Aliases for GTF3A Gene
External Ids for GTF3A Gene
Previous GeneCards Identifiers for GTF3A Gene
The product of this gene is a zinc finger protein with nine Cis-His zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for GTF3A Gene
GTF3A (General Transcription Factor IIIA) is a Protein Coding gene. Diseases associated with GTF3A include Thrombasthenia and Breast Squamous Cell Carcinoma. Among its related pathways are Transcription of tRNA and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ZNF513.
UniProtKB/Swiss-Prot Summary for GTF3A Gene
Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity).