Aliases for GUCY1A2 Gene
External Ids for GUCY1A2 Gene
Previous HGNC Symbols for GUCY1A2 Gene
Previous GeneCards Identifiers for GUCY1A2 Gene
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for GUCY1A2 Gene
GUCY1A2 (Guanylate Cyclase 1 Soluble Subunit Alpha 2) is a Protein Coding gene. Diseases associated with GUCY1A2 include Nemaline Myopathy 7. Among its related pathways are G-Beta Gamma Signaling and Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2. Gene Ontology (GO) annotations related to this gene include GTP binding and phosphorus-oxygen lyase activity. An important paralog of this gene is GUCY1A1.
UniProtKB/Swiss-Prot Summary for GUCY1A2 Gene
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. There are two main groups of guanylyl cyclase.