The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] See more...

Aliases for GSTO2 Gene

Aliases for GSTO2 Gene

  • Glutathione S-Transferase Omega 2 2 3 5
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 2-2 3 4
  • Glutathione S-Transferase Omega-2 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • EC 2.5.1.18 4 52
  • GSTO 2-2 3 4
  • GSTO-2 3 4
  • BA127L20.1 (Novel Glutathione-S-Transferase) 3
  • Glutathione-S-Transferase-Like Protein 3
  • EC 1.20.4.2 4
  • BA127L20.1 3
  • EC 1.8.5.1 4

External Ids for GSTO2 Gene

Previous GeneCards Identifiers for GSTO2 Gene

  • GC10P106165
  • GC10P105699
  • GC10P105693
  • GC10P106018
  • GC10P099660

Summaries for GSTO2 Gene

Entrez Gene Summary for GSTO2 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO2 Gene

GSTO2 (Glutathione S-Transferase Omega 2) is a Protein Coding gene. Diseases associated with GSTO2 include Barrett's Adenocarcinoma and Skin Carcinoma. Among its related pathways are Drug metabolism - cytochrome P450 and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and protein disulfide oxidoreductase activity. An important paralog of this gene is GSTO1.

UniProtKB/Swiss-Prot Summary for GSTO2 Gene

  • Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

Gene Wiki entry for GSTO2 Gene

Additional gene information for GSTO2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTO2 Gene

Genomics for GSTO2 Gene

GeneHancer (GH) Regulatory Elements for GSTO2 Gene

Promoters and enhancers for GSTO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTO2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTO2

Top Transcription factor binding sites by QIAGEN in the GSTO2 gene promoter:
  • AREB6
  • c-Ets-1
  • CREB
  • deltaCREB
  • FOXL1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • p53

Genomic Locations for GSTO2 Gene

Genomic Locations for GSTO2 Gene
chr10:104,268,416-104,304,950
(GRCh38/hg38)
Size:
36,535 bases
Orientation:
Plus strand
chr10:106,028,631-106,064,703
(GRCh37/hg19)
Size:
36,073 bases
Orientation:
Plus strand

Genomic View for GSTO2 Gene

Genes around GSTO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO2 Gene

Proteins for GSTO2 Gene

  • Protein details for GSTO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Y5-GSTO2_HUMAN
    Recommended name:
    Glutathione S-transferase omega-2
    Protein Accession:
    Q9H4Y5
    Secondary Accessions:
    • A8K771
    • B4DJW6
    • E7ESD6
    • Q49TW5
    • Q5GM70
    • Q5JU15
    • Q86WP3

    Protein attributes for GSTO2 Gene

    Size:
    243 amino acids
    Molecular mass:
    28254 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GSTO2 Gene

    Alternative splice isoforms for GSTO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTO2 Gene

Selected DME Specific Peptides for GSTO2 Gene

Q9H4Y5:
  • WPWFERL
  • PPGPVPEG
  • YSMRFCP

Post-translational modifications for GSTO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GSTO2 Gene

Gene Families for GSTO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GSTO2 Gene

Blocks:
  • Glutathione S-transferase, N-terminal
  • Omega-class glutathione S-transferase signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GSTO2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52232, highly similar to Glutathione transferase omega-2 (EC 2.5.1.18) (B4DJW6_HUMAN)
  • cDNA FLJ51997, highly similar to Glutathione transferase omega-2 (EC 2.5.1.18) (B4DML4_HUMAN)
  • Glutathione S-transferase omega-2 (GSTO2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H4Y5

UniProtKB/Swiss-Prot:

GSTO2_HUMAN :
  • Belongs to the GST superfamily. Omega family.
Family:
  • Belongs to the GST superfamily. Omega family.
genes like me logo Genes that share domains with GSTO2: view

Function for GSTO2 Gene

Molecular function for GSTO2 Gene

UniProtKB/Swiss-Prot Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate; Xref=Rhea:RHEA:24424, ChEBI:CHEBI:38290, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:58539; EC=1.8.5.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid; Xref=Rhea:RHEA:15969, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17826, ChEBI:CHEBI:33409, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.20.4.2; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:15970797};

Enzyme Numbers (IUBMB) for GSTO2 Gene

Phenotypes From GWAS Catalog for GSTO2 Gene

Gene Ontology (GO) - Molecular Function for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA --
GO:0005515 protein binding IPI,IEA 25416956
GO:0016491 oxidoreductase activity IEA,IDA 15970797
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with GSTO2: view
genes like me logo Genes that share phenotypes with GSTO2: view

Animal Models for GSTO2 Gene

MGI Knock Outs for GSTO2:
  • Gsto2 Gsto2<tm2a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTO2

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTO2 Gene

Localization for GSTO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTO2 gene
Compartment Confidence
cytosol 5
extracellular 3
nucleus 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GSTO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GSTO2 Gene

Pathways & Interactions for GSTO2 Gene

genes like me logo Genes that share pathways with GSTO2: view

Pathways by source for GSTO2 Gene

Gene Ontology (GO) - Biological Process for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process IDA 15970797
GO:0019852 L-ascorbic acid metabolic process TAS,IDA --
GO:0055114 oxidation-reduction process IBA,IDA 15970797
GO:0071243 cellular response to arsenic-containing substance IDA 15970797
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GSTO2: view

No data available for SIGNOR curated interactions for GSTO2 Gene

Drugs & Compounds for GSTO2 Gene

(8) Drugs for GSTO2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Trichloroethylene Approved Pharma 5
Water Approved Pharma 0
Vitamin C Approved Nutra 739,739

(41) Additional Compounds for GSTO2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane
genes like me logo Genes that share compounds with GSTO2: view

Transcripts for GSTO2 Gene

mRNA/cDNA for GSTO2 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - - - -
SP2:
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - - - -
SP7: - - - - - - -

Relevant External Links for GSTO2 Gene

GeneLoc Exon Structure for
GSTO2

Expression for GSTO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTO2 Gene

This gene is overexpressed in Testis (x5.5).

Protein differential expression in normal tissues from HIPED for GSTO2 Gene

This gene is overexpressed in Platelet (36.9), Testis (20.0), and Ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GSTO2 Gene



Protein tissue co-expression partners for GSTO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTO2

SOURCE GeneReport for Unigene cluster for GSTO2 Gene:

Hs.203634

mRNA Expression by UniProt/SwissProt for GSTO2 Gene:

Q9H4Y5-GSTO2_HUMAN
Tissue specificity: Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis.

Evidence on tissue expression from TISSUES for GSTO2 Gene

  • Nervous system(4.3)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with GSTO2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTO2 Gene

Orthologs for GSTO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTO2 31 30
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GSTO2 31 30
  • 88.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GSTO2 31 30
  • 86.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsto2 30
  • 86.42 (n)
mouse
(Mus musculus)
Mammalia Gsto2 17 31 30
  • 84.36 (n)
oppossum
(Monodelphis domestica)
Mammalia GSTO2 31
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves GSTO1 31
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gsto2 30
  • 59.2 (n)
zebrafish
(Danio rerio)
Actinopterygii gsto1 31
  • 48 (a)
ManyToMany
gsto2 31
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta se 31
  • 37 (a)
ManyToMany
CG6776 31
  • 35 (a)
ManyToMany
CG6662 31
  • 31 (a)
ManyToMany
CG6673 31
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gst-44 31
  • 32 (a)
ManyToMany
gsto-1 31
  • 30 (a)
ManyToMany
C02D5.4 31
  • 30 (a)
ManyToMany
gsto-2 31
  • 30 (a)
ManyToMany
gsto-3 31
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3044 31
  • 34 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Species where no ortholog for GSTO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTO2 Gene

ENSEMBL:
Gene Tree for GSTO2 (if available)
TreeFam:
Gene Tree for GSTO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTO2: view image

Paralogs for GSTO2 Gene

(1) SIMAP similar genes for GSTO2 Gene using alignment to 3 proteins:

  • GSTO2_HUMAN
  • B4DML4_HUMAN
  • J3KQ23_HUMAN
genes like me logo Genes that share paralogs with GSTO2: view

Variants for GSTO2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTO2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
780890 Likely Benign: not provided 104,275,312(+) G/A MISSENSE_VARIANT
rs156697 - p.Asn142Asp
rs45582439 - p.Cys130Tyr

Additional dbSNP identifiers (rs#s) for GSTO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GSTO2 Gene

Variant ID Type Subtype PubMed ID
nsv1039166 CNV loss 25217958
nsv552062 CNV loss 21841781
nsv831971 CNV gain 17160897

Variation tolerance for GSTO2 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTO2 Gene

Human Gene Mutation Database (HGMD)
GSTO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO2 Gene

Disorders for GSTO2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GSTO2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
skin carcinoma
  • carcinoma of skin
alcohol-induced mental disorder
  • psychoses, alcoholic
hepatocellular carcinoma
  • hcc
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search GSTO2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTO2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GSTO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO2 Gene

Publications for GSTO2 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread AK … Board PG (Pharmacogenetics 2003) 2 3 4 23 26 54
  2. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 23 41 54
  3. Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. (PMID: 19430957) Rafiee L … Saadat M (Molecular biology reports 2010) 3 23 41 54
  4. Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. (PMID: 18398695) Masoudi M … Saadat M (Molecular biology reports 2009) 3 23 41 54
  5. Lack of association of glutathione-S-transferase omega 1(A140D) and omega 2 (N142D) gene polymorphisms with urinary arsenic profile and oxidative stress status in arsenic-exposed population. (PMID: 19635583) Xu Y … Sun G (Mutation research 2009) 3 23 41 54

Products for GSTO2 Gene

Sources for GSTO2 Gene