Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010] See more...

Aliases for GTF2A1 Gene

Aliases for GTF2A1 Gene

  • General Transcription Factor IIA Subunit 1 2 3 4 5
  • Transcription Initiation Factor TFIIA 42 KDa Subunit 3 4
  • Transcription Initiation Factor IIA Subunit 1 3 4
  • General Transcription Factor IIA, 1, 19/37kDa 2 3
  • Glucose Regulated Protein, 58kD Pseudogene 2 3
  • General Transcription Factor IIA 1 2 3
  • TFIIA Alpha/Beta Subunits 2 3
  • TFIIA-42 3 4
  • TFIIAL 3 4
  • TF2A1 3 4
  • TFIIA Alpha, P55 3
  • TFIIA 3

External Ids for GTF2A1 Gene

Previous GeneCards Identifiers for GTF2A1 Gene

  • GC14M079152
  • GC14M075463
  • GC14M079634
  • GC14M079636
  • GC14M080716
  • GC14M081646
  • GC14M061813

Summaries for GTF2A1 Gene

Entrez Gene Summary for GTF2A1 Gene

  • Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]

GeneCards Summary for GTF2A1 Gene

GTF2A1 (General Transcription Factor IIA Subunit 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transcription coactivator activity. An important paralog of this gene is GTF2A1L.

UniProtKB/Swiss-Prot Summary for GTF2A1 Gene

  • TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Gene Wiki entry for GTF2A1 Gene

Additional gene information for GTF2A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GTF2A1 Gene

Genomics for GTF2A1 Gene

GeneHancer (GH) Regulatory Elements for GTF2A1 Gene

Promoters and enhancers for GTF2A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J081218 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 529.1 +0.8 848 5.1 FOXK2 HNRNPK ZNF217 EP300 SIN3A TCF12 MYC POLR2G USF1 SP1 GTF2A1 ENSG00000273783 LOC101928504 lnc-GTF2A1-2 piR-32293 lnc-TSHR-2 CEP128
GH14J081398 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -179.4 -179408 4.5 ZNF217 ZSCAN5C ZIC2 POLR2A REST RFX1 MEF2C MYC EP300 CTBP1 GTF2A1 STON2 LINC02308 piR-35031-017 hsa-miR-1273e-020
GH14J081434 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -214.5 -214462 3.1 EP300 NRF1 REST ZBTB10 ZBTB26 RFX1 HES1 MYC ZBTB7A CTBP1 STON2 GTF2A1 LINC02308 lnc-SEL1L-11
GH14J080996 Enhancer 0.9 FANTOM5 Ensembl 21.3 +224.7 224676 1 CTCF FOS REST RAD21 TRIM22 SMC3 RBM25 CEBPG FOSL2 CEBPB GTF2A1 CEP128 SNORA79 NMNAT1P1 RPL17P3 lnc-NRXN3-4 TSHR
GH14J081169 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 11.2 +51.0 51047 1.9 CTCF SIN3A NRF1 TCF12 POLR2G NCOR1 PHF8 JUND TEAD4 FOS ENSG00000284959 ENSG00000286686 LOC101928462 lnc-TSHR-1 SNORA79 GTF2A1 CEP128 LOC105370594
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GTF2A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GTF2A1

Top Transcription factor binding sites by QIAGEN in the GTF2A1 gene promoter:
  • FOXJ2
  • GATA-1
  • MyoD
  • POU6F1 (c2)
  • ZID

Genomic Locations for GTF2A1 Gene

Genomic Locations for GTF2A1 Gene
chr14:81,175,452-81,221,377
(GRCh38/hg38)
Size:
45,926 bases
Orientation:
Minus strand
chr14:81,641,796-81,687,721
(GRCh37/hg19)
Size:
45,926 bases
Orientation:
Minus strand

Genomic View for GTF2A1 Gene

Genes around GTF2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF2A1 Gene

Proteins for GTF2A1 Gene

  • Protein details for GTF2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52655-TF2AA_HUMAN
    Recommended name:
    Transcription initiation factor IIA subunit 1
    Protein Accession:
    P52655
    Secondary Accessions:
    • Q3KNQ9

    Protein attributes for GTF2A1 Gene

    Size:
    376 amino acids
    Molecular mass:
    41514 Da
    Quaternary structure:
    • TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP.

    Three dimensional structures from OCA and Proteopedia for GTF2A1 Gene

    Alternative splice isoforms for GTF2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF2A1 Gene

Post-translational modifications for GTF2A1 Gene

  • The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GTF2A1 Gene

No data available for DME Specific Peptides for GTF2A1 Gene

Domains & Families for GTF2A1 Gene

Protein Domains for GTF2A1 Gene

Blocks:
  • Transcription factor IIA, alpha/beta subunit
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GTF2A1 Gene

GenScript: Design optimal peptide antigens:
  • Transcription initiation factor TFIIA 42 kDa subunit (TF2AA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52655

UniProtKB/Swiss-Prot:

TF2AA_HUMAN :
  • Belongs to the TFIIA subunit 1 family.
Family:
  • Belongs to the TFIIA subunit 1 family.
genes like me logo Genes that share domains with GTF2A1: view

Function for GTF2A1 Gene

Molecular function for GTF2A1 Gene

UniProtKB/Swiss-Prot Function:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

Phenotypes From GWAS Catalog for GTF2A1 Gene

Gene Ontology (GO) - Molecular Function for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IEA --
GO:0003677 DNA binding IDA 7724559
GO:0003713 transcription coactivator activity TAS 8224850
GO:0005515 protein binding IPI 8006019
GO:0008134 transcription factor binding IPI 8626665
genes like me logo Genes that share ontologies with GTF2A1: view
genes like me logo Genes that share phenotypes with GTF2A1: view

Animal Models for GTF2A1 Gene

MGI Knock Outs for GTF2A1:

Animal Model Products

CRISPR Products

miRNA for GTF2A1 Gene

miRTarBase miRNAs that target GTF2A1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF2A1 Gene

Localization for GTF2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF2A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF2A1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005672 transcription factor TFIIA complex IDA,IBA 7724559
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GTF2A1: view

Pathways & Interactions for GTF2A1 Gene

genes like me logo Genes that share pathways with GTF2A1: view

Pathways by source for GTF2A1 Gene

1 GeneGo (Thomson Reuters) pathway for GTF2A1 Gene
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
8 Qiagen pathways for GTF2A1 Gene
  • Assembly of RNA Polymerase-II Initiation Complex
  • Crosstalk Between CARM1 and ESRs
  • Estrogen Pathway
  • Glucocorticoid Receptor Signaling
  • Nuclear Receptor Activation by Vitamin-A

SIGNOR curated interactions for GTF2A1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GTF2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS,IDA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0042795 snRNA transcription by RNA polymerase II TAS --
GO:1903508 positive regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with GTF2A1: view

Drugs & Compounds for GTF2A1 Gene

No Compound Related Data Available

Transcripts for GTF2A1 Gene

mRNA/cDNA for GTF2A1 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF2A1 Gene

No ASD Table

Relevant External Links for GTF2A1 Gene

GeneLoc Exon Structure for
GTF2A1

Expression for GTF2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GTF2A1 Gene

Protein differential expression in normal tissues from HIPED for GTF2A1 Gene

This gene is overexpressed in Fetal Brain (9.6), CD4 Tcells (8.6), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GTF2A1 Gene



Protein tissue co-expression partners for GTF2A1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GTF2A1

SOURCE GeneReport for Unigene cluster for GTF2A1 Gene:

Hs.592334

Evidence on tissue expression from TISSUES for GTF2A1 Gene

  • Liver(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with GTF2A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF2A1 Gene

Orthologs for GTF2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GTF2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF2A1 31 30
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GTF2A1 31 30
  • 94.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GTF2A1 31 30
  • 93.26 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF2A1 31
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gtf2a1 30
  • 92.11 (n)
mouse
(Mus musculus)
Mammalia Gtf2a1 17 31 30
  • 90.07 (n)
Gm5435 31
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia GTF2A1 31
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF2A1 31 30
  • 84.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF2A1 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf2a1 30
  • 77.87 (n)
Str.5955 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.29248 30
zebrafish
(Danio rerio)
Actinopterygii gtf2a1 31 30
  • 71.59 (n)
OneToOne
Dr.24669 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1071 30
fruit fly
(Drosophila melanogaster)
Insecta TfIIA-L 31
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea Cin.3030 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3030 30
Species where no ortholog for GTF2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GTF2A1 Gene

ENSEMBL:
Gene Tree for GTF2A1 (if available)
TreeFam:
Gene Tree for GTF2A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GTF2A1: view image

Paralogs for GTF2A1 Gene

Paralogs for GTF2A1 Gene

genes like me logo Genes that share paralogs with GTF2A1: view

Variants for GTF2A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GTF2A1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
VAR_035667 A breast cancer sample p.Leu30Val
rs17111579 - p.Ala109Pro

Additional dbSNP identifiers (rs#s) for GTF2A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GTF2A1 Gene

Variant ID Type Subtype PubMed ID
esv3581341 CNV loss 25503493
esv3581342 CNV loss 25503493
esv3635076 CNV gain 21293372
nsv832841 CNV gain 17160897

Variation tolerance for GTF2A1 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GTF2A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF2A1 Gene

Disorders for GTF2A1 Gene

Additional Disease Information for GTF2A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GTF2A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF2A1 Gene

Publications for GTF2A1 Gene

  1. A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA. (PMID: 8224848) DeJong J … Roeder RG (Genes & development 1993) 2 3 4 23 54
  2. Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. (PMID: 15257296) Høiby T … Stunnenberg HG (The EMBO journal 2004) 3 4 23 54
  3. Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. (PMID: 11278496) Solow S … Lieberman PM (The Journal of biological chemistry 2001) 3 4 23 54
  4. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 41 54
  5. TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability. (PMID: 17681538) Hieb AR … Goodrich JA (Journal of molecular biology 2007) 3 23 54

Products for GTF2A1 Gene

  • Boster Bio Antibodies for GTF2A1
  • Boster Bio ELISA Kits for GTF2A1

Sources for GTF2A1 Gene