This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestin... See more...

Aliases for GUCA2B Gene

Aliases for GUCA2B Gene

  • Guanylate Cyclase Activator 2B 2 3 4 5
  • Prepro-Uroguanylin 2 3
  • Guanylate Cyclase Activator 2B (Uroguanylin) 2
  • Uroguanylin 3
  • GCAP-II 3
  • UGN 3

External Ids for GUCA2B Gene

Previous GeneCards Identifiers for GUCA2B Gene

  • GC01P042647
  • GC01P041622
  • GC01P042082
  • GC01P042032
  • GC01P042288
  • GC01P042391
  • GC01P042621
  • GC01P040738

Summaries for GUCA2B Gene

Entrez Gene Summary for GUCA2B Gene

  • This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]

GeneCards Summary for GUCA2B Gene

GUCA2B (Guanylate Cyclase Activator 2B) is a Protein Coding gene. Diseases associated with GUCA2B include Secretory Diarrhea and Colorectal Cancer. Among its related pathways are Metabolism and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include calcium sensitive guanylate cyclase activator activity and guanylate cyclase activator activity. An important paralog of this gene is GUCA2A.

UniProtKB/Swiss-Prot Summary for GUCA2B Gene

  • Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Additional gene information for GUCA2B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GUCA2B Gene

Genomics for GUCA2B Gene

GeneHancer (GH) Regulatory Elements for GUCA2B Gene

Promoters and enhancers for GUCA2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J042152 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 500.7 -0.6 -639 1.7 ZNF217 TGIF2 CTBP1 RBM25 FOXA2 NR2F2 ESRRA ZKSCAN1 ESR1 ZBTB33 GUCA2B MG828436
GH01J042333 Promoter/Enhancer 1.8 EPDnew ENCODE CraniofacialAtlas 10.3 +182.1 182056 4.5 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 ZSCAN5C NRF1 TCF12 MYC FOXJ3 lnc-RIMKLA-1 CCDC30 PPIH CLDN19 GUCA2B RNU6-536P ENSG00000236180 ENSG00000228452 YBX1
GH01J041894 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.7 -254.5 -254543 9.6 JUND FOS REST TRIM28 EP300 CTBP1 HINFP RBM25 NR2F2 NCOR1 GUCA2B ENSG00000230638 ENSG00000230881 HIVEP3 piR-59564 piR-47592-001 lnc-HIVEP3-1
GH01J041889 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.7 -261.6 -261618 3.8 SIN3A CTCF RCOR1 RAD21 TRIM22 POLR2A MXI1 RBM25 NCOR1 TCF12 GUCA2B HIVEP3 piR-59564 piR-47592-001 lnc-HIVEP3-1
GH01J042214 Enhancer 1 Ensembl ENCODE 11 +61.0 60990 2.8 TCF12 TCF7 ZBTB25 SKI TEAD1 ZKSCAN8 ZSCAN9 FOXA2 KMT2B NR2F2 GUCA2B ZNF691 P3H1 PPIH PPCS ZMYND12 YBX1 FOXJ3 piR-48553-003 GUCA2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GUCA2B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GUCA2B

Top Transcription factor binding sites by QIAGEN in the GUCA2B gene promoter:
  • AML1a
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • FOXC1
  • MRF-2
  • Pax-5

Genomic Locations for GUCA2B Gene

Genomic Locations for GUCA2B Gene
chr1:42,153,410-42,155,824
(GRCh38/hg38)
Size:
2,415 bases
Orientation:
Plus strand
chr1:42,619,092-42,621,495
(GRCh37/hg19)
Size:
2,404 bases
Orientation:
Plus strand

Genomic View for GUCA2B Gene

Genes around GUCA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCA2B Gene

Proteins for GUCA2B Gene

  • Protein details for GUCA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16661-GUC2B_HUMAN
    Recommended name:
    Guanylate cyclase activator 2B
    Protein Accession:
    Q16661
    Secondary Accessions:
    • Q52LV0

    Protein attributes for GUCA2B Gene

    Size:
    112 amino acids
    Molecular mass:
    12069 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GUCA2B Gene

neXtProt entry for GUCA2B Gene

Post-translational modifications for GUCA2B Gene

No Post-translational modifications

Other Protein References for GUCA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GUCA2B Gene

Domains & Families for GUCA2B Gene

Gene Families for GUCA2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for GUCA2B Gene

Blocks:
  • Guanylin precursor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GUCA2B Gene

GenScript: Design optimal peptide antigens:
  • Guanylate cyclase activator 2B (GUC2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16661

UniProtKB/Swiss-Prot:

GUC2B_HUMAN :
  • Belongs to the guanylin family.
Family:
  • Belongs to the guanylin family.
genes like me logo Genes that share domains with GUCA2B: view

Function for GUCA2B Gene

Molecular function for GUCA2B Gene

UniProtKB/Swiss-Prot Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
GENATLAS Biochemistry:
uroguanylin,guanylate cyclase C binding protein 2B (activator) peptide regulator of intestinal salt and water transport,activating guanylate cyclase C and increasing intracellular cGMP

Phenotypes From GWAS Catalog for GUCA2B Gene

Gene Ontology (GO) - Molecular Function for GUCA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008048 calcium sensitive guanylate cyclase activator activity TAS 8605041
GO:0030250 guanylate cyclase activator activity IBA 21873635
genes like me logo Genes that share ontologies with GUCA2B: view
genes like me logo Genes that share phenotypes with GUCA2B: view

Animal Models for GUCA2B Gene

MGI Knock Outs for GUCA2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for GUCA2B

CRISPR Products

miRNA for GUCA2B Gene

miRTarBase miRNAs that target GUCA2B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GUCA2B Gene

Localization for GUCA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCA2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GUCA2B gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GUCA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0005576 extracellular region TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GUCA2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GUCA2B Gene

Pathways & Interactions for GUCA2B Gene

genes like me logo Genes that share pathways with GUCA2B: view

Pathways by source for GUCA2B Gene

1 BioSystems pathway for GUCA2B Gene
2 Reactome pathways for GUCA2B Gene

Interacting Proteins for GUCA2B Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000361662 Q16661-GUC2B_HUMAN for GUCA2B Gene via STRING IID

;

SIGNOR curated interactions for GUCA2B Gene

Activates:

Gene Ontology (GO) - Biological Process for GUCA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion TAS --
GO:0007588 excretion IEA --
GO:0007589 body fluid secretion IEA --
GO:0019934 cGMP-mediated signaling IEA --
GO:0031284 positive regulation of guanylate cyclase activity IEA --
genes like me logo Genes that share ontologies with GUCA2B: view

Drugs & Compounds for GUCA2B Gene

(9) Drugs for GUCA2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for GUCA2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GUCA2B: view

Transcripts for GUCA2B Gene

mRNA/cDNA for GUCA2B Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCA2B Gene

No ASD Table

Relevant External Links for GUCA2B Gene

GeneLoc Exon Structure for
GUCA2B

Expression for GUCA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GUCA2B Gene

mRNA differential expression in normal tissues according to GTEx for GUCA2B Gene

This gene is overexpressed in Colon - Transverse (x28.9), Small Intestine - Terminal Ileum (x17.5), and Stomach (x4.1).

Protein differential expression in normal tissues from HIPED for GUCA2B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GUCA2B Gene



Protein tissue co-expression partners for GUCA2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GUCA2B

SOURCE GeneReport for Unigene cluster for GUCA2B Gene:

Hs.32966

mRNA Expression by UniProt/SwissProt for GUCA2B Gene:

Q16661-GUC2B_HUMAN
Tissue specificity: Stomach and intestine.

Evidence on tissue expression from TISSUES for GUCA2B Gene

  • Intestine(4.5)
  • Blood(4)
genes like me logo Genes that share expression patterns with GUCA2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCA2B Gene

Orthologs for GUCA2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GUCA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GUCA2B 31 30
  • 99.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GUCA2B 31 30
  • 82.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GUCA2B 31 30
  • 81.85 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Guca2b 17 31 30
  • 75.56 (n)
rat
(Rattus norvegicus)
Mammalia Guca2b 30
  • 74.07 (n)
oppossum
(Monodelphis domestica)
Mammalia GUCA2B 31
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GUCA2B 31
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves GUCA2A 31
  • 38 (a)
OneToOne
Species where no ortholog for GUCA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GUCA2B Gene

ENSEMBL:
Gene Tree for GUCA2B (if available)
TreeFam:
Gene Tree for GUCA2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GUCA2B: view image

Paralogs for GUCA2B Gene

Paralogs for GUCA2B Gene

(1) SIMAP similar genes for GUCA2B Gene using alignment to 1 proteins:

  • GUC2B_HUMAN
genes like me logo Genes that share paralogs with GUCA2B: view

Variants for GUCA2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GUCA2B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2297567 - p.Pro11Thr

Additional dbSNP identifiers (rs#s) for GUCA2B Gene

Structural Variations from Database of Genomic Variants (DGV) for GUCA2B Gene

Variant ID Type Subtype PubMed ID
nsv527531 CNV loss 19592680

Variation tolerance for GUCA2B Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GUCA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GUCA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCA2B Gene

Disorders for GUCA2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GUCA2B Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
secretory diarrhea
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GUCA2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GUCA2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCA2B Gene

Publications for GUCA2B Gene

  1. Genomic structure and chromosomal localization of human uroguanylin. (PMID: 9268639) Miyazato M … Matsuo H (Genomics 1997) 2 3 4 23 54
  2. Cloning and characterization of a cDNA encoding a precursor for human uroguanylin. (PMID: 8605041) Miyazato M … Matsukura S (Biochemical and biophysical research communications 1996) 2 3 4 23 54
  3. [Association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis]. (PMID: 17582287) Guo HF … Wang JG (Zhonghua xin xue guan bing za zhi 2007) 3 23 41 54
  4. Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension. (PMID: 18037771) Yoshikawa Y … Usami R (Hypertension research : official journal of the Japanese Society of Hypertension 2007) 3 23 41 54
  5. One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers. (PMID: 9774236) Marx UC … Adermann K (The journal of peptide research : official journal of the American Peptide Society 1998) 3 4 23 54

Products for GUCA2B Gene

Sources for GUCA2B Gene