Aliases for GSTZ1 Gene
External Ids for GSTZ1 Gene
Previous GeneCards Identifiers for GSTZ1 Gene
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]
GeneCards Summary for GSTZ1 Gene
GSTZ1 (Glutathione S-Transferase Zeta 1) is a Protein Coding gene. Diseases associated with GSTZ1 include Maleylacetoacetate Isomerase Deficiency and Tyrosinemia, Type I. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and glutathione peroxidase activity. An important paralog of this gene is GSTT2B.
UniProtKB/Swiss-Prot Summary for GSTZ1 Gene
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.