Aliases for GTF3C4 Gene

Aliases for GTF3C4 Gene

  • General Transcription Factor IIIC Subunit 4 2 3 5
  • General Transcription Factor IIIC, Polypeptide 4, 90kDa 2 3
  • General Transcription Factor 3C Polypeptide 4 3 4
  • Transcription Factor IIIC 90 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit Delta 3 4
  • TFIIIC 90 KDa Subunit 3 4
  • TF3C-Delta 3 4
  • TFIIIC90 3 4
  • General Transcription Factor IIIC, Polypeptide 4 (90kD) 2
  • General Transcription Factor 3C 4 3
  • TFIIICDELTA 3
  • EC 2.3.1.48 4
  • TFIIIC290 3
  • TFIII90 3
  • KAT12 3

External Ids for GTF3C4 Gene

Previous GeneCards Identifiers for GTF3C4 Gene

  • GC09P126570
  • GC09P127102
  • GC09P128899
  • GC09P130821
  • GC09P132574
  • GC09P134535
  • GC09P135545
  • GC09P105039

Summaries for GTF3C4 Gene

GeneCards Summary for GTF3C4 Gene

GTF3C4 (General Transcription Factor IIIC Subunit 4) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity and enzyme activator activity.

UniProtKB/Swiss-Prot Summary for GTF3C4 Gene

  • Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.

Gene Wiki entry for GTF3C4 Gene

Additional gene information for GTF3C4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF3C4 Gene

Genomics for GTF3C4 Gene

GeneHancer (GH) Regulatory Elements for GTF3C4 Gene

Promoters and enhancers for GTF3C4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J132668 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 510.8 +0.7 666 4.2 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 TCF12 MYC POLR2G USF1 GTF2E2 DDX31 GTF3C4 lnc-DDX31-3 piR-50566 piR-48348-092 MED22 SETX TSC1 TTF1 GTF3C5
GH09J133029 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 37.1 +360.6 360566 3.6 ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A ZNF300 TCF12 POLR2G SP1 NCOR1 GTF3C5 LOC105376306 RF00017-8034 TTF1 TSC1 DDX31 GTF3C4 MED22 SETX BRD3OS
GH09J132240 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.7 -428.3 -428317 3.4 NRF1 ZNF10 ZIC2 ZBTB10 CLOCK ZNF423 ZBTB26 MYC ZNF662 ZEB1 HSALNG0074922 GTF3C4 DDX31 PRRC2B GTF3C5 NTNG2 piR-48325-144
GH09J133333 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 12 +665.3 665256 4.2 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 MYC TCF12 USF1 SURF6 lnc-MED22-1 SURF1 WDR5 GTF3C4 BRD3 DDX31 ENSG00000235138 REXO4 MED22
GH09J133534 Enhancer 1.1 ENCODE dbSUPER 24.2 +863.2 863209 0.2 ZNF217 CTCF TEAD4 PHB2 ZNF639 ZIC2 ZBTB10 ZNF423 REST KLF7 ADAMTSL2 GTF3C4 GTF3C5 DDX31 MED22 WDR5 TSC1 BRD3OS BRD3 RPL7A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF3C4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GTF3C4

Top Transcription factor binding sites by QIAGEN in the GTF3C4 gene promoter:
  • C/EBPalpha
  • E2F
  • E2F-1
  • E47
  • Hand1
  • Nkx2-2
  • POU2F1
  • POU2F1a
  • YY1
  • ZIC2

Genomic Locations for GTF3C4 Gene

Genomic Locations for GTF3C4 Gene
chr9:132,670,035-132,694,953
(GRCh38/hg38)
Size:
24,919 bases
Orientation:
Plus strand
chr9:135,545,422-135,570,342
(GRCh37/hg19)
Size:
24,921 bases
Orientation:
Plus strand

Genomic View for GTF3C4 Gene

Genes around GTF3C4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C4 Gene

Proteins for GTF3C4 Gene

  • Protein details for GTF3C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKN8-TF3C4_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 4
    Protein Accession:
    Q9UKN8
    Secondary Accessions:
    • Q5VZJ7

    Protein attributes for GTF3C4 Gene

    Size:
    822 amino acids
    Molecular mass:
    91982 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F.
    SequenceCaution:
    • Sequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for GTF3C4 Gene

Post-translational modifications for GTF3C4 Gene

  • Ubiquitination at Lys123, Lys225, Lys364, Lys467, and Lys807
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF3C4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF3C4 Gene

Domains & Families for GTF3C4 Gene

Gene Families for GTF3C4 Gene

Protein Domains for GTF3C4 Gene

Suggested Antigen Peptide Sequences for GTF3C4 Gene

GenScript: Design optimal peptide antigens:
  • GTF3C4 protein (Q05CN7_HUMAN)
  • Transcription factor IIIC subunit delta (TF3C4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UKN8

UniProtKB/Swiss-Prot:

TF3C4_HUMAN :
  • Belongs to the TFIIIC subunit 4 family.
Family:
  • Belongs to the TFIIIC subunit 4 family.
genes like me logo Genes that share domains with GTF3C4: view

Function for GTF3C4 Gene

Molecular function for GTF3C4 Gene

UniProtKB/Swiss-Prot Function:
Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;.

Enzyme Numbers (IUBMB) for GTF3C4 Gene

Phenotypes From GWAS Catalog for GTF3C4 Gene

Gene Ontology (GO) - Molecular Function for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 contributes_to DNA binding IC 17409385
GO:0004402 histone acetyltransferase activity IEA,TAS --
GO:0005515 protein binding IEA,IPI 17409385
GO:0008047 enzyme activator activity TAS 10523658
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GTF3C4: view
genes like me logo Genes that share phenotypes with GTF3C4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GTF3C4

CRISPR Products

miRNA for GTF3C4 Gene

miRTarBase miRNAs that target GTF3C4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C4 Gene

Localization for GTF3C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3C4 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 1
cytoskeleton 1
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Mitochondria (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with GTF3C4: view

Pathways & Interactions for GTF3C4 Gene

genes like me logo Genes that share pathways with GTF3C4: view

Pathways by source for GTF3C4 Gene

2 Qiagen pathways for GTF3C4 Gene
  • Assembly of RNA Polymerase-III Initiation Complex
  • Transcription of tRNA

Gene Ontology (GO) - Biological Process for GTF3C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription by RNA polymerase III IC 17409385
GO:0006384 transcription initiation from RNA polymerase III promoter TAS 10523658
GO:0016573 histone acetylation IEA --
GO:0042791 5S class rRNA transcription by RNA polymerase III IC 17409385
GO:0042797 tRNA transcription by RNA polymerase III IC 17409385
genes like me logo Genes that share ontologies with GTF3C4: view

No data available for SIGNOR curated interactions for GTF3C4 Gene

Drugs & Compounds for GTF3C4 Gene

(1) Drugs for GTF3C4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Investigational Nutra 0

(1) Additional Compounds for GTF3C4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
72-89-9
genes like me logo Genes that share compounds with GTF3C4: view

Transcripts for GTF3C4 Gene

mRNA/cDNA for GTF3C4 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C4 Gene

No ASD Table

Relevant External Links for GTF3C4 Gene

GeneLoc Exon Structure for
GTF3C4

Expression for GTF3C4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF3C4 Gene

Protein differential expression in normal tissues from HIPED for GTF3C4 Gene

This gene is overexpressed in Cerebrospinal fluid (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF3C4 Gene



Protein tissue co-expression partners for GTF3C4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTF3C4

SOURCE GeneReport for Unigene cluster for GTF3C4 Gene:

Hs.656646

Evidence on tissue expression from TISSUES for GTF3C4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GTF3C4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C4 Gene

Orthologs for GTF3C4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C4 31 30
  • 98.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C4 31 30
  • 91.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GTF3C4 31 30
  • 88.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3c4 17 31 30
  • 87.52 (n)
rat
(Rattus norvegicus)
Mammalia Gtf3c4 30
  • 87.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C4 31
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GTF3C4 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C4 31 30
  • 79.71 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c4 30
  • 68.11 (n)
Str.14605 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14576 30
zebrafish
(Danio rerio)
Actinopterygii gtf3c4 31 30
  • 60.82 (n)
OneToOne
Dr.10245 30
Species where no ortholog for GTF3C4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C4 Gene

ENSEMBL:
Gene Tree for GTF3C4 (if available)
TreeFam:
Gene Tree for GTF3C4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF3C4: view image

Paralogs for GTF3C4 Gene

No data available for Paralogs for GTF3C4 Gene

Variants for GTF3C4 Gene

Additional dbSNP identifiers (rs#s) for GTF3C4 Gene

Variation tolerance for GTF3C4 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF3C4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for GTF3C4 Gene

Disorders for GTF3C4 Gene

Additional Disease Information for GTF3C4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GTF3C4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C4 Gene

Publications for GTF3C4 Gene

  1. The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. (PMID: 10523658) Hsieh YJ … Roeder RG (Molecular and cellular biology 1999) 2 3 4 54
  2. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H … Teichmann M (The Journal of biological chemistry 2007) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3 54
  5. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3 54

Products for GTF3C4 Gene

Sources for GTF3C4 Gene