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Aliases for GTPBP6 Gene

Aliases for GTPBP6 Gene

  • GTP Binding Protein 6 (Putative) 2 3 5
  • PGPL 3 4
  • Pseudoautosomal GTP-Binding Protein-Like 4
  • Pseudoautosomal GTP Binding Protein-Like 2
  • Putative GTP-Binding Protein 6 3

External Ids for GTPBP6 Gene

Previous GeneCards Identifiers for GTPBP6 Gene

  • GC0YM000160
  • GC0XM000161
  • GC00U931416

Summaries for GTPBP6 Gene

Entrez Gene Summary for GTPBP6 Gene

  • This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. [provided by RefSeq, Nov 2011]

GeneCards Summary for GTPBP6 Gene

GTPBP6 (GTP Binding Protein 6 (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding.

Gene Wiki entry for GTPBP6 Gene

Additional gene information for GTPBP6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTPBP6 Gene

Genomics for GTPBP6 Gene

GeneHancer (GH) Regulatory Elements for GTPBP6 Gene

Promoters and enhancers for GTPBP6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ000317 Promoter 0.7 Ensembl 650.7 -0.4 -382 3.2 L3MBTL2 MLLT1 LINC00685 GTPBP6 GC0XP000380
GH0XJ000373 Promoter/Enhancer 1.2 Ensembl dbSUPER 12.7 -55.0 -54982 0.8 MXI1 PKNOX1 USF1 SAP130 SUZ12 DMAP1 KMT2B ZNF48 ZNF335 CTBP1 LINC00685 GTPBP6 GC0XP000380 PPP2R3B
GH0XJ000367 Enhancer 0.8 Ensembl dbSUPER 13.2 -51.1 -51059 3.9 ZIC2 ZNF316 GLIS2 POLR2A NFE2 ZBTB33 MAFK EMSY GTPBP6 LINC00685 GC0XP000380 PPP2R3B
GH0XJ000372 Enhancer 0.5 Ensembl dbSUPER 13.2 -53.4 -53382 0.4 MGA GTPBP6 LINC00685 GC0XP000380 PPP2R3B
GH0XJ000356 Enhancer 0.5 Ensembl 11 -38.6 -38582 1.6 POLR2A JUN ZNF629 ZNF548 IL3RA GTPBP6 GC0XP000380 PPP2R3B LINC00685
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTPBP6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTPBP6 gene promoter:
  • Brachyury
  • CRE-BP1
  • ATF-2
  • HEN1
  • CREB

Genomic Locations for GTPBP6 Gene

Genomic Locations for GTPBP6 Gene
15,463 bases
Minus strand
10,863 bases
Minus strand

Genomic View for GTPBP6 Gene

Genes around GTPBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTPBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTPBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTPBP6 Gene

Proteins for GTPBP6 Gene

  • Protein details for GTPBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative GTP-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • H0Y2S1
    • Q53F77
    • Q5HYX8

    Protein attributes for GTPBP6 Gene

    516 amino acids
    Molecular mass:
    56897 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    • Sequence=AAH14636.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD97132.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA74749.2; Type=Frameshift; Positions=64; Evidence={ECO:0000305};

neXtProt entry for GTPBP6 Gene

Post-translational modifications for GTPBP6 Gene

  • Ubiquitination at Lys509 and isoforms=155
  • Modification sites at PhosphoSitePlus

Other Protein References for GTPBP6 Gene

No data available for DME Specific Peptides for GTPBP6 Gene

Domains & Families for GTPBP6 Gene

Gene Families for GTPBP6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GTPBP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
genes like me logo Genes that share domains with GTPBP6: view

Function for GTPBP6 Gene

Gene Ontology (GO) - Molecular Function for GTPBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
GO:0043022 ribosome binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GTPBP6: view
genes like me logo Genes that share phenotypes with GTPBP6: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GTPBP6 Gene

Localization for GTPBP6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTPBP6 gene
Compartment Confidence
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GTPBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with GTPBP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GTPBP6 Gene

Pathways & Interactions for GTPBP6 Gene

SuperPathways for GTPBP6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GTPBP6 Gene


No data available for Pathways by source and SIGNOR curated interactions for GTPBP6 Gene

Drugs & Compounds for GTPBP6 Gene

(1) Drugs for GTPBP6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GTPBP6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTPBP6: view

Transcripts for GTPBP6 Gene

Unigene Clusters for GTPBP6 Gene

GTP binding protein 6 (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTPBP6 Gene

No ASD Table

Relevant External Links for GTPBP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTPBP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTPBP6 Gene

Protein differential expression in normal tissues from HIPED for GTPBP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.6), Blymphocyte (10.6), Pancreas (9.6), and Ovary (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTPBP6 Gene

Protein tissue co-expression partners for GTPBP6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTPBP6 Gene:


SOURCE GeneReport for Unigene cluster for GTPBP6 Gene:


mRNA Expression by UniProt/SwissProt for GTPBP6 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for GTPBP6 Gene

  • Muscle(4.2)
  • Nervous system(2.8)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with GTPBP6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTPBP6 Gene

Orthologs for GTPBP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTPBP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GTPBP6 34 33
  • 78.71 (n)
(Bos Taurus)
Mammalia GTPBP6 33
  • 77.69 (n)
(Mus musculus)
Mammalia Gtpbp6 16 34 33
  • 68.26 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
-- 34
  • 37 (a)
(Monodelphis domestica)
Mammalia GTPBP6 34
  • 46 (a)
(Gallus gallus)
Aves GTPBP6 34 33
  • 64.97 (n)
(Anolis carolinensis)
Reptilia GTPBP6 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtpbp6 33
  • 62.19 (n)
(Danio rerio)
Actinopterygii wu:fc56b07 33
  • 62.05 (n)
gtpbp6 34
  • 35 (a)
wufl82e09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13061 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003969 33
  • 53.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5116 34 33
  • 50.4 (n)
(Caenorhabditis elegans)
Secernentea F46B6.4 34 33
  • 45.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5044 34
  • 28 (a)
Species where no ortholog for GTPBP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTPBP6 Gene

Gene Tree for GTPBP6 (if available)
Gene Tree for GTPBP6 (if available)
Evolutionary constrained regions (ECRs) for GTPBP6: view image

Paralogs for GTPBP6 Gene

No data available for Paralogs for GTPBP6 Gene

Variants for GTPBP6 Gene

Sequence variations from dbSNP and Humsavar for GTPBP6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000079997 -- 307,386(-) A/G coding_sequence_variant, synonymous_variant
rs1000157476 -- 310,832(-) A/G intron_variant
rs1000637681 -- 310,951(-) G/C intron_variant
rs1000675767 -- 306,377(-) C/T intron_variant
rs1001171690 -- 306,183(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GTPBP6 Gene

Variant ID Type Subtype PubMed ID
esv2352842 CNV deletion 18987734
esv2673995 CNV deletion 23128226
esv27600 CNV gain+loss 19812545
esv2969346 CNV duplication 24192839
nsv1077604 CNV duplication 25765185
nsv1132797 CNV duplication 24896259
nsv1140084 CNV duplication 24896259
nsv1147800 CNV duplication 26484159
nsv1153299 CNV duplication 26484159

Variation tolerance for GTPBP6 Gene

Gene Damage Index Score: 5.28; 70.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTPBP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTPBP6 Gene

Disorders for GTPBP6 Gene

Additional Disease Information for GTPBP6

No disorders were found for GTPBP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTPBP6 Gene

Publications for GTPBP6 Gene

  1. A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. (PMID: 9466997) Gianfrancesco F … Forabosco A (Human molecular genetics 1998) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for GTPBP6 Gene

Sources for GTPBP6 Gene

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