The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex rec... See more...

Aliases for GTF3A Gene

Aliases for GTF3A Gene

  • General Transcription Factor IIIA 2 3 5
  • Transcription Factor IIIA 3 4
  • TFIIIA 3 4
  • AP2 3

External Ids for GTF3A Gene

Previous GeneCards Identifiers for GTF3A Gene

  • GC13P025978
  • GC13P021978
  • GC13P026928
  • GC13P025796
  • GC13P026896
  • GC13P027998
  • GC13P008820

Summaries for GTF3A Gene

Entrez Gene Summary for GTF3A Gene

  • The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTF3A Gene

GTF3A (General Transcription Factor IIIA) is a Protein Coding gene. Diseases associated with GTF3A include Thrombasthenia and Prostate Carcinoma In Situ. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ZNF324B.

UniProtKB/Swiss-Prot Summary for GTF3A Gene

  • Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity).

Gene Wiki entry for GTF3A Gene

Additional gene information for GTF3A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF3A Gene

Genomics for GTF3A Gene

GeneHancer (GH) Regulatory Elements for GTF3A Gene

Promoters and enhancers for GTF3A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J027423 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 510.1 +2.0 2046 6 ZNF217 EP300 CTCF SIN3A NRF1 MYC USF1 POLR2G PHF8 JUND GTF3A MTIF3 lnc-MTIF3-2
GH13J027444 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.3 +23.7 23689 8.1 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 PHF8 ZFX MTIF3 GTF3A lnc-GTF3A-4 lnc-LNX2-2 piR-43872 lnc-MTIF3-2
GH13J027459 Enhancer 0.7 ENCODE 16.9 +35.2 35191 0.5 PCBP1 RELA RBM14 CHD2 ELK1 SMARCB1 MAZ MXI1 NRF1 TAF15 lnc-GTF3A-3 PAN3 SNORA27 GTF3A RPL21 MTIF3 RASL11A RNU6-63P lnc-MTIF3-1
GH13J027372 Enhancer 0.9 Ensembl ENCODE 11.8 -50.7 -50676 2.9 CTCF TCF12 MYC REST RFX1 RAD21 TRIM22 SMC3 CREB1 FOXA2 LINC01079 LOC105370126 GTF3A LNX2 POLR1D RNU6-63P
GH13J027380 Enhancer 0.9 Ensembl ENCODE 11.8 -43.7 -43743 2.4 ZNF217 CTCF REST RAD21 SMC3 ZNF316 ZBTB17 YY1 MAFK ELF1 RNU6-70P GTF3A RNU6-63P LNX2 POLR1D RASL11A GSX1 PLUT PDX1 LOC105370126
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF3A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GTF3A

Genomic Locations for GTF3A Gene

Genomic Locations for GTF3A Gene
chr13:27,424,544-27,435,823
(GRCh38/hg38)
Size:
11,280 bases
Orientation:
Plus strand
chr13:27,998,681-28,009,958
(GRCh37/hg19)
Size:
11,278 bases
Orientation:
Plus strand

Genomic View for GTF3A Gene

Genes around GTF3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3A Gene

Proteins for GTF3A Gene

  • Protein details for GTF3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92664-TF3A_HUMAN
    Recommended name:
    Transcription factor IIIA
    Protein Accession:
    Q92664
    Secondary Accessions:
    • B7ZBK5
    • Q12963
    • Q13097

    Protein attributes for GTF3A Gene

    Size:
    365 amino acids
    Molecular mass:
    41515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA06988.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA06988.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for GTF3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3A Gene

Post-translational modifications for GTF3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF3A Gene

No data available for DME Specific Peptides for GTF3A Gene

Domains & Families for GTF3A Gene

Gene Families for GTF3A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for GTF3A Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GTF3A Gene

GenScript: Design optimal peptide antigens:
  • General transcription factor IIIA (B7ZBK4_HUMAN)
  • Transcription factor IIIA (TF3A_HUMAN)
genes like me logo Genes that share domains with GTF3A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GTF3A Gene

Function for GTF3A Gene

Molecular function for GTF3A Gene

UniProtKB/Swiss-Prot Function:
Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity).
GENATLAS Biochemistry:
general transcription factor IIIA,Xenopus homolog,required for initiation of transcription of 5S RNA

Phenotypes From GWAS Catalog for GTF3A Gene

Gene Ontology (GO) - Molecular Function for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0008097 5S rRNA binding IDA 24120868
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GTF3A: view
genes like me logo Genes that share phenotypes with GTF3A: view

Animal Model Products

CRISPR Products

miRNA for GTF3A Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF3A Gene

Localization for GTF3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3A gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with GTF3A: view

Pathways & Interactions for GTF3A Gene

genes like me logo Genes that share pathways with GTF3A: view

Pathways by source for GTF3A Gene

Gene Ontology (GO) - Biological Process for GTF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription by RNA polymerase III TAS 7789179
GO:0009303 rRNA transcription TAS 8063702
GO:0042254 ribosome biogenesis IEA --
GO:0042273 ribosomal large subunit biogenesis IMP 24120868
genes like me logo Genes that share ontologies with GTF3A: view

No data available for SIGNOR curated interactions for GTF3A Gene

Drugs & Compounds for GTF3A Gene

(11) Drugs for GTF3A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for GTF3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTF3A: view

Transcripts for GTF3A Gene

mRNA/cDNA for GTF3A Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - -
SP9: -
SP10: - - - -
SP11:

Relevant External Links for GTF3A Gene

GeneLoc Exon Structure for
GTF3A

Expression for GTF3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF3A Gene

Protein differential expression in normal tissues from HIPED for GTF3A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GTF3A Gene



Protein tissue co-expression partners for GTF3A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTF3A

SOURCE GeneReport for Unigene cluster for GTF3A Gene:

Hs.445977

mRNA Expression by UniProt/SwissProt for GTF3A Gene:

Q92664-TF3A_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GTF3A Gene

  • Nervous system(4.7)
  • Intestine(2.8)
  • Heart(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with GTF3A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3A Gene

Orthologs for GTF3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3A 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTF3A 31 30
  • 86.2 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf3a 30
  • 80.94 (n)
cow
(Bos Taurus)
Mammalia GTF3A 31 30
  • 80.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf3a 17 31 30
  • 80.2 (n)
oppossum
(Monodelphis domestica)
Mammalia GTF3A 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3A 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3A 31 30
  • 68.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3A 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3a 30
  • 61.06 (n)
Str.17731 30
African clawed frog
(Xenopus laevis)
Amphibia LOC397777 30
zebrafish
(Danio rerio)
Actinopterygii gtf3aa 31 30
  • 61.49 (n)
OneToMany
gtf3ab 31
  • 41 (a)
OneToMany
GTF3A (2 of 3) 31
  • 29 (a)
OneToMany
Dr.14750 30
fruit fly
(Drosophila melanogaster)
Insecta CG9609 31 32 30
  • 42.89 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWI5 31
  • 6 (a)
ManyToMany
ACE2 31
  • 5 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sfc2 30
  • 50 (n)
Species where no ortholog for GTF3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF3A Gene

ENSEMBL:
Gene Tree for GTF3A (if available)
TreeFam:
Gene Tree for GTF3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF3A: view image

Paralogs for GTF3A Gene

Paralogs for GTF3A Gene

genes like me logo Genes that share paralogs with GTF3A: view

Variants for GTF3A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GTF3A Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs7323 - p.Val245Leu

Additional dbSNP identifiers (rs#s) for GTF3A Gene

Variation tolerance for GTF3A Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GTF3A Gene

Disorders for GTF3A Gene

MalaCards: The human disease database

(3) MalaCards diseases for GTF3A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thrombasthenia
prostate carcinoma in situ
  • carcinoma in situ of prostate
digeorge syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards
Search GTF3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GTF3A

genes like me logo Genes that share disorders with GTF3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF3A Gene

Publications for GTF3A Gene

  1. Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA. (PMID: 7789179) Arakawa H … Nakamura Y (Cytogenetics and cell genetics 1995) 2 3 4 23 54
  2. Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA. (PMID: 7622052) Drew PD … Becker KG (Gene 1995) 3 4 23 54
  3. Purification and characterization of human transcription factor IIIA. (PMID: 8063702) Moorefield B … Roeder RG (The Journal of biological chemistry 1994) 3 4 23 54
  4. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. (PMID: 24120868) Sloan KE … Watkins NJ (Cell reports 2013) 3 4 54
  5. cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA. (PMID: 11814676) Hanas JS … Moreland RJ (Gene 2002) 3 23 54

Products for GTF3A Gene

Sources for GTF3A Gene