Aliases for GSTO1 Gene
External Ids for GSTO1 Gene
Previous GeneCards Identifiers for GSTO1 Gene
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for GSTO1 Gene
GSTO1 (Glutathione S-Transferase Omega 1) is a Protein Coding gene. Diseases associated with GSTO1 include Barrett's Adenocarcinoma and Hepatocellular Carcinoma. Among its related pathways are arsenate detoxification I (glutaredoxin) and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.
UniProtKB/Swiss-Prot Summary for GSTO1 Gene
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.