Aliases for GTF2H3 Gene
Aliases for GTF2H3 Gene
- General Transcription Factor IIH Subunit 3 2 3 5
- General Transcription Factor IIH, Polypeptide 3, 34kDa 2 3
- TFIIH Basal Transcription Factor Complex P34 Subunit 3 4
- Basic Transcription Factor 2 34 KDa Subunit 3 4
- General Transcription Factor IIH, Polypeptide 3 (34kD Subunit) 2
- General Transcription Factor IIH Polypeptide 3 4
External Ids for GTF2H3 Gene
- HGNC: 4657
- Entrez Gene: 2967
- Ensembl: ENSG00000111358
- OMIM: 601750
- UniProtKB: Q13889
Previous GeneCards Identifiers for GTF2H3 Gene
- GC12P122750
- GC12M123751
- GC12P123842
- GC12P122471
- GC12P122643
- GC12P122684
- GC12P124118
- GC12P121079
Summaries for GTF2H3 Gene
-
This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]
GeneCards Summary for GTF2H3 Gene
GTF2H3 (General Transcription Factor IIH Subunit 3) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein N-terminus binding.
UniProtKB/Swiss-Prot for GTF2H3 Gene
-
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB.
Additional gene information for GTF2H3 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2H3 Gene
Genomics for GTF2H3 Gene
GeneHancer (GH) Regulatory Elements for GTF2H3 Gene
Promoters and enhancers for GTF2H3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GTF2H3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GTF2H3 Gene
Genomic Locations for GTF2H3 Gene
- chr12:123,633,739-123,662,606
- (GRCh38/hg38)
- Size:
- 28,868 bases
- Orientation:
- Plus strand
- chr12:124,118,375-124,147,153
- (GRCh37/hg19)
Genomic View for GTF2H3 Gene
Genes around GTF2H3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by Ensembl
- 12q24.31 by Entrez Gene
- 12q24.31 by HGNC
GTF2H3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GTF2H3 Gene
Proteins for GTF2H3 Gene
-
Protein details for GTF2H3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13889-TF2H3_HUMAN
- Recommended name:
- General transcription factor IIH subunit 3
- Protein Accession:
- Q13889
- B2R819
- B4DNZ6
- Q7L0G0
- Q96AT7
Protein attributes for GTF2H3 Gene
- Size:
- 308 amino acids
- Molecular mass:
- 34378 Da
- Quaternary structure:
-
- Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27193682). One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor (PubMed:9852112). Interacts with RARA; the interaction requires prior phosphorylation of RARA on Ser-369 which then enhances interaction of RARA with CDK7 (By similarity).
- SequenceCaution:
-
- Sequence=CAA82909.1; Type=Frameshift; Positions=302; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for GTF2H3 Gene
Protein Expression for GTF2H3 Gene
Post-translational modifications for GTF2H3 Gene
Other Protein References for GTF2H3 Gene
Antibody Products
- Novus Biologicals Antibodies for GTF2H3
- Invitrogen Antibodies for GTF2H3
- antibodies-online: Search results for 23 available GTF2H3 Antibodies ranked by validation data
- Compare Top GTF2H3 Antibodies
-
Recommended
- GeneTex GTF2H3 antibody for GTF2H3
Protein Products
-
OriGene Purified Proteins for GTF2H3
- Search Origene for MassSpec and Protein Over-expression Lysates for GTF2H3
- Origene Custom Protein Services for GTF2H3
- Search GeneTex for Proteins for GTF2H3
-
Abcam proteins for GTF2H3
Assay Products
No data available for DME Specific Peptides for GTF2H3 Gene
Domains & Families for GTF2H3 Gene
Gene Families for GTF2H3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GTF2H3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GTF2H3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13889- Family:
-
- Belongs to the TFB4 family.
Function for GTF2H3 Gene
Molecular function for GTF2H3 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB.
Phenotypes From GWAS Catalog for GTF2H3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003684 | damaged DNA binding | TAS | 8194529 |
| GO:0003700 | DNA binding transcription factor activity | NAS | 8194529 |
| GO:0004672 | contributes_to protein kinase activity | IDA | 9852112 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008094 | contributes_to DNA-dependent ATPase activity | IDA | 9852112 |
Phenotypes for GTF2H3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GTF2H3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GTF2H3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GTF2H3 gene
- Search ViGene Biosciences for GTF2H3
CRISPR Products
-
OriGene CRISPR knockouts for GTF2H3
- genomics-online: gRNA clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- Applied Biological Materials CRISPR for GTF2H3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GTF2H3
- GenScript: Design CRISPR guide RNA sequences for GTF2H3
miRNA for GTF2H3 Gene
- miRTarBase miRNAs that target GTF2H3
-
- hsa-mir-33a-5p (MIRT028194)
- hsa-mir-484 (MIRT042315)
- hsa-mir-5096 (MIRT617280)
- hsa-mir-197-3p (MIRT617281)
- hsa-mir-411-5p (MIRT617282)
- hsa-mir-6832-5p (MIRT617283)
- hsa-mir-4524a-3p (MIRT617284)
- hsa-mir-4716-5p (MIRT617285)
- hsa-mir-6823-5p (MIRT617286)
- hsa-mir-4307 (MIRT617287)
- hsa-mir-4524b-3p (MIRT617288)
- hsa-mir-5089-5p (MIRT689780)
- hsa-mir-6878-3p (MIRT689781)
- hsa-mir-6807-5p (MIRT689782)
- hsa-mir-7151-3p (MIRT689783)
- hsa-mir-5095 (MIRT689784)
- hsa-mir-6744-3p (MIRT689785)
- hsa-mir-4757-5p (MIRT689786)
- hsa-mir-5589-5p (MIRT689787)
- hsa-mir-4731-5p (MIRT689788)
- hsa-mir-6778-3p (MIRT689789)
- hsa-mir-6506-5p (MIRT689790)
- hsa-mir-619-5p (MIRT689791)
- hsa-mir-150-5p (MIRT689792)
- hsa-mir-186-3p (MIRT689793)
- hsa-mir-520h (MIRT689794)
- hsa-mir-520g-3p (MIRT689795)
- hsa-mir-6504-3p (MIRT689796)
- hsa-mir-512-3p (MIRT689797)
- hsa-mir-4438 (MIRT689798)
- hsa-mir-520e (MIRT689799)
- hsa-mir-520d-3p (MIRT689800)
- hsa-mir-520c-3p (MIRT689801)
- hsa-mir-520b (MIRT689802)
- hsa-mir-520a-3p (MIRT689803)
- hsa-mir-373-3p (MIRT689804)
- hsa-mir-372-3p (MIRT689805)
- hsa-mir-302e (MIRT689806)
- hsa-mir-302d-3p (MIRT689807)
- hsa-mir-302c-3p (MIRT689808)
- hsa-mir-302b-3p (MIRT689809)
- hsa-mir-302a-3p (MIRT689810)
- hsa-mir-93-5p (MIRT689811)
- hsa-mir-526b-3p (MIRT689812)
- hsa-mir-519d-3p (MIRT689813)
- hsa-mir-20b-5p (MIRT689814)
- hsa-mir-20a-5p (MIRT689815)
- hsa-mir-17-5p (MIRT689816)
- hsa-mir-106b-5p (MIRT689817)
- hsa-mir-106a-5p (MIRT689818)
miRNA Products
- Search ViGene Biosciences for GTF2H3
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for GTF2H3
- Browse OriGene Inhibitory RNA Products For GTF2H3
- genomics-online: shRNA clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for GTF2H3 gene
Clone Products
- Sino Biological Human cDNA Clone for GTF2H3
- VectorBuilder custom plasmid, inducible vectors for GTF2H3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GTF2H3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GTF2H3
- genomics-online: cdna clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pLenti-C-Myc-DDK
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- orf clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- Applied Biological Materials Clones for GTF2H3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for GTF2H3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GTF2H3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GTF2H3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2H3 Gene
Localization for GTF2H3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GTF2H3 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000438 | core TFIIH complex portion of holo TFIIH complex | IDA | 27193682 |
| GO:0000439 | core TFIIH complex | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 27193682 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005669 | transcription factor TFIID complex | IDA | 27193682 |
Pathways & Interactions for GTF2H3 Gene
Pathways by source for GTF2H3 Gene
1 BioSystems pathway for GTF2H3 Gene
48 Reactome pathways for GTF2H3 Gene
3 KEGG pathways for GTF2H3 Gene
2 GeneGo (Thomson Reuters) pathways for GTF2H3 Gene
11 Qiagen pathways for GTF2H3 Gene
Interacting Proteins for GTF2H3 Gene
Selected Interacting proteins:
ENSP00000445162
Q13889-TF2H3_HUMAN
for GTF2H3 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000717 | nucleotide-excision repair, DNA duplex unwinding | TAS | -- |
| GO:0006281 | DNA repair | TAS | 8194529 |
| GO:0006283 | transcription-coupled nucleotide-excision repair | TAS | -- |
| GO:0006289 | nucleotide-excision repair | IEA,IBA | -- |
| GO:0006293 | nucleotide-excision repair, preincision complex stabilization | TAS | -- |
No data available for SIGNOR curated interactions for GTF2H3 Gene
Transcripts for GTF2H3 Gene
mRNA/cDNA for GTF2H3 Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GTF2H3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GTF2H3
- genomics-online: gRNA clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- Applied Biological Materials CRISPR for GTF2H3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GTF2H3
- GenScript: Design CRISPR guide RNA sequences for GTF2H3
miRNA Products
- Search ViGene Biosciences for GTF2H3
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for GTF2H3
- Browse OriGene Inhibitory RNA Products For GTF2H3
- genomics-online: shRNA clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for GTF2H3 gene
Clone Products
- Sino Biological Human cDNA Clone for GTF2H3
- VectorBuilder custom plasmid, inducible vectors for GTF2H3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GTF2H3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GTF2H3
- genomics-online: cdna clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pLenti-C-Myc-DDK
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- orf clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- Applied Biological Materials Clones for GTF2H3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | - |
Expression for GTF2H3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
-
Testis (Reproductive System)
This gene is overexpressed in Breast (36.3), Lymph node (8.2), Testis (7.9), and CD8 Tcells (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF2H3 Gene
NURSA nuclear receptor signaling pathways regulating expression of GTF2H3 Gene:
GTF2H3SOURCE GeneReport for Unigene cluster for GTF2H3 Gene:
Hs.355348Evidence on tissue expression from TISSUES for GTF2H3 Gene
- Nervous system(4.7)
- Eye(4.1)
Primer Products
-
OriGene qPCR primer pairs for GTF2H3
-
OriGene qPCR primer pairs and template standards for GTF2H3
- genomics-online: primer clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
-
Recommended
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
- pPB-C-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pcDNA3.1+C-(K)-DYK
- pCMV6-Entry
- pCMV6-AC
- pCMV6-XL5
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2H3 Gene
Orthologs for GTF2H3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GTF2H3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GTF2H3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | GTF2H3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GTF2H3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Gtf2h3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gtf2h3 33 |
|
||
| chicken (Gallus gallus) |
Aves | GTF2H3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GTF2H3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gtf2h3 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24760 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gtf2h3 34 |
|
OneToOne | |
| gtf2h3-2 33 |
|
||||
| Dr.27486 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6345 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008522 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Tfb4 35 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ZK1128.4 34 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADL323C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B08569g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TFB4 33 34 36 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G18340 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0125800 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tfb4 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3315 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01580 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.6370 33 |
|
- Species where no ortholog for GTF2H3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GTF2H3 Gene
Pseudogenes.org Pseudogenes for GTF2H3 Gene
No data available for Paralogs for GTF2H3 Gene
Variants for GTF2H3 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34827093 | benign, Leukoencephalopathy with vanishing white matter | 123,633,701(+) | C/G | upstream_transcript_variant | |
| rs535812755 | uncertain-significance, Leukoencephalopathy with vanishing white matter | 123,633,703(+) | T/A/C/G | upstream_transcript_variant | |
| rs558453538 | uncertain-significance, Leukoencephalopathy with vanishing white matter | 123,633,740(+) | G/A/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs571053026 | uncertain-significance, Leukoencephalopathy with vanishing white matter | 123,633,642(+) | C/T | upstream_transcript_variant | |
| rs576953141 | uncertain-significance, Leukoencephalopathy with vanishing white matter | 123,633,750(+) | C/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1566n100 | CNV | gain | 25217958 |
| dgv1567n100 | CNV | gain | 25217958 |
| dgv1568n100 | CNV | loss | 25217958 |
| dgv2926n54 | CNV | gain | 21841781 |
| dgv309e214 | CNV | gain | 21293372 |
| esv2759918 | CNV | gain | 17122850 |
| esv35148 | CNV | gain | 17911159 |
| nsv1042181 | CNV | gain | 25217958 |
| nsv1051385 | CNV | gain | 25217958 |
| nsv1052065 | CNV | gain+loss | 25217958 |
| nsv442292 | CNV | gain | 18776908 |
| nsv455733 | CNV | gain | 19166990 |
| nsv524660 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.99;
20.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GTF2H3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GTF2H3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2H3 Gene
Disorders for GTF2H3 Gene
Additional Disease Information for GTF2H3
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GTF2H3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2H3 Gene
Publications for GTF2H3 Gene
- p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair. (PMID: 8194529) Humbert S … Moncollin V (The EMBO journal 1994) 2 3 4 58
- Near-atomic resolution visualization of human transcription promoter opening. (PMID: 27193682) He Y … Nogales E (Nature 2016) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PMID: 9852112) Kershnar E … Chiang CM (The Journal of biological chemistry 1998) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for GTF2H3 Gene
- Browse R&D Systems for Antibodies
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- Browse Immunoprecipitation Assays
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- Browse OriGene ELISA Kits
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- OriGene Purified Proteins for GTF2H3
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- Origene Custom Protein Services for GTF2H3
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- OriGene qPCR primer pairs for GTF2H3
- OriGene CRISPR knockouts for GTF2H3
- OriGene ORF clones in human for GTF2H3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for GTF2H3
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for GTF2H3
- Novus Biologicals lysates and proteins for GTF2H3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
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- Browse ELISA Kits
- Abcam proteins for GTF2H3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for GTF2H3
- VectorBuilder custom plasmid, inducible vectors for GTF2H3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GTF2H3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GTF2H3
- antibodies-online: Search results for 23 available GTF2H3 Antibodies ranked by validation data
- Compare Top GTF2H3 Antibodies
- Recommended
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- Compare Top GTF2H3 Proteins
- GeneTex GTF2H3 antibody for GTF2H3
- Search GeneTex for Proteins for GTF2H3
- ViGene Biosciences adenoviral particle packaged cDNA for GTF2H3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for GTF2H3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for GTF2H3 gene
- Search ViGene Biosciences for GTF2H3
- genomics-online: cdna clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- orf clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- genomics-online: gRNA clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- genomics-online: primer clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- genomics-online: shRNA clones - Search results for 101 available GTF2H3 gene related products
- Overview of 101 available GTF2H3 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-C-His
Sources for GTF2H3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
