Aliases for GTF2H2C_2 Gene

Aliases for GTF2H2C_2 Gene

  • GTF2H2 Family Member C, Copy 2 2 3
  • General Transcription Factor IIH Polypeptide 2-Like Protein 3 4
  • General Transcription Factor IIH Subunit 2-Like Protein 3 4
  • General Transcription Factor IIH, Polypeptide 2D 2 3
  • GTF2H2D 3 4
  • LOC730394 2

External Ids for GTF2H2C_2 Gene

Previous HGNC Symbols for GTF2H2C_2 Gene

  • GTF2H2D

Previous GeneCards Identifiers for GTF2H2C_2 Gene

  • GC05U901954

Summaries for GTF2H2C_2 Gene

GeneCards Summary for GTF2H2C_2 Gene

GTF2H2C_2 (GTF2H2 Family Member C, Copy 2) is a Protein Coding gene. Among its related pathways are Nucleotide excision repair and RNA Polymerase II Transcription Initiation And Promoter Clearance.

UniProtKB/Swiss-Prot Summary for GTF2H2C_2 Gene

  • Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

Additional gene information for GTF2H2C_2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF2H2C_2 Gene

Genomics for GTF2H2C_2 Gene

Genomic Locations for GTF2H2C_2 Gene

Genomic Locations for GTF2H2C_2 Gene
chr5:965,642-997,938
(GRCh38/hg38)
Size:
32,297 bases
Orientation:
Minus strand

Genomic View for GTF2H2C_2 Gene

Genes around GTF2H2C_2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for GTF2H2C_2 Gene

Proteins for GTF2H2C_2 Gene

  • Protein details for GTF2H2C_2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1K8-T2H2L_HUMAN
    Recommended name:
    General transcription factor IIH subunit 2-like protein
    Protein Accession:
    Q6P1K8
    Secondary Accessions:
    • A6NED9
    • A8K8J6
    • B2RCU4
    • B7ZW39

    Protein attributes for GTF2H2C_2 Gene

    Size:
    395 amino acids
    Molecular mass:
    44452 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GTF2H2C_2 Gene

Post-translational modifications for GTF2H2C_2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2H2C_2 Gene

No data available for DME Specific Peptides for GTF2H2C_2 Gene

Domains & Families for GTF2H2C_2 Gene

Protein Domains for GTF2H2C_2 Gene

Suggested Antigen Peptide Sequences for GTF2H2C_2 Gene

GenScript: Design optimal peptide antigens:
  • General transcription factor IIH polypeptide 2-like protein (T2H2L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P1K8

UniProtKB/Swiss-Prot:

T2H2L_HUMAN :
  • Belongs to the GTF2H2 family.
Family:
  • Belongs to the GTF2H2 family.
genes like me logo Genes that share domains with GTF2H2C_2: view

No data available for Gene Families for GTF2H2C_2 Gene

Function for GTF2H2C_2 Gene

Molecular function for GTF2H2C_2 Gene

UniProtKB/Swiss-Prot Function:
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

Gene Ontology (GO) - Molecular Function for GTF2H2C_2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with GTF2H2C_2: view
genes like me logo Genes that share phenotypes with GTF2H2C_2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GTF2H2C_2 Gene

Localization for GTF2H2C_2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2H2C_2 Gene

Gene Ontology (GO) - Cellular Components for GTF2H2C_2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000439 transcription factor TFIIH core complex IEA --
GO:0005675 transcription factor TFIIH holo complex IBA 21873635
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with GTF2H2C_2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GTF2H2C_2 Gene

Pathways & Interactions for GTF2H2C_2 Gene

genes like me logo Genes that share pathways with GTF2H2C_2: view

Pathways by source for GTF2H2C_2 Gene

Gene Ontology (GO) - Biological Process for GTF2H2C_2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006289 nucleotide-excision repair IBA 21873635
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with GTF2H2C_2: view

No data available for SIGNOR curated interactions for GTF2H2C_2 Gene

Drugs & Compounds for GTF2H2C_2 Gene

No Compound Related Data Available

Transcripts for GTF2H2C_2 Gene

mRNA/cDNA for GTF2H2C_2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2H2C_2 Gene

No ASD Table

Relevant External Links for GTF2H2C_2 Gene

GeneLoc Exon Structure for
GTF2H2C_2

Expression for GTF2H2C_2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF2H2C_2 Gene

Protein differential expression in normal tissues from HIPED for GTF2H2C_2 Gene

This gene is overexpressed in Lung (26.6), Breast (22.3), and Liver (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF2H2C_2 Gene



Protein tissue co-expression partners for GTF2H2C_2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTF2H2C_2

genes like me logo Genes that share expression patterns with GTF2H2C_2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2H2C_2 Gene

Orthologs for GTF2H2C_2 Gene

No data available for Orthologs and Evolution for GTF2H2C_2 Gene

Paralogs for GTF2H2C_2 Gene

No data available for Paralogs for GTF2H2C_2 Gene

Variants for GTF2H2C_2 Gene

Additional dbSNP identifiers (rs#s) for GTF2H2C_2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTF2H2C_2 Gene

Variant ID Type Subtype PubMed ID
dgv134e203 CNV gain+loss 21179565
dgv27n14 CNV loss 18776910
dgv5695n100 CNV gain 25217958
dgv5696n100 CNV loss 25217958
dgv5697n100 CNV gain+loss 25217958
dgv7e224 CNV loss 25118596
dgv9833n54 CNV loss 21841781
dgv9834n54 CNV gain 21841781
dgv9837n54 CNV loss 21841781
dgv9838n54 CNV loss 21841781
dgv9839n54 CNV loss 21841781
dgv9840n54 CNV loss 21841781
dgv9845n54 CNV loss 21841781
dgv9857n54 CNV loss 21841781
dgv9859n54 CNV gain 21841781
dgv9860n54 CNV gain 21841781
dgv9861n54 CNV gain 21841781
dgv9862n54 CNV loss 21841781
dgv9863n54 CNV gain 21841781
dgv9864n54 CNV loss 21841781
dgv9866n54 CNV gain 21841781
dgv9867n54 CNV gain 21841781
dgv9868n54 CNV gain 21841781
dgv9870n54 CNV loss 21841781
dgv9872n54 CNV loss 21841781
esv1009388 CNV gain 20482838
esv1011240 CNV gain 20482838
esv22113 CNV gain+loss 19812545
esv2669461 CNV deletion 23128226
esv2673843 CNV deletion 23128226
esv2759348 CNV gain+loss 17122850
esv32787 CNV gain+loss 17666407
esv32846 CNV loss 17666407
esv3570183 CNV loss 25503493
esv3584530 CNV gain 24956385
esv3605385 CNV loss 21293372
esv3890644 CNV gain+loss 25118596
esv3890648 CNV loss 25118596
esv3890652 CNV loss 25118596
esv3890654 CNV loss 25118596
esv3894207 CNV loss 25118596
nsv1023116 CNV gain 25217958
nsv1033366 CNV gain 25217958
nsv1034024 CNV gain 25217958
nsv10707 CNV gain+loss 18304495
nsv1074306 CNV deletion 25765185
nsv1074837 CNV deletion 25765185
nsv1122110 CNV deletion 24896259
nsv1133602 CNV deletion 24896259
nsv428117 CNV gain+loss 18775914
nsv433371 CNV gain 18776910
nsv433373 CNV gain 18776910
nsv471498 CNV gain 19718026
nsv511107 OTHER complex 20534489
nsv511290 CNV gain 21212237
nsv515025 CNV gain 21397061
nsv598430 CNV gain 21841781
nsv598439 CNV gain+loss 21841781
nsv598447 CNV loss 21841781
nsv598448 CNV loss 21841781
nsv598454 CNV loss 21841781
nsv598456 CNV loss 21841781
nsv598457 CNV loss 21841781
nsv598458 CNV loss 21841781
nsv598459 CNV loss 21841781
nsv598460 CNV gain 21841781
nsv598462 CNV gain 21841781
nsv598533 CNV loss 21841781
nsv598536 CNV gain 21841781
nsv598561 CNV loss 21841781
nsv598587 CNV gain+loss 21841781
nsv598620 CNV loss 21841781
nsv7371 OTHER inversion 18451855
nsv821643 CNV loss 15273396
nsv830339 CNV gain 17160897
nsv950086 CNV deletion 24416366
nsv968189 CNV duplication 23825009
nsv980677 CNV duplication 23825009

Additional Variant Information for GTF2H2C_2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2H2C_2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for GTF2H2C_2 Gene

Disorders for GTF2H2C_2 Gene

Additional Disease Information for GTF2H2C_2

No disorders were found for GTF2H2C_2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2H2C_2 Gene

Publications for GTF2H2C_2 Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. (PMID: 27637333) Gabriel CH … Baumgrass R (The Journal of biological chemistry 2016) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3

Products for GTF2H2C_2 Gene

Sources for GTF2H2C_2 Gene