Aliases for GTF3C6 Gene
External Ids for GTF3C6 Gene
Previous HGNC Symbols for GTF3C6 Gene
Previous GeneCards Identifiers for GTF3C6 Gene
RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]
GeneCards Summary for GTF3C6 Gene
GTF3C6 (General Transcription Factor IIIC Subunit 6) is a Protein Coding gene. Diseases associated with GTF3C6 include Contagious Pustular Dermatitis and Cleft Palate With Or Without Ankyloglossia, X-Linked. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation.
UniProtKB/Swiss-Prot Summary for GTF3C6 Gene
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.