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Aliases for GTF2F1 Gene

Aliases for GTF2F1 Gene

  • General Transcription Factor IIF Subunit 1 2 3 4 5
  • General Transcription Factor IIF, Polypeptide 1, 74kDa 2 3
  • Transcription Initiation Factor IIF Subunit Alpha 3 4
  • General Transcription Factor IIF 74 KDa Subunit 3 4
  • Transcription Initiation Factor RAP74 3 4
  • TFIIF-Alpha 3 4
  • RAP74 3 4
  • General Transcription Factor IIF, Polypeptide 1 (74kD Subunit) 2
  • TF2F1 3
  • TFIIF 3
  • BTF4 3

External Ids for GTF2F1 Gene

Previous GeneCards Identifiers for GTF2F1 Gene

  • GC19M006474
  • GC19M006319
  • GC19M006330
  • GC19M006235
  • GC19M006139

Summaries for GTF2F1 Gene

GeneCards Summary for GTF2F1 Gene

GTF2F1 (General Transcription Factor IIF Subunit 1) is a Protein Coding gene. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for GTF2F1 Gene

  • TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

Gene Wiki entry for GTF2F1 Gene

Additional gene information for GTF2F1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2F1 Gene

Genomics for GTF2F1 Gene

GeneHancer (GH) Regulatory Elements for GTF2F1 Gene

Promoters and enhancers for GTF2F1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006392 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 612.9 +0.2 181 3.6 ZFX MNT ZNF148 NKRF CSDE1 ZNF687 MAFK YY1 ELF1 SP7 GTF2F1 MIR6790 LOC390877 KHSRP SNRPEP4 CLPP SLC25A41
GH19J006527 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 75.5 -136.9 -136904 6.6 ZNF473 SP1 ELF3 CC2D1A ZFX ZNF148 NKRF POLR2A MLLT1 GTF2F1 TNFSF9 ZNF557 KHSRP DUS3L SAFB SAFB2 SNRPEP4 RANBP3 GTF2F1 ENSG00000267571
GH19J005689 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48.9 +701.9 701884 5 ZFX SP1 ELF3 CTCF MNT NKRF POLR2A MLLT1 ZNF121 GTF2F1 RPL36 KHSRP DUS3L SAFB SNRPEP4 ENSG00000267571 SAFB2 KDM4B GTF2F1 RANBP3
GH19J006371 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.4 +21.2 21179 4.4 SP1 CC2D1A ZFX ELF3 CBFA2T2 ZNF148 NKRF MLLT1 GTF2F1 FOS ALKBH7 KHSRP DUS3L ZNF557 SAFB RANBP3 SNRPEP4 GTF2F1 SAFB2 TRIP10
GH19J005679 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.4 +713.3 713284 3 ZNF473 SP1 ZFX ELF3 SIX5 CBFA2T2 NKRF MLLT1 RERE POLR2A HSD11B1L MICOS13 DUS3L SAFB KHSRP ENSG00000267571 KDM4B RANBP3 SAFB2 GTF2F1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF2F1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTF2F1 gene promoter:
  • AhR
  • AREB6
  • Arnt
  • c-Myc
  • HEN1
  • Ik-1
  • Max1
  • Olf-1
  • XBP-1
  • Zic3

Genomic Locations for GTF2F1 Gene

Genomic Locations for GTF2F1 Gene
chr19:6,379,569-6,393,981
(GRCh38/hg38)
Size:
14,413 bases
Orientation:
Minus strand
chr19:6,379,580-6,393,992
(GRCh37/hg19)
Size:
14,413 bases
Orientation:
Minus strand

Genomic View for GTF2F1 Gene

Genes around GTF2F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2F1 Gene

Proteins for GTF2F1 Gene

  • Protein details for GTF2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35269-T2FA_HUMAN
    Recommended name:
    General transcription factor IIF subunit 1
    Protein Accession:
    P35269
    Secondary Accessions:
    • B2RCS0
    • Q9BWN0

    Protein attributes for GTF2F1 Gene

    Size:
    517 amino acids
    Molecular mass:
    58240 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2, CTDP1, TAF6/TAFII80 and URI1. Interacts with GTF2B (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2 (PubMed:8662660, PubMed:12931194).

    Three dimensional structures from OCA and Proteopedia for GTF2F1 Gene

neXtProt entry for GTF2F1 Gene

Post-translational modifications for GTF2F1 Gene

  • Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.
  • Ubiquitination at isoforms=169
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2F1 Gene

No data available for DME Specific Peptides for GTF2F1 Gene

Domains & Families for GTF2F1 Gene

Gene Families for GTF2F1 Gene

Suggested Antigen Peptide Sequences for GTF2F1 Gene

GenScript: Design optimal peptide antigens:
  • GTF2F1 protein (Q6IBK5_HUMAN)
  • Transcription initiation factor RAP74 (T2FA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35269

UniProtKB/Swiss-Prot:

T2FA_HUMAN :
  • Belongs to the TFIIF alpha subunit family.
Family:
  • Belongs to the TFIIF alpha subunit family.
genes like me logo Genes that share domains with GTF2F1: view

Function for GTF2F1 Gene

Molecular function for GTF2F1 Gene

UniProtKB/Swiss-Prot Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection.
GENATLAS Biochemistry:
general transcription factor IIF,polypeptide 1 (74kDa),increasing the average rate of RNA chain elongation across DNA templates

Phenotypes From GWAS Catalog for GTF2F1 Gene

Gene Ontology (GO) - Molecular Function for GTF2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 7854423
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 7590250
GO:0008134 transcription factor binding IPI 8625415
genes like me logo Genes that share ontologies with GTF2F1: view
genes like me logo Genes that share phenotypes with GTF2F1: view

Animal Model Products

CRISPR Products

miRNA for GTF2F1 Gene

miRTarBase miRNAs that target GTF2F1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2F1

Clone Products

  • Applied Biological Materials (abm): Clones for GTF2F1 - Now 50% OFF >
  • * GTF2F1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GTF2F1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2F1 Gene

Localization for GTF2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2F1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2F1 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (4)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP,IEA 15723517
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005674 transcription factor TFIIF complex TAS 1734283
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GTF2F1: view

Pathways & Interactions for GTF2F1 Gene

PathCards logo

SuperPathways for GTF2F1 Gene

SuperPathway Contained pathways
1 Formation of HIV-1 elongation complex containing HIV-1 Tat
2 RNA Polymerase II Transcription Initiation And Promoter Clearance
3 HIV Life Cycle
.45
4 Signaling by FGFR2 in disease
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with GTF2F1: view

SIGNOR curated interactions for GTF2F1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for GTF2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS,IEA --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
genes like me logo Genes that share ontologies with GTF2F1: view

Drugs & Compounds for GTF2F1 Gene

(2) Drugs for GTF2F1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with GTF2F1: view

Transcripts for GTF2F1 Gene

mRNA/cDNA for GTF2F1 Gene

Unigene Clusters for GTF2F1 Gene

General transcription factor IIF, polypeptide 1, 74kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2F1

Clone Products

  • Applied Biological Materials (abm): Clones for GTF2F1 - Now 50% OFF >
  • * GTF2F1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GTF2F1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2F1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a ·
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: -
SP8: - - - - -

ExUns: 18b · 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GTF2F1 Gene

GeneLoc Exon Structure for
GTF2F1
ECgene alternative splicing isoforms for
GTF2F1

Expression for GTF2F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF2F1 Gene

Protein differential expression in normal tissues from HIPED for GTF2F1 Gene

This gene is overexpressed in Adrenal (20.8), Peripheral blood mononuclear cells (15.2), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF2F1 Gene



Protein tissue co-expression partners for GTF2F1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF2F1 Gene:

GTF2F1

SOURCE GeneReport for Unigene cluster for GTF2F1 Gene:

Hs.68257

Evidence on tissue expression from TISSUES for GTF2F1 Gene

  • Eye(4.4)
  • Liver(4.3)
  • Muscle(4.3)
  • Stomach(4.3)
  • Nervous system(3.6)
  • Kidney(2)
genes like me logo Genes that share expression patterns with GTF2F1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2F1 Gene

Orthologs for GTF2F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTF2F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2F1 35 34
  • 98.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2F1 34 35
  • 87.81 (n)
cow
(Bos Taurus)
Mammalia GTF2F1 34 35
  • 86.91 (n)
rat
(Rattus norvegicus)
Mammalia Gtf2f1 34
  • 86.35 (n)
mouse
(Mus musculus)
Mammalia Gtf2f1 17 35 34
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2F1 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2F1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2f1 34
  • 68.69 (n)
Str.6357 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398325 34
zebrafish
(Danio rerio)
Actinopterygii gtf2f1 34 35
  • 67.77 (n)
wufd13c08 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002779 34
  • 53.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta TfIIFalpha 36 35
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea C01F1.1 35
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToOne
Species where no ortholog for GTF2F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2F1 Gene

ENSEMBL:
Gene Tree for GTF2F1 (if available)
TreeFam:
Gene Tree for GTF2F1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF2F1: view image

Paralogs for GTF2F1 Gene

No data available for Paralogs for GTF2F1 Gene

Variants for GTF2F1 Gene

Sequence variations from dbSNP and Humsavar for GTF2F1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000029043 -- 6,380,251(-) G/A/C/T 3_prime_UTR_variant
rs1000091228 -- 6,381,231(-) A/C intron_variant
rs1000708854 -- 6,383,409(-) T/A coding_sequence_variant, missense_variant
rs1001197030 -- 6,387,099(-) G/A intron_variant
rs1001257736 -- 6,389,088(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2F1 Gene

Variant ID Type Subtype PubMed ID
esv2667354 CNV deletion 23128226
esv3555946 CNV deletion 23714750
esv3643555 CNV loss 21293372
esv3643556 CNV gain 21293372
esv3643557 CNV loss 21293372
nsv513757 CNV insertion 21212237

Variation tolerance for GTF2F1 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF2F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2F1 Gene

Disorders for GTF2F1 Gene

Additional Disease Information for GTF2F1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GTF2F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2F1 Gene

Publications for GTF2F1 Gene

  1. A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. (PMID: 1734284) Finkelstein A … Burton ZF (Nature 1992) 2 3 4 23 58
  2. Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. (PMID: 12578358) Nguyen BD … Omichinski JG (Biochemistry 2003) 3 4 23 58
  3. Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF. (PMID: 12591941) Kamada K … Burley SK (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 23 58
  4. NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. (PMID: 12732728) Nguyen BD … Omichinski JG (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 23 58
  5. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). (PMID: 12737519) Wei W … Murakami S (Cell research 2003) 3 4 23 58

Products for GTF2F1 Gene

Sources for GTF2F1 Gene

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