The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] See more...

Aliases for GTF3C3 Gene

Aliases for GTF3C3 Gene

  • General Transcription Factor IIIC Subunit 3 2 3 5
  • TFIIIC102 2 3 4
  • General Transcription Factor IIIC, Polypeptide 3, 102kDa 2 3
  • General Transcription Factor 3C Polypeptide 3 3 4
  • Transcription Factor IIIC Subunit Gamma 3 4
  • TFIIIC 102 KDa Subunit 3 4
  • TFiiiC2-102 2 3
  • TF3C-Gamma 3 4
  • General Transcription Factor IIIC, Polypeptide 3 (102kD) 2
  • Transcription Factor IIIC 102 KDa Subunit 4
  • TFIIICgamma 3
  • GTF3C3 5

External Ids for GTF3C3 Gene

Previous GeneCards Identifiers for GTF3C3 Gene

  • GC02M195817
  • GC02M196341
  • GC02M197592
  • GC02M197831
  • GC02M197454
  • GC02M197336
  • GC02M189481

Summaries for GTF3C3 Gene

Entrez Gene Summary for GTF3C3 Gene

  • The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for GTF3C3 Gene

GTF3C3 (General Transcription Factor IIIC Subunit 3) is a Protein Coding gene. Diseases associated with GTF3C3 include Vitreoretinal Degeneration, Snowflake Type. Among its related pathways are Transcription of tRNA and Gene Expression.

UniProtKB/Swiss-Prot Summary for GTF3C3 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Additional gene information for GTF3C3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF3C3 Gene

Genomics for GTF3C3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GTF3C3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF3C3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GTF3C3

Top Transcription factor binding sites by QIAGEN in the GTF3C3 gene promoter:
  • aMEF-2
  • CUTL1
  • HSF2
  • HTF
  • LCR-F1
  • MEF-2A
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pax-6

Genomic Locations for GTF3C3 Gene

Genomic Locations for GTF3C3 Gene
chr2:196,763,035-196,799,725
(GRCh38/hg38)
Size:
36,691 bases
Orientation:
Minus strand
chr2:197,627,756-197,664,492
(GRCh37/hg19)
Size:
36,737 bases
Orientation:
Minus strand

Genomic View for GTF3C3 Gene

Genes around GTF3C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C3 Gene

Proteins for GTF3C3 Gene

  • Protein details for GTF3C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q9-TF3C3_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 3
    Protein Accession:
    Q9Y5Q9
    Secondary Accessions:
    • Q4ZG48
    • Q86XJ8
    • Q8WX84
    • Q96B44
    • Q9H5I8
    • Q9NT97

    Protein attributes for GTF3C3 Gene

    Size:
    886 amino acids
    Molecular mass:
    101272 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1 and TBP.
    SequenceCaution:
    • Sequence=BAB15638.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be due to exon skipping.

    Alternative splice isoforms for GTF3C3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C3 Gene

Post-translational modifications for GTF3C3 Gene

  • Ubiquitination at Lys41, Lys234, Lys245, Lys268, Lys298, Lys481, and Lys595
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GTF3C3 Gene

Domains & Families for GTF3C3 Gene

Gene Families for GTF3C3 Gene

Protein Domains for GTF3C3 Gene

Suggested Antigen Peptide Sequences for GTF3C3 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor IIIC subunit gamma (TF3C3_HUMAN)
genes like me logo Genes that share domains with GTF3C3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GTF3C3 Gene

Function for GTF3C3 Gene

Molecular function for GTF3C3 Gene

UniProtKB/Swiss-Prot Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Phenotypes From GWAS Catalog for GTF3C3 Gene

Gene Ontology (GO) - Molecular Function for GTF3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001004 RNA polymerase III transcription regulator recruiting activity IEA --
GO:0003677 contributes_to DNA binding IC 17409385
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with GTF3C3: view
genes like me logo Genes that share phenotypes with GTF3C3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C3 Gene

Localization for GTF3C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3C3 gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IBA,IDA 17409385
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GTF3C3: view

Pathways & Interactions for GTF3C3 Gene

genes like me logo Genes that share pathways with GTF3C3: view

Pathways by source for GTF3C3 Gene

2 Qiagen pathways for GTF3C3 Gene
  • Assembly of RNA Polymerase-III Initiation Complex
  • Transcription of tRNA

Gene Ontology (GO) - Biological Process for GTF3C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription by RNA polymerase III IBA,IC 17409385
GO:0042791 5S class rRNA transcription by RNA polymerase III IC 17409385
GO:0042797 tRNA transcription by RNA polymerase III IC 17409385
genes like me logo Genes that share ontologies with GTF3C3: view

No data available for SIGNOR curated interactions for GTF3C3 Gene

Drugs & Compounds for GTF3C3 Gene

No Compound Related Data Available

Transcripts for GTF3C3 Gene

mRNA/cDNA for GTF3C3 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C3

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for GTF3C3 Gene

GeneLoc Exon Structure for
GTF3C3

Expression for GTF3C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF3C3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTF3C3 Gene

This gene is overexpressed in Lung (9.7) and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF3C3 Gene



Protein tissue co-expression partners for GTF3C3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTF3C3

SOURCE GeneReport for Unigene cluster for GTF3C3 Gene:

Hs.470996

Evidence on tissue expression from TISSUES for GTF3C3 Gene

  • Nervous system(4.8)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with GTF3C3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C3 Gene

Orthologs for GTF3C3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF3C3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GTF3C3 30 31
  • 99.77 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GTF3C3 30 31
  • 92.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GTF3C3 30 31
  • 91.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GTF3C3 31
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gtf3c3 30 17 31
  • 89.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gtf3c3 30
  • 88.6 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-1364 31
  • 54 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GTF3C3 30 31
  • 80.04 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GTF3C3 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488740 30
  • 72.75 (n)
Zebrafish
(Danio rerio)
Actinopterygii gtf3c3 30 31
  • 65.75 (n)
OneToOne
Dr.21469 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4700 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010426 30
  • 48.04 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8950 30 31 32
  • 45.4 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea tag-315 30
  • 43.54 (n)
ZK856.13 32
  • 27 (a)
tftc-3 31
  • 23 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFC4 31 33
  • 20 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G17680 30
  • 42.55 (n)
Rice
(Oryza sativa)
Liliopsida Os11g0266800 30
  • 43.04 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToOne
Species where no ortholog for GTF3C3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GTF3C3 Gene

ENSEMBL:
Gene Tree for GTF3C3 (if available)
TreeFam:
Gene Tree for GTF3C3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF3C3: view image

Paralogs for GTF3C3 Gene

No data available for Paralogs for GTF3C3 Gene

Variants for GTF3C3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GTF3C3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs11559078 - p.Asn70Ser

Additional dbSNP identifiers (rs#s) for GTF3C3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTF3C3 Gene

Variant ID Type Subtype PubMed ID
esv3575323 CNV gain 25503493

Variation tolerance for GTF3C3 Gene

Residual Variation Intolerance Score: 8.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF3C3 Gene

Human Gene Mutation Database (HGMD)
GTF3C3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C3 Gene

Disorders for GTF3C3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTF3C3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vitreoretinal degeneration, snowflake type
  • svd
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with GTF3C3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF3C3 Gene

Publications for GTF3C3 Gene

  1. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PMID: 10373544) Hsieh YJ … Roeder RG (Molecular and cellular biology 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. (PMID: 31073040) Choi JH … Beutler B (Science (New York, N.Y.) 2019) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for GTF3C3 Gene

Sources for GTF3C3 Gene