Aliases for GUCA2B Gene
External Ids for GUCA2B Gene
Previous GeneCards Identifiers for GUCA2B Gene
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]
GeneCards Summary for GUCA2B Gene
GUCA2B (Guanylate Cyclase Activator 2B) is a Protein Coding gene. Diseases associated with GUCA2B include Secretory Diarrhea and Colorectal Cancer. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium sensitive guanylate cyclase activator activity and guanylate cyclase activator activity. An important paralog of this gene is GUCA2A.
UniProtKB/Swiss-Prot Summary for GUCA2B Gene
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.