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Aliases for GSTO2 Gene

Aliases for GSTO2 Gene

  • Glutathione S-Transferase Omega 2 2 3 5
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 2-2 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • GSTO 2-2 3 4
  • GSTO-2 3 4
  • BA127L20.1 (Novel Glutathione-S-Transferase) 3
  • Glutathione-S-Transferase-Like Protein 3
  • Glutathione S-Transferase Omega-2 3
  • EC 2.5.1.18 4
  • EC 1.20.4.2 4
  • BA127L20.1 3
  • EC 1.8.5.1 4

External Ids for GSTO2 Gene

Previous GeneCards Identifiers for GSTO2 Gene

  • GC10P106165
  • GC10P105699
  • GC10P105693
  • GC10P106018
  • GC10P099660

Summaries for GSTO2 Gene

Entrez Gene Summary for GSTO2 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO2 Gene

GSTO2 (Glutathione S-Transferase Omega 2) is a Protein Coding gene. Diseases associated with GSTO2 include Parkinson Disease, Late-Onset. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and protein disulfide oxidoreductase activity. An important paralog of this gene is GSTO1.

UniProtKB/Swiss-Prot for GSTO2 Gene

  • Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

Gene Wiki entry for GSTO2 Gene

Additional gene information for GSTO2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTO2 Gene

Genomics for GSTO2 Gene

GeneHancer (GH) Regulatory Elements for GSTO2 Gene

Promoters and enhancers for GSTO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J104267 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 684.8 +0.1 113 2.8 HDGF PKNOX1 SIN3A ZNF2 BRCA1 YY1 ETS1 ZNF207 ZNF143 FOS GSTO2 MIR4482 CFAP43 PDCD11 TAF5 GSTO1 PCGF6 CFAP58 CFAP58-DT GC10P104302
GH10J104274 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 690.1 +6.7 6744 1.7 CLOCK MZF1 SIN3A KLF5 RAD21 YY1 ZNF335 ZNF121 GLIS2 ZNF143 GSTO2 GSTO1 ENSG00000260461 PDCD11 CFAP58 CFAP58-DT GC10P104302
GH10J104249 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29.2 -14.7 -14699 7.6 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GSTO1 GSTO2 ENSG00000260461 PDCD11 CFAP58 CFAP58-DT GC10M104249 MIR4482
GH10J104316 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.1 +60.4 60355 24.8 FEZF1 YY1 ZNF213 ZNF143 ZNF548 SP3 MEF2D ZNF610 GLIS1 NBN ITPRIP CFAP58 GSTO2 PDCD11 SFR1 CFAP58-DT PCGF6 TAF5 ENSG00000260461 GSTO1
GH10J104258 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 35.6 -8.0 -8004 3 TEAD4 TAL1 JUN FOSL1 TCF12 POLR2A NCOR1 ZFP91 CBFA2T2 FOS GSTO2 GSTO1 MIR609 SFR1 SLK CFAP58 ITPRIP GC10M104249 MIR4482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GSTO2 gene promoter:
  • p53
  • c-Ets-1
  • HOXA9
  • AREB6
  • HOXA9B
  • Meis-1
  • Meis-1a
  • deltaCREB
  • CREB
  • FOXL1

Genomic Locations for GSTO2 Gene

Genomic Locations for GSTO2 Gene
chr10:104,268,416-104,304,948
(GRCh38/hg38)
Size:
36,533 bases
Orientation:
Plus strand
chr10:106,028,631-106,064,703
(GRCh37/hg19)
Size:
36,073 bases
Orientation:
Plus strand

Genomic View for GSTO2 Gene

Genes around GSTO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO2 Gene

Proteins for GSTO2 Gene

  • Protein details for GSTO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Y5-GSTO2_HUMAN
    Recommended name:
    Glutathione S-transferase omega-2
    Protein Accession:
    Q9H4Y5
    Secondary Accessions:
    • A8K771
    • B4DJW6
    • E7ESD6
    • Q49TW5
    • Q5GM70
    • Q5JU15
    • Q86WP3

    Protein attributes for GSTO2 Gene

    Size:
    243 amino acids
    Molecular mass:
    28254 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GSTO2 Gene

    Alternative splice isoforms for GSTO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTO2 Gene

Post-translational modifications for GSTO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GSTO2 Gene

Domains & Families for GSTO2 Gene

Gene Families for GSTO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9H4Y5

UniProtKB/Swiss-Prot:

GSTO2_HUMAN :
  • Belongs to the GST superfamily. Omega family.
Family:
  • Belongs to the GST superfamily. Omega family.
genes like me logo Genes that share domains with GSTO2: view

Function for GSTO2 Gene

Molecular function for GSTO2 Gene

UniProtKB/Swiss-Prot Function:
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
UniProtKB/Swiss-Prot CatalyticActivity:
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.5. {ECO:0000269 PubMed:15970797};

Enzyme Numbers (IUBMB) for GSTO2 Gene

Phenotypes From GWAS Catalog for GSTO2 Gene

Gene Ontology (GO) - Molecular Function for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA,IDA 15970797
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with GSTO2: view
genes like me logo Genes that share phenotypes with GSTO2: view

Animal Models for GSTO2 Gene

MGI Knock Outs for GSTO2:
  • Gsto2 Gsto2<tm2a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTO2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTO2 Gene

Localization for GSTO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTO2 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GSTO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GSTO2 Gene

Pathways & Interactions for GSTO2 Gene

genes like me logo Genes that share pathways with GSTO2: view

Gene Ontology (GO) - Biological Process for GSTO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA --
GO:0006805 xenobiotic metabolic process IDA 15970797
GO:0008152 metabolic process IEA --
GO:0009407 toxin catabolic process IBA --
GO:0019852 L-ascorbic acid metabolic process IDA,TAS --
genes like me logo Genes that share ontologies with GSTO2: view

No data available for SIGNOR curated interactions for GSTO2 Gene

Drugs & Compounds for GSTO2 Gene

(6) Drugs for GSTO2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Trichloroethylene Approved Pharma 5
Water Approved Pharma 0
Vitamin C Approved Nutra 581,581

(43) Additional Compounds for GSTO2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane
genes like me logo Genes that share compounds with GSTO2: view

Transcripts for GSTO2 Gene

Unigene Clusters for GSTO2 Gene

Glutathione S-transferase omega 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - - - -
SP2:
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - - - -
SP7: - - - - - - -

Relevant External Links for GSTO2 Gene

GeneLoc Exon Structure for
GSTO2
ECgene alternative splicing isoforms for
GSTO2

Expression for GSTO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GSTO2 Gene

This gene is overexpressed in Testis (x5.5).

Protein differential expression in normal tissues from HIPED for GSTO2 Gene

This gene is overexpressed in Platelet (36.9), Testis (20.0), and Ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GSTO2 Gene



Protein tissue co-expression partners for GSTO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTO2 Gene:

GSTO2

SOURCE GeneReport for Unigene cluster for GSTO2 Gene:

Hs.203634

mRNA Expression by UniProt/SwissProt for GSTO2 Gene:

Q9H4Y5-GSTO2_HUMAN
Tissue specificity: Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis.

Evidence on tissue expression from TISSUES for GSTO2 Gene

  • Nervous system(4.3)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with GSTO2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTO2 Gene

Orthologs for GSTO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTO2 34 33
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GSTO2 34 33
  • 88.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GSTO2 34 33
  • 86.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gsto2 33
  • 86.42 (n)
mouse
(Mus musculus)
Mammalia Gsto2 16 34 33
  • 84.36 (n)
oppossum
(Monodelphis domestica)
Mammalia GSTO2 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves GSTO1 34
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gsto2 33
  • 59.2 (n)
zebrafish
(Danio rerio)
Actinopterygii gsto1 34
  • 48 (a)
ManyToMany
gsto2 34
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta se 34
  • 37 (a)
ManyToMany
CG6776 34
  • 35 (a)
ManyToMany
CG6662 34
  • 31 (a)
ManyToMany
CG6673 34
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gst-44 34
  • 32 (a)
ManyToMany
gsto-1 34
  • 30 (a)
ManyToMany
C02D5.4 34
  • 30 (a)
ManyToMany
gsto-2 34
  • 30 (a)
ManyToMany
gsto-3 34
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3044 34
  • 34 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Species where no ortholog for GSTO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTO2 Gene

ENSEMBL:
Gene Tree for GSTO2 (if available)
TreeFam:
Gene Tree for GSTO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTO2: view image

Paralogs for GSTO2 Gene

Paralogs for GSTO2 Gene

(1) SIMAP similar genes for GSTO2 Gene using alignment to 3 proteins:

  • GSTO2_HUMAN
  • B4DML4_HUMAN
  • J3KQ23_HUMAN
genes like me logo Genes that share paralogs with GSTO2: view

Variants for GSTO2 Gene

Sequence variations from dbSNP and Humsavar for GSTO2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000046388 -- 104,300,331(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000148362 -- 104,275,765(+) C/G intron_variant
rs1000161384 -- 104,281,877(+) C/A intron_variant
rs1000304365 -- 104,282,567(+) AAGAAGAAGAAGAAG/AAGAAGAAGAAG intron_variant
rs1000323864 -- 104,275,583(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTO2 Gene

Variant ID Type Subtype PubMed ID
nsv1039166 CNV loss 25217958
nsv552062 CNV loss 21841781
nsv831971 CNV gain 17160897

Variation tolerance for GSTO2 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTO2 Gene

Human Gene Mutation Database (HGMD)
GSTO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO2 Gene

Disorders for GSTO2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GSTO2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search GSTO2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTO2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GSTO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO2 Gene

Publications for GSTO2 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread AK … Board PG (Pharmacogenetics 2003) 2 3 4 22 25 58
  2. Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. (PMID: 19430957) Rafiee L … Saadat M (Molecular biology reports 2010) 3 22 44 58
  3. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 22 44 58
  4. Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer. (PMID: 18398695) Masoudi M … Saadat M (Molecular biology reports 2009) 3 22 44 58
  5. Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia. (PMID: 18941778) Pongstaporn W … Petmitr S (Journal of cancer research and clinical oncology 2009) 3 22 44 58

Products for GSTO2 Gene

Sources for GSTO2 Gene

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