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Aliases for GTF2E1 Gene

Aliases for GTF2E1 Gene

  • General Transcription Factor IIE Subunit 1 2 3 3 5
  • General Transcription Factor IIE, Polypeptide 1, Alpha 56kDa 2 3
  • Transcription Initiation Factor IIE Subunit Alpha 3 4
  • General Transcription Factor IIE 56 KDa Subunit 3 4
  • TFIIE Alpha Subunit 2 3
  • TFIIE-Alpha 3 4
  • TF2E1 3 4
  • General Transcription Factor IIE, Polypeptide 1 (Alpha Subunit, 56kD) 2
  • TFIIE-A 3
  • FE 3

External Ids for GTF2E1 Gene

Previous GeneCards Identifiers for GTF2E1 Gene

  • GC03P117106
  • GC03P120110
  • GC03P121742
  • GC03P121790
  • GC03P121952
  • GC03P120461
  • GC03P117835

Summaries for GTF2E1 Gene

GeneCards Summary for GTF2E1 Gene

GTF2E1 (General Transcription Factor IIE Subunit 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding.

UniProtKB/Swiss-Prot for GTF2E1 Gene

  • Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Gene Wiki entry for GTF2E1 Gene

Additional gene information for GTF2E1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2E1 Gene

Genomics for GTF2E1 Gene

GeneHancer (GH) Regulatory Elements for GTF2E1 Gene

Promoters and enhancers for GTF2E1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J120741 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 657.7 +0.2 154 3.1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 IRF4 YY1 E2F8 ZNF143 GTF2E1 RABL3
GH03J121544 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.7 +803.2 803237 2.5 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B E2F8 ZNF143 POLQ IQCB1 GOLGB1 GTF2E1 LOC102723582 STXBP5L RPL7AP11 GC03M121324
GH03J120090 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -648.7 -648699 7.1 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B GSK3B ENSG00000242622 POGLUT1 TMEM39A GTF2E1 GC03M119752
GH03J120595 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.2 -146.0 -145999 2.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF143 SP5 NDUFB4 FSTL1 GTF2E1 RABL3 PIR48626
GH03J120641 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -100.0 -100008 1.4 HDAC1 ATF1 TAF9B NFRKB ZNF766 EGR1 ATF7 CREM NCOA1 ZNF592 HGD RABL3 GTF2E1 PIR48626
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF2E1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTF2E1 gene promoter:
  • S8
  • HNF-4alpha2
  • HNF-4alpha1
  • AML1a
  • TGIF
  • ZID
  • Pax-4a
  • AP-1
  • c-Fos
  • LUN-1

Genomic Locations for GTF2E1 Gene

Genomic Locations for GTF2E1 Gene
chr3:120,742,637-120,783,070
(GRCh38/hg38)
Size:
40,434 bases
Orientation:
Plus strand
chr3:120,461,484-120,501,916
(GRCh37/hg19)
Size:
40,433 bases
Orientation:
Plus strand

Genomic View for GTF2E1 Gene

Genes around GTF2E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2E1 Gene

Proteins for GTF2E1 Gene

  • Protein details for GTF2E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29083-T2EA_HUMAN
    Recommended name:
    General transcription factor IIE subunit 1
    Protein Accession:
    P29083
    Secondary Accessions:
    • Q16103

    Protein attributes for GTF2E1 Gene

    Size:
    439 amino acids
    Molecular mass:
    49452 Da
    Quaternary structure:
    • Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with varicella-zoster virus IE63 protein.

    Three dimensional structures from OCA and Proteopedia for GTF2E1 Gene

neXtProt entry for GTF2E1 Gene

Post-translational modifications for GTF2E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2E1 Gene

No data available for DME Specific Peptides for GTF2E1 Gene

Domains & Families for GTF2E1 Gene

Gene Families for GTF2E1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GTF2E1 Gene

Graphical View of Domain Structure for InterPro Entry

P29083

UniProtKB/Swiss-Prot:

T2EA_HUMAN :
  • Belongs to the TFIIE alpha subunit family.
Family:
  • Belongs to the TFIIE alpha subunit family.
genes like me logo Genes that share domains with GTF2E1: view

Function for GTF2E1 Gene

Molecular function for GTF2E1 Gene

UniProtKB/Swiss-Prot Function:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
GENATLAS Biochemistry:
general transcription factor IIE,alpha polypeptide (56kDa)

Phenotypes From GWAS Catalog for GTF2E1 Gene

Gene Ontology (GO) - Molecular Function for GTF2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IBA --
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IBA --
GO:0001097 TFIIH-class transcription factor binding IBA --
GO:0005515 protein binding IPI 7667268
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with GTF2E1: view
genes like me logo Genes that share phenotypes with GTF2E1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2E1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2E1 Gene

Localization for GTF2E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2E1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2E1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (4)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9841876
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005673 transcription factor TFIIE complex IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with GTF2E1: view

Pathways & Interactions for GTF2E1 Gene

genes like me logo Genes that share pathways with GTF2E1: view

Gene Ontology (GO) - Biological Process for GTF2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001113 transcriptional open complex formation at RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006366 transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with GTF2E1: view

No data available for SIGNOR curated interactions for GTF2E1 Gene

Drugs & Compounds for GTF2E1 Gene

No Compound Related Data Available

Transcripts for GTF2E1 Gene

mRNA/cDNA for GTF2E1 Gene

Unigene Clusters for GTF2E1 Gene

General transcription factor IIE, polypeptide 1, alpha 56kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2E1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2E1 Gene

No ASD Table

Relevant External Links for GTF2E1 Gene

GeneLoc Exon Structure for
GTF2E1
ECgene alternative splicing isoforms for
GTF2E1

Expression for GTF2E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF2E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GTF2E1 Gene

This gene is overexpressed in Lymph node (11.6) and Pancreas (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF2E1 Gene



Protein tissue co-expression partners for GTF2E1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF2E1 Gene:

GTF2E1

SOURCE GeneReport for Unigene cluster for GTF2E1 Gene:

Hs.445272
genes like me logo Genes that share expression patterns with GTF2E1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2E1 Gene

Orthologs for GTF2E1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF2E1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2E1 34 33
  • 99.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2E1 34 33
  • 92.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GTF2E1 34 33
  • 91.93 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gtf2e1 16 34 33
  • 88.69 (n)
rat
(Rattus norvegicus)
Mammalia Gtf2e1 33
  • 88.36 (n)
oppossum
(Monodelphis domestica)
Mammalia GTF2E1 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2E1 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2E1 34 33
  • 74.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2E1 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2e1 33
  • 66.74 (n)
Str.637 33
African clawed frog
(Xenopus laevis)
Amphibia tfiiealpha-prov 33
zebrafish
(Danio rerio)
Actinopterygii gtf2e1 34 33
  • 67.43 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006355 33
  • 50.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta TfIIEalpha 34 35 33
  • 49.59 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_ZK550.4 33
  • 46.76 (n)
ZK550.4 34 35
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFA1 36 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToOne
Species where no ortholog for GTF2E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2E1 Gene

ENSEMBL:
Gene Tree for GTF2E1 (if available)
TreeFam:
Gene Tree for GTF2E1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF2E1: view image

Paralogs for GTF2E1 Gene

No data available for Paralogs for GTF2E1 Gene

Variants for GTF2E1 Gene

Sequence variations from dbSNP and Humsavar for GTF2E1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000161894 -- 120,747,407(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000174333 -- 120,752,467(+) C/T intron_variant
rs1000249083 -- 120,748,091(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000250442 -- 120,766,421(+) C/T intron_variant
rs1000280459 -- 120,759,000(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2E1 Gene

Variant ID Type Subtype PubMed ID
dgv1404e212 CNV loss 25503493
dgv4847n100 CNV gain 25217958
nsv507121 OTHER sequence alteration 20534489
nsv829699 CNV loss 17160897
nsv829700 CNV gain+loss 17160897

Variation tolerance for GTF2E1 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF2E1 Gene

Human Gene Mutation Database (HGMD)
GTF2E1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2E1 Gene

Disorders for GTF2E1 Gene

Additional Disease Information for GTF2E1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GTF2E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2E1 Gene

Publications for GTF2E1 Gene

  1. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 44 58
  2. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PMID: 19106100) Liu L … Nakao M (The Journal of biological chemistry 2009) 3 4 58
  3. p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH. (PMID: 18160537) Di Lello P … Omichinski JG (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 22 58
  4. Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PMID: 7667268) Hisatake K … Roeder RG (Proceedings of the National Academy of Sciences of the United States of America 1995) 3 4 58
  5. Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome. (PMID: 8162052) Heng HH … Tsui LC (Human molecular genetics 1994) 2 3 58

Products for GTF2E1 Gene

Sources for GTF2E1 Gene

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