The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found ... See more...

Aliases for GSTO1 Gene

Aliases for GSTO1 Gene

  • Glutathione S-Transferase Omega 1 2 3 5
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 1-1 3 4
  • Glutathione S-Transferase Omega-1 3 4
  • S-(Phenacyl)Glutathione Reductase 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • EC 2.5.1.18 4 51
  • GSTO 1-1 3 4
  • GSTTLp28 2 3
  • SPG-R 3 4
  • P28 2 3
  • Epididymis Secretory Protein Li 21 3
  • Glutathione-S-Transferase Like 3
  • EC 1.20.4.2 4
  • EC 1.8.5.1 4
  • HEL-S-21 3
  • GSTTLP28 4
  • GSTO-1 4
  • GSTO1 5

External Ids for GSTO1 Gene

Previous GeneCards Identifiers for GSTO1 Gene

  • GC10P106145
  • GC10P105679
  • GC10P106004
  • GC10P099645

Summaries for GSTO1 Gene

Entrez Gene Summary for GSTO1 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO1 Gene

GSTO1 (Glutathione S-Transferase Omega 1) is a Protein Coding gene. Diseases associated with GSTO1 include Barrett's Adenocarcinoma and Night Blindness, Congenital Stationary, Type 1A. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.

UniProtKB/Swiss-Prot Summary for GSTO1 Gene

  • Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Gene Wiki entry for GSTO1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTO1 Gene

Genomics for GSTO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GSTO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J104249 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 616.7 +18.4 18361 7.6 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 REST TFE3 LEF1 SOX13 IKZF1 GSTO1 GSTO2 ENSG00000260461 PDCD11 CFAP58-DT CFAP58 lnc-CFAP43-6 piR-40348-010
GH10J104231 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -3.2 -3155 2 SP1 PRDM10 ZNF629 RFX1 NFKBIZ KDM1A ZNF692 FOS TARDBP FOXA1 CFAP43 GSTO1 GSTO2 MIR609 SFR1
GH10J104267 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.6 +33.3 33309 3.1 BRCA1 SP1 CREB1 PRDM10 ZNF629 ZNF692 POLR2A BACH1 FOS LARP7 GSTO2 MN297008 MIR4482 lnc-CFAP43-4 CFAP43 GSTO1 PDCD11 PCGF6 CFAP58-DT CFAP58
GH10J104274 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 16.5 +39.8 39804 1.7 CTCF PRDM10 RFX1 KDM1A ZHX2 ZNF143 IRF2 ZNF501 POLR2A TRIM22 GSTO2 GSTO1 CFAP58 CFAP58-DT MN297008 piR-43107-052 ITPRIP
GH10J104258 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 23.9 +25.1 25056 3 IKZF1 JUND PRDM1 RBFOX2 DPF2 SOX6 TCF12 EP300 MGA FOS lnc-CFAP43-1 GSTO2 GSTO1 MIR609 SFR1 SLK CFAP58 ITPRIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTO1

Top Transcription factor binding sites by QIAGEN in the GSTO1 gene promoter:
  • Arnt
  • c-Ets-1
  • CREB
  • deltaCREB
  • E47
  • GCNF
  • GCNF-1
  • GCNF-2
  • HEN1
  • Tal-1beta

Genomic Locations for GSTO1 Gene

Genomic Locations for GSTO1 Gene
chr10:104,235,356-104,267,464
(GRCh38/hg38)
Size:
32,109 bases
Orientation:
Plus strand
chr10:105,995,114-106,027,222
(GRCh37/hg19)
Size:
32,109 bases
Orientation:
Plus strand

Genomic View for GSTO1 Gene

Genes around GSTO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO1 Gene

Proteins for GSTO1 Gene

  • Protein details for GSTO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78417-GSTO1_HUMAN
    Recommended name:
    Glutathione S-transferase omega-1
    Protein Accession:
    P78417
    Secondary Accessions:
    • D3DRA3
    • F5H7H0
    • Q5TA03
    • Q7Z3T2

    Protein attributes for GSTO1 Gene

    Size:
    241 amino acids
    Molecular mass:
    27566 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAD97673.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSTO1 Gene

    Alternative splice isoforms for GSTO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTO1 Gene

Selected DME Specific Peptides for GSTO1 Gene

P78417:
  • WPWFERL
  • PVLENSQ
  • PPGPVPEG
  • YSMRFCP

Post-translational modifications for GSTO1 Gene

  • Ubiquitination at Lys11
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTO1 Gene

Domains & Families for GSTO1 Gene

Gene Families for GSTO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GSTO1 Gene

InterPro:
Blocks:
  • Glutathione S-transferase, N-terminal
  • Omega-class glutathione S-transferase signature
ProtoNet:

Suggested Antigen Peptide Sequences for GSTO1 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione S-transferase omega-1 (GSTO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78417

UniProtKB/Swiss-Prot:

GSTO1_HUMAN :
  • Belongs to the GST superfamily. Omega family.
Family:
  • Belongs to the GST superfamily. Omega family.
genes like me logo Genes that share domains with GSTO1: view

Function for GSTO1 Gene

Molecular function for GSTO1 Gene

UniProtKB/Swiss-Prot Function:
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate; Xref=Rhea:RHEA:24424, ChEBI:CHEBI:38290, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:58539; EC=1.8.5.1; Evidence={ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid; Xref=Rhea:RHEA:15969, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17826, ChEBI:CHEBI:33409, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.20.4.2; Evidence={ECO:0000269|PubMed:11511179};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8. {ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937};
UniProtKB/Swiss-Prot EnzymeRegulation:
Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.

Enzyme Numbers (IUBMB) for GSTO1 Gene

Phenotypes From GWAS Catalog for GSTO1 Gene

Gene Ontology (GO) - Molecular Function for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 11511179
GO:0005515 protein binding IPI 25277244
GO:0016491 oxidoreductase activity IEA,IDA 11511179
GO:0016740 transferase activity IEA --
GO:0045174 glutathione dehydrogenase (ascorbate) activity IBA,IDA 11511179
genes like me logo Genes that share ontologies with GSTO1: view
genes like me logo Genes that share phenotypes with GSTO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GSTO1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTO1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTO1 Gene

Localization for GSTO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTO1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTO1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 11511179
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GSTO1: view

Pathways & Interactions for GSTO1 Gene

genes like me logo Genes that share pathways with GSTO1: view

Gene Ontology (GO) - Biological Process for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA 11035031
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC 11035031
GO:0014810 positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC 11035031
GO:0019852 L-ascorbic acid metabolic process IDA 11511179
GO:0032259 methylation TAS --
genes like me logo Genes that share ontologies with GSTO1: view

No data available for SIGNOR curated interactions for GSTO1 Gene

Drugs & Compounds for GSTO1 Gene

(15) Drugs for GSTO1 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Vitamin E Approved, Vet_approved Nutra Enzyme, inhibitor 526,534
alpha-Tocopherol acetate Approved, Vet_approved Nutra Enzyme, inhibitor 0
alpha-Tocopherol succinate Approved, Vet_approved Nutra Enzyme, inhibitor 0
Oxidized glutathione Approved, Experimental, Investigational Pharma 0

(45) Additional Compounds for GSTO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane

(2) ApexBio Compounds for GSTO1 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTO1: view

Drug Products

Transcripts for GSTO1 Gene

mRNA/cDNA for GSTO1 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTO1

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - -
SP7: - -

Relevant External Links for GSTO1 Gene

GeneLoc Exon Structure for
GSTO1

Expression for GSTO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTO1 Gene

Protein differential expression in normal tissues from HIPED for GSTO1 Gene

This gene is overexpressed in Liver, secretome (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTO1 Gene



Protein tissue co-expression partners for GSTO1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTO1

SOURCE GeneReport for Unigene cluster for GSTO1 Gene:

Hs.190028

mRNA Expression by UniProt/SwissProt for GSTO1 Gene:

P78417-GSTO1_HUMAN
Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.

Evidence on tissue expression from TISSUES for GSTO1 Gene

  • Liver(4.7)
  • Eye(4.4)
  • Skin(4.1)
  • Lung(3.8)
  • Nervous system(3.7)
  • Heart(3)
  • Muscle(2.9)
  • Kidney(2.9)
  • Intestine(2.8)
  • Blood(2.8)
  • Pancreas(2.6)
  • Stomach(2.4)
  • Spleen(2.3)
  • Thyroid gland(2.3)
  • Lymph node(2.3)
  • Adrenal gland(2.3)
  • Bone marrow(2.3)
genes like me logo Genes that share expression patterns with GSTO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTO1 Gene

Orthologs for GSTO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GSTO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GSTO1 30 31
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GSTO1 30 31
  • 86.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GSTO1 30
  • 85.48 (n)
-- 31
  • 83 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Gsto1 30
  • 80.08 (n)
Mouse
(Mus musculus)
Mammalia Gsto1 30 17 31
  • 76.94 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 69 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia GSTO1 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GSTO1 30 31
  • 66.95 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 66 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24164 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.1986 30
Zebrafish
(Danio rerio)
Actinopterygii gsto1 30 31
  • 62.71 (n)
ManyToMany
gsto2 31
  • 56 (a)
ManyToMany
Dr.16014 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11014 30
Fruit Fly
(Drosophila melanogaster)
Insecta se 30 31
  • 52.61 (n)
ManyToMany
CG6776 31
  • 35 (a)
ManyToMany
CG6673 31
  • 31 (a)
ManyToMany
CG6662 31
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GSTO1 30
  • 48.27 (n)
Worm
(Caenorhabditis elegans)
Secernentea gst-44 30 31
  • 48.38 (n)
ManyToMany
gsto-2 31
  • 33 (a)
ManyToMany
C02D5.4 31
  • 33 (a)
ManyToMany
gsto-1 31
  • 32 (a)
ManyToMany
gsto-3 31
  • 24 (a)
ManyToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU00549 30
  • 48.43 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3044 31
  • 35 (a)
ManyToMany
-- 31
  • 32 (a)
ManyToMany
Species where no ortholog for GSTO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GSTO1 Gene

ENSEMBL:
Gene Tree for GSTO1 (if available)
TreeFam:
Gene Tree for GSTO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTO1: view image

Paralogs for GSTO1 Gene

(1) SIMAP similar genes for GSTO1 Gene using alignment to 3 proteins:

  • GSTO1_HUMAN
  • Q5TA01_HUMAN
  • Q5TA02_HUMAN

Pseudogenes.org Pseudogenes for GSTO1 Gene

genes like me logo Genes that share paralogs with GSTO1: view

Variants for GSTO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTO1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
715814 Likely Benign: not provided 104,266,106(+) C/T MISSENSE_VARIANT
777194 Likely Benign: not provided 104,254,969(+) C/A INTRON_VARIANT
782535 Benign: not provided 104,254,967(+) G/A INTRON_VARIANT
787591 Benign: not provided 104,254,948(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
rs11509436 - p.Ser86Cys

Additional dbSNP identifiers (rs#s) for GSTO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GSTO1 Gene

Variant ID Type Subtype PubMed ID
nsv1039166 CNV loss 25217958
nsv552062 CNV loss 21841781
nsv831971 CNV gain 17160897

Variation tolerance for GSTO1 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.70; 86.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTO1 Gene

Human Gene Mutation Database (HGMD)
GSTO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO1 Gene

Disorders for GSTO1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GSTO1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
barrett's adenocarcinoma
  • adenocarcinoma arising in barrett's mucosa
night blindness, congenital stationary, type 1a
  • night blindness, congenital stationary, type 2a
hepatocellular carcinoma
  • hcc
parkinson disease, late-onset
  • pd
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search GSTO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTO1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GSTO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO1 Gene

Publications for GSTO1 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread AK … Board PG (Pharmacogenetics 2003) 2 3 4 23
  2. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 23 41
  3. No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova IE … Brauch H (Breast cancer research and treatment 2010) 3 23 41
  4. Synergistic effect of polymorphisms of paraoxonase gene cluster and arsenic exposure on electrocardiogram abnormality. (PMID: 19152805) Liao YT … Wang SL (Toxicology and applied pharmacology 2009) 3 23 41
  5. An analysis of methylenetetrahydrofolate reductase and glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia. (PMID: 19624857) Peddareddygari LR … Grewal RP (BMC neurology 2009) 3 23 41

Products for GSTO1 Gene

Sources for GSTO1 Gene