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Aliases for GSTT4 Gene

Aliases for GSTT4 Gene

  • Glutathione S-Transferase Theta 4 2 3 5
  • Glutathione S-Transferase Theta Pseudogene 1 2 3 4
  • Glutathione S-Transferase Theta-4 3 4
  • GST Class-Theta-4 3 4
  • GSTTP1 3 4
  • EC 2.5.1.18 4
  • HS322B1A 3

External Ids for GSTT4 Gene

Previous HGNC Symbols for GSTT4 Gene

  • GSTTP1

Previous GeneCards Identifiers for GSTT4 Gene

  • GC22M026763
  • GC22M026203
  • GC22M026383
  • GC22M026574

Summaries for GSTT4 Gene

GeneCards Summary for GSTT4 Gene

GSTT4 (Glutathione S-Transferase Theta 4) is a Protein Coding gene. Among its related pathways are Glutathione metabolism. An important paralog of this gene is GSTT2B.

UniProtKB/Swiss-Prot for GSTT4 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Additional gene information for GSTT4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT4 Gene

Genomics for GSTT4 Gene

GeneHancer (GH) Regulatory Elements for GSTT4 Gene

Promoters and enhancers for GSTT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J024005 Promoter/Enhancer 0.9 EPDnew Ensembl 600.7 -0.2 -248 1 PKNOX1 ZFX GSTT4 ENSG00000235689
GH22J024000 Enhancer 0.5 Ensembl 0.7 +4.8 4752 0.2 MLLT1 NFIB ZNF544 ZBTB17 NFIC LCORL SMARCB1 MIF-AS1 GSTT4 ENSG00000224205
GH22J023996 Enhancer 0.7 Ensembl 0.4 +8.8 8752 1 ZNF644 KAT8 CEBPA GATAD2A RXRB SAP130 MIER3 FOXP1 CEBPB HNF4A ENSG00000273295 DDT ENSG00000224205 GSTT4
GH22J024002 Enhancer 0.2 Ensembl 0.7 +2.8 2752 0.2 GSTT2 GSTT4 ENSG00000224205
GH22J024001 Enhancer 0.2 Ensembl 0.7 +4.1 4053 0.8 GSTT4 ENSG00000224205
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTT4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GSTT4 Gene

Genomic Locations for GSTT4 Gene
chr22:23,998,401-24,005,453
(GRCh38/hg38)
Size:
7,053 bases
Orientation:
Minus strand
chr22:24,340,595-24,347,258
(GRCh37/hg19)
Size:
6,664 bases
Orientation:
Minus strand

Genomic View for GSTT4 Gene

Genes around GSTT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTT4 Gene

Proteins for GSTT4 Gene

  • Protein details for GSTT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A1W2PR19-GSTT4_HUMAN
    Recommended name:
    Glutathione S-transferase theta-4
    Protein Accession:
    A0A1W2PR19

    Protein attributes for GSTT4 Gene

    Size:
    241 amino acids
    Molecular mass:
    27942 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for GSTT4 Gene

Post-translational modifications for GSTT4 Gene

No Post-translational modifications

Other Protein References for GSTT4 Gene

No data available for DME Specific Peptides for GSTT4 Gene

Domains & Families for GSTT4 Gene

Gene Families for GSTT4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GSTT4 Gene

GenScript: Design optimal peptide antigens:
  • GST class-theta-4 (GSTT4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A0A1W2PR19

UniProtKB/Swiss-Prot:

GSTT4_HUMAN :
  • Belongs to the GST superfamily. Theta family.
Family:
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT4: view

Function for GSTT4 Gene

Molecular function for GSTT4 Gene

UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=. ;.

Enzyme Numbers (IUBMB) for GSTT4 Gene

Phenotypes From GWAS Catalog for GSTT4 Gene

Gene Ontology (GO) - Molecular Function for GSTT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA --
GO:0005515 protein binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GSTT4: view
genes like me logo Genes that share phenotypes with GSTT4: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTT4 Gene

Localization for GSTT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT4 Gene

Gene Ontology (GO) - Cellular Components for GSTT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with GSTT4: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GSTT4 Gene

Pathways & Interactions for GSTT4 Gene

PathCards logo

SuperPathways for GSTT4 Gene

SuperPathway Contained pathways
1 Glutathione metabolism
genes like me logo Genes that share pathways with GSTT4: view

Pathways by source for GSTT4 Gene

1 BioSystems pathway for GSTT4 Gene

Interacting Proteins for GSTT4 Gene

Gene Ontology (GO) - Biological Process for GSTT4 Gene

None

No data available for SIGNOR curated interactions for GSTT4 Gene

Drugs & Compounds for GSTT4 Gene

(1) Drugs for GSTT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra 0
genes like me logo Genes that share compounds with GSTT4: view

Transcripts for GSTT4 Gene

mRNA/cDNA for GSTT4 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT4 Gene

No ASD Table

Relevant External Links for GSTT4 Gene

GeneLoc Exon Structure for
GSTT4
ECgene alternative splicing isoforms for
GSTT4

Expression for GSTT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTT4 Gene:

GSTT4
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTT4 Gene

Orthologs for GSTT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GSTT4 Gene

Organism Taxonomy Gene Similarity Type Details
zebrafish
(Danio rerio)
Actinopterygii -- 34
Species where no ortholog for GSTT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTT4 Gene

ENSEMBL:
Gene Tree for GSTT4 (if available)
TreeFam:
Gene Tree for GSTT4 (if available)

Paralogs for GSTT4 Gene

genes like me logo Genes that share paralogs with GSTT4: view

Variants for GSTT4 Gene

Sequence variations from dbSNP and Humsavar for GSTT4 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000416694 -- 24,006,727(-) T/C upstream_transcript_variant
rs1000449967 -- 23,996,375(-) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000618022 -- 24,004,744(-) G/A intron_variant
rs1000751748 -- 23,995,924(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000788985 -- 24,006,519(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTT4 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv4535n100 CNV gain 25217958
dgv4536n100 CNV loss 25217958
dgv4543n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2421686 OTHER complex 20811451
esv2724041 CNV deletion 23290073
esv33747 CNV gain 17666407
esv3575443 CNV gain 25503493
esv3575444 CNV gain 25503493
esv3584777 CNV loss 24956385
esv3647423 CNV loss 21293372
esv3647424 CNV gain 21293372
esv3893452 CNV gain+loss 25118596
nsv1055830 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv1160736 OTHER complex 26073780
nsv442792 CNV loss 18776908
nsv469844 CNV loss 16826518
nsv511075 OTHER complex 20534489
nsv511643 CNV loss 21212237
nsv526567 CNV gain 19592680
nsv588651 CNV gain 21841781
nsv588669 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv829109 CNV loss 20364138
nsv829110 CNV loss 20364138
nsv834155 CNV gain+loss 17160897
nsv834156 CNV gain+loss 17160897
nsv979656 CNV duplication 23825009

Additional Variant Information for GSTT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GSTT4 Gene

Disorders for GSTT4 Gene

No disorders were found for GSTT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTT4 Gene

Publications for GSTT4 Gene

  1. Genetic polymorphism of glutathione S-transferase P1 gene and lung cancer risk. (PMID: 10334644) To-Figueras J … Corbella J (Cancer causes & control : CCC 1999) 2 3 58
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for GSTT4 Gene

Sources for GSTT4 Gene

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