Aliases for GSTO1 Gene
Aliases for GSTO1 Gene
- Glutathione S-Transferase Omega 1 2 3 5
- Glutathione-Dependent Dehydroascorbate Reductase 3 4
- Glutathione S-Transferase Omega 1-1 3 4
- S-(Phenacyl)Glutathione Reductase 3 4
- Monomethylarsonic Acid Reductase 3 4
- MMA(V) Reductase 3 4
- GSTO 1-1 3 4
- SPG-R 3 4
- Epididymis Secretory Protein Li 21 3
- Glutathione S-Transferase Omega-1 3
External Ids for GSTO1 Gene
- HGNC: 13312
- Entrez Gene: 9446
- Ensembl: ENSG00000148834
- OMIM: 605482
- UniProtKB: P78417
Previous GeneCards Identifiers for GSTO1 Gene
- GC10P106145
- GC10P105679
- GC10P106004
- GC10P099645
Summaries for GSTO1 Gene
-
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for GSTO1 Gene
GSTO1 (Glutathione S-Transferase Omega 1) is a Protein Coding gene. Diseases associated with GSTO1 include Proliferative Type Fibrocystic Change Of Breast and Intracystic Papillary Adenoma. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.
UniProtKB/Swiss-Prot for GSTO1 Gene
-
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Additional gene information for GSTO1 Gene
- Monarch Initiative
- Search for GSTO1 at DataMed
- Search for GSTO1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTO1 Gene
Genomics for GSTO1 Gene
GeneHancer (GH) Regulatory Elements for GSTO1 Gene
Promoters and enhancers for GSTO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSTO1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GSTO1 gene promoter:
-
- c-Ets-1
- deltaCREB
- CREB
- Arnt
- HEN1
- E47
- Tal-1beta
- GCNF
- GCNF-1
- GCNF-2
Regulatory Element Products
Genomic Locations for GSTO1 Gene
Genomic Locations for GSTO1 Gene
- chr10:104,235,356-104,267,464
- (GRCh38/hg38)
- Size:
- 32,109 bases
- Orientation:
- Plus strand
- chr10:105,995,114-106,027,222
- (GRCh37/hg19)
- Size:
- 32,109 bases
- Orientation:
- Plus strand
Genomic View for GSTO1 Gene
Genes around GSTO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.1 by Entrez Gene
- 10q25.1 by HGNC
- 10q25.1 by Ensembl
GSTO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSTO1 Gene
Proteins for GSTO1 Gene
-
Protein details for GSTO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78417-GSTO1_HUMAN
- Recommended name:
- Glutathione S-transferase omega-1
- Protein Accession:
- P78417
- D3DRA3
- F5H7H0
- Q5TA03
- Q7Z3T2
Protein attributes for GSTO1 Gene
- Size:
- 241 amino acids
- Molecular mass:
- 27566 Da
- Quaternary structure:
-
- Homodimer.
- SequenceCaution:
-
- Sequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for GSTO1 Gene
Protein Expression for GSTO1 Gene
Post-translational modifications for GSTO1 Gene
Other Protein References for GSTO1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GSTO1
-
Abcam antibodies for GSTO1
- Invitrogen Antibodies for GSTO1
- GeneTex GSTO1 Antibody for GSTO1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GSTO1
Protein Products
-
OriGene Purified Proteins for GSTO1
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTO1
- Origene Custom Protein Services for GSTO1
- Search GeneTex for Proteins for GSTO1
-
Abcam proteins for GSTO1
Assay Products
No data available for DME Specific Peptides for GSTO1 Gene
Domains & Families for GSTO1 Gene
Gene Families for GSTO1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GSTO1 Gene
Suggested Antigen Peptide Sequences for GSTO1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P78417- Family:
-
- Belongs to the GST superfamily. Omega family.
Function for GSTO1 Gene
Molecular function for GSTO1 Gene
- UniProtKB/Swiss-Prot Function:
- Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
- UniProtKB/Swiss-Prot CatalyticActivity:
- RX + glutathione = HX + R-S-glutathione.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:11511179, ECO:0000269 PubMed:17226937};
Enzyme Numbers (IUBMB) for GSTO1 Gene
Phenotypes From GWAS Catalog for GSTO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 25277244 |
| GO:0016491 | oxidoreductase activity | IDA,IEA | 11511179 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0045174 | glutathione dehydrogenase (ascorbate) activity | IDA,IEA | 11511179 |
Phenotypes for GSTO1 Gene
- MGI mutant phenotypes for GSTO1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GSTO1:
Animal Model Products
-
Taconic Biosciences Mouse Models for GSTO1
- Cyagen custom Knockout/knockin (KOKI) mouse models for GSTO1
-
CRISPR Products
-
OriGene CRISPR knockouts for GSTO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTO1
- genomics-online: gRNA clones - Search results for available GSTO1 gene related products
- Applied Biological Materials CRISPR for GSTO1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTO1
- GenScript: Design CRISPR guide RNA sequences for GSTO1
miRNA for GSTO1 Gene
- miRTarBase miRNAs that target GSTO1
-
- hsa-mir-1-3p (MIRT023892)
- hsa-mir-197-3p (MIRT048048)
- hsa-mir-1275 (MIRT762109)
- hsa-mir-193b-5p (MIRT763451)
- hsa-mir-30a-3p (MIRT764552)
- hsa-mir-30d-3p (MIRT764741)
- hsa-mir-30e-3p (MIRT764746)
- hsa-mir-4260 (MIRT768196)
- hsa-mir-4291 (MIRT768404)
- hsa-mir-4310 (MIRT768542)
- hsa-mir-450a-2-3p (MIRT769871)
- hsa-mir-4665-5p (MIRT770821)
- hsa-mir-5572 (MIRT774690)
- hsa-mir-6503-3p (MIRT776565)
- hsa-mir-6751-5p (MIRT778349)
- hsa-mir-6752-5p (MIRT778358)
- hsa-mir-6803-5p (MIRT779508)
- hsa-mir-6835-5p (MIRT780037)
- hsa-mir-6842-5p (MIRT780208)
- hsa-mir-7109-5p (MIRT781428)
- hsa-mir-7110-5p (MIRT781434)
- hsa-mir-7157-5p (MIRT781558)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTO1
- Browse OriGene Inhibitory RNA Products For GSTO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTO1
- genomics-online: shRNA clones - Search results for available GSTO1 gene related products
Clone Products
-
OriGene ORF clones in human for GSTO1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GSTO1
- VectorBuilder custom plasmid, inducible vectors for GSTO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSTO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTO1
- genomics-online: cdna clones - Search results for available GSTO1 gene related products
- orf clones - Search results for available GSTO1 gene related products
- Applied Biological Materials Clones for GSTO1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GSTO1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTO1 Gene
Localization for GSTO1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTO1 Gene
- Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 11511179 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GSTO1 Gene
Pathways & Interactions for GSTO1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Cytochrome P450 - arranged by substrate type |
.01
|
|
| 3 | Glutathione metabolism | ||
| 4 | Metabolism of water-soluble vitamins and cofactors | ||
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for GSTO1 Gene
4 BioSystems pathways for GSTO1 Gene
8 Reactome pathways for GSTO1 Gene
9 KEGG pathways for GSTO1 Gene
1 GeneGo (Thomson Reuters) pathway for GSTO1 Gene
Interacting Proteins for GSTO1 Gene
Selected Interacting proteins:
ENSP00000358727
P78417-GSTO1_HUMAN
for GSTO1 Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for GSTO1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | IBA | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0009407 | toxin catabolic process | IBA | -- |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | IDA | 11035031 |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | IC | 11035031 |
No data available for SIGNOR curated interactions for GSTO1 Gene
Drugs & Compounds for GSTO1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutathione | Approved, Investigational | Nutra | Target | 0 | ||
| Vitamin E | Approved, Vet_approved | Nutra | Enzyme, inhibitor | 434,438 | ||
| alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Enzyme, inhibitor | 0 | ||
| alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Enzyme, inhibitor | 0 | ||
| Oxidized glutathione | Approved, Experimental, Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S,2R)-Naphthalene 1,2-oxide |
|
|
||||
| 1,1-Dichloroethylene epoxide |
|
|
Drug Products
Transcripts for GSTO1 Gene
mRNA/cDNA for GSTO1 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (479) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000470554 547 bps (uc057vuf.1)
- ENST00000493946 874 bps (uc057vug.1)
- ENST00000369713 972 bps (uc001kya.4)
- ENST00000445155 829 bps (uc057vuh.1)
- ENST00000432659 592 bps (uc057vui.1)
Unigene Clusters for GSTO1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GSTO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTO1
- genomics-online: gRNA clones - Search results for available GSTO1 gene related products
- Applied Biological Materials CRISPR for GSTO1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTO1
- GenScript: Design CRISPR guide RNA sequences for GSTO1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTO1
- Browse OriGene Inhibitory RNA Products For GSTO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTO1
- genomics-online: shRNA clones - Search results for available GSTO1 gene related products
Clone Products
-
OriGene ORF clones in human for GSTO1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GSTO1
- VectorBuilder custom plasmid, inducible vectors for GSTO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSTO1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTO1
- genomics-online: cdna clones - Search results for available GSTO1 gene related products
- orf clones - Search results for available GSTO1 gene related products
- Applied Biological Materials Clones for GSTO1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||
| SP7: | - | - |
Expression for GSTO1 Gene
This gene is overexpressed in Liver, secretome (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTO1 Gene
NURSA nuclear receptor signaling pathways regulating expression of GSTO1 Gene:
GSTO1SOURCE GeneReport for Unigene cluster for GSTO1 Gene:
Hs.190028mRNA Expression by UniProt/SwissProt for GSTO1 Gene:
P78417-GSTO1_HUMAN
Tissue specificity:
Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
Evidence on tissue expression from TISSUES for GSTO1 Gene
- Liver(4.6)
- Eye(4.2)
- Skin(3.9)
- Nervous system(3.8)
- Lung(3.6)
- Muscle(2.8)
- Heart(2.7)
- Kidney(2.4)
- Blood(2.3)
- Bone marrow(2.3)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for GSTO1
-
OriGene qPCR primer pairs for GSTO1
- genomics-online: primer clones - Search results for available GSTO1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTO1 Gene
Orthologs for GSTO1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GSTO1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GSTO1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GSTO1 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Gsto1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Gsto1 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | GSTO1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GSTO1 34 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1986 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24164 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gsto1 34 33 |
|
ManyToMany | |
| gsto2 34 |
|
ManyToMany | |||
| Dr.16014 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11014 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | se 34 33 |
|
ManyToMany | |
| CG6776 34 |
|
ManyToMany | |||
| CG6673 34 |
|
ManyToMany | |||
| CG6662 34 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | GSTO1 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | gst-44 34 33 |
|
ManyToMany | |
| gsto-2 34 |
|
ManyToMany | |||
| C02D5.4 34 |
|
ManyToMany | |||
| gsto-1 34 |
|
ManyToMany | |||
| gsto-3 34 |
|
ManyToMany | |||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00549 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3044 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for GSTO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for GSTO1 Gene
- ENSEMBL:
- Gene Tree for GSTO1 (if available)
- TreeFam:
- Gene Tree for GSTO1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSTO1: view image
Paralogs for GSTO1 Gene
(1) SIMAP similar genes for GSTO1 Gene using alignment to 3 proteins:
- GSTO1_HUMAN
- Q5TA01_HUMAN
- Q5TA02_HUMAN
Pseudogenes.org Pseudogenes for GSTO1 Gene
Variants for GSTO1 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000117213 | -- | 104,256,127(+) | C/A | intron_variant | |
| rs1000490830 | -- | 104,255,806(+) | G/T | intron_variant | |
| rs1000711862 | -- | 104,258,798(+) | C/G/T | intron_variant | |
| rs1000825968 | -- | 104,265,893(+) | T/G | intron_variant | |
| rs1000997548 | -- | 104,264,667(+) | A/G | intron_variant |
Residual Variation Intolerance Score:
78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.70;
86.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSTO1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO1 Gene
Disorders for GSTO1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| proliferative type fibrocystic change of breast |
|
|
| intracystic papillary adenoma |
|
|
| cavernous sinus meningioma |
|
|
| patella, chondromalacia of |
|
|
| facial neuralgia |
|
|
Search GSTO1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GSTO1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO1 Gene
Publications for GSTO1 Gene
- Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread AK … Board PG (Pharmacogenetics 2003) 2 3 4 22 58
- No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova IE … Brauch H (Breast cancer research and treatment 2010) 3 22 44 58
- Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 22 44 58
- Lack of association of glutathione-S-transferase omega 1(A140D) and omega 2 (N142D) gene polymorphisms with urinary arsenic profile and oxidative stress status in arsenic-exposed population. (PMID: 19635583) Xu Y … Sun G (Mutation research 2009) 3 22 44 58
- An analysis of methylenetetrahydrofolate reductase and glutathione S-transferase omega-1 genes as modifiers of the cerebral response to ischemia. (PMID: 19624857) Peddareddygari LR … Grewal RP (BMC neurology 2009) 3 22 44 58
Products for GSTO1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GSTO1
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTO1
- Origene Custom Protein Services for GSTO1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTO1
- Browse OriGene Inhibitory RNA Products For GSTO1
- OriGene qPCR primer pairs and template standards for GSTO1
- OriGene qPCR primer pairs for GSTO1
- OriGene CRISPR knockouts for GSTO1
- OriGene ORF clones in human for GSTO1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GSTO1
- GenScript: Next-day shipping of latest version cDNA ORF clones for GSTO1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GSTO1
- GenScript Custom Assay Services for GSTO1
- GenScript Custom overexpressing Cell Line Services for GSTO1
- GenScript: Design CRISPR guide RNA sequences for GSTO1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GSTO1
- Sino Biological Human cDNA Clone for GSTO1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GSTO1
- Novus Biologicals lysates and proteins for GSTO1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GSTO1
- Abcam proteins for GSTO1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for GSTO1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GSTO1
- Cyagen custom Knockout/knockin (KOKI) mouse models for GSTO1
- VectorBuilder custom plasmid, inducible vectors for GSTO1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GSTO1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 67 available GSTO1 Antibodies ranked by validation data
- Compare Top GSTO1 Antibodies
- antibodies-online: Search results for 41 available GSTO1 Elisa Kits ranked by validation data
- Compare Top GSTO1 Elisa Kits
- antibodies-online: Search results for 30 available GSTO1 Proteins ranked by validation data
- Compare Top GSTO1 Proteins
- GeneTex GSTO1 Antibody for GSTO1
- Search GeneTex for Proteins for GSTO1
- Santa Cruz Biotechnology (SCBT) Antibodies for GSTO1
- Search Santa Cruz Biotechnology (SCBT) for GSTO1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GSTO1
- Horizon Cell Lines for GSTO1
- genomics-online: cdna clones - Search results for available GSTO1 gene related products
- orf clones - Search results for available GSTO1 gene related products
- genomics-online: gRNA clones - Search results for available GSTO1 gene related products
- genomics-online: primer clones - Search results for available GSTO1 gene related products
- genomics-online: shRNA clones - Search results for available GSTO1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTO1
- GeneCopoeia miRNA 3'UTR Target clone products for GSTO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTO1
Sources for GSTO1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt