Aliases for GTF2E2 Gene
External Ids for GTF2E2 Gene
Previous GeneCards Identifiers for GTF2E2 Gene
The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]
GeneCards Summary for GTF2E2 Gene
GTF2E2 (General Transcription Factor IIE Subunit 2) is a Protein Coding gene. Diseases associated with GTF2E2 include Trichothiodystrophy 6, Nonphotosensitive and Trichothiodystrophy. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Apoptotic Pathways in Synovial Fibroblasts.
UniProtKB/Swiss-Prot Summary for GTF2E2 Gene
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.