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Aliases for GTF2A2 Gene

Aliases for GTF2A2 Gene

  • General Transcription Factor IIA Subunit 2 2 3 4 5
  • Transcription Initiation Factor IIA Gamma Chain 3 4
  • General Transcription Factor IIA, 2, 12kDa 2 3
  • General Transcription Factor IIA 2 2 3
  • TFIIA Gamma Subunit 2 3
  • TFIIA P12 Subunit 3 4
  • TFIIA-Gamma 3 4
  • TFIIA-12 3 4
  • TFIIAS 3 4
  • TF2A2 3 4
  • General Transcription Factor IIA, 2 (12kD Subunit) 2
  • Transcription Initiation Factor IIA Subunit 2 3
  • HsT18745 3
  • T18745 3
  • TFIIA 3

External Ids for GTF2A2 Gene

Previous GeneCards Identifiers for GTF2A2 Gene

  • GC15M055489
  • GC15M052979
  • GC15M057510
  • GC15M057647
  • GC15M057718
  • GC15M059930
  • GC15M036752

Summaries for GTF2A2 Gene

Entrez Gene Summary for GTF2A2 Gene

  • Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]

GeneCards Summary for GTF2A2 Gene

GTF2A2 (General Transcription Factor IIA Subunit 2) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Viral carcinogenesis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot for GTF2A2 Gene

  • TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Additional gene information for GTF2A2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF2A2 Gene

Genomics for GTF2A2 Gene

GeneHancer (GH) Regulatory Elements for GTF2A2 Gene

Promoters and enhancers for GTF2A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J059656 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 673.6 +0.4 421 2.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 GTF2A2 SLTM ICE2 RPS3AP6 GC15M059646 ENSG00000227161
GH15J059684 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.8 -30.0 -30037 7.1 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 YY1 BNIP2 ENSG00000259238 GTF2A2 SLTM RNF111 ICE2 PIR36988
GH15J059611 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.4 +45.2 45233 2.2 ELF3 FOXA2 ZFP64 ARID4B SIN3A RARA ZBTB11 USF2 ELF1 REST GCNT3 PIGHP1 BNIP2 GTF2A2 RNF111 RPS3AP6 GC15M059584 GC15P059642
GH15J059614 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 10.4 +41.8 41831 2.4 CTCF JUN MAX CEBPG ZBTB40 RAD21 POLR2A NFYB SMC3 FOSL2 GCNT3 GTF2A2 GC15M059584 GC15P059642
GH15J059699 Enhancer 0.6 ENCODE 24.1 -42.9 -42941 1.6 SOX6 JUN CEBPB EP300 BRCA1 RFX5 FOSL1 JUND PRDM6 SMARCA4 GTF2A2 BNIP2 GC15M059729
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF2A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GTF2A2 gene promoter:
  • AREB6
  • CUTL1
  • Zic3
  • TBP
  • AP-4
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • POU3F2 (N-Oct-5b)
  • FOXJ2
  • FOXJ2 (long isoform)

Genomic Locations for GTF2A2 Gene

Genomic Locations for GTF2A2 Gene
19,480 bases
Minus strand
19,480 bases
Minus strand

Genomic View for GTF2A2 Gene

Genes around GTF2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2A2 Gene

Proteins for GTF2A2 Gene

  • Protein details for GTF2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription initiation factor IIA subunit 2
    Protein Accession:
    Secondary Accessions:
    • A8MYQ7
    • Q6FGB5

    Protein attributes for GTF2A2 Gene

    109 amino acids
    Molecular mass:
    12457 Da
    Quaternary structure:
    • TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma (By similarity). It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12) (By similarity). Interacts with NCOA6 general coactivator (PubMed:10567404). TFIIA forms a complex with TBP (PubMed:11030333). Interacts with HSF1 (via transactivation domain) (PubMed:11005381).
    • (Microbial infection) Interacts with SV40 Large T antigen.

    Three dimensional structures from OCA and Proteopedia for GTF2A2 Gene

neXtProt entry for GTF2A2 Gene

Post-translational modifications for GTF2A2 Gene

  • Ubiquitination at Lys101
  • Modification sites at PhosphoSitePlus

Other Protein References for GTF2A2 Gene

No data available for DME Specific Peptides for GTF2A2 Gene

Domains & Families for GTF2A2 Gene

Gene Families for GTF2A2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GTF2A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TFIIA subunit 2 family.
  • Belongs to the TFIIA subunit 2 family.
genes like me logo Genes that share domains with GTF2A2: view

Function for GTF2A2 Gene

Molecular function for GTF2A2 Gene

UniProtKB/Swiss-Prot Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Gene Ontology (GO) - Molecular Function for GTF2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IEA --
GO:0003713 transcription coactivator activity IDA 7958899
GO:0005515 protein binding IPI 7724559
GO:0008134 transcription factor binding IPI 8626665
GO:0017025 TBP-class protein binding IPI 7724559
genes like me logo Genes that share ontologies with GTF2A2: view
genes like me logo Genes that share phenotypes with GTF2A2: view

Animal Model Products

miRNA for GTF2A2 Gene

miRTarBase miRNAs that target GTF2A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GTF2A2 Gene

Localization for GTF2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2A2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2A2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GTF2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005672 transcription factor TFIIA complex IDA,IEA 7724559
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GTF2A2: view

Pathways & Interactions for GTF2A2 Gene

genes like me logo Genes that share pathways with GTF2A2: view

SIGNOR curated interactions for GTF2A2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GTF2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS,IDA --
GO:0006367 transcription initiation from RNA polymerase II promoter IEA,TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with GTF2A2: view

Drugs & Compounds for GTF2A2 Gene

No Compound Related Data Available

Transcripts for GTF2A2 Gene

mRNA/cDNA for GTF2A2 Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GTF2A2 Gene

General transcription factor IIA, 2, 12kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - - - - -
SP6: -

Relevant External Links for GTF2A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GTF2A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF2A2 Gene

Protein differential expression in normal tissues from HIPED for GTF2A2 Gene

This gene is overexpressed in Ovary (11.8), Oral epithelium (10.7), and CD8 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF2A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GTF2A2 Gene:


SOURCE GeneReport for Unigene cluster for GTF2A2 Gene:


Evidence on tissue expression from TISSUES for GTF2A2 Gene

  • Lung(4.5)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with GTF2A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2A2 Gene

Orthologs for GTF2A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GTF2A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GTF2A2 34 33
  • 99.39 (n)
(Monodelphis domestica)
Mammalia GTF2A2 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia GTF2A2 34
  • 97 (a)
(Canis familiaris)
Mammalia GTF2A2 34 33
  • 96.02 (n)
(Mus musculus)
Mammalia Gtf2a2 16 34 33
  • 95.11 (n)
(Bos Taurus)
Mammalia GTF2A2 34 33
  • 95.11 (n)
(Rattus norvegicus)
Mammalia Gtf2a2 33
  • 95.11 (n)
(Gallus gallus)
Aves GTF2A2 34 33
  • 84.4 (n)
(Anolis carolinensis)
Reptilia GTF2A2 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2a2 33
  • 80.73 (n)
Str.7380 33
African clawed frog
(Xenopus laevis)
Amphibia TFIIAg 33
(Danio rerio)
Actinopterygii gtf2a2 34 33
  • 77.98 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1417 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004370 33
  • 68.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta TfIIA-S 34 35 33
  • 66.34 (n)
TfIIA-S-2 34
  • 49 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y111B2A.13 33
  • 53.59 (n)
Y111B2A.13 34
  • 44 (a)
B0336.13 34
  • 32 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12815g 33
  • 51.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOA2 34 33
  • 49.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR071W 33
  • 46.8 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24440 33
  • 54.88 (n)
(Oryza sativa)
Liliopsida Os05g0107700 33
  • 61.17 (n)
Os.12011 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 74 (a)
Cin.4078 33
bread mold
(Neurospora crassa)
Ascomycetes NCU09748 33
  • 54.46 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC553.11c 33
  • 52.88 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4078 33
Species where no ortholog for GTF2A2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF2A2 Gene

Gene Tree for GTF2A2 (if available)
Gene Tree for GTF2A2 (if available)
Evolutionary constrained regions (ECRs) for GTF2A2: view image

Paralogs for GTF2A2 Gene Pseudogenes for GTF2A2 Gene

genes like me logo Genes that share paralogs with GTF2A2: view

No data available for Paralogs for GTF2A2 Gene

Variants for GTF2A2 Gene

Sequence variations from dbSNP and Humsavar for GTF2A2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000315430 -- 59,638,990(-) A/C 3_prime_UTR_variant
rs1000331502 -- 59,638,560(-) G/C 3_prime_UTR_variant
rs1000399653 -- 59,642,754(-) T/C intron_variant
rs1000583614 -- 59,647,010(-) T/C intron_variant
rs1000821168 -- 59,657,413(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GTF2A2 Gene

Variant ID Type Subtype PubMed ID
esv2668729 CNV deletion 23128226
esv3569653 CNV gain 25503493
esv3636644 CNV loss 21293372
esv3636646 CNV gain 21293372
esv3636647 CNV gain 21293372
nsv1043693 CNV loss 25217958
nsv1122972 CNV deletion 24896259
nsv527307 CNV gain 19592680
nsv569605 CNV loss 21841781
nsv7266 OTHER inversion 18451855

Variation tolerance for GTF2A2 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF2A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2A2 Gene

Disorders for GTF2A2 Gene

Additional Disease Information for GTF2A2

No disorders were found for GTF2A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2A2 Gene

Publications for GTF2A2 Gene

  1. Potential targets for HSF1 within the preinitiation complex. (PMID: 11005381) Yuan CX … Gurley WB (Cell stress & chaperones 2000) 3 4 22 58
  2. Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. (PMID: 7958899) Ozer J … Lieberman PM (Genes & development 1994) 2 3 4 58
  3. Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF). (PMID: 14570910) Nakadai T … Tamura TA (The Journal of biological chemistry 2004) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II. (PMID: 11509574) Langelier MF … Coulombe B (The Journal of biological chemistry 2001) 3 22 58

Products for GTF2A2 Gene

Sources for GTF2A2 Gene

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