Aliases for GSTT2B Gene
External Ids for GSTT2B Gene
Previous GeneCards Identifiers for GSTT2B Gene
The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
GeneCards Summary for GSTT2B Gene
GSTT2B (Glutathione S-Transferase Theta 2B) is a Protein Coding gene. Diseases associated with GSTT2B include Exudative Vitreoretinopathy 2, X-Linked. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity and glutathione transferase activity. An important paralog of this gene is GSTT2.
UniProtKB/Swiss-Prot Summary for GSTT2B Gene
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.