Aliases for GTF3C2 Gene

Aliases for GTF3C2 Gene

  • General Transcription Factor IIIC Subunit 2 2 3 5
  • General Transcription Factor IIIC, Polypeptide 2, Beta 110kDa 2 3
  • General Transcription Factor 3C Polypeptide 2 3 4
  • Transcription Factor IIIC 110 KDa Subunit 3 4
  • Transcription Factor IIIC Subunit Beta 3 4
  • TFIIIC 110 KDa Subunit 3 4
  • TF3C-Beta 3 4
  • TFIIIC110 3 4
  • General Transcription Factor IIIC, Polypeptide 2 (Beta Subunit, 110kD) 2
  • TFIIIC-BETA 3
  • KIAA0011 4

External Ids for GTF3C2 Gene

Previous GeneCards Identifiers for GTF3C2 Gene

  • GC02M027470
  • GC02M027641
  • GC02M027523
  • GC02M027460
  • GC02M027402
  • GC02M027548
  • GC02M027290

Summaries for GTF3C2 Gene

GeneCards Summary for GTF3C2 Gene

GTF3C2 (General Transcription Factor IIIC Subunit 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Transcription of tRNA.

UniProtKB/Swiss-Prot Summary for GTF3C2 Gene

  • Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

Gene Wiki entry for GTF3C2 Gene

Additional gene information for GTF3C2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF3C2 Gene

Genomics for GTF3C2 Gene

GeneHancer (GH) Regulatory Elements for GTF3C2 Gene

Promoters and enhancers for GTF3C2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J027355 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 793.7 +0.1 119 3.8 FOXK2 SIN3A ZBTB40 SIX5 ZBTB6 MLX SMARCE1 RBPJ POLR2A USF2 GTF3C2 ENSG00000234072 LOC105374363 piR-36393-273 piR-50308-342 SNX17 NRBP1 GPN1 CAD EIF2B4
GH02J027662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 115.8 -307.2 -307167 3.6 FOXK2 E2F8 SIN3A SP1 ZBTB40 SIX5 LCORL SMARCE1 RBPJ POLR2A SUPT7L SLC4A1AP GTF3C2 GPN1 CAD IFT172 EIF2B4 NRBP1 GTF3C2-AS1 SNX17
GH02J027069 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 67.6 +277.6 277572 20.9 E2F8 ZNF785 SIN3A ZNF24 ZBTB40 SP1 CTCF SIX5 ZBTB6 MLX KHK EMILIN1 OST4 NRBP1 GTF3C2 CAD SNX17 GPN1 ATRAID ENSG00000234072
GH02J027368 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 46.8 -13.7 -13723 4.5 SIN3A ZBTB40 SP1 CTCF SIX5 ZBTB6 LCORL MLX RBPJ POLR2A SNX17 EIF2B4 GTF3C2 GPN1 CAD NRBP1 GTF3C2-AS1 ATRAID ZNF512 SUPT7L
GH02J027626 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 29.9 -271.3 -271293 4.1 SIN3A SP1 ZBTB40 MLX RBPJ POLR2A ATF1 HCFC1 ZNF362 MYC GPN1 CCDC121 NRBP1 SNX17 GTF3C2 ATRAID EIF2B4 GTF3C2-AS1 PPM1G TMEM214
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF3C2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTF3C2 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • AREB6
  • Chx10
  • CP2
  • Ik-2
  • Pax-4a
  • POU3F2

Genomic Locations for GTF3C2 Gene

Genomic Locations for GTF3C2 Gene
chr2:27,325,849-27,357,034
(GRCh38/hg38)
Size:
31,186 bases
Orientation:
Minus strand
chr2:27,548,716-27,579,868
(GRCh37/hg19)
Size:
31,153 bases
Orientation:
Minus strand

Genomic View for GTF3C2 Gene

Genes around GTF3C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C2 Gene

Proteins for GTF3C2 Gene

  • Protein details for GTF3C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUA4-TF3C2_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 2
    Protein Accession:
    Q8WUA4
    Secondary Accessions:
    • D6W557
    • Q16632
    • Q9BWI7

    Protein attributes for GTF3C2 Gene

    Size:
    911 amino acids
    Molecular mass:
    100680 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.

    Alternative splice isoforms for GTF3C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C2 Gene

Post-translational modifications for GTF3C2 Gene

  • Ubiquitination at Lys602
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GTF3C2 Gene

Domains & Families for GTF3C2 Gene

Gene Families for GTF3C2 Gene

Suggested Antigen Peptide Sequences for GTF3C2 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor IIIC subunit beta (TF3C2_HUMAN)
genes like me logo Genes that share domains with GTF3C2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GTF3C2 Gene

Function for GTF3C2 Gene

Molecular function for GTF3C2 Gene

UniProtKB/Swiss-Prot Function:
Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

Phenotypes From GWAS Catalog for GTF3C2 Gene

Gene Ontology (GO) - Molecular Function for GTF3C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000995 contributes_to RNA polymerase III general transcription initiation factor activity IBA 21873635
GO:0003677 contributes_to DNA binding IDA 17409385
GO:0005515 protein binding IPI,IEA 20543138
genes like me logo Genes that share ontologies with GTF3C2: view
genes like me logo Genes that share phenotypes with GTF3C2: view

Animal Model Products

CRISPR Products

miRNA for GTF3C2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3C2 Gene

Localization for GTF3C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3C2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GTF3C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3C2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GTF3C2 Gene

Pathways & Interactions for GTF3C2 Gene

genes like me logo Genes that share pathways with GTF3C2: view

Pathways by source for GTF3C2 Gene

2 Qiagen pathways for GTF3C2 Gene
  • Assembly of RNA Polymerase-III Initiation Complex
  • Transcription of tRNA

Gene Ontology (GO) - Biological Process for GTF3C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription by RNA polymerase III IDA,IBA 17409385
GO:0042791 5S class rRNA transcription by RNA polymerase III IC 17409385
GO:0042797 tRNA transcription by RNA polymerase III IC 17409385
genes like me logo Genes that share ontologies with GTF3C2: view

No data available for SIGNOR curated interactions for GTF3C2 Gene

Drugs & Compounds for GTF3C2 Gene

No Compound Related Data Available

Transcripts for GTF3C2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF3C2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - - -
SP4: -
SP5: -
SP6: - - - - - -
SP7: - - -
SP8:
SP9: - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -

ExUns: 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b
SP1: - -
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:

Relevant External Links for GTF3C2 Gene

GeneLoc Exon Structure for
GTF3C2
ECgene alternative splicing isoforms for
GTF3C2

Expression for GTF3C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF3C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTF3C2 Gene

This gene is overexpressed in Serum (23.7) and Lung (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF3C2 Gene



Protein tissue co-expression partners for GTF3C2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF3C2 Gene:

GTF3C2

SOURCE GeneReport for Unigene cluster for GTF3C2 Gene:

Hs.75782

Evidence on tissue expression from TISSUES for GTF3C2 Gene

  • Nervous system(4.8)
  • Bone marrow(4.2)
  • Intestine(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with GTF3C2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C2 Gene

Orthologs for GTF3C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GTF3C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C2 33 32
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3C2 33 32
  • 92.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GTF3C2 33 32
  • 90.98 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3c2 32
  • 88.62 (n)
mouse
(Mus musculus)
Mammalia Gtf3c2 17 33 32
  • 88.45 (n)
oppossum
(Monodelphis domestica)
Mammalia GTF3C2 33
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C2 33
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C2 33 32
  • 63.6 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C2 33
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497817 32
  • 56.58 (n)
zebrafish
(Danio rerio)
Actinopterygii gtf3c2 33 32
  • 52.98 (n)
OneToOne
Species where no ortholog for GTF3C2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3C2 Gene

ENSEMBL:
Gene Tree for GTF3C2 (if available)
TreeFam:
Gene Tree for GTF3C2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF3C2: view image

Paralogs for GTF3C2 Gene

No data available for Paralogs for GTF3C2 Gene

Variants for GTF3C2 Gene

Sequence variations from dbSNP and Humsavar for GTF3C2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000001619 -- 27,353,119(-) G/A intron_variant
rs1000054444 -- 27,357,770(-) A/G upstream_transcript_variant
rs1000167052 -- 27,334,501(-) T/C intron_variant
rs1000205247 -- 27,354,276(-) T/G intron_variant
rs1000424488 -- 27,340,087(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GTF3C2 Gene

Variant ID Type Subtype PubMed ID
esv3575209 CNV gain 25503493
nsv2654 CNV insertion 18451855
nsv581244 CNV loss 21841781
nsv833614 CNV gain 17160897

Variation tolerance for GTF3C2 Gene

Residual Variation Intolerance Score: 4.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF3C2 Gene

Human Gene Mutation Database (HGMD)
GTF3C2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C2 Gene

Disorders for GTF3C2 Gene

Additional Disease Information for GTF3C2

No disorders were found for GTF3C2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C2 Gene

Publications for GTF3C2 Gene

  1. Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors. (PMID: 7729686) Sinn E … Roeder RG (Genes & development 1995) 2 3 4 23 56
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 3 4 56
  5. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 56

Products for GTF3C2 Gene

  • Boster Bio Antibodies for GTF3C2
  • Boster Bio ELISA Kits for GTF3C2

Sources for GTF3C2 Gene