GTF2B Gene (Protein Coding)

General Transcription Factor IIB

GC01M088853
GIFtS:
43
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequen... See more...

Aliases for GTF2B Gene

Aliases for GTF2B Gene

  • General Transcription Factor IIB 2 3 5
  • TFIIB 2 3 4
  • Transcription Initiation Factor IIB 3 4
  • General Transcription Factor TFIIB 3 4
  • S300-II 3 4
  • TF2B 3 4
  • RNA Polymerase II Transcription Factor IIB 3
  • EC 2.3.1.48 4
  • GTF2B 5

External Ids for GTF2B Gene

Previous GeneCards Identifiers for GTF2B Gene

  • GC01M089795
  • GC01M088488
  • GC01M088655
  • GC01M088785
  • GC01M089030
  • GC01M089318
  • GC01M087435

Summaries for GTF2B Gene

Entrez Gene Summary for GTF2B Gene

  • This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTF2B Gene

GTF2B (General Transcription Factor IIB) is a Protein Coding gene. Diseases associated with GTF2B include Herpes Simplex and Xeroderma Pigmentosum, Complementation Group B. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include transcription factor binding and thyroid hormone receptor binding. An important paralog of this gene is BRF1.

UniProtKB/Swiss-Prot Summary for GTF2B Gene

  • General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841). Modulates transcription start site selection (PubMed:10318856). Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194).

Gene Wiki entry for GTF2B Gene

Additional gene information for GTF2B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF2B Gene

Genomics for GTF2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GTF2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GTF2B

Top Transcription factor binding sites by QIAGEN in the GTF2B gene promoter:
  • AP-1
  • c-Jun
  • FOXO1
  • FOXO1a
  • TBP
  • TFIID

Genomic Locations for GTF2B Gene

Latest Assembly
chr1:88,852,633-88,891,944
(GRCh38/hg38)
Size:
39,312 bases
Orientation:
Minus strand

Previous Assembly
chr1:89,318,316-89,357,250
(GRCh37/hg19 by Entrez Gene)
Size:
38,935 bases
Orientation:
Minus strand

chr1:89,318,615-89,357,627
(GRCh37/hg19 by Ensembl)
Size:
39,013 bases
Orientation:
Minus strand

Genomic View for GTF2B Gene

Genes around GTF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GTF2B Gene

Proteins for GTF2B Gene

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  • Protein details for GTF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00403-TF2B_HUMAN
    Recommended name:
    Transcription initiation factor IIB
    Protein Accession:
    Q00403
    Secondary Accessions:
    • A8K1A7
    • Q5JS30

    Protein attributes for GTF2B Gene

    Size:
    316 amino acids
    Molecular mass:
    34833 Da
    Quaternary structure:
    • Found in a ternary complex with TATA box-bound TBP (PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:10619841, PubMed:29158257). Part of a TFIID-containing RNA polymerase II pre-initiation complex (PIC) that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27193682). Associates with TFIID-TFIIA (DA complex) to form TFIID-TFIIA-TFIIB (DAB complex), which is then recognized by RNA polymerase II (Pol II) (PubMed:1876184, PubMed:2247058). Found in a RNA polymerase II initiation complex (PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8516312, PubMed:7601352). Interacts (via C-terminus) with TBP; this interaction with TATA box-bound TBP guides Pol II into the PIC (PubMed:8504927, PubMed:10619841). Interacts (via N-terminus) with Pol II (PubMed:8504927, PubMed:8413225). Interacts (via C-terminus) with SSU72; this interaction is inhibited by SYMPK (PubMed:29158257). Interacts with NR2F1; this interaction is direct (PubMed:1517211). Interacts with PGR (PubMed:1517211). Interacts with ESR1 (PubMed:1517211). Interacts with GTF2F1 (via C-terminus and preferentially via acetylated form); this interaction prevents binding of GTF2B to GTF2F2 (PubMed:8662660, PubMed:12931194). Interacts with GTF2F2 (via N-terminus); this interaction is inhibited in presence of GTF2F1 (PubMed:8504927, PubMed:8662660). Interacts with the transcription elongation factor TCEA2 (PubMed:8566795). Interacts with HSF1 (via transactivation domain) (PubMed:11005381). Interacts with GPBP1 (By similarity).
    • (Microbial infection) Interacts with HIV-1 Vpr.
    • (Microbial infection) Interacts with Epstein-Barr virus EBNA2.
    • (Microbial infection) Interacts with Herpes simplex virus 1 protein ICP4.
    • (Microbial infection) Interacts (via C-terminus) with the Herpes simplex virus activator VP16; this interaction stimulates RNA Pol II transcription by increasing the extent of pre-initiation complex assembly.

    Three dimensional structures from OCA and Proteopedia for GTF2B Gene

neXtProt entry for GTF2B Gene

Protein Expression for GTF2B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GTF2B Gene

  • Acetylated (PubMed:24441171). Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation (PubMed:12931194).
  • Ubiquitination at Lys100 and Lys178
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GTF2B Gene

Domains & Families for GTF2B Gene

Gene Families for GTF2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GTF2B Gene

InterPro:
Blocks:
  • Cyclin
  • Transcription factor TFIIB family
  • Zinc finger, TFIIB-type
ProtoNet:

Suggested Antigen Peptide Sequences for GTF2B Gene

GenScript: Design optimal peptide antigens:
  • General transcription factor IIB (B1APE1_HUMAN)
  • S300-II (TF2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q00403

UniProtKB/Swiss-Prot:

TF2B_HUMAN :
  • The TFIIB-type zinc-binding domain is necessary for the interaction and recruitment of RNA polymerase II to the core promoter, the formation of a fully competent pre-initiation complex (PIC) assembly and basal transcription initiation (PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:8413225). The C-terminus is necessary and sufficient for interaction with the TATA box-bound TBP complex and for the formation of PIC (PubMed:8515820, PubMed:8516311, PubMed:8413225).
  • Belongs to the TFIIB family.
Domain:
  • The TFIIB-type zinc-binding domain is necessary for the interaction and recruitment of RNA polymerase II to the core promoter, the formation of a fully competent pre-initiation complex (PIC) assembly and basal transcription initiation (PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:8413225). The C-terminus is necessary and sufficient for interaction with the TATA box-bound TBP complex and for the formation of PIC (PubMed:8515820, PubMed:8516311, PubMed:8413225).
Family:
  • Belongs to the TFIIB family.
genes like me logo Genes that share domains with GTF2B: view

Function for GTF2B Gene

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  6. Cell Lines for research

Molecular function for GTF2B Gene

UniProtKB/Swiss-Prot Function:
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed:1876184, PubMed:1946368, PubMed:1517211, PubMed:3818643, PubMed:3029109, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312, PubMed:7601352, PubMed:9420329, PubMed:12931194, PubMed:27193682). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed:8504927, PubMed:8413225, PubMed:8515820, PubMed:8516311, PubMed:8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed:7601352). Associates with chromatin to core promoter-specific regions (PubMed:12931194, PubMed:24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed:9420329, PubMed:16230532, PubMed:7675079, PubMed:10619841). Modulates transcription start site selection (PubMed:10318856). Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed:12931194).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269|PubMed:12931194};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.117 mM for acetyl-CoA {ECO:0000269|PubMed:12931194};
GENATLAS Biochemistry:
general transcription factor IIB,35 kDa

Enzyme Numbers (IUBMB) for GTF2B Gene

Phenotypes From GWAS Catalog for GTF2B Gene

Gene Ontology (GO) - Molecular Function for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IBA,IDA 7675079
GO:0000993 RNA polymerase II complex binding IDA 8413225
GO:0003677 DNA binding IEA --
GO:0004402 histone acetyltransferase activity IEA --
GO:0005515 protein binding IPI 1517211
genes like me logo Genes that share ontologies with GTF2B: view
genes like me logo Genes that share phenotypes with GTF2B: view

Animal Models for GTF2B Gene

MGI Knock Outs for GTF2B:
  • Gtf2b Gtf2b<tm1b(EUCOMM)Wtsi>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2B

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF2B Gene

Localization for GTF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2B Gene

Nucleus. Chromosome. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis (PubMed:24441171). Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle (PubMed:24441171). {ECO:0000269 PubMed:24441171}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2B gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 9841876
GO:0005654 nucleoplasm IDA,TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005694 chromosome IEA,IDA 24441171
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with GTF2B: view

Pathways & Interactions for GTF2B Gene

genes like me logo Genes that share pathways with GTF2B: view

Pathways by source for GTF2B Gene

1 BioSystems pathway for GTF2B Gene
1 GeneGo (Thomson Reuters) pathway for GTF2B Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
11 Qiagen pathways for GTF2B Gene
  • AHR Pathway
  • Androgen Signaling
  • Assembly of RNA Polymerase-II Initiation Complex
  • CREB Pathway
  • Crosstalk Between CARM1 and ESRs
1 Cell Signaling Technology pathway for GTF2B Gene

SIGNOR curated interactions for GTF2B Gene

Activates:

Gene Ontology (GO) - Biological Process for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001174 transcriptional start site selection at RNA polymerase II promoter IBA,IMP 10318856
GO:0006352 DNA-templated transcription, initiation IEA,IBA 21873635
GO:0006366 transcription by RNA polymerase II IDA,TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006473 protein acetylation IBA,IDA 12931194
genes like me logo Genes that share ontologies with GTF2B: view

Drugs & Compounds for GTF2B Gene

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(12) Drugs for GTF2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for GTF2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTF2B: view

Transcripts for GTF2B Gene

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mRNA/cDNA for GTF2B Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2B

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for GTF2B Gene

GeneLoc Exon Structure for
GTF2B

Expression for GTF2B Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF2B Gene

mRNA expression in normal human tissues for GTF2B Gene
mRNA expression by BioGPS for GTF2B GenemRNA expression by GTEx for GTF2B Gene

Protein differential expression in normal tissues from HIPED for GTF2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1) and Lung (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF2B Gene



Protein tissue co-expression partners for GTF2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTF2B

SOURCE GeneReport for Unigene cluster for GTF2B Gene:

Hs.481852

mRNA Expression by UniProt/SwissProt for GTF2B Gene:

Q00403-TF2B_HUMAN
Tissue specificity: Expressed in the inner cell mass forming the embryoblast (PubMed:24441171). Not detected in cells from the outer thin layer trophoblast (at protein level) (PubMed:24441171).

Evidence on tissue expression from TISSUES for GTF2B Gene

  • Nervous system(4.7)
  • Skin(2.5)
  • Bone marrow(2.5)
  • Liver(2.5)
  • Kidney(2.4)
  • Blood(2.3)
  • Intestine(2.2)
  • Muscle(2.2)
  • Thyroid gland(2.2)
  • Heart(2)
  • Lymph node(2)
  • Spleen(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with GTF2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2B Gene

Orthologs for GTF2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GTF2B 30 31
  • 99.37 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia GTF2B 31
  • 99 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia GTF2B 31
  • 96 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GTF2B 30 31
  • 95.68 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GTF2B 30 31
  • 93.67 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Gtf2b 30 17 31
  • 89.98 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gtf2b 30
  • 89.87 (n)
Chicken
(Gallus gallus)
 Aves GTF2B 30 31
  • 85.55 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GTF2B 31
  • 97 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gtf2b 30
  • 80.49 (n)
Str.18092 30
African clawed frog
(Xenopus laevis)
 Amphibia gtf2b-A 30
Zebrafish
(Danio rerio)
 Actinopterygii gtf2b 30 31
  • 78.06 (n)
 OneToOne
wufc44c11 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.422 30
Fruit Fly
(Drosophila melanogaster)
 Insecta TfIIB 30 31 32
  • 65.71 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009558 30
  • 64.33 (n)
Worm
(Caenorhabditis elegans)
 Secernentea ttb-1 30 31 32
  • 60.67 (n)
 OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D13640g 30
  • 48.45 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SUA7 30 31 33
  • 48.15 (n)
 OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ADR007C 30
  • 46.44 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons TFIIB 30
  • 55.64 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.3214 30
Rice
(Oryza sativa)
 Liliopsida Os09g0534800 30
  • 53.78 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.6926 31
  • 72 (a)
 OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC16E8.16 30
  • 51.46 (n)
Bread mold
(Neurospora crassa)
 Ascomycetes NCU07289 30
  • 49.25 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.2391 30
Species where no ortholog for GTF2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GTF2B Gene

ENSEMBL:
Gene Tree for GTF2B (if available)
TreeFam:
Gene Tree for GTF2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF2B: view image

Paralogs for GTF2B Gene

Paralogs for GTF2B Gene

genes like me logo Genes that share paralogs with GTF2B: view

Variants for GTF2B Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GTF2B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs144944840 A colorectal cancer sample p.Arg132Gln
rs1804499 - p.Pro19Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GTF2B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GTF2B Gene

Variant ID Type Subtype PubMed ID
dgv22n27 CNV gain 19166990
dgv360n54 CNV gain 21841781
esv3586748 CNV loss 21293372
nsv462472 CNV loss 19166990
nsv546784 CNV loss 21841781
nsv830514 CNV loss 17160897
nsv830525 CNV loss 17160897
nsv830537 CNV gain 17160897

Variation tolerance for GTF2B Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2B Gene

Disorders for GTF2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GTF2B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
xeroderma pigmentosum, complementation group b
  • xpb
- elite association - COSMIC cancer census association via MalaCards
Search GTF2B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GTF2B

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GTF2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF2B Gene

Publications for GTF2B Gene

  1. Cloning of a human gene encoding the general transcription initiation factor IIB. (PMID: 1876184) Ha I ā€¦ Reinberg D (Nature 1991) 2 3 4 23
  2. A core promoter element downstream of the TATA box that is recognized by TFIIB. (PMID: 16230532) Deng W ā€¦ Roberts SG (Genes & development 2005) 3 4 23
  3. Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB. (PMID: 14641108) Ghosh M ā€¦ Ikura M (The Biochemical journal 2004) 3 4 23
  4. Transcription factor IIB acetylates itself to regulate transcription. (PMID: 12931194) Choi CH ā€¦ Usheva A (Nature 2003) 3 4 23
  5. Potential targets for HSF1 within the preinitiation complex. (PMID: 11005381) Yuan CX ā€¦ Gurley WB (Cell stress & chaperones 2000) 3 4 23

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