The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GST... See more...

Aliases for GSTT1 Gene

Aliases for GSTT1 Gene

  • Glutathione S-Transferase Theta 1 2 3
  • Glutathione S-Transferase Theta-1 3 4
  • Glutathione Transferase T1-1 3 4
  • GST Class-Theta-1 3 4
  • EC 2.5.1.18 4 51

External Ids for GSTT1 Gene

Previous GeneCards Identifiers for GSTT1 Gene

  • GC22M021072
  • GC22M020995
  • GC22M022700
  • GC22M022706
  • GC22M024377
  • GC22M024341
  • GC22M007324
  • GC22M024378
  • GC22M024380
  • GC22M024506
  • GC22M024776
  • GC22M024952
  • GC22M025171

Summaries for GSTT1 Gene

Entrez Gene Summary for GSTT1 Gene

  • The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for GSTT1 Gene

GSTT1 (Glutathione S-Transferase Theta 1) is a Protein Coding gene. Diseases associated with GSTT1 include Senile Cataract and Leukoplakia. Among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.

UniProtKB/Swiss-Prot Summary for GSTT1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

Gene Wiki entry for GSTT1 Gene

PharmGKB "VIP" Summary for GSTT1 Gene

Additional gene information for GSTT1 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for GSTT1 Gene

Genomics for GSTT1 Gene

GeneHancer (GH) Regulatory Elements Pubs


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTT1

Top Transcription factor binding sites by QIAGEN in the GSTT1 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for GSTT1 Gene

Genomic Locations for GSTT1 Gene
chr22:270,308-278,486
(GRCh38/hg38)
Size:
8,179 bases
Orientation:
Minus strand
chr22:24,376,133-24,384,680
(GRCh37/hg19)
Size:
8,548 bases
Orientation:
Minus strand

Genomic View for GSTT1 Gene

Genes around GSTT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GSTT1 Gene

Proteins for GSTT1 Gene

  • Protein details for GSTT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30711-GSTT1_HUMAN
    Recommended name:
    Glutathione S-transferase theta-1
    Protein Accession:
    P30711
    Secondary Accessions:
    • O00226
    • Q5TZY2
    • Q6IC69
    • Q969K8
    • Q96IY3

    Protein attributes for GSTT1 Gene

    Size:
    240 amino acids
    Molecular mass:
    27335 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTT1 Gene

    Alternative splice isoforms for GSTT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTT1 Gene

Selected DME Specific Peptides for GSTT1 Gene

P30711:
  • YIFAKKN
  • ARVDEYLAWQHT

Post-translational modifications for GSTT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GSTT1 Gene

Gene Families for GSTT1 Gene

Protein Domains for GSTT1 Gene

Suggested Antigen Peptide Sequences for GSTT1 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione transferase T1-1 (GSTT1_HUMAN)
  • Glutathione S-transferase theta 1 (Q4GZS9_HUMAN)
  • Glutathione S-transferase theta 1 (Q4W252_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30711

UniProtKB/Swiss-Prot:

GSTT1_HUMAN :
  • Belongs to the GST superfamily. Theta family.
Family:
  • Belongs to the GST superfamily. Theta family.
genes like me logo Genes that share domains with GSTT1: view

Function for GSTT1 Gene

Molecular function for GSTT1 Gene

UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:16298388, ECO:0000269|PubMed:20097269};.
GENATLAS Biochemistry:
glutathione-S-transferase 1,theta class,deleted in bladder cancer

Enzyme Numbers (IUBMB) for GSTT1 Gene

Phenotypes From GWAS Catalog for GSTT1 Gene

Gene Ontology (GO) - Molecular Function for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA, IBA 9307035
GO:0004602 glutathione peroxidase activity IDA 9307035
GO:0005515 protein binding IPI 25910212
genes like me logo Genes that share ontologies with GSTT1: view
genes like me logo Genes that share phenotypes with GSTT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTT1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GSTT1 Gene

Localization for GSTT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTT1 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA, TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GSTT1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GSTT1 Gene

Pathways & Interactions for GSTT1 Gene

genes like me logo Genes that share pathways with GSTT1: view

Interacting Proteins for GSTT1 Gene

Gene Ontology (GO) - Biological Process for GSTT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IDA, IBA 9307035
GO:0098869 cellular oxidant detoxification IEA --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTT1: view

No data available for SIGNOR curated interactions for GSTT1 Gene

Drugs & Compounds for GSTT1 Gene

(41) Drugs for GSTT1 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3412
Glutathione Approved, Investigational Nutra Target 0
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1944
Trichloroethylene Approved Pharma 0
Carboplatin Approved Pharma Enzyme, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 2588

(83) Additional Compounds for GSTT1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane
genes like me logo Genes that share compounds with GSTT1: view

Transcripts for GSTT1 Gene

mRNA/cDNA for GSTT1 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTT1

Alternative Splicing Database (ASD) splice patterns (SP) for GSTT1 Gene

No ASD Table

Relevant External Links for GSTT1 Gene

GeneLoc Exon Structure for
GSTT1

Expression for GSTT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTT1 Gene

Protein differential expression in normal tissues from HIPED for GSTT1 Gene

This gene is overexpressed in Uterus (11.0) and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTT1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTT1

SOURCE GeneReport for Unigene cluster for GSTT1 Gene:

Hs.268573

mRNA Expression by UniProt/SwissProt for GSTT1 Gene:

P30711-GSTT1_HUMAN
Tissue specificity: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
genes like me logo Genes that share expression patterns with GSTT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTT1 Gene

Orthologs for GSTT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GSTT1 Gene

Organism Taxonomy Gene Similarity Type Details
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.935 30
Species where no ortholog for GSTT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

No data available for Evolution for GSTT1 Gene

Paralogs for GSTT1 Gene

(4) SIMAP similar genes for GSTT1 Gene using alignment to 12 proteins:

  • GSTT1_HUMAN
  • C9JA47_HUMAN
  • F8WCF3_HUMAN
  • G3XAK0_HUMAN
  • G5E9I8_HUMAN
  • G5E9K8_HUMAN
  • G5E9P7_HUMAN
  • H7BZG9_HUMAN
  • Q4GZS9_HUMAN
  • Q4W251_HUMAN
  • Q4W252_HUMAN
  • Q6IC69_HUMAN
genes like me logo Genes that share paralogs with GSTT1: view

No data available for Paralogs for GSTT1 Gene

Variants for GSTT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GSTT1 Gene

GSTT1_HUMAN-P30711
The GSTT1 gene is absent from 38% of the population. The presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) and non-conjugator (GSTT1-) phenotypes respectively. The GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTT1 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs2234953 - p.Glu173Lys
rs2266633 - p.Asp141Asn
rs2266635 - p.Ala21Thr
rs2266637 - p.Val169Ile

Additional dbSNP identifiers (rs#s) for GSTT1 Gene

Variation tolerance for GSTT1 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTT1 Gene

Human Gene Mutation Database (HGMD)
GSTT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTT1

SNP Genotyping and Copy Number Assay Products

No data available for Structural Variations from Database of Genomic Variants (DGV) for GSTT1 Gene

Disorders for GSTT1 Gene

MalaCards: The human disease database

(20) MalaCards diseases for GSTT1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
senile cataract
leukoplakia
mutagen sensitivity
oral cancer
  • lip and oral cavity carcinoma
sister chromatid exchange, frequency of
  • sce, frequency of
- elite association - COSMIC cancer census association via MalaCards
Search GSTT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GSTT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTT1 Gene

Publications for GSTT1 Gene

  1. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PMID: 17372252) Schwartzbaum JA … Feychting M (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 23 26 41
  2. Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. (PMID: 17333241) Jönsson LS … Jönsson BA (International archives of occupational and environmental health 2007) 3 23 26 41
  3. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 23 41
  4. Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population. (PMID: 20377137) Nguyen TV … Jansent JB (Oncology research 2010) 3 23 41
  5. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 23 41

Products for GSTT1 Gene

  • Signalway ELISA kits for GSTT1

Sources for GSTT1 Gene