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Aliases for GSTM5 Gene

Aliases for GSTM5 Gene

  • Glutathione S-Transferase Mu 5 2 3 5
  • Glutathione S-Transferase M5 2 3
  • GST Class-Mu 5 3 4
  • EC 2.5.1.18 4 56
  • GSTM5-5 3 4
  • S-(Hydroxyalkyl)Glutathione Lyase M5 3
  • Glutathione S-Aralkyltransferase M5 3
  • Glutathione S-Alkyltransferase M5 3
  • Glutathione S-Aryltransferase M5 3
  • GTM5 3

External Ids for GSTM5 Gene

Previous GeneCards Identifiers for GSTM5 Gene

  • GC01P110733
  • GC01P109184
  • GC01P109356
  • GC01P109553
  • GC01P109966
  • GC01P110056
  • GC01P110255
  • GC01P108124
  • GC01P110256

Summaries for GSTM5 Gene

Entrez Gene Summary for GSTM5 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTM5 Gene

GSTM5 (Glutathione S-Transferase Mu 5) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity. An important paralog of this gene is GSTM1.

UniProtKB/Swiss-Prot for GSTM5 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Additional gene information for GSTM5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTM5 Gene

Genomics for GSTM5 Gene

GeneHancer (GH) Regulatory Elements for GSTM5 Gene

Promoters and enhancers for GSTM5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I109711 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 574 +0.6 575 1.5 POLR2A SCRT2 GSTM5 GSTM3 GSTM1 SORT1 ENSG00000241720
GH01I109709 Enhancer 0.3 dbSUPER 575.5 -1.6 -1564 1.4 ZNF280A GSTM5 GSTM3 GSTM4 GC01P109707 GSTM2
GH01I109718 Enhancer 1.1 ENCODE dbSUPER 20.5 +7.5 7501 1.3 PKNOX1 ATF1 ARNT ZNF766 FOS ATF7 CAVIN1 JUNB REST ZNF592 GSTM5 EPS8L3 AMIGO1 GPR61 ENSG00000254942 CSF1 UBL4B CYB561D1 ENSG00000241720
GH01I109482 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.6 -227.7 -227657 2.3 CLOCK YBX1 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 ATXN7L2 ENSG00000258634 RPL17P7 PRPF38B STRIP1 CLCC1 SYPL2 RPS27P6 ENSG00000273373 RBM15
GH01I109725 Enhancer 1.1 ENCODE dbSUPER 18.6 +14.2 14247 1.6 CLOCK ARNT TCF12 CBX5 GATA2 FOS ATF7 NCOA1 ZNF184 SMARCA4 ENSG00000241720 GSTM3 GSTM5 EPS8L3 ENSG00000228703 AMPD2 AHCYL1 GPR61 ENSG00000225113 AMIGO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GSTM5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GSTM5 gene promoter:

Genomic Locations for GSTM5 Gene

Genomic Locations for GSTM5 Gene
chr1:109,711,761-109,775,428
(GRCh38/hg38)
Size:
63,668 bases
Orientation:
Plus strand
chr1:110,254,864-110,318,050
(GRCh37/hg19)

Genomic View for GSTM5 Gene

Genes around GSTM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTM5 Gene

Proteins for GSTM5 Gene

  • Protein details for GSTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46439-GSTM5_HUMAN
    Recommended name:
    Glutathione S-transferase Mu 5
    Protein Accession:
    P46439
    Secondary Accessions:
    • A8K0V8
    • Q6PD78

    Protein attributes for GSTM5 Gene

    Size:
    218 amino acids
    Molecular mass:
    25675 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for GSTM5 Gene

Selected DME Specific Peptides for GSTM5 Gene

P46439:
  • WLNEKFK
  • KISAYMK
  • IRLLLEYT
  • TEEEKIRVDI
  • TQSNAILRY
  • FLGKRPWF
  • RFEGLKKIS
  • IRVDILENQ
  • LGYWDIRG
  • APDYDRSQWL
  • LDFPNLPYL
  • VDFLAYD
  • CGETEEE
  • KITQSNAI
  • NLKDFISRFEGL

Post-translational modifications for GSTM5 Gene

No Post-translational modifications

Other Protein References for GSTM5 Gene

Domains & Families for GSTM5 Gene

Gene Families for GSTM5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GSTM5 Gene

Graphical View of Domain Structure for InterPro Entry

P46439

UniProtKB/Swiss-Prot:

GSTM5_HUMAN :
  • Belongs to the GST superfamily. Mu family.
Family:
  • Belongs to the GST superfamily. Mu family.
genes like me logo Genes that share domains with GSTM5: view

Function for GSTM5 Gene

Molecular function for GSTM5 Gene

GENATLAS Biochemistry:
glutathione-S-transferase 5,mu class
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Enzyme Numbers (IUBMB) for GSTM5 Gene

Gene Ontology (GO) - Molecular Function for GSTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with GSTM5: view
genes like me logo Genes that share phenotypes with GSTM5: view

Animal Models for GSTM5 Gene

MGI Knock Outs for GSTM5:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GSTM5

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTM5 Gene

Localization for GSTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTM5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTM5 gene
Compartment Confidence
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GSTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with GSTM5: view

Pathways & Interactions for GSTM5 Gene

genes like me logo Genes that share pathways with GSTM5: view

Gene Ontology (GO) - Biological Process for GSTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IDA 10587441
GO:0008152 metabolic process IEA --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with GSTM5: view

No data available for SIGNOR curated interactions for GSTM5 Gene

Drugs & Compounds for GSTM5 Gene

(3) Drugs for GSTM5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Water Approved Pharma 0
Trichloroethylene Pharma 5

(39) Additional Compounds for GSTM5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with GSTM5: view

Transcripts for GSTM5 Gene

mRNA/cDNA for GSTM5 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GSTM5 Gene

Glutathione S-transferase mu 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for GSTM5

Alternative Splicing Database (ASD) splice patterns (SP) for GSTM5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3: -

Relevant External Links for GSTM5 Gene

GeneLoc Exon Structure for
GSTM5
ECgene alternative splicing isoforms for
GSTM5

Expression for GSTM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTM5 Gene

mRNA differential expression in normal tissues according to GTEx for GSTM5 Gene

This gene is overexpressed in Ovary (x6.5).

Protein differential expression in normal tissues from HIPED for GSTM5 Gene

This gene is overexpressed in Ovary (20.5), Skin (16.1), and Brain (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GSTM5 Gene



NURSA nuclear receptor signaling pathways regulating expression of GSTM5 Gene:

GSTM5

SOURCE GeneReport for Unigene cluster for GSTM5 Gene:

Hs.75652

Evidence on tissue expression from TISSUES for GSTM5 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with GSTM5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTM5 Gene

Orthologs for GSTM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTM5 33 34
  • 98.93 (n)
rat
(Rattus norvegicus)
Mammalia Gstm1 33
  • 81.65 (n)
cow
(Bos Taurus)
Mammalia GSTM2 34
  • 81 (a)
ManyToMany
GSTM4 34
  • 81 (a)
ManyToMany
GSTM1 34 34
  • 79 (a)
ManyToMany
-- 34
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gstm2 34
  • 81 (a)
ManyToMany
Gstm7 34
  • 81 (a)
ManyToMany
Gstm1 33 16 34
  • 80.73 (n)
Gstm4 34
  • 79 (a)
ManyToMany
Gm6665 34
  • 78 (a)
ManyToMany
Gstm3 34
  • 75 (a)
ManyToMany
Gm4845 34
  • 74 (a)
ManyToMany
Gstm6 34
  • 74 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 71 (a)
ManyToMany
-- 34
  • 69 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gstm 34
  • 63 (a)
ManyToMany
zgc:173994 34
  • 63 (a)
ManyToMany
gstm3 34
  • 61 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea gst-1 34
  • 30 (a)
ManyToMany
gst-23 34
  • 29 (a)
ManyToMany
gst-25 34
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
Species where no ortholog for GSTM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GSTM5 Gene

ENSEMBL:
Gene Tree for GSTM5 (if available)
TreeFam:
Gene Tree for GSTM5 (if available)

Paralogs for GSTM5 Gene

Paralogs for GSTM5 Gene

(6) SIMAP similar genes for GSTM5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GSTM5 Gene

genes like me logo Genes that share paralogs with GSTM5: view

Variants for GSTM5 Gene

Sequence variations from dbSNP and Humsavar for GSTM5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000705435 -- 109,712,157(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001380103 -- 109,714,063(+) A/AA intron_variant
rs1001897857 -- 109,718,080(+) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1002383375 -- 109,717,588(+) T/A 3_prime_UTR_variant
rs1002786945 -- 109,712,969(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTM5 Gene

Variant ID Type Subtype PubMed ID
nsv946134 CNV duplication 23825009
nsv547495 CNV gain+loss 21841781
nsv547491 CNV gain 21841781
nsv547487 CNV gain 21841781
nsv2332 CNV insertion 18451855
nsv2310 CNV deletion 18451855
nsv10617 CNV gain 18304495
nsv1007399 CNV loss 25217958
nsv1003914 CNV gain 25217958
nsv1003510 CNV loss 25217958
nsv1001758 CNV gain 25217958
esv25172 CNV gain+loss 19812545
esv1003982 CNV deletion 20482838
dgv502n54 CNV gain 21841781
dgv501n54 CNV gain 21841781
dgv500n54 CNV gain 21841781
dgv276n100 CNV loss 25217958
dgv273n100 CNV loss 25217958
dgv270n100 CNV gain 25217958
dgv265n100 CNV gain 25217958

Variation tolerance for GSTM5 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTM5 Gene

Disorders for GSTM5 Gene

Additional Disease Information for GSTM5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GSTM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTM5 Gene

Publications for GSTM5 Gene

  1. A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5. (PMID: 8473333) Takahashi Y … Listowsky I (The Journal of biological chemistry 1993) 2 3 4 58
  2. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y … Huang W (Journal of human genetics 2010) 3 44 58
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
  4. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  5. Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1. (PMID: 19856098) Yu KD … Shao ZM (Breast cancer research and treatment 2010) 3 44 58

Products for GSTM5 Gene

  • Addgene plasmids for GSTM5

Sources for GSTM5 Gene

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