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Aliases for GSTT2 Gene

Aliases for GSTT2 Gene

  • Glutathione S-Transferase Theta 2 (Gene/Pseudogene) 2 3 5
  • GST Class-Theta-2 3 4
  • Glutathione S-Transferase Theta-2 3
  • Glutathione S-Transferase Theta 2 2
  • EC 2.5.1.18 4

External Ids for GSTT2 Gene

Previous GeneCards Identifiers for GSTT2 Gene

  • GC22P021018
  • GC22P022646
  • GC22P022652
  • GC22P024322
  • GC22P007270

Summaries for GSTT2 Gene

Entrez Gene Summary for GSTT2 Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

GeneCards Summary for GSTT2 Gene

GSTT2 (Glutathione S-Transferase Theta 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with GSTT2 include Colon Adenoma and Deafness, Autosomal Recessive 12. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTT2B.

UniProtKB/Swiss-Prot for GSTT2 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Gene Wiki entry for GSTT2 Gene

Additional gene information for GSTT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTT2 Gene

Genomics for GSTT2 Gene

GeneHancer (GH) Regulatory Elements for GSTT2 Gene

Promoters and enhancers for GSTT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J023979 Promoter 1 EPDnew Ensembl 650.7 0.0 -27 1.2 DDT GSTT2 ENSG00000250470
GH22J024010 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +31.7 31657 2.6 PKNOX1 CLOCK FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF766 E2F8 ZNF207 CABIN1 ENSG00000272973 ZDHHC8P1 MIF-AS1 SNRPD3 SUSD2 RN7SL268P GNAZ ZNF70 ENSG00000272578
GH22J023907 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -68.0 -67979 8.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 GC22M026417 GC22M026479 GC22M026501 GC22M026502 GC22M026512 GC22M026538 GC22M026539 GC22P023911 PIR47448 PIR31855
GH22J023892 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.8 -84.8 -84839 4.7 HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B E2F8 ZNF416 GC22M026481 GC22M026483 GC22M026488 GC22M026493 GC22M026495 GC22M026496 GC22M026505 GC22M026506 GC22M026508 GC22M026511
GH22J023955 Enhancer 0.9 Ensembl ENCODE 21.9 -23.5 -23507 1.6 CTCF RB1 ARID4B KLF5 RAD21 CC2D1A ARID2 SMC3 ZNF143 PRDM10 GC22M026387 ENSG00000273295 GSTT2 MIF-AS1 GSTT2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GSTT2 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • p53
  • GR-beta
  • GR-alpha
  • GR
  • SREBP-1a
  • SREBP-1c

Genomic Locations for GSTT2 Gene

Genomic Locations for GSTT2 Gene
chr22:23,980,028-23,983,915
(GRCh38/hg38)
Size:
3,888 bases
Orientation:
Plus strand
chr22:24,322,314-24,326,106
(GRCh37/hg19)
Size:
3,793 bases
Orientation:
Plus strand

Genomic View for GSTT2 Gene

Genes around GSTT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTT2 Gene

Proteins for GSTT2 Gene

  • Protein details for GSTT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG29-GST2_HUMAN
    Recommended name:
    Glutathione S-transferase theta-2
    Protein Accession:
    P0CG29
    Secondary Accessions:
    • O60665
    • P30712
    • Q6IPV7
    • Q9HD76

    Protein attributes for GSTT2 Gene

    Size:
    244 amino acids
    Molecular mass:
    27506 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT2 Gene

neXtProt entry for GSTT2 Gene

Post-translational modifications for GSTT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTT2 Gene

No data available for DME Specific Peptides for GSTT2 Gene

Domains & Families for GSTT2 Gene

Gene Families for GSTT2 Gene

Suggested Antigen Peptide Sequences for GSTT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG29

UniProtKB/Swiss-Prot:

GST2_HUMAN :
  • Belongs to the GST superfamily. Theta family.
Family:
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT2: view

Function for GSTT2 Gene

Molecular function for GSTT2 Gene

UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
GENATLAS Biochemistry:
glutathione-S-transferase 2,theta class,separated by 50kb from GSTT1,tighlty linked to DDT,in head to head disposition,likely a pseudogene with a splice site abnormality and a premature translation stop signal

Enzyme Numbers (IUBMB) for GSTT2 Gene

Phenotypes From GWAS Catalog for GSTT2 Gene

Gene Ontology (GO) - Molecular Function for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IBA --
genes like me logo Genes that share ontologies with GSTT2: view
genes like me logo Genes that share phenotypes with GSTT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTT2

miRNA for GSTT2 Gene

miRTarBase miRNAs that target GSTT2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTT2 Gene

Localization for GSTT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTT2 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GSTT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GSTT2 Gene

Pathways & Interactions for GSTT2 Gene

genes like me logo Genes that share pathways with GSTT2: view

Interacting Proteins for GSTT2 Gene

Gene Ontology (GO) - Biological Process for GSTT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA --
genes like me logo Genes that share ontologies with GSTT2: view

No data available for SIGNOR curated interactions for GSTT2 Gene

Drugs & Compounds for GSTT2 Gene

(3) Drugs for GSTT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Glutathione Approved, Investigational Nutra 0
S-Hexylglutathione Experimental Pharma Target 0

(11) Additional Compounds for GSTT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-Dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
2-Hydroxyestrone-4-S-glutathione
  • 2,3-Dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
4-Hydroxyestrone-2-S-glutathione
  • 3,4-Dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Adrenochrome
  • AdChr
  • Adrenochrome O-quinone
  • Adrenochrome oxidised
  • N-Methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-hydroxyindole
  • N-Methyl-5,6-dioxo-2,3,5,6-tetrahydro-3-indolol
54-06-8
Estrone-2,3-quinone
  • Catecholestrogen quinone
40551-33-5
genes like me logo Genes that share compounds with GSTT2: view

Transcripts for GSTT2 Gene

mRNA/cDNA for GSTT2 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(94) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSTT2 Gene

Glutathione S-transferase theta 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT2 Gene

No ASD Table

Relevant External Links for GSTT2 Gene

GeneLoc Exon Structure for
GSTT2
ECgene alternative splicing isoforms for
GSTT2

Expression for GSTT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTT2 Gene

mRNA differential expression in normal tissues according to GTEx for GSTT2 Gene

This gene is overexpressed in Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for GSTT2 Gene

This gene is overexpressed in Skin (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTT2 Gene



Protein tissue co-expression partners for GSTT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTT2 Gene:

GSTT2

SOURCE GeneReport for Unigene cluster for GSTT2 Gene:

Hs.654462

mRNA Expression by UniProt/SwissProt for GSTT2 Gene:

P0CG29-GST2_HUMAN
Tissue specificity: Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.

Evidence on tissue expression from TISSUES for GSTT2 Gene

  • Liver(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with GSTT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTT2 Gene

Orthologs for GSTT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTT2B 34
  • 99 (a)
OneToMany
GSTT2 33
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia LOC100686488 33
  • 81.56 (n)
-- 34
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gstt2 33
  • 80.46 (n)
mouse
(Mus musculus)
Mammalia Gstt2 34 33
  • 79.37 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 45 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24816 33
zebrafish
(Danio rerio)
Actinopterygii zgc:66350 34
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30000 34
  • 31 (a)
ManyToMany
CG1681 34
  • 30 (a)
ManyToMany
CG30005 34
  • 28 (a)
ManyToMany
CG1702 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for GSTT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GSTT2 Gene

ENSEMBL:
Gene Tree for GSTT2 (if available)
TreeFam:
Gene Tree for GSTT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTT2: view image

Paralogs for GSTT2 Gene

Paralogs for GSTT2 Gene

(3) SIMAP similar genes for GSTT2 Gene using alignment to 6 proteins:

  • GST2_HUMAN
  • B5MCL2_HUMAN
  • G9J6Q4_HUMAN
  • G9J6Q5_HUMAN
  • G9J6Q6_HUMAN
  • Q6IB75_HUMAN
genes like me logo Genes that share paralogs with GSTT2: view

Variants for GSTT2 Gene

Sequence variations from dbSNP and Humsavar for GSTT2 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000959418 -- 23,982,069(+) C/G intron_variant
rs1004081892 -- 23,984,174(+) A/G downstream_transcript_variant
rs1004855495 -- 23,980,808(+) G/A intron_variant
rs1007882230 -- 23,982,230(+) T/G intron_variant
rs1007913414 -- 23,983,662(+) T/C non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTT2 Gene

Variant ID Type Subtype PubMed ID
dgv35n47 CNV loss 21111241
dgv4528n100 CNV gain 25217958
dgv4532n100 CNV gain 25217958
dgv4534n100 CNV loss 25217958
dgv4535n100 CNV gain 25217958
dgv4536n100 CNV loss 25217958
dgv751n67 CNV loss 20364138
dgv8039n54 CNV gain 21841781
dgv826e199 CNV deletion 23128226
esv1449016 OTHER inversion 17803354
esv2421686 OTHER complex 20811451
esv2593346 CNV deletion 19546169
esv2656467 CNV deletion 23128226
esv2656800 CNV deletion 23128226
esv2667916 CNV deletion 23128226
esv2724041 CNV deletion 23290073
esv2724066 CNV deletion 23290073
esv2966013 CNV deletion 24192839
esv3034901 CNV deletion 24192839
esv3557984 CNV deletion 23714750
esv3575443 CNV gain 25503493
esv3575444 CNV gain 25503493
esv3584777 CNV loss 24956385
esv3893452 CNV gain+loss 25118596
esv3893453 CNV loss 25118596
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
esv6716 CNV loss 19470904
esv999560 CNV deletion 20482838
nsv1057737 CNV loss 25217958
nsv1059397 CNV gain 25217958
nsv1063251 CNV gain+loss 25217958
nsv1066891 CNV gain 25217958
nsv1072628 CNV deletion 25765185
nsv1072629 CNV deletion 25765185
nsv1110863 OTHER inversion 24896259
nsv1145372 CNV deletion 24896259
nsv1153441 CNV deletion 26484159
nsv1160735 CNV deletion 26073780
nsv1160736 OTHER complex 26073780
nsv197 CNV deletion 15895083
nsv436348 CNV deletion 17901297
nsv442792 CNV loss 18776908
nsv469844 CNV loss 16826518
nsv471424 CNV gain 19718026
nsv482074 CNV gain 20164927
nsv511075 OTHER complex 20534489
nsv511643 CNV loss 21212237
nsv512650 CNV loss 21212237
nsv526567 CNV gain 19592680
nsv588651 CNV gain 21841781
nsv588669 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv829105 CNV loss 20364138
nsv829109 CNV loss 20364138
nsv834155 CNV gain+loss 17160897
nsv953055 CNV deletion 24416366
nsv964607 CNV duplication 23825009
nsv979656 CNV duplication 23825009

Variation tolerance for GSTT2 Gene

Gene Damage Index Score: 7.80; 83.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTT2 Gene

Human Gene Mutation Database (HGMD)
GSTT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT2 Gene

Disorders for GSTT2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GSTT2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
colon adenoma
  • adenomatous polyp of colon
deafness, autosomal recessive 12
  • dfnb12
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
- elite association - COSMIC cancer census association via MalaCards
Search GSTT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GSTT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT2 Gene

Publications for GSTT2 Gene

  1. Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. (PMID: 18449862) Matsuzawa D … Iyo M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 22 44 58
  2. Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. (PMID: 18268125) Wang S … Perera FP (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 22 44 58
  3. GSTT2 promoter polymorphisms and colorectal cancer risk. (PMID: 17250773) Jang SG … Park JG (BMC cancer 2007) 3 22 44 58
  4. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M … Board P (The Biochemical journal 1998) 2 3 22 58
  5. Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. (PMID: 7789971) Tan KL … Board PG (Genomics 1995) 2 3 22 58

Products for GSTT2 Gene

Sources for GSTT2 Gene

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