Aliases for GUCA2A Gene

Aliases for GUCA2A Gene

  • Guanylate Cyclase Activator 2A 2 3 4 5
  • Guanylate Cyclase-Activating Protein 1 3 4
  • Guanylate Cyclase-Activating Protein I 3 4
  • Prepro-Guanylin 2 3
  • Guanylin 3 4
  • GCAP-I 3 4
  • GUCA2 3 4
  • STARA 2 3
  • Guanylate Cyclase Activator 2A (Guanylin 2, Intestinal, Heat-Stable) 3
  • Guanylate Cyclase Activator 2A (Guanylin) 2
  • GUCA2A 5

External Ids for GUCA2A Gene

Previous HGNC Symbols for GUCA2A Gene

  • GUCA2

Previous GeneCards Identifiers for GUCA2A Gene

  • GC01M042656
  • GC01M041631
  • GC01M042091
  • GC01M042041
  • GC01M042297
  • GC01M042400
  • GC01M042628
  • GC01M040747

Summaries for GUCA2A Gene

GeneCards Summary for GUCA2A Gene

GUCA2A (Guanylate Cyclase Activator 2A) is a Protein Coding gene. Diseases associated with GUCA2A include Large Intestine Adenoma and Osmotic Diarrhea. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Metabolism. Gene Ontology (GO) annotations related to this gene include hormone activity and guanylate cyclase activator activity. An important paralog of this gene is GUCA2B.

UniProtKB/Swiss-Prot Summary for GUCA2A Gene

  • Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

Additional gene information for GUCA2A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GUCA2A Gene

Genomics for GUCA2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GUCA2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J042164 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.7 -1.7 -1656 5.2 ARHGAP35 GATAD2A PRDM10 ZNF692 TARDBP ZNF300 FOXA1 PRDM1 ZIC2 ZNF776 GUCA2A PPIH FOXJ3 P3H1 CCDC30 ZNF691 ENSG00000227527 MN309174-004
GH01J042177 Enhancer 1.1 Ensembl ENCODE 0.4 -13.8 -13755 3.8 CTCF PRDM10 ZNF629 ZNF692 PRDM1 ZNF143 ZIC2 ZNF776 ZSCAN4 PATZ1 FOXJ3 ZNF691 P3H1 PPIH GUCA2A MN309174-004
GH01J042170 Enhancer 0.8 ENCODE 0.4 -8.7 -8709 5.8 CEBPG CTCF SOX13 ZNF692 ZNF7 ZNF143 ZIC2 ZSCAN4 PKNOX1 RXRB FOXJ3 C1orf50 SVBP RIMKLA GUCA2A MN309174-004
GH01J042214 Enhancer 1 Ensembl ENCODE 0.3 -49.7 -49655 2.8 GATAD2A TFE3 SOX13 RCOR2 FOXA1 RXRB IRF2 SP1 GABPA CEBPA GUCA2B ZNF691 P3H1 PPIH PPCS ZMYND12 YBX1 FOXJ3 MN309174-004 GUCA2A
GH01J042185 Enhancer 0.7 Ensembl ENCODE 0.4 -20.4 -20363 3.8 JUND PCBP1 NR2F6 JUN TEAD4 ZNF362 CBFA2T2 GATA2 CBFA2T3 FOXJ3 SVBP GUCA2A MN309174-004
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GUCA2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GUCA2A

Top Transcription factor binding sites by QIAGEN in the GUCA2A gene promoter:
  • Evi-1
  • FOXC1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Pax-5
  • S8
  • SRY
  • Zic3

Genomic Locations for GUCA2A Gene

Genomic Locations for GUCA2A Gene
chr1:42,162,690-42,164,745
(GRCh38/hg38)
Size:
2,056 bases
Orientation:
Minus strand
chr1:42,628,362-42,630,395
(GRCh37/hg19)
Size:
2,034 bases
Orientation:
Minus strand

Genomic View for GUCA2A Gene

Genes around GUCA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCA2A Gene

Proteins for GUCA2A Gene

  • Protein details for GUCA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02747-GUC2A_HUMAN
    Recommended name:
    Guanylin
    Protein Accession:
    Q02747

    Protein attributes for GUCA2A Gene

    Size:
    115 amino acids
    Molecular mass:
    12388 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GUCA2A Gene

neXtProt entry for GUCA2A Gene

Post-translational modifications for GUCA2A Gene

No Post-translational modifications

Other Protein References for GUCA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GUCA2A Gene

Domains & Families for GUCA2A Gene

Gene Families for GUCA2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for GUCA2A Gene

InterPro:
Blocks:
  • Guanylin precursor signature
ProtoNet:

Suggested Antigen Peptide Sequences for GUCA2A Gene

GenScript: Design optimal peptide antigens:
  • Guanylate cyclase-activating protein I (GUC2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q02747

UniProtKB/Swiss-Prot:

GUC2A_HUMAN :
  • Belongs to the guanylin family.
Family:
  • Belongs to the guanylin family.
genes like me logo Genes that share domains with GUCA2A: view

Function for GUCA2A Gene

Molecular function for GUCA2A Gene

UniProtKB/Swiss-Prot Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
GENATLAS Biochemistry:
guanylin,cyclase C binding protein 2A,increasing intracellular cGMP

Gene Ontology (GO) - Molecular Function for GUCA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity NAS 7947768
GO:0030250 guanylate cyclase activator activity NAS 8095028
genes like me logo Genes that share ontologies with GUCA2A: view
genes like me logo Genes that share phenotypes with GUCA2A: view

Animal Models for GUCA2A Gene

MGI Knock Outs for GUCA2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for GUCA2A

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GUCA2A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GUCA2A Gene

Localization for GUCA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCA2A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GUCA2A gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GUCA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with GUCA2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GUCA2A Gene

Pathways & Interactions for GUCA2A Gene

genes like me logo Genes that share pathways with GUCA2A: view

Pathways by source for GUCA2A Gene

1 BioSystems pathway for GUCA2A Gene
2 Reactome pathways for GUCA2A Gene

Interacting Proteins for GUCA2A Gene

SIGNOR curated interactions for GUCA2A Gene

Activates:

Gene Ontology (GO) - Biological Process for GUCA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007586 digestion TAS --
GO:0031284 positive regulation of guanylate cyclase activity IEA --
genes like me logo Genes that share ontologies with GUCA2A: view

Drugs & Compounds for GUCA2A Gene

(17) Drugs for GUCA2A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for GUCA2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GUCA2A: view

Transcripts for GUCA2A Gene

mRNA/cDNA for GUCA2A Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GUCA2A

Alternative Splicing Database (ASD) splice patterns (SP) for GUCA2A Gene

No ASD Table

Relevant External Links for GUCA2A Gene

GeneLoc Exon Structure for
GUCA2A

Expression for GUCA2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GUCA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GUCA2A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x26.8) and Colon - Transverse (x25.0).

Protein differential expression in normal tissues from HIPED for GUCA2A Gene

This gene is overexpressed in Urine (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GUCA2A Gene



Protein tissue co-expression partners for GUCA2A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GUCA2A

SOURCE GeneReport for Unigene cluster for GUCA2A Gene:

Hs.778

mRNA Expression by UniProt/SwissProt for GUCA2A Gene:

Q02747-GUC2A_HUMAN
Tissue specificity: Highly expressed in ileum and colon. Found in plasma.

Evidence on tissue expression from TISSUES for GUCA2A Gene

  • Intestine(4.7)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with GUCA2A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCA2A Gene

Orthologs for GUCA2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GUCA2A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GUCA2A 30 31
  • 99.13 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GUCA2A 30 31
  • 81.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GUCA2A 30 31
  • 75.84 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Guca2a 30 17 31
  • 75.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Guca2a 30
  • 74.2 (n)
Oppossum
(Monodelphis domestica)
Mammalia GUCA2A 31
  • 57 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GUCA2A 31
  • 48 (a)
OneToOne
Species where no ortholog for GUCA2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for GUCA2A Gene

ENSEMBL:
Gene Tree for GUCA2A (if available)
TreeFam:
Gene Tree for GUCA2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GUCA2A: view image

Paralogs for GUCA2A Gene

Paralogs for GUCA2A Gene

(1) SIMAP similar genes for GUCA2A Gene using alignment to 1 proteins:

  • GUC2A_HUMAN
genes like me logo Genes that share paralogs with GUCA2A: view

Variants for GUCA2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GUCA2A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2071499 - p.Ser7Phe

Additional dbSNP identifiers (rs#s) for GUCA2A Gene

Structural Variations from Database of Genomic Variants (DGV) for GUCA2A Gene

Variant ID Type Subtype PubMed ID
nsv527531 CNV loss 19592680

Variation tolerance for GUCA2A Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GUCA2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GUCA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCA2A Gene

Disorders for GUCA2A Gene

MalaCards: The human disease database

(10) MalaCards diseases for GUCA2A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
large intestine adenoma
  • adenoma of large intestine
osmotic diarrhea
anismus
secretory diarrhea
cystic fibrosis
  • cf
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with GUCA2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCA2A Gene

Publications for GUCA2A Gene

  1. Analysis of the human guanylin gene and the processing and cellular localization of the peptide. (PMID: 7892222) Hill O … Mägert HJ (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 23
  2. Human guanylin: cDNA isolation, structure, and activity. (PMID: 1327879) Wiegand RC … Currie MG (FEBS letters 1992) 2 3 4 23
  3. Solution structure of human proguanylin: the role of a hormone prosequence. (PMID: 12707255) Lauber T … Marx UC (The Journal of biological chemistry 2003) 3 4 23
  4. The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kDa). (PMID: 8095028) Kuhn M … Forssmann WG (FEBS letters 1993) 3 4 23
  5. Precursor structure, expression, and tissue distribution of human guanylin. (PMID: 1409606) de Sauvage FJ … Goeddel DV (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 23

Products for GUCA2A Gene

  • Signalway ELISA kits for GUCA2A

Sources for GUCA2A Gene