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The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found ... See more...
Aliases for GSTO1 Gene
Aliases for GSTO1 Gene
- Glutathione S-Transferase Omega 1 2 3 5
- Glutathione-Dependent Dehydroascorbate Reductase 3 4
- Glutathione S-Transferase Omega 1-1 3 4
- Glutathione S-Transferase Omega-1 3 4
- S-(Phenacyl)Glutathione Reductase 3 4
- Monomethylarsonic Acid Reductase 3 4
- MMA(V) Reductase 3 4
- EC 2.5.1.18 4 51
- GSTO 1-1 3 4
- GSTTLp28 2 3
External Ids for GSTO1 Gene
- HGNC: 13312
- Entrez Gene: 9446
- Ensembl: ENSG00000148834
- OMIM: 605482
- UniProtKB: P78417
Previous GeneCards Identifiers for GSTO1 Gene
- GC10P106145
- GC10P105679
- GC10P106004
- GC10P099645
Summaries for GSTO1 Gene
-
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for GSTO1 Gene
GSTO1 (Glutathione S-Transferase Omega 1) is a Protein Coding gene. Diseases associated with GSTO1 include Barrett's Adenocarcinoma and Night Blindness, Congenital Stationary, Type 1A. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.
UniProtKB/Swiss-Prot Summary for GSTO1 Gene
-
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Additional gene information for GSTO1 Gene
- HGNC(13312)
- Entrez Gene(9446)
- Ensembl(ENSG00000148834)
- OMIM(605482)
- UniProtKB(P78417)
- Open Targets Platform(ENSG00000148834)
- Monarch Initiative
- Search for GSTO1 at DataMed
- Search for GSTO1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTO1 Gene
Genomics for GSTO1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GSTO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSTO1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTO1
- Top Transcription factor binding sites by QIAGEN in the GSTO1 gene promoter:
-
- Arnt
- c-Ets-1
- CREB
- deltaCREB
- E47
- GCNF
- GCNF-1
- GCNF-2
- HEN1
- Tal-1beta
Genomic Locations for GSTO1 Gene
Genomic Locations for GSTO1 Gene
- chr10:104,235,356-104,267,464
- (GRCh38/hg38)
- Size:
- 32,109 bases
- Orientation:
- Plus strand
- chr10:105,995,114-106,027,222
- (GRCh37/hg19)
- Size:
- 32,109 bases
- Orientation:
- Plus strand
Genomic View for GSTO1 Gene
Genes around GSTO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.1 by HGNC
- 10q25.1 by Entrez Gene
- 10q25.1 by Ensembl
GSTO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSTO1 Gene
Proteins for GSTO1 Gene
-
Protein details for GSTO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78417-GSTO1_HUMAN
- Recommended name:
- Glutathione S-transferase omega-1
- Protein Accession:
- P78417
- D3DRA3
- F5H7H0
- Q5TA03
- Q7Z3T2
Protein attributes for GSTO1 Gene
- Size:
- 241 amino acids
- Molecular mass:
- 27566 Da
- Quaternary structure:
-
- Homodimer.
- SequenceCaution:
-
- Sequence=CAD97673.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for GSTO1 Gene
Protein Expression for GSTO1 Gene
Selected DME Specific Peptides for GSTO1 Gene
- P78417:
-
- WPWFERL
- PVLENSQ
- PPGPVPEG
- YSMRFCP
Post-translational modifications for GSTO1 Gene
Other Protein References for GSTO1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-GSTO1 antibody [N1C3] and Anti-GSTO1 antibody
- Creative Diagnostics Anti-GSTO1 monoclonal antibody, clone FQS9481(C)
- Creative Biolabs Recombinant Mouse Anti-Human GSTO1 Antibody
- Novus Biologicals Antibodies for GSTO1
-
Abcam antibodies for GSTO1
- Invitrogen Antibodies for GSTO1 (AFLGC-GSTO1)
-
Boster Bio Antibodies for GSTO1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GSTO1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTO1
- Origene Custom Protein Services for GSTO1
-
Abcam proteins for GSTO1
Assay Products
- Creative Diagnostics Human GSTO1 ELISA Matched Antibody Pair
- antibodies-online: Show 52 available GSTO1 Elisa Kits ranked by validation data
- Compare Top GSTO1 Elisa Kits
-
Quality Products:
- ABIN1115176
- ABIN840232
- ABIN415241
- ABIN1570185
- ABIN5669422
- ABIN509978
- ABIN5654716
- ABIN2533969
- ABIN2947919
- ABIN4969673
- ABIN1115177
- ABIN424424
- ABIN1570186
- ABIN5670232
- ABIN627914
- ABIN5654717
- ABIN2533970
- ABIN2947920
- ABIN4969674
- ABIN6229584
- ABIN1115175
- ABIN5670918
- ABIN627100
- ABIN5594739
- ABIN2947933
- ABIN6229587
- ABIN5072467
- ABIN585216
- ABIN775007
- ABIN1562743
- ABIN6229586
-
Signalway ELISA kits for GSTO1
Domains & Families for GSTO1 Gene
Gene Families for GSTO1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GSTO1 Gene
- InterPro:
- Blocks:
-
- Glutathione S-transferase, N-terminal
- Omega-class glutathione S-transferase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for GSTO1 Gene
- GenScript: Design optimal peptide antigens:
-
- Glutathione S-transferase omega-1 (GSTO1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P78417- Family:
-
- Belongs to the GST superfamily. Omega family.
Function for GSTO1 Gene
Molecular function for GSTO1 Gene
- UniProtKB/Swiss-Prot Function:
- Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937, ECO:0000269|PubMed:18028863, ECO:0000269|PubMed:21106529};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate; Xref=Rhea:RHEA:24424, ChEBI:CHEBI:38290, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:58539; EC=1.8.5.1; Evidence={ECO:0000269|PubMed:10783391, ECO:0000269|PubMed:11511179};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid; Xref=Rhea:RHEA:15969, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17826, ChEBI:CHEBI:33409, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.20.4.2; Evidence={ECO:0000269|PubMed:11511179};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 8. {ECO:0000269|PubMed:11511179, ECO:0000269|PubMed:17226937};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
Enzyme Numbers (IUBMB) for GSTO1 Gene
Phenotypes From GWAS Catalog for GSTO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | IDA | 11511179 |
| GO:0005515 | protein binding | IPI | 25277244 |
| GO:0016491 | oxidoreductase activity | IEA,IDA | 11511179 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0045174 | glutathione dehydrogenase (ascorbate) activity | IBA,IDA | 11511179 |
Phenotypes for GSTO1 Gene
- MGI mutant phenotypes for GSTO1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for GSTO1:
Animal Model Products
-
Taconic Biosciences Mouse Models for GSTO1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSTO1 - Select products 50% OFF >
- * GSTO1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSTO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTO1
miRNA for GSTO1 Gene
- miRTarBase miRNAs that target GSTO1
-
- mmu-miR-34b-5p (MIRT012856)
- hsa-miR-1-3p (MIRT023892)
- hsa-miR-197-3p (MIRT048048)
- hsa-miR-1275 (MIRT762109)
- hsa-miR-193b-5p (MIRT763451)
- hsa-miR-30a-3p (MIRT764552)
- hsa-miR-30d-3p (MIRT764741)
- hsa-miR-30e-3p (MIRT764746)
- hsa-miR-4260 (MIRT768196)
- hsa-miR-4291 (MIRT768404)
- hsa-miR-4310 (MIRT768542)
- hsa-miR-450a-2-3p (MIRT769871)
- hsa-miR-4665-5p (MIRT770821)
- hsa-miR-5572 (MIRT774690)
- hsa-miR-6503-3p (MIRT776565)
- hsa-miR-6751-5p (MIRT778349)
- hsa-miR-6752-5p (MIRT778358)
- hsa-miR-6803-5p (MIRT779508)
- hsa-miR-6835-5p (MIRT780037)
- hsa-miR-6842-5p (MIRT780208)
- hsa-miR-7109-5p (MIRT781428)
- hsa-miR-7110-5p (MIRT781434)
- hsa-miR-7157-5p (MIRT781558)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTO1
- Browse OriGene Inhibitory RNA Products For GSTO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTO1
Clone Products
- Applied Biological Materials (abm): Clones for GSTO1 - Select products 50% OFF >
- * GSTO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202949
- MR202949
- MR202949L3
- MR202949L4
- RC200362
- RC200362L1
- RC200362L2
- RC200362L3
- RC200362L4
- RC230777
- RC230777L3
- RC230777L4
- RC231053
- RC231053L3
- RC231053L4
- RG200362
- RG230777
- RG231053
- RR211060
- RR211060L3
- RR211060L4
- MR202949L3V
- MR202949L4V
- RC200362L1V
- RC200362L2V
- RC200362L3V
- RC200362L4V
- RC230777L3V
- RC230777L4V
- RC231053L3V
- RC231053L4V
- RR211060L3V
- RR211060L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GSTO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTO1
Cell Line Products
-
Horizon Cell Lines for GSTO1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTO1 Gene
Localization for GSTO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTO1 Gene
- Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 11511179 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for GSTO1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type |
.01
|
|
| 3 | Glutathione metabolism |
Glutathione metabolism
.60
|
|
| 4 | Metabolism of water-soluble vitamins and cofactors | ||
| 5 | Metabolism |
.40
|
|
Pathways by source for GSTO1 Gene
4 BioSystems pathways for GSTO1 Gene
8 Reactome pathways for GSTO1 Gene
10 KEGG pathways for GSTO1 Gene
1 GeneGo (Thomson Reuters) pathway for GSTO1 Gene
- Glutathione metabolism
Interacting Proteins for GSTO1 Gene
Selected Interacting proteins:
P78417-GSTO1_HUMAN
ENSP00000358727
for GSTO1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GSTO1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | IDA | 11035031 |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | IC | 11035031 |
| GO:0014810 | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | IC | 11035031 |
| GO:0019852 | L-ascorbic acid metabolic process | IDA | 11511179 |
| GO:0032259 | methylation | TAS | -- |
No data available for SIGNOR curated interactions for GSTO1 Gene
Drugs & Compounds for GSTO1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutathione | Approved, Investigational | Nutra | Target | 0 | ||
| Vitamin E | Approved, Vet_approved | Nutra | Enzyme, inhibitor | 526,534 | ||
| alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Enzyme, inhibitor | 0 | ||
| alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Enzyme, inhibitor | 0 | ||
| Oxidized glutathione | Approved, Experimental, Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S,2R)-Naphthalene 1,2-oxide |
|
|
||||
| 1,1-Dichloroethylene epoxide |
|
|
(2) ApexBio Compounds for GSTO1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| LB42708 | Selective FTase inhibitor | 226929-39-1 |
| Lonafarnib | Ftase inhibitor,potent and selective | 193275-84-2 |
Transcripts for GSTO1 Gene
mRNA/cDNA for GSTO1 Gene
- 3 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369710 900 nts (view in UCSC)
- ENST00000369713 813 nts (view in UCSC)
- ENST00000432659 592 nts (view in UCSC)
- ENST00000445155 829 nts (view in UCSC)
- ENST00000470554 547 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GSTO1 - Select products 50% OFF >
- * GSTO1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GSTO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTO1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTO1
- Browse OriGene Inhibitory RNA Products For GSTO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTO1
Clone Products
- Applied Biological Materials (abm): Clones for GSTO1 - Select products 50% OFF >
- * GSTO1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202949
- MR202949
- MR202949L3
- MR202949L4
- RC200362
- RC200362L1
- RC200362L2
- RC200362L3
- RC200362L4
- RC230777
- RC230777L3
- RC230777L4
- RC231053
- RC231053L3
- RC231053L4
- RG200362
- RG230777
- RG231053
- RR211060
- RR211060L3
- RR211060L4
- MR202949L3V
- MR202949L4V
- RC200362L1V
- RC200362L2V
- RC200362L3V
- RC200362L4V
- RC230777L3V
- RC230777L4V
- RC231053L3V
- RC231053L4V
- RR211060L3V
- RR211060L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GSTO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTO1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||
| SP7: | - | - |
Relevant External Links for GSTO1 Gene
- GeneLoc Exon Structure for
- GSTO1
Expression for GSTO1 Gene
This gene is overexpressed in Liver, secretome (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTO1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTO1
SOURCE GeneReport for Unigene cluster for GSTO1 Gene:
Hs.190028mRNA Expression by UniProt/SwissProt for GSTO1 Gene:
P78417-GSTO1_HUMAN
Tissue specificity:
Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
Evidence on tissue expression from TISSUES for GSTO1 Gene
- Liver(4.7)
- Eye(4.4)
- Skin(4.1)
- Lung(3.8)
- Nervous system(3.7)
- Heart(3)
- Muscle(2.9)
- Kidney(2.9)
- Intestine(2.8)
- Blood(2.8)
- Pancreas(2.6)
- Stomach(2.4)
- Spleen(2.3)
- Thyroid gland(2.3)
- Lymph node(2.3)
- Adrenal gland(2.3)
- Bone marrow(2.3)
Primer Products
-
OriGene qPCR primer pairs for GSTO1
-
OriGene qPCR primer pairs and template standards for GSTO1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTO1 Gene
Orthologs for GSTO1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GSTO1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GSTO1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GSTO1 30 |
|
||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Gsto1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Gsto1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | GSTO1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GSTO1 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24164 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.1986 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gsto1 30 31 |
|
ManyToMany | |
| gsto2 31 |
|
ManyToMany | |||
| Dr.16014 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11014 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | se 30 31 |
|
ManyToMany | |
| CG6776 31 |
|
ManyToMany | |||
| CG6673 31 |
|
ManyToMany | |||
| CG6662 31 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | GSTO1 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | gst-44 30 31 |
|
ManyToMany | |
| gsto-2 31 |
|
ManyToMany | |||
| C02D5.4 31 |
|
ManyToMany | |||
| gsto-1 31 |
|
ManyToMany | |||
| gsto-3 31 |
|
ManyToMany | |||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU00549 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3044 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for GSTO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GSTO1 Gene
- ENSEMBL:
- Gene Tree for GSTO1 (if available)
- TreeFam:
- Gene Tree for GSTO1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSTO1: view image
Paralogs for GSTO1 Gene
Paralogs for GSTO1 Gene
(1) SIMAP similar genes for GSTO1 Gene using alignment to 3 proteins:
- GSTO1_HUMAN
- Q5TA01_HUMAN
- Q5TA02_HUMAN
Pseudogenes.org Pseudogenes for GSTO1 Gene
Variants for GSTO1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTO1 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 715814 | Likely Benign: not provided | 104,266,106(+) | C/T | MISSENSE_VARIANT | |
| 777194 | Likely Benign: not provided | 104,254,969(+) | C/A | INTRON_VARIANT | |
| 782535 | Benign: not provided | 104,254,967(+) | G/A | INTRON_VARIANT | |
| 787591 | Benign: not provided | 104,254,948(+) | G/A | MISSENSE_VARIANT,INTRON_VARIANT | |
| rs11509436 | - | p.Ser86Cys |
Residual Variation Intolerance Score:
78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.70;
86.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSTO1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO1 Gene
Disorders for GSTO1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| barrett's adenocarcinoma |
|
|
| night blindness, congenital stationary, type 1a |
|
|
| hepatocellular carcinoma |
|
|
| parkinson disease, late-onset |
|
|
| alzheimer disease |
|
Search GSTO1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GSTO1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO1 Gene
Publications for GSTO1 Gene
- Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread AK … Board PG (Pharmacogenetics 2003) 2 3 4 23
- Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 23 41
- No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova IE … Brauch H (Breast cancer research and treatment 2010) 3 23 41
- Synergistic effect of polymorphisms of paraoxonase gene cluster and arsenic exposure on electrocardiogram abnormality. (PMID: 19152805) Liao YT … Wang SL (Toxicology and applied pharmacology 2009) 3 23 41
- An analysis of methylenetetrahydrofolate reductase and glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia. (PMID: 19624857) Peddareddygari LR … Grewal RP (BMC neurology 2009) 3 23 41
ExternalLinks
Products for GSTO1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTO1
- Origene Custom Protein Services for GSTO1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTO1
- Browse OriGene Inhibitory RNA Products For GSTO1
- OriGene qPCR primer pairs for GSTO1
- OriGene qPCR primer pairs and template standards for GSTO1
- OriGene CRISPR knockouts for GSTO1
- MG202949
- MR202949
- MR202949L3
- MR202949L4
- RC200362
- RC200362L1
- RC200362L2
- RC200362L3
- RC200362L4
- RC230777
- RC230777L3
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- RC231053
- RC231053L3
- RC231053L4
- RG200362
- RG230777
- RG231053
- RR211060
- RR211060L3
- RR211060L4
- MR202949L3V
- MR202949L4V
- RC200362L1V
- RC200362L2V
- RC200362L3V
- RC200362L4V
- RC230777L3V
- RC230777L4V
- RC231053L3V
- RC231053L4V
- RR211060L3V
- RR211060L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GSTO1
- Sino Biological Human cDNA Clone for GSTO1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GSTO1
- Novus Biologicals proteins and lysates for GSTO1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GSTO1
- Abcam proteins for GSTO1
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for GSTO1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GSTO1 (AFLGC-GSTO1)
- ApexBio compounds for GSTO1
- VectorBuilder Custom and pre-made DNA vectors for GSTO1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GSTO1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GSTO1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GSTO1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GSTO1
- antibodies-online: Show 18 available GSTO1 Antibodies ranked by validation data
- Compare Top GSTO1 Antibodies
- antibodies-online: Show 52 available GSTO1 Elisa Kits ranked by validation data
- Compare Top GSTO1 Elisa Kits
- Quality Products:
- ABIN1115176
- ABIN840232
- ABIN415241
- ABIN1570185
- ABIN5669422
- ABIN509978
- ABIN5654716
- ABIN2533969
- ABIN2947919
- ABIN4969673
- ABIN1115177
- ABIN424424
- ABIN1570186
- ABIN5670232
- ABIN627914
- ABIN5654717
- ABIN2533970
- ABIN2947920
- ABIN4969674
- ABIN6229584
- ABIN1115175
- ABIN5670918
- ABIN627100
- ABIN5594739
- ABIN2947933
- ABIN6229587
- ABIN5072467
- ABIN585216
- ABIN775007
- ABIN1562743
- ABIN6229586
- antibodies-online: Show 27 available GSTO1 Proteins ranked by validation data
- Compare Top GSTO1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for GSTO1
- Search Santa Cruz Biotechnology (SCBT) for GSTO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GSTO1
- Horizon Cell Lines for GSTO1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTO1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GSTO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTO1
- Boster Bio Antibodies for GSTO1
- Browse Boster Bio ELISA Kits
Sources for GSTO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB