The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and G... See more...

Aliases for GSTT2B Gene

Aliases for GSTT2B Gene

  • Glutathione S-Transferase Theta 2B 2 3
  • Glutathione S-Transferase Theta 2B (Gene/Pseudogene) 2 5
  • Glutathione S-Transferase Theta-2B 3 4
  • GST Class-Theta-2 3 4
  • GSTT2P 2 3
  • Glutathione S-Transferase Theta 2 3
  • Glutathione S-Transferase Theta-2 4
  • EC 2.5.1.18 4
  • GSTT2B 5
  • GSTT2 4

External Ids for GSTT2B Gene

Previous GeneCards Identifiers for GSTT2B Gene

  • GC22M022631
  • GC22M024299

Summaries for GSTT2B Gene

Entrez Gene Summary for GSTT2B Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

GeneCards Summary for GSTT2B Gene

GSTT2B (Glutathione S-Transferase Theta 2B) is a Protein Coding gene. Diseases associated with GSTT2B include Exudative Vitreoretinopathy 2, X-Linked. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity and glutathione transferase activity. An important paralog of this gene is GSTT2.

UniProtKB/Swiss-Prot Summary for GSTT2B Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Additional gene information for GSTT2B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTT2B Gene

Genomics for GSTT2B Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around GSTT2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTT2B

Top Transcription factor binding sites by QIAGEN in the GSTT2B gene promoter:
  • AP-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for GSTT2B Gene

Genomic Locations for GSTT2B Gene
chr22:23,957,414-23,961,206
(GRCh38/hg38)
Size:
3,793 bases
Orientation:
Minus strand
chr22:24,299,601-24,303,373
(GRCh37/hg19)
Size:
3,773 bases
Orientation:
Minus strand

Genomic View for GSTT2B Gene

Genes around GSTT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTT2B Gene

Proteins for GSTT2B Gene

  • Protein details for GSTT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG30-GSTT2_HUMAN
    Recommended name:
    Glutathione S-transferase theta-2B
    Protein Accession:
    P0CG30
    Secondary Accessions:
    • O60665
    • P30712
    • Q6IPV7
    • Q9HD76

    Protein attributes for GSTT2B Gene

    Size:
    244 amino acids
    Molecular mass:
    27507 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT2B Gene

neXtProt entry for GSTT2B Gene

Post-translational modifications for GSTT2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTT2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GSTT2B Gene

Domains & Families for GSTT2B Gene

Gene Families for GSTT2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GSTT2B Gene

GenScript: Design optimal peptide antigens:
  • Glutathione S-transferase theta-2 (GSTT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CG30

UniProtKB/Swiss-Prot:

GSTT2_HUMAN :
  • Belongs to the GST superfamily. Theta family.
Family:
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT2B: view

Function for GSTT2B Gene

Molecular function for GSTT2B Gene

UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18;.

Enzyme Numbers (IUBMB) for GSTT2B Gene

Phenotypes From GWAS Catalog for GSTT2B Gene

Gene Ontology (GO) - Molecular Function for GSTT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IBA,NAS 7789971
GO:0005515 protein binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GSTT2B: view

Phenotypes for GSTT2B Gene

MGI mutant phenotypes for GSTT2B:
inferred from 1 alleles
GenomeRNAi human phenotypes for GSTT2B:
genes like me logo Genes that share phenotypes with GSTT2B: view

Animal Model Products

CRISPR Products

miRNA for GSTT2B Gene

miRTarBase miRNAs that target GSTT2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTT2B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTT2B Gene

Localization for GSTT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT2B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTT2B gene
Compartment Confidence
extracellular 4
nucleus 4
cytosol 4
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GSTT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA,TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GSTT2B: view

Pathways & Interactions for GSTT2B Gene

genes like me logo Genes that share pathways with GSTT2B: view

Pathways by source for GSTT2B Gene

1 BioSystems pathway for GSTT2B Gene
1 GeneGo (Thomson Reuters) pathway for GSTT2B Gene
  • Glutathione metabolism

Gene Ontology (GO) - Biological Process for GSTT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA 21873635
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTT2B: view

No data available for SIGNOR curated interactions for GSTT2B Gene

Drugs & Compounds for GSTT2B Gene

(5) Drugs for GSTT2B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxidized glutathione Approved, Experimental, Investigational Pharma Target, activator 0
Trichloroethylene Approved Pharma 0
Water Approved Pharma 0
Glutathione Approved, Investigational Nutra 0
Hydrochloric acid Experimental Pharma 0

(37) Additional Compounds for GSTT2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane
genes like me logo Genes that share compounds with GSTT2B: view

Transcripts for GSTT2B Gene

mRNA/cDNA for GSTT2B Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTT2B

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT2B Gene

No ASD Table

Relevant External Links for GSTT2B Gene

GeneLoc Exon Structure for
GSTT2B

Expression for GSTT2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTT2B Gene

This gene is overexpressed in Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for GSTT2B Gene

This gene is overexpressed in Fetal heart (19.4), Ovary (18.6), Fetal ovary (7.0), and Fetal testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GSTT2B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTT2B

SOURCE GeneReport for Unigene cluster for GSTT2B Gene:

Hs.656498

mRNA Expression by UniProt/SwissProt for GSTT2B Gene:

P0CG30-GSTT2_HUMAN
Tissue specificity: Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.

Evidence on tissue expression from TISSUES for GSTT2B Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Lung(4.3)
  • Intestine(2.1)
  • Skin(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with GSTT2B: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTT2B Gene

Orthologs for GSTT2B Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTT2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GSTT2B 31
  • 99 (a)
OneToMany
GSTT2 30
  • 98.91 (n)
Dog
(Canis familiaris)
Mammalia LOC100686488 30
  • 81.56 (n)
-- 31
  • 75 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Gstt2 30
  • 80.46 (n)
Mouse
(Mus musculus)
Mammalia Gstt2 30 17 31
  • 79.37 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 60 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia GSTT3 31
  • 52 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 50 (a)
OneToMany
Chicken
(Gallus gallus)
Aves GSTT1 31
  • 43 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 46 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii gstt1b 31
  • 47 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG30000 31
  • 30 (a)
ManyToMany
CG1681 31
  • 30 (a)
ManyToMany
CG1702 31
  • 27 (a)
ManyToMany
CG30005 31
  • 27 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToMany
Species where no ortholog for GSTT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GSTT2B Gene

ENSEMBL:
Gene Tree for GSTT2B (if available)
TreeFam:
Gene Tree for GSTT2B (if available)

Paralogs for GSTT2B Gene

(3) SIMAP similar genes for GSTT2B Gene using alignment to 1 proteins:

  • GSTT2_HUMAN
genes like me logo Genes that share paralogs with GSTT2B: view

Variants for GSTT2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTT2B Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs1622002 - p.Met139Ile

Additional dbSNP identifiers (rs#s) for GSTT2B Gene

Structural Variations from Database of Genomic Variants (DGV) for GSTT2B Gene

Variant ID Type Subtype PubMed ID
dgv35n47 CNV loss 21111241
dgv4528n100 CNV gain 25217958
dgv4532n100 CNV gain 25217958
dgv4534n100 CNV loss 25217958
dgv4535n100 CNV gain 25217958
dgv4536n100 CNV loss 25217958
dgv751n67 CNV loss 20364138
dgv8039n54 CNV gain 21841781
dgv826e199 CNV deletion 23128226
esv1449016 OTHER inversion 17803354
esv2421686 OTHER complex 20811451
esv2593346 CNV deletion 19546169
esv2656467 CNV deletion 23128226
esv2656800 CNV deletion 23128226
esv2667916 CNV deletion 23128226
esv2724041 CNV deletion 23290073
esv2724066 CNV deletion 23290073
esv2966013 CNV deletion 24192839
esv3034901 CNV deletion 24192839
esv3557984 CNV deletion 23714750
esv3575443 CNV gain 25503493
esv3575444 CNV gain 25503493
esv3584777 CNV loss 24956385
esv3893452 CNV gain+loss 25118596
esv3893453 CNV loss 25118596
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
esv6716 CNV loss 19470904
esv999560 CNV deletion 20482838
nsv1057737 CNV loss 25217958
nsv1059397 CNV gain 25217958
nsv1063251 CNV gain+loss 25217958
nsv1066891 CNV gain 25217958
nsv1072628 CNV deletion 25765185
nsv1072629 CNV deletion 25765185
nsv1110863 OTHER inversion 24896259
nsv1145372 CNV deletion 24896259
nsv1153441 CNV deletion 26484159
nsv1160735 CNV deletion 26073780
nsv1160736 OTHER complex 26073780
nsv197 CNV deletion 15895083
nsv436348 CNV deletion 17901297
nsv442792 CNV loss 18776908
nsv469844 CNV loss 16826518
nsv471424 CNV gain 19718026
nsv482074 CNV gain 20164927
nsv511075 OTHER complex 20534489
nsv511643 CNV loss 21212237
nsv512650 CNV loss 21212237
nsv526567 CNV gain 19592680
nsv588651 CNV gain 21841781
nsv588669 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv829105 CNV loss 20364138
nsv829109 CNV loss 20364138
nsv834155 CNV gain+loss 17160897
nsv953055 CNV deletion 24416366
nsv964607 CNV duplication 23825009
nsv979656 CNV duplication 23825009

Variation tolerance for GSTT2B Gene

Gene Damage Index Score: 4.53; 64.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTT2B Gene

Human Gene Mutation Database (HGMD)
GSTT2B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTT2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT2B Gene

Disorders for GSTT2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for GSTT2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 2, x-linked
  • evr2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GSTT2B

genes like me logo Genes that share disorders with GSTT2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT2B Gene

Publications for GSTT2B Gene

  1. Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes. (PMID: 19424424) Zhao Y … Tanaka H (PLoS genetics 2009) 2 3
  2. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M … Board P (The Biochemical journal 1998) 2 3
  3. Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. (PMID: 7789971) Tan KL … Board PG (Genomics 1995) 3 4
  4. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for GSTT2B Gene

Sources for GSTT2B Gene