Aliases for GTSE1 Gene
External Ids for GTSE1 Gene
Previous GeneCards Identifiers for GTSE1 Gene
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for GTSE1 Gene
GTSE1 (G2 And S-Phase Expressed 1) is a Protein Coding gene. Diseases associated with GTSE1 include Candidal Paronychia and Interstitial Emphysema. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. An important paralog of this gene is PSRC1.
UniProtKB/Swiss-Prot Summary for GTSE1 Gene
May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.