GUCY1A2.

UniProtKB/Swiss-Prot for GUCY1B1 Gene

  • Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.

Gene Wiki entry for GUCY1B1 Gene

Additional gene information for GUCY1B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY1B1 Gene

Genomics for GUCY1B1 Gene

GeneHancer (GH) Regulatory Elements for GUCY1B1 Gene

Promoters and enhancers for GUCY1B1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J155757 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 655.6 +0.4 409 2.8 HDGF PKNOX1 GLI4 ZNF2 GLIS2 ZNF207 ZNF143 ATF7 FOS SP3 GUCY1B1 LOC105377506 GC04M155710
GH04J155675 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.2 -82.7 -82656 1.5 PKNOX1 INSM2 FEZF1 ZNF2 ZNF335 ZNF366 ZSCAN5C OVOL3 TSHZ1 ZEB2 GUCY1B1 GUCY1A1 ENSG00000260244
GH04J155679 Enhancer 0.7 dbSUPER 11.4 -77.9 -77933 3.4 ZSCAN4 MZF1 ZNF121 ZNF366 ZSCAN5C ZNF350 PRDM10 ZNF600 L3MBTL2 GFI1B GUCY1B1 GUCY1A1 ENSG00000260244
GH04J155628 Enhancer 0.7 Ensembl ENCODE 10.7 -129.5 -129520 1.8 PRDM6 JUN IKZF1 GFI1B MLLT1 GUCY1B1 GUCY1A1 LOC105377504
GH04J155683 Enhancer 0.6 dbSUPER 11.4 -74.5 -74482 2 PKNOX1 USF1 ZNF680 ELF1 NR2F2 FOXM1 PRDM6 CTBP1 GUCY1B1 GUCY1A1 ENSG00000260244
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GUCY1B1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GUCY1B1 Gene

Genomic Locations for GUCY1B1 Gene
48,670 bases
Plus strand
48,658 bases
Plus strand

Genomic View for GUCY1B1 Gene

Genes around GUCY1B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY1B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY1B1 Gene

Proteins for GUCY1B1 Gene

  • Protein details for GUCY1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanylate cyclase soluble subunit beta-1
    Protein Accession:
    Secondary Accessions:
    • B7Z426
    • Q86WY5

    Protein attributes for GUCY1B1 Gene

    619 amino acids
    Molecular mass:
    70514 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1A1 (PubMed:1352257, PubMed:23505436, PubMed:24669844). Can also form inactive homodimers in vitro (PubMed:23505436, PubMed:24669844).
    • There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

    Three dimensional structures from OCA and Proteopedia for GUCY1B1 Gene

    Alternative splice isoforms for GUCY1B1 Gene


neXtProt entry for GUCY1B1 Gene

Post-translational modifications for GUCY1B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GUCY1B1 Gene

Domains & Families for GUCY1B1 Gene

Gene Families for GUCY1B1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY1B1: view

Function for GUCY1B1 Gene

Molecular function for GUCY1B1 Gene

UniProtKB/Swiss-Prot Function:
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by nitric oxide in the presence of magnesium or manganese ions.

Enzyme Numbers (IUBMB) for GUCY1B1 Gene

Gene Ontology (GO) - Molecular Function for GUCY1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IBA,IEA --
GO:0004383 guanylate cyclase activity IEA,IDA 23505436
GO:0005515 protein binding IPI 23505436
GO:0005525 GTP binding IEA --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with GUCY1B1: view
genes like me logo Genes that share phenotypes with GUCY1B1: view

Animal Models for GUCY1B1 Gene

MGI Knock Outs for GUCY1B1:

Animal Model Products

miRNA for GUCY1B1 Gene

miRTarBase miRNAs that target GUCY1B1

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GUCY1B1 Gene

Localization for GUCY1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY1B1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GUCY1B1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GUCY1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA --
GO:0008074 guanylate cyclase complex, soluble IDA 23505436
GO:0048786 presynaptic active zone IEA,IBA --
genes like me logo Genes that share ontologies with GUCY1B1: view

Pathways & Interactions for GUCY1B1 Gene

genes like me logo Genes that share pathways with GUCY1B1: view

Gene Ontology (GO) - Biological Process for GUCY1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006171 cAMP biosynthetic process IEA --
GO:0006182 cGMP biosynthetic process IEA,IDA 23505436
GO:0007165 signal transduction IBA --
GO:0007263 nitric oxide mediated signal transduction TAS 9742212
GO:0008015 blood circulation TAS 9742212
genes like me logo Genes that share ontologies with GUCY1B1: view

No data available for SIGNOR curated interactions for GUCY1B1 Gene

Drugs & Compounds for GUCY1B1 Gene

(15) Drugs for GUCY1B1 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riociguat Approved Pharma Soluble guanylate cyclase (sGC) stimulator 0
Phosphoric acid Approved Pharma 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
Cyclic GMP Experimental Pharma 0

(1) Additional Compounds for GUCY1B1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE

(5) Tocris Compounds for GUCY1B1 Gene

Compound Action Cas Number
A 350619 hydrochloride Soluble guanylyl cyclase (sGC) activator 1217201-17-6
BAY 41-2272 Soluble guanylyl cyclase (sGC) activator 256376-24-6
BPIPP Non-competitive GC inhibitor. Also AC inhibitor 325746-94-9
CFM 1571 hydrochloride Soluble guanylyl cyclase (sGC) activator 1215548-30-3
YC 1 Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest 170632-47-0
genes like me logo Genes that share compounds with GUCY1B1: view

Transcripts for GUCY1B1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1B1 Gene

No ASD Table

Relevant External Links for GUCY1B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCY1B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GUCY1B1 Gene:


mRNA Expression by UniProt/SwissProt for GUCY1B1 Gene:

Tissue specificity: Detected in brain cortex and cerebellum (at protein level).

Evidence on tissue expression from TISSUES for GUCY1B1 Gene

  • Nervous system(4.9)
  • Kidney(4.4)
  • Lung(4.4)
  • Eye(2.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY1B1 Gene

Orthologs for GUCY1B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY1B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GUCY1B3 34 33
  • 99.78 (n)
(Bos Taurus)
Mammalia GUCY1B1 34
  • 99 (a)
GUCY1B3 33
  • 90.41 (n)
(Monodelphis domestica)
Mammalia GUCY1B3 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia GUCY1B3 34
  • 97 (a)
(Canis familiaris)
Mammalia GUCY1B3 34 33
  • 92.84 (n)
(Mus musculus)
Mammalia Gucy1b3 34 33
  • 88.69 (n)
Gucy1b1 16
(Rattus norvegicus)
Mammalia Gucy1b3 33
  • 88.42 (n)
(Gallus gallus)
Aves GUCY1B3 34 33
  • 83.98 (n)
(Anolis carolinensis)
Reptilia GUCY1B3 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy1b3 33
  • 80.53 (n)
(Danio rerio)
Actinopterygii gucy1b3 34 33
  • 77.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gycbeta100B 34 33
  • 58.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000214 33
  • 57.91 (n)
(Caenorhabditis elegans)
Secernentea gcy-34 33
  • 48.04 (n)
gcy-31 34
  • 27 (a)
gcy-37 34
  • 25 (a)
gcy-33 34
  • 18 (a)
acy-3 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Cin.13250 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13250 33
Species where no ortholog for GUCY1B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY1B1 Gene

Gene Tree for GUCY1B1 (if available)
Gene Tree for GUCY1B1 (if available)
Evolutionary constrained regions (ECRs) for GUCY1B1: view image

Paralogs for GUCY1B1 Gene

Paralogs for GUCY1B1 Gene Pseudogenes for GUCY1B1 Gene

genes like me logo Genes that share paralogs with GUCY1B1: view

Variants for GUCY1B1 Gene

Sequence variations from dbSNP and Humsavar for GUCY1B1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000028198 -- 155,767,712(+) C/T intron_variant
rs1000181745 -- 155,789,242(+) A/C intron_variant
rs1000214956 -- 155,795,901(+) A/G intron_variant
rs1000241336 -- 155,788,301(+) A/G intron_variant
rs10003470 -- 155,788,060(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY1B1 Gene

Variant ID Type Subtype PubMed ID
nsv1029122 CNV gain 25217958
nsv521382 CNV loss 19592680
nsv818286 CNV gain 17921354

Variation tolerance for GUCY1B1 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GUCY1B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCY1B1 Gene

Disorders for GUCY1B1 Gene

Additional Disease Information for GUCY1B1

No disorders were found for GUCY1B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GUCY1B1 Gene

Publications for GUCY1B1 Gene

  1. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. (PMID: 1352257) Giuili G … Guellaën G (FEBS letters 1992) 2 3 4 58
  2. Crystal structures of the catalytic domain of human soluble guanylate cyclase. (PMID: 23505436) Allerston CK … Gileadi O (PloS one 2013) 3 4 58
  3. Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction. (PMID: 16528291) Mateos-Cáceres PJ … López-Farré AJ (International journal of impotence research 2006) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Heterogeneity in human soluble guanylate cyclase due to alternative splicing. (PMID: 1680753) Chhajlani V … Wikberg JE (FEBS letters 1991) 3 4 58

Products for GUCY1B1 Gene

Sources for GUCY1B1 Gene

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