Aliases for GTF2A1 Gene
External Ids for GTF2A1 Gene
Previous GeneCards Identifiers for GTF2A1 Gene
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]
GeneCards Summary for GTF2A1 Gene
GTF2A1 (General Transcription Factor IIA Subunit 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and transcription coactivator activity. An important paralog of this gene is GTF2A1L.
UniProtKB/Swiss-Prot Summary for GTF2A1 Gene
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.