Aliases for GTF2F2 Gene

Aliases for GTF2F2 Gene

  • General Transcription Factor IIF Subunit 2 2 3 4 5
  • General Transcription Factor IIF, Polypeptide 2, 30kDa 2 3
  • Transcription Initiation Factor IIF Subunit Beta 3 4
  • General Transcription Factor IIF 30 KDa Subunit 3 4
  • Transcription Initiation Factor RAP30 3 4
  • ATP-Dependent Helicase GTF2F2 3 4
  • TFIIF-Beta 3 4
  • RAP30 3 4
  • General Transcription Factor IIF, Polypeptide 1 (74kD Subunit) 2
  • EC 3.6.4.12 4
  • EC 3.6.1 52
  • TF2F2 3
  • TFIIF 3
  • BTF4 3

External Ids for GTF2F2 Gene

Previous GeneCards Identifiers for GTF2F2 Gene

  • GC13P043694
  • GC13P039681
  • GC13P044631
  • GC13P043492
  • GC13P044592
  • GC13P045694
  • GC13P026496

Summaries for GTF2F2 Gene

GeneCards Summary for GTF2F2 Gene

GTF2F2 (General Transcription Factor IIF Subunit 2) is a Protein Coding gene. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include helicase activity and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot Summary for GTF2F2 Gene

  • TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.

Gene Wiki entry for GTF2F2 Gene

Additional gene information for GTF2F2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF2F2 Gene

Genomics for GTF2F2 Gene

GeneHancer (GH) Regulatory Elements for GTF2F2 Gene

Promoters and enhancers for GTF2F2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J045119 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 511 +0.3 250 3.4 ZNF217 EP300 CTCF NRF1 TCF12 MYC POLR2G PHF8 REST POLR2A GTF2F2 lnc-KCTD4-1 TPT1-AS1
GH13J045204 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +86.8 86836 5.4 ZSCAN5C JUND FOS RELA BCL11A ZNF316 CBFB MAFF FOSL2 CEBPB GTF2F2 KCTD4 TPT1 COG3 RF00017-1412
GH13J045177 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.7 +59.3 59337 4.8 ZSCAN5C NCOR1 FOS ZNF639 ZNF10 TRIM28 ATF2 ZEB1 OSR2 BCL11A KCTD4 GTF2F2 ERICH6B TPT1-AS1 RF00017-1412 piR-50437-142
GH13J045252 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 +135.1 135137 6.8 EP300 ZSCAN5C JUND FOS ZBTB25 TEAD1 ATF2 TBX3 FOXA2 CEBPB GTF2F2 KCTD4 ENSG00000270381 lnc-COG3-5 piR-44883-004
GH13J045238 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +120.6 120599 5.9 JUND ZNF10 ZBTB17 FOS CTCF ZNF384 PRDM6 ZNF664 RXRA HNF4A GTF2F2 KCTD4 SLC25A30 LOC105370190
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF2F2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GTF2F2

Top Transcription factor binding sites by QIAGEN in the GTF2F2 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • Egr-2
  • LCR-F1
  • MyoD
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU6F1 (c2)

Genomic Locations for GTF2F2 Gene

Genomic Locations for GTF2F2 Gene
chr13:45,120,464-45,284,893
(GRCh38/hg38)
Size:
164,430 bases
Orientation:
Plus strand
chr13:45,694,631-45,858,240
(GRCh37/hg19)
Size:
163,610 bases
Orientation:
Plus strand

Genomic View for GTF2F2 Gene

Genes around GTF2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2F2 Gene

Proteins for GTF2F2 Gene

  • Protein details for GTF2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13984-T2FB_HUMAN
    Recommended name:
    General transcription factor IIF subunit 2
    Protein Accession:
    P13984
    Secondary Accessions:
    • A6NNS5
    • Q5W0H3

    Protein attributes for GTF2F2 Gene

    Size:
    249 amino acids
    Molecular mass:
    28380 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with HTATSF1 and GPBP1 (By similarity). Interacts with URI1. Interacts with GTF2B (via N-terminus); this interaction is inhibited in presence of GTF2F1 (PubMed:8504927, PubMed:8662660).

    Three dimensional structures from OCA and Proteopedia for GTF2F2 Gene

neXtProt entry for GTF2F2 Gene

Selected DME Specific Peptides for GTF2F2 Gene

P13984:
  • KDLVDITKQPV
  • AFEKHQYYN
  • HKNTWELKPEYRHYQ
  • QIEESSKP
  • GVWLVKVPKY
  • GAKQNTG
  • GRGEVGKLRI
  • NHQYNIEYE

Post-translational modifications for GTF2F2 Gene

  • Ubiquitination at Lys13, Lys137, Lys147, Lys154, and Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2F2 Gene

Domains & Families for GTF2F2 Gene

Gene Families for GTF2F2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GTF2F2 Gene

Blocks:
  • Transcription initiation factor IIF, beta subunit
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GTF2F2 Gene

GenScript: Design optimal peptide antigens:
  • Transcription initiation factor RAP30 (T2FB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13984

UniProtKB/Swiss-Prot:

T2FB_HUMAN :
  • Belongs to the TFIIF beta subunit family.
Family:
  • Belongs to the TFIIF beta subunit family.
genes like me logo Genes that share domains with GTF2F2: view

Function for GTF2F2 Gene

Molecular function for GTF2F2 Gene

UniProtKB/Swiss-Prot Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;.
GENATLAS Biochemistry:
general transcription factor IIF,polypeptide 2(30kDa),increasing the average rate of RNA chain elongation across DNA templates

Enzyme Numbers (IUBMB) for GTF2F2 Gene

Phenotypes From GWAS Catalog for GTF2F2 Gene

Gene Ontology (GO) - Molecular Function for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003678 DNA helicase activity IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 7854423
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GTF2F2: view
genes like me logo Genes that share phenotypes with GTF2F2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2F2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2F2 Gene

Localization for GTF2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2F2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2F2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9841876
GO:0005654 nucleoplasm TAS --
GO:0005674 transcription factor TFIIF complex IBA 21873635
GO:0015630 microtubule cytoskeleton IDA --
GO:0097550 transcriptional preinitiation complex IDA 9841876
genes like me logo Genes that share ontologies with GTF2F2: view

Pathways & Interactions for GTF2F2 Gene

PathCards logo

SuperPathways for GTF2F2 Gene

SuperPathway Contained pathways
1 Formation of HIV-1 elongation complex containing HIV-1 Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
.91
.91
.51
.32
3 HIV Life Cycle
.45
4 Signaling by FGFR2 in disease
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with GTF2F2: view

Pathways by source for GTF2F2 Gene

1 GeneGo (Thomson Reuters) pathway for GTF2F2 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
6 Qiagen pathways for GTF2F2 Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Protein Acetylation and Deacetylation
  • RAR-Gamma-RXR-Alpha Degradation

Gene Ontology (GO) - Biological Process for GTF2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
genes like me logo Genes that share ontologies with GTF2F2: view

No data available for SIGNOR curated interactions for GTF2F2 Gene

Drugs & Compounds for GTF2F2 Gene

(4) Drugs for GTF2F2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(2) Additional Compounds for GTF2F2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with GTF2F2: view

Transcripts for GTF2F2 Gene

mRNA/cDNA for GTF2F2 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2F2

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for GTF2F2 Gene

GeneLoc Exon Structure for
GTF2F2

Expression for GTF2F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF2F2 Gene

Protein differential expression in normal tissues from HIPED for GTF2F2 Gene

This gene is overexpressed in Fetal testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF2F2 Gene



Protein tissue co-expression partners for GTF2F2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTF2F2

SOURCE GeneReport for Unigene cluster for GTF2F2 Gene:

Hs.654582

Evidence on tissue expression from TISSUES for GTF2F2 Gene

  • Kidney(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with GTF2F2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2F2 Gene

Orthologs for GTF2F2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2F2 31 30
  • 99.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 95 (a)
OneToMany
-- 31
  • 95 (a)
OneToMany
GTF2F2 30
  • 93.71 (n)
cow
(Bos Taurus)
Mammalia GTF2F2 31 30
  • 92.1 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2f2 30
  • 90.5 (n)
mouse
(Mus musculus)
Mammalia Gtf2f2 17 31 30
  • 90.09 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 89 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2F2 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2F2 31 30
  • 81.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2F2 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2f2 30
  • 75.81 (n)
MGC75790 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398333 30
zebrafish
(Danio rerio)
Actinopterygii gtf2f2a 31 30
  • 73.23 (n)
OneToMany
gtf2f2b 31
  • 71 (a)
OneToMany
wufb39a05 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6892 30
fruit fly
(Drosophila melanogaster)
Insecta TfIIFbeta 31 30
  • 55.32 (n)
OneToOne
TfIIF&bgr; 32
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007002 30
  • 54.04 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y39B6A.36 30
  • 49.38 (n)
Y39B6A.36 31 32
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFG2 33 31
  • 16 (a)
Species where no ortholog for GTF2F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2F2 Gene

ENSEMBL:
Gene Tree for GTF2F2 (if available)
TreeFam:
Gene Tree for GTF2F2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF2F2: view image

Paralogs for GTF2F2 Gene

Pseudogenes.org Pseudogenes for GTF2F2 Gene

genes like me logo Genes that share paralogs with GTF2F2: view

No data available for Paralogs for GTF2F2 Gene

Variants for GTF2F2 Gene

Additional dbSNP identifiers (rs#s) for GTF2F2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTF2F2 Gene

Variant ID Type Subtype PubMed ID
esv2656529 CNV deletion 23128226
esv2660215 CNV deletion 23128226
esv3631947 CNV loss 21293372
esv3631948 CNV loss 21293372
nsv1046200 CNV gain 25217958
nsv1122814 CNV deletion 24896259
nsv518593 CNV loss 19592680
nsv832596 CNV loss 17160897

Variation tolerance for GTF2F2 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF2F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GTF2F2 Gene

Disorders for GTF2F2 Gene

Additional Disease Information for GTF2F2

No disorders were found for GTF2F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2F2 Gene

Publications for GTF2F2 Gene

  1. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PMID: 12737519) Wei W … Murakami S (Cell research 2003) 3 4 23 54
  2. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PMID: 10454543) Kim JB … Sharp PA (Molecular and cellular biology 1999) 3 4 23 54
  3. Mutational analysis of human RNA polymerase II subunit 5 (RPB5): the residues critical for interactions with TFIIF subunit RAP30 and hepatitis B virus X protein. (PMID: 16169872) Le TT … Murakami S (Journal of biochemistry 2005) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. (PMID: 14612417) Hsu LC … Yeung CY (Molecular and cellular biology 2003) 3 23 54

Products for GTF2F2 Gene

Sources for GTF2F2 Gene