Aliases for GTF3C5 Gene

Aliases for GTF3C5 Gene

  • General Transcription Factor IIIC Subunit 5 2 3 5
  • General Transcription Factor IIIC, Polypeptide 5, 63kDa 2 3
  • General Transcription Factor 3C Polypeptide 5 3 4
  • Transcription Factor IIIC Subunit Epsilon 3 4
  • Transcription Factor IIIC 63 KDa Subunit 3 4
  • Transcription Factor IIIC, 63 KD 2 3
  • TFIIIC 63 KDa Subunit 3 4
  • TF3C-Epsilon 3 4
  • TFIIIC63 3 4
  • General Transcription Factor IIIC, Polypeptide 5 (63kD) 2
  • TFIIICepsilon 3
  • TFiiiC2-63 3

External Ids for GTF3C5 Gene

Previous GeneCards Identifiers for GTF3C5 Gene

  • GC09P126930
  • GC09P127462
  • GC09P129259
  • GC09P131182
  • GC09P132935
  • GC09P134895
  • GC09P135906
  • GC09P105399

Summaries for GTF3C5 Gene

GeneCards Summary for GTF3C5 Gene

GTF3C5 (General Transcription Factor IIIC Subunit 5) is a Protein Coding gene. Diseases associated with GTF3C5 include Cataract 31, Multiple Types. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression.

UniProtKB/Swiss-Prot Summary for GTF3C5 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Gene Wiki entry for GTF3C5 Gene

Additional gene information for GTF3C5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF3C5 Gene

Genomics for GTF3C5 Gene

GeneHancer (GH) Regulatory Elements for GTF3C5 Gene

Promoters and enhancers for GTF3C5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF3C5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GTF3C5

Top Transcription factor binding sites by QIAGEN in the GTF3C5 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Cart-1
  • E47
  • GCNF-2
  • NF-1
  • Tal-1beta
  • TBP

Genomic Locations for GTF3C5 Gene

Genomic Locations for GTF3C5 Gene
chr9:133,030,675-133,058,503
(GRCh38/hg38)
Size:
27,829 bases
Orientation:
Plus strand
chr9:135,906,062-135,933,890
(GRCh37/hg19)
Size:
27,829 bases
Orientation:
Plus strand

Genomic View for GTF3C5 Gene

Genes around GTF3C5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C5 Gene

Proteins for GTF3C5 Gene

  • Protein details for GTF3C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q8-TF3C5_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 5
    Protein Accession:
    Q9Y5Q8
    Secondary Accessions:
    • A6NI44
    • A6NJB9
    • Q5T7U2
    • Q5T7U3
    • Q8N2U7
    • Q8N857
    • Q96GD9
    • Q9H4P2

    Protein attributes for GTF3C5 Gene

    Size:
    519 amino acids
    Molecular mass:
    59571 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP.

    Alternative splice isoforms for GTF3C5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C5 Gene

Post-translational modifications for GTF3C5 Gene

  • Ubiquitination at Lys38, Lys256, and Lys367
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GTF3C5 Gene

Domains & Families for GTF3C5 Gene

Gene Families for GTF3C5 Gene

Protein Domains for GTF3C5 Gene

Suggested Antigen Peptide Sequences for GTF3C5 Gene

GenScript: Design optimal peptide antigens:
  • General transcription factor IIIC, polypeptide 5, 63kDa (Q5T7T9_HUMAN)
  • General transcription factor IIIC, polypeptide 5, 63kDa (Q5T7U5_HUMAN)
  • Transcription factor IIIC subunit epsilon (TF3C5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5Q8

UniProtKB/Swiss-Prot:

TF3C5_HUMAN :
  • Belongs to the TFIIIC subunit 5 family.
Family:
  • Belongs to the TFIIIC subunit 5 family.
genes like me logo Genes that share domains with GTF3C5: view

Function for GTF3C5 Gene

Molecular function for GTF3C5 Gene

UniProtKB/Swiss-Prot Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Phenotypes From GWAS Catalog for GTF3C5 Gene

Gene Ontology (GO) - Molecular Function for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000995 contributes_to RNA polymerase III general transcription initiation factor activity IBA 21873635
GO:0001002 contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IBA 21873635
GO:0001003 contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IBA 21873635
GO:0001004 contributes_to RNA polymerase III transcription regulator recruiting activity IBA 21873635
GO:0003677 contributes_to DNA binding IC 17409385
genes like me logo Genes that share ontologies with GTF3C5: view
genes like me logo Genes that share phenotypes with GTF3C5: view

Animal Models for GTF3C5 Gene

MGI Knock Outs for GTF3C5:
  • Gtf3c5 Gtf3c5<tm2a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF3C5 Gene

Localization for GTF3C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3C5 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS,IDA --
genes like me logo Genes that share ontologies with GTF3C5: view

Pathways & Interactions for GTF3C5 Gene

genes like me logo Genes that share pathways with GTF3C5: view

Pathways by source for GTF3C5 Gene

2 Qiagen pathways for GTF3C5 Gene
  • Assembly of RNA Polymerase-III Initiation Complex
  • Transcription of tRNA

Gene Ontology (GO) - Biological Process for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription by RNA polymerase III IC 17409385
GO:0006384 transcription initiation from RNA polymerase III promoter IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0042791 5S class rRNA transcription by RNA polymerase III IC 17409385
GO:0042797 tRNA transcription by RNA polymerase III IC 17409385
genes like me logo Genes that share ontologies with GTF3C5: view

No data available for SIGNOR curated interactions for GTF3C5 Gene

Drugs & Compounds for GTF3C5 Gene

No Compound Related Data Available

Transcripts for GTF3C5 Gene

mRNA/cDNA for GTF3C5 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a ·
SP1: - -
SP2: - - - - - - - -
SP3:
SP4: - - - - -
SP5: - - -
SP6: - - - - - - - - - - - -
SP7:
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - - - - - -
SP11:
SP12: - - - - - - - - - - - - - - - -
SP13: -
SP14: - - - - - - - - - - -
SP15: - - - - - - - - -
SP16: - - -

ExUns: 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for GTF3C5 Gene

GeneLoc Exon Structure for
GTF3C5

Expression for GTF3C5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF3C5 Gene

Protein differential expression in normal tissues from HIPED for GTF3C5 Gene

This gene is overexpressed in Lung (28.2), Peripheral blood mononuclear cells (7.7), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF3C5 Gene



Protein tissue co-expression partners for GTF3C5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTF3C5

SOURCE GeneReport for Unigene cluster for GTF3C5 Gene:

Hs.495417

Evidence on tissue expression from TISSUES for GTF3C5 Gene

  • Nervous system(5)
  • Kidney(4.6)
  • Skin(4.4)
  • Spleen(4.3)
  • Intestine(3.2)
  • Eye(3.1)
  • Lung(3.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with GTF3C5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C5 Gene

Orthologs for GTF3C5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF3C5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C5 31 30
  • 98.87 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C5 31 30
  • 86.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GTF3C5 31 30
  • 85.32 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c5 17 31 30
  • 83.69 (n)
rat
(Rattus norvegicus)
Mammalia Gtf3c5 30
  • 83.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C5 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTF3C5 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C5 31
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C5 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c5 30
  • 70.31 (n)
Str.13723 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.4179 30
zebrafish
(Danio rerio)
Actinopterygii gtf3c5 31 30
  • 59.69 (n)
OneToOne
Dr.17162 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009321 30
  • 45.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cd 31 30
  • 44.53 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T02C12.3 30
  • 40.78 (n)
tftc-5 31
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFC1 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToOne
Species where no ortholog for GTF3C5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF3C5 Gene

ENSEMBL:
Gene Tree for GTF3C5 (if available)
TreeFam:
Gene Tree for GTF3C5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF3C5: view image

Paralogs for GTF3C5 Gene

No data available for Paralogs for GTF3C5 Gene

Variants for GTF3C5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GTF3C5 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs637435 - p.Asp445Asn

Additional dbSNP identifiers (rs#s) for GTF3C5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTF3C5 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
esv2761264 CNV loss 21179565
esv3621930 CNV loss 21293372
nsv466606 CNV loss 19166990
nsv508564 CNV deletion 20534489
nsv520759 CNV loss 19592680
nsv615596 CNV loss 21841781
nsv6746 CNV insertion 18451855
nsv819112 CNV gain 19587683
nsv831744 CNV gain+loss 17160897

Variation tolerance for GTF3C5 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF3C5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C5 Gene

Disorders for GTF3C5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTF3C5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 31, multiple types
  • ctrct31
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GTF3C5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GTF3C5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF3C5 Gene

Publications for GTF3C5 Gene

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H … Teichmann M (The Journal of biological chemistry 2007) 3 4 23 54
  2. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PMID: 10373544) Hsieh YJ … Roeder RG (Molecular and cellular biology 1999) 2 3 4 54
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for GTF3C5 Gene

Sources for GTF3C5 Gene