GSTM4 Gene (Protein Coding)

Glutathione S-Transferase Mu 4

GC01P109657
GIFtS:
41
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enz... See more...

Aliases for GSTM4 Gene

Aliases for GSTM4 Gene

  • Glutathione S-Transferase Mu 4 2 3 3 4 5
  • Leukotriene C4 Synthase GSTM4 3 4
  • Glutathione S-Transferase M4 2 3
  • GST Class-Mu 4 3 4
  • EC 2.5.1.18 4 51
  • GSTM4-4 3 4
  • GST-Mu2 3 4
  • Testis Tissue Sperm-Binding Protein Li 60n 3
  • S-(Hydroxyalkyl)Glutathione Lyase M4 3
  • Glutathione S-Aralkyltransferase M4 3
  • Glutathione S-Alkyltransferase M4 3
  • Glutathione S-Aryltransferase M4 3
  • EC 4.4.1.20 4
  • GTS-Mu2 3
  • GSTM4 5
  • GTM4 3

External Ids for GSTM4 Gene

Previous GeneCards Identifiers for GSTM4 Gene

  • GC01P110677
  • GC01P109128
  • GC01P109300
  • GC01P109497
  • GC01P109910
  • GC01P110000
  • GC01P110198
  • GC01P108086

Summaries for GSTM4 Gene

Entrez Gene Summary for GSTM4 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTM4 Gene

GSTM4 (Glutathione S-Transferase Mu 4) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is GSTM1.

UniProtKB/Swiss-Prot Summary for GSTM4 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009).

Gene Wiki entry for GSTM4 Gene

Additional gene information for GSTM4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTM4 Gene

Genomics for GSTM4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GSTM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J109655 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 302 +0.3 316 2.4 TBP MXD4 NR2C1 MNT IKZF1 SMAD5 MBD2 ZNF217 ZBTB7B ELF1 GSTM4 GSTM1 GPR61 SLC6A17 AHCYL1 KCNA2 WDR47 KCNC4 PSRC1 CELSR2
GH01J109640 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 44.6 -14.3 -14275 5.6 ZBTB10 DEK ZNF217 CTCF BHLHE40 ZEB1 NONO ZIC2 ARNT REST GSTM4 GSTM3 GNAT2 AMPD2 GNAI3 MIR197 ENSG00000225113 RNU6V GSTM2 GSTM1
GH01J109631 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 35.7 -23.7 -23728 2.1 POLR2A ZIC2 ZNF341 ZNF189 ZNF664 GLIS1 RCOR1 ZNF398 SP7 EGR2 piR-47698 GSTM4 HSALNG0005910 GNAT2 AMPD2 RPL7P8
GH01J109667 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 16.4 +12.0 12015 1.4 TBP IKZF1 ZIC2 ARNT NFATC3 VEZF1 SAP130 GABPB1 SKIL DRAP1 GSTM2 GSTM4 piR-43107-019 GSTM1 HSALNG0005910
GH01J109650 Enhancer 0.4 Ensembl 50 -5.4 -5375 1.4 CEBPB EP300 CTCF JUND RPL7P8 lnc-GSTM4-3 GSTM4 GNAI3 GPR61 ENSG00000254942 AMPD2 GNAT2 ENSG00000225113 RNU6V
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTM4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTM4

Top Transcription factor binding sites by QIAGEN in the GSTM4 gene promoter:
  • FOXO4
  • HNF-3beta
  • LyF-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • YY1

Genomic Locations for GSTM4 Gene

Latest Assembly
chr1:109,656,076-109,674,836
(GRCh38/hg38)
Size:
18,761 bases
Orientation:
Plus strand

Previous Assembly
chr1:110,198,721-110,208,119
(GRCh37/hg19 by Entrez Gene)
Size:
9,399 bases
Orientation:
Plus strand

chr1:110,198,703-110,208,118
(GRCh37/hg19 by Ensembl)
Size:
9,416 bases
Orientation:
Plus strand

Genomic View for GSTM4 Gene

Genes around GSTM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTM4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GSTM4 Gene

Proteins for GSTM4 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for GSTM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03013-GSTM4_HUMAN
    Recommended name:
    Glutathione S-transferase Mu 4
    Protein Accession:
    Q03013
    Secondary Accessions:
    • A8K765
    • Q05465
    • Q32NC1
    • Q4JNT8
    • Q6FH87

    Protein attributes for GSTM4 Gene

    Size:
    218 amino acids
    Molecular mass:
    25561 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTM4 Gene

    Alternative splice isoforms for GSTM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTM4 Gene

Protein Expression for GSTM4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GSTM4 Gene

Q03013:
  • WLNEKFK
  • KISAYMK
  • IRLLLEYT
  • TEEEKIRVDI
  • FLGKRPWF
  • IRVDILENQ
  • LGYWDIRG
  • FPNLKDF
  • APDYDRSQWL
  • LDFPNLPYL
  • VDFLAYD
  • CGETEEE
  • CYSPDFE
  • KITQSNAI
  • CLDAFPNL
  • NLKDFISRFEGL

Post-translational modifications for GSTM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GSTM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for GSTM4
  • Boster Bio Antibodies for GSTM4

Domains & Families for GSTM4 Gene

Gene Families for GSTM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GSTM4 Gene

InterPro:
Blocks:
  • Glutathione S-transferase, N-terminal
  • Mu-class glutathione S-transferase signature
ProtoNet:

Suggested Antigen Peptide Sequences for GSTM4 Gene

GenScript: Design optimal peptide antigens:
  • GSTM4-4 (GSTM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q03013

UniProtKB/Swiss-Prot:

GSTM4_HUMAN :
  • Belongs to the GST superfamily. Mu family.
Family:
  • Belongs to the GST superfamily. Mu family.
genes like me logo Genes that share domains with GSTM4: view

Function for GSTM4 Gene

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  6. Cell Lines for research

Molecular function for GSTM4 Gene

UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:8203914, ECO:0000269|PubMed:8373352};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+); Xref=Rhea:RHEA:51220, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996, ChEBI:CHEBI:34718, ChEBI:CHEBI:57925, ChEBI:CHEBI:133977; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:8203914, ECO:0000269|PubMed:8373352};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate; Xref=Rhea:RHEA:53508, ChEBI:CHEBI:57925, ChEBI:CHEBI:131958, ChEBI:CHEBI:137407; Evidence={ECO:0000269|PubMed:27791009};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=leukotriene C4 = glutathione + leukotriene A4; Xref=Rhea:RHEA:17617, ChEBI:CHEBI:57463, ChEBI:CHEBI:57925, ChEBI:CHEBI:57973; EC=4.4.1.20; Evidence={ECO:0000269|PubMed:27791009};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.8 mM for glutathione {ECO:0000269|PubMed:8203914}; KM=98 uM for leukotriene A4 {ECO:0000269|PubMed:27791009}; KM=42.5 mM for (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate {ECO:0000269|PubMed:27791009}; KM=9.0 mM for 1-chloro-2,4-dinitrobenzene {ECO:0000269|PubMed:8203914}; Vmax=1.6 mmol/min/mg enzyme with leukotriene A4 as substrate {ECO:0000269|PubMed:27791009}; Vmax=5.1 mmol/min/mg enzyme with (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate as substrate {ECO:0000269|PubMed:27791009};
GENATLAS Biochemistry:
glutathione-S-transferase 4,mu class

Enzyme Numbers (IUBMB) for GSTM4 Gene

Phenotypes From GWAS Catalog for GSTM4 Gene

Gene Ontology (GO) - Molecular Function for GSTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA,IDA 8203914
GO:0004464 leukotriene-C4 synthase activity IEA,IDA 27791009
GO:0005515 protein binding IEA,IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with GSTM4: view
genes like me logo Genes that share phenotypes with GSTM4: view

Animal Models for GSTM4 Gene

MGI Knock Outs for GSTM4:
  • Gstm4 Gstm4<tm2b(EUCOMM)Hmgu>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTM4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GSTM4 Gene

Localization for GSTM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTM4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTM4 gene
Compartment Confidence
cytosol 5
extracellular 4
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GSTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 8373352
GO:0005829 cytosol IDA,TAS --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with GSTM4: view

Pathways & Interactions for GSTM4 Gene

genes like me logo Genes that share pathways with GSTM4: view

Pathways by source for GSTM4 Gene

1 GeneGo (Thomson Reuters) pathway for GSTM4 Gene
  • Glutathione metabolism

Gene Ontology (GO) - Biological Process for GSTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006749 glutathione metabolic process IEA,IDA 8373352
GO:0018916 nitrobenzene metabolic process IEA --
GO:0042178 xenobiotic catabolic process IDA 8373352
GO:0042759 long-chain fatty acid biosynthetic process IDA,TAS --
genes like me logo Genes that share ontologies with GSTM4: view

No data available for SIGNOR curated interactions for GSTM4 Gene

Drugs & Compounds for GSTM4 Gene

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(10) Drugs for GSTM4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Oxidized glutathione Approved, Experimental, Investigational Pharma Target, activator 0
Trichloroethylene Approved Pharma 0
Water Approved Pharma 0
1-Hydroxy-2-S-glutathionyl-3-para-nitrophenoxy-propane Experimental Pharma Target 0

(38) Additional Compounds for GSTM4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane
genes like me logo Genes that share compounds with GSTM4: view

Transcripts for GSTM4 Gene

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mRNA/cDNA for GSTM4 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTM4

Alternative Splicing Database (ASD) splice patterns (SP) for GSTM4 Gene

No ASD Table

Relevant External Links for GSTM4 Gene

GeneLoc Exon Structure for
GSTM4

Expression for GSTM4 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTM4 Gene

mRNA expression in normal human tissues for GSTM4 Gene
mRNA expression by BioGPS for GSTM4 GenemRNA expression by GTEx for GSTM4 Gene

Protein differential expression in normal tissues from HIPED for GSTM4 Gene

This gene is overexpressed in Liver, secretome (21.2) and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTM4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTM4

SOURCE GeneReport for Unigene cluster for GSTM4 Gene:

Hs.348387

mRNA Expression by UniProt/SwissProt for GSTM4 Gene:

Q03013-GSTM4_HUMAN
Tissue specificity: Expressed in a wide variety of tissues.

Evidence on tissue expression from TISSUES for GSTM4 Gene

  • Muscle(4.6)
  • Blood(4.4)
  • Lung(4.3)
  • Eye(4.3)
  • Liver(2.6)
  • Kidney(2.5)
  • Nervous system(2.4)
  • Intestine(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with GSTM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTM4 Gene

Orthologs for GSTM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTM4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GSTM4 30 31
  • 99.39 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gstm4 30
  • 86.09 (n)
Mouse
(Mus musculus)
 Mammalia Gstm4 30 17 31
  • 85.47 (n)
 ManyToMany
Gstm2 31
  • 81 (a)
 ManyToMany
Gstm7 31
  • 79 (a)
 ManyToMany
Gm4845 31
  • 78 (a)
 ManyToMany
Gm6665 31
  • 78 (a)
 ManyToMany
Gstm6 31
  • 75 (a)
 ManyToMany
Gstm3 31
  • 74 (a)
 ManyToMany
Gstm1 31
  • 72 (a)
 ManyToMany
Cow
(Bos Taurus)
 Mammalia LOC615514 30
  • 84.56 (n)
GSTM4 31
  • 82 (a)
 ManyToMany
GSTM1 31 31
  • 81 (a)
 ManyToMany
GSTM2 31
  • 80 (a)
 ManyToMany
-- 31
  • 76 (a)
 ManyToMany
Dog
(Canis familiaris)
 Mammalia GSTM1 30
  • 84.1 (n)
-- 31
  • 78 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 71 (a)
 ManyToMany
-- 31
  • 70 (a)
 ManyToMany
-- 31
  • 69 (a)
 ManyToMany
Zebrafish
(Danio rerio)
 Actinopterygii zgc:173994 31
  • 65 (a)
 ManyToMany
gstm 31
  • 64 (a)
 ManyToMany
gstm3 31
  • 63 (a)
 ManyToMany
Worm
(Caenorhabditis elegans)
 Secernentea gst-1 31
  • 30 (a)
 ManyToMany
gst-23 31
  • 30 (a)
 ManyToMany
gst-25 31
  • 26 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 43 (a)
 ManyToMany
-- 31
  • 40 (a)
 ManyToMany
-- 31
  • 39 (a)
 ManyToMany
-- 31
  • 28 (a)
 ManyToMany
Species where no ortholog for GSTM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for GSTM4 Gene

ENSEMBL:
Gene Tree for GSTM4 (if available)
TreeFam:
Gene Tree for GSTM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTM4: view image

Paralogs for GSTM4 Gene

Paralogs for GSTM4 Gene

(6) SIMAP similar genes for GSTM4 Gene using alignment to 2 proteins:

  • GSTM4_HUMAN
  • A6NNT0_HUMAN
genes like me logo Genes that share paralogs with GSTM4: view

Variants for GSTM4 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTM4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs112330158 - p.Tyr209Phe
rs112611763 - p.Leu208Val
rs149370166 - p.Val212Met
rs17838158 - p.Ala160Val
rs200675176 - p.Arg211Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GSTM4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GSTM4 Gene

Variant ID Type Subtype PubMed ID
dgv15n111 CNV deletion 26073780
dgv253n100 CNV gain 25217958
dgv254n100 CNV gain+loss 25217958
dgv255n100 CNV gain 25217958
dgv256n100 CNV loss 25217958
dgv257n100 CNV gain 25217958
dgv258n100 CNV gain 25217958
dgv259n100 CNV gain+loss 25217958
dgv77e212 CNV loss 25503493
esv25172 CNV gain+loss 19812545
esv3587153 CNV loss 21293372
nsv1001758 CNV gain 25217958
nsv2299 CNV deletion 18451855
nsv510951 OTHER complex 20534489
nsv547486 CNV loss 21841781
nsv946133 CNV duplication 23825009

Variation tolerance for GSTM4 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTM4 Gene

Human Gene Mutation Database (HGMD)
GSTM4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTM4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTM4 Gene

Disorders for GSTM4 Gene

Additional Disease Information for GSTM4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GSTM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTM4 Gene

Publications for GSTM4 Gene

  1. Screening for inter-individual splicing differences in human GSTM4 and the discovery of a single nucleotide substitution related to the tandem skipping of two exons. (PMID: 16854533) Denson J … Zhang J (Gene 2006) 3 4 23
  2. A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer. (PMID: 12140136) Liloglou T … Field JK (Lung cancer (Amsterdam, Netherlands) 2002) 3 23 41
  3. Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4. (PMID: 8349586) Comstock KE … Henner WD (The Journal of biological chemistry 1993) 3 4 23
  4. Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4. (PMID: 8471052) Zhong S … Wolf CR (The Biochemical journal 1993) 3 4 23
  5. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. (PMID: 27791009) Dalli J … Serhan CN (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 4

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