Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GTF2B Gene

Aliases for GTF2B Gene

  • General Transcription Factor IIB 2 3 5
  • General Transcription Factor TFIIB 3 4
  • S300-II 3 4
  • TFIIB 3 4
  • TF2B 3 4
  • RNA Polymerase II Transcription Factor IIB 3
  • Transcription Initiation Factor IIB 3

External Ids for GTF2B Gene

Previous GeneCards Identifiers for GTF2B Gene

  • GC01M089795
  • GC01M088488
  • GC01M088655
  • GC01M088785
  • GC01M089030
  • GC01M089318
  • GC01M087435

Summaries for GTF2B Gene

Entrez Gene Summary for GTF2B Gene

  • This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GeneCards Summary for GTF2B Gene

GTF2B (General Transcription Factor IIB) is a Protein Coding gene. Diseases associated with GTF2B include Herpes Simplex. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include transcription factor binding and thyroid hormone receptor binding.

UniProtKB/Swiss-Prot for GTF2B Gene

  • General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Gene Wiki entry for GTF2B Gene

Additional gene information for GTF2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2B Gene

Genomics for GTF2B Gene

GeneHancer (GH) Regulatory Elements for GTF2B Gene

Promoters and enhancers for GTF2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J088889 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 650.7 +0.4 358 4 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 GTF2B KYAT3 PKN2 ELOCP19 LOC100130455 PTGES3P1 RBMXL1 GC01M088841
GH01J089523 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 28.5 -633.1 -633111 3.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LRRC8B PKN2 GTF2B LOC100130455 KYAT3 ELOCP19 GC01M089607
GH01J089271 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14 -381.8 -381758 4 NFATC3 CEBPG RAD21 RELA YY1 POLR2A ETV6 STAT1 RXRA CEBPB GBP5 GBP1 GBP4 GBP2 GTF2B GBP3 LRRC8C GC01P089283 LOC100421401
GH01J089762 Promoter/Enhancer 1.5 Ensembl ENCODE 15.1 -870.9 -870885 1.9 HDGF PKNOX1 ATF1 ZNF2 IRF4 ZNF48 ZNF213 E2F8 ARID2 ZNF143 GC01P089762 LOC101927952 LOC101927975 LRRC8C GTF2B LRRC8C-DT LOC100130455 KYAT3 LRRC8D GC01M089737
GH01J089128 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 8.8 -237.3 -237339 1.8 HDAC1 TAF9B ARNT ZBTB40 RAD21 YY1 E2F8 EGR1 ZNF143 ATF7 LOC105378842 GBP1 GBP5 GBP4 GBP2 GBP7 GTF2B GBP3 PTGES3P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTF2B gene promoter:
  • TBP
  • AP-1
  • FOXO1a
  • FOXO1
  • c-Jun

Genomic Locations for GTF2B Gene

Genomic Locations for GTF2B Gene
39,307 bases
Minus strand
39,307 bases
Minus strand

Genomic View for GTF2B Gene

Genes around GTF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2B Gene

Proteins for GTF2B Gene

  • Protein details for GTF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription initiation factor IIB
    Protein Accession:
    Secondary Accessions:
    • A8K1A7
    • Q5JS30

    Protein attributes for GTF2B Gene

    316 amino acids
    Molecular mass:
    34833 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2 (PubMed:8566795). Interacts with GPBP1 (By similarity). Interacts with HSF1 (via transactivation domain) (PubMed:11005381).
    • (Microbial infection) Interacts with HIV-1 Vpr.
    • (Microbial infection) Interacts with Epstein-Barr virus EBNA2.
    • (Microbial infection) Interacts with Herpes simplex virus 1 protein ICP4.

    Three dimensional structures from OCA and Proteopedia for GTF2B Gene

neXtProt entry for GTF2B Gene

Post-translational modifications for GTF2B Gene

  • Ubiquitination at isoforms=178 and isoforms=100
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2B Gene

No data available for DME Specific Peptides for GTF2B Gene

Domains & Families for GTF2B Gene

Gene Families for GTF2B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GTF2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TFIIB family.
  • Belongs to the TFIIB family.
genes like me logo Genes that share domains with GTF2B: view

Function for GTF2B Gene

Molecular function for GTF2B Gene

UniProtKB/Swiss-Prot Function:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
GENATLAS Biochemistry:
general transcription factor IIB,35 kDa

Phenotypes From GWAS Catalog for GTF2B Gene

Gene Ontology (GO) - Molecular Function for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA 9420329
GO:0000993 RNA polymerase II core binding IDA 8413225
GO:0001047 core promoter binding IDA 7675079
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 1517211
genes like me logo Genes that share ontologies with GTF2B: view
genes like me logo Genes that share phenotypes with GTF2B: view

Animal Models for GTF2B Gene

MGI Knock Outs for GTF2B:
  • Gtf2b Gtf2b<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF2B Gene

Localization for GTF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2B gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9841876
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005694 chromosome IDA 24441171
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with GTF2B: view

Pathways & Interactions for GTF2B Gene

genes like me logo Genes that share pathways with GTF2B: view

Pathways by source for GTF2B Gene

Gene Ontology (GO) - Biological Process for GTF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001174 transcriptional start site selection at RNA polymerase II promoter IMP 10318856
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with GTF2B: view

No data available for SIGNOR curated interactions for GTF2B Gene

Drugs & Compounds for GTF2B Gene

(12) Drugs for GTF2B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for GTF2B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GTF2B: view

Transcripts for GTF2B Gene

mRNA/cDNA for GTF2B Gene

Unigene Clusters for GTF2B Gene

General transcription factor IIB:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GTF2B

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for GTF2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTF2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF2B Gene

Protein differential expression in normal tissues from HIPED for GTF2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.1) and Lung (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF2B Gene

Protein tissue co-expression partners for GTF2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF2B Gene:


SOURCE GeneReport for Unigene cluster for GTF2B Gene:


Evidence on tissue expression from TISSUES for GTF2B Gene

  • Nervous system(4.6)
  • Bone marrow(2.3)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with GTF2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2B Gene

Orthologs for GTF2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GTF2B 34 33
  • 99.37 (n)
(Monodelphis domestica)
Mammalia GTF2B 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia GTF2B 34
  • 96 (a)
(Canis familiaris)
Mammalia GTF2B 34 33
  • 95.68 (n)
(Bos Taurus)
Mammalia GTF2B 34 33
  • 93.67 (n)
(Mus musculus)
Mammalia Gtf2b 16 34 33
  • 89.98 (n)
(Rattus norvegicus)
Mammalia Gtf2b 33
  • 89.87 (n)
(Gallus gallus)
Aves GTF2B 34 33
  • 85.55 (n)
(Anolis carolinensis)
Reptilia GTF2B 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2b 33
  • 80.49 (n)
Str.18092 33
African clawed frog
(Xenopus laevis)
Amphibia gtf2b-A 33
(Danio rerio)
Actinopterygii gtf2b 34 33
  • 78.06 (n)
wufc44c11 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.422 33
fruit fly
(Drosophila melanogaster)
Insecta TfIIB 34 35 33
  • 65.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009558 33
  • 64.33 (n)
(Caenorhabditis elegans)
Secernentea ttb-1 34 35 33
  • 60.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13640g 33
  • 48.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUA7 36 34 33
  • 48.15 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR007C 33
  • 46.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TFIIB 33
  • 55.64 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3214 33
(Oryza sativa)
Liliopsida Os09g0534800 33
  • 53.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6926 34
  • 72 (a)
Cin.2391 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC16E8.16 33
  • 51.46 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07289 33
  • 49.25 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2391 33
Species where no ortholog for GTF2B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2B Gene

Gene Tree for GTF2B (if available)
Gene Tree for GTF2B (if available)
Evolutionary constrained regions (ECRs) for GTF2B: view image

Paralogs for GTF2B Gene

No data available for Paralogs for GTF2B Gene

Variants for GTF2B Gene

Sequence variations from dbSNP and Humsavar for GTF2B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs144944840 A colorectal cancer sample 88,860,150(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000022599 -- 88,862,638(-) A/G intron_variant
rs1000053928 -- 88,872,765(-) G/A intron_variant
rs1000056187 -- 88,867,159(-) T/C intron_variant
rs1000065667 -- 88,866,350(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2B Gene

Variant ID Type Subtype PubMed ID
dgv22n27 CNV gain 19166990
dgv360n54 CNV gain 21841781
esv3586748 CNV loss 21293372
nsv462472 CNV loss 19166990
nsv546784 CNV loss 21841781
nsv830514 CNV loss 17160897
nsv830525 CNV loss 17160897
nsv830537 CNV gain 17160897

Variation tolerance for GTF2B Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2B Gene

Disorders for GTF2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for GTF2B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards
Search GTF2B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GTF2B

genes like me logo Genes that share disorders with GTF2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GTF2B Gene

Publications for GTF2B Gene

  1. Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription. (PMID: 11045620) Chen HT … Scott RA (Protein science : a publication of the Protein Society 2000) 3 4 22 58
  2. The HIV-1 Vpr co-activator induces a conformational change in TFIIB. (PMID: 10359081) Agostini I … Sire J (FEBS letters 1999) 3 4 22 58
  3. The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB. (PMID: 8800208) Agostini I … Sire J (Journal of molecular biology 1996) 3 4 22 58
  4. Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. (PMID: 7671313) Bagby S … Ikura M (Cell 1995) 3 4 22 58
  5. Cloning of a human gene encoding the general transcription initiation factor IIB. (PMID: 1876184) Ha I … Reinberg D (Nature 1991) 2 3 4 58

Products for GTF2B Gene

Sources for GTF2B Gene

Loading form....