The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul ... See more...

Aliases for GTSE1 Gene

Aliases for GTSE1 Gene

  • G2 And S-Phase Expressed 1 2 3 5
  • G2 And S Phase-Expressed Protein 1 3 4
  • G-2 And S-Phase Expressed 1 2 3
  • Protein B99 Homolog 3 4
  • GTSE-1 4
  • B99 3

External Ids for GTSE1 Gene

Previous GeneCards Identifiers for GTSE1 Gene

  • GC22P043259
  • GC22P044905
  • GC22P045013
  • GC22P045071
  • GC22P046692
  • GC22P029636

Summaries for GTSE1 Gene

Entrez Gene Summary for GTSE1 Gene

  • The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTSE1 Gene

GTSE1 (G2 And S-Phase Expressed 1) is a Protein Coding gene. Diseases associated with GTSE1 include Candidal Paronychia and Interstitial Emphysema. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. An important paralog of this gene is PSRC1.

UniProtKB/Swiss-Prot Summary for GTSE1 Gene

  • May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

Gene Wiki entry for GTSE1 Gene

Additional gene information for GTSE1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTSE1 Gene

Genomics for GTSE1 Gene

GeneHancer (GH) Regulatory Elements for GTSE1 Gene

Promoters and enhancers for GTSE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J046294 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.7 718 3.7 ZBTB40 ZNF217 SIN3A NRF1 POLR2G SP1 SIX5 ZFX ZNF639 ZIC2 GTSE1 GTSE1-DT piR-56587 TTC38 PKDREJ CDPF1 TRMU KR153194-123 lnc-CDPF1-1
GH22J046096 Promoter/Enhancer 1.6 EPDnew FANTOM5 ENCODE dbSUPER 500.1 -192.1 -192084 14.9 POLR2G NCOR1 ZIC2 ZBTB10 TCF7 ZBTB7A SKI TEAD1 MXI1 ZNF341 GTSE1 MIRLET7BHG PPARA PRR34 MIRLET7A3 MIR3619
GH22J046328 Promoter 0.3 EPDnew 500.3 +32.9 32866 0.1 TRMU lnc-TRMU-1 GTSE1 CELSR1 ENSG00000234869 PPARA KR153194-123 lnc-CDPF1-1
GH22J046303 Enhancer 0.6 Ensembl ENCODE 0.4 +7.6 7635 1.3 FOS ZNF362 PRDM10 ZNF600 KR153194-123 TTC38 PKDREJ GTSE1 lnc-TRMU-1 TRMU lnc-CDPF1-1
GH22J046314 Enhancer 0.7 ENCODE 0.4 +18.4 18445 0.2 CTCF MYC USF1 REST RAD21 TRIM22 SMC3 ZNF282 MAX E2F6 TTC38 PKDREJ CDPF1 PPARA KR153194-123 lnc-TRMU-1 GTSE1 TRMU lnc-CDPF1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTSE1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GTSE1

Top Transcription factor binding sites by QIAGEN in the GTSE1 gene promoter:
  • AML1a
  • AP-4
  • Arnt
  • Bach2
  • c-Myb
  • E47
  • NCX
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1

Genomic Locations for GTSE1 Gene

Genomic Locations for GTSE1 Gene
chr22:46,296,014-46,333,699
(GRCh38/hg38)
Size:
37,686 bases
Orientation:
Plus strand
chr22:46,692,638-46,726,707
(GRCh37/hg19)
Size:
34,070 bases
Orientation:
Plus strand

Genomic View for GTSE1 Gene

Genes around GTSE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTSE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTSE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTSE1 Gene

Proteins for GTSE1 Gene

  • Protein details for GTSE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYZ3-GTSE1_HUMAN
    Recommended name:
    G2 and S phase-expressed protein 1
    Protein Accession:
    Q9NYZ3
    Secondary Accessions:
    • B0QYM3
    • Q20WK2
    • Q53GX5
    • Q5R3I6
    • Q6DHX4
    • Q9BRE0
    • Q9UGZ9
    • Q9Y557

    Protein attributes for GTSE1 Gene

    Size:
    720 amino acids
    Molecular mass:
    76645 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GTSE1 Gene

neXtProt entry for GTSE1 Gene

Post-translational modifications for GTSE1 Gene

Other Protein References for GTSE1 Gene

No data available for DME Specific Peptides for GTSE1 Gene

Domains & Families for GTSE1 Gene

Gene Families for GTSE1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GTSE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GTSE1 Gene

GenScript: Design optimal peptide antigens:
  • Protein B99 homolog (GTSE1_HUMAN)
genes like me logo Genes that share domains with GTSE1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GTSE1 Gene

Function for GTSE1 Gene

Molecular function for GTSE1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

Phenotypes From GWAS Catalog for GTSE1 Gene

Gene Ontology (GO) - Molecular Function for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 20577264
genes like me logo Genes that share ontologies with GTSE1: view
genes like me logo Genes that share phenotypes with GTSE1: view

Animal Model Products

CRISPR Products

miRNA for GTSE1 Gene

miRTarBase miRNAs that target GTSE1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTSE1

Clone Products

  • Addgene plasmids for GTSE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTSE1 Gene

Localization for GTSE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTSE1 Gene

Cytoplasm, cytoskeleton. Note=Associated with microtubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTSE1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with GTSE1: view

Pathways & Interactions for GTSE1 Gene

genes like me logo Genes that share pathways with GTSE1: view

Pathways by source for GTSE1 Gene

1 KEGG pathway for GTSE1 Gene

SIGNOR curated interactions for GTSE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GTSE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest NAS 10974554
GO:0007017 microtubule-based process NAS 10974554
GO:0030335 positive regulation of cell migration TAS --
GO:0046827 positive regulation of protein export from nucleus TAS --
GO:0050821 protein stabilization TAS --
genes like me logo Genes that share ontologies with GTSE1: view

Drugs & Compounds for GTSE1 Gene

No Compound Related Data Available

Transcripts for GTSE1 Gene

mRNA/cDNA for GTSE1 Gene

1 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTSE1

Clone Products

  • Addgene plasmids for GTSE1

Alternative Splicing Database (ASD) splice patterns (SP) for GTSE1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2:
SP3: - - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for GTSE1 Gene

GeneLoc Exon Structure for
GTSE1

Expression for GTSE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTSE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GTSE1 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for GTSE1 Gene

This gene is overexpressed in Brain (29.9), Liver, secretome (22.0), and Pancreatic juice (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTSE1 Gene



Protein tissue co-expression partners for GTSE1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTSE1

SOURCE GeneReport for Unigene cluster for GTSE1 Gene:

Hs.386189

Evidence on tissue expression from TISSUES for GTSE1 Gene

  • Nervous system(4.8)
  • Liver(4.1)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with GTSE1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTSE1 Gene

Orthologs for GTSE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTSE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTSE1 31 30
  • 98.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTSE1 31 30
  • 72.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gtse1 17 31 30
  • 69.41 (n)
rat
(Rattus norvegicus)
Mammalia Gtse1 30
  • 68.81 (n)
cow
(Bos Taurus)
Mammalia GTSE1 31
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTSE1 31
  • 40 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTSE1 31
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTSE1 31 30
  • 49.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTSE1 31
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtse1 30
  • 49.17 (n)
Str.2510 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.17513 30
zebrafish
(Danio rerio)
Actinopterygii gtse1 31
  • 27 (a)
OneToOne
Species where no ortholog for GTSE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTSE1 Gene

ENSEMBL:
Gene Tree for GTSE1 (if available)
TreeFam:
Gene Tree for GTSE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTSE1: view image

Paralogs for GTSE1 Gene

Paralogs for GTSE1 Gene

genes like me logo Genes that share paralogs with GTSE1: view

Variants for GTSE1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GTSE1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
707839 Benign: not provided 46,308,730(+) C/G SYNONYMOUS_VARIANT
720064 Likely Benign: not provided 46,316,124(+) C/T MISSENSE_VARIANT
726835 Likely Benign: not provided 46,312,259(+) G/A MISSENSE_VARIANT
736730 Benign: not provided 46,297,440(+) C/G MISSENSE_VARIANT
777735 Benign: not provided 46,308,142(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GTSE1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTSE1 Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
esv2758844 CNV gain+loss 17122850
esv3568458 CNV loss 25503493
esv3568459 CNV loss 25503493
esv3647951 CNV loss 21293372
nsv1066139 CNV gain 25217958
nsv1139073 CNV deletion 24896259
nsv1152661 OTHER inversion 26484159
nsv428393 CNV gain 18775914
nsv471214 CNV loss 18288195
nsv525512 CNV loss 19592680
nsv589136 CNV gain 21841781
nsv829281 CNV gain 20364138
nsv829293 CNV gain 20364138
nsv834225 CNV loss 17160897

Variation tolerance for GTSE1 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTSE1 Gene

Human Gene Mutation Database (HGMD)
GTSE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTSE1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTSE1 Gene

Disorders for GTSE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GTSE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
candidal paronychia
  • candidiasis of skin
interstitial emphysema
enterobiasis
  • enterobius vermicularis infection
- elite association - COSMIC cancer census association via MalaCards
Search GTSE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GTSE1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GTSE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTSE1 Gene

Publications for GTSE1 Gene

  1. Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene. (PMID: 10974554) Monte M … Schneider C (Gene 2000) 2 3 4 23 54
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41 54
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for GTSE1 Gene

Sources for GTSE1 Gene