Aliases for GTPBP4 Gene
External Ids for GTPBP4 Gene
Previous GeneCards Identifiers for GTPBP4 Gene
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]
GeneCards Summary for GTPBP4 Gene
GTPBP4 (GTP Binding Protein 4) is a Protein Coding gene. Diseases associated with GTPBP4 include Melanomatosis and Meningeal Melanomatosis. Among its related pathways are Ribosome biogenesis in eukaryotes. Gene Ontology (GO) annotations related to this gene include GTPase activity. An important paralog of this gene is MTG2.
UniProtKB/Swiss-Prot Summary for GTPBP4 Gene
Involved in the biogenesis of the 60S ribosomal subunit.