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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
GSTM3 (Glutathione S-Transferase Mu 3) is a Protein Coding gene. Diseases associated with GSTM3 include Larynx Cancer and Pharynx Cancer. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is GSTM4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004364 | glutathione transferase activity | IEA,IDA | 8373352 |
GO:0005515 | protein binding | IEA,IPI | 23355646 |
GO:0016740 | transferase activity | IEA | -- |
GO:0019899 | enzyme binding | IPI | 8373352 |
GO:0042802 | identical protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005737 | cytoplasm | IEA,IDA | 8373352 |
GO:0005829 | cytosol | IDA,TAS | -- |
GO:0035686 | sperm fibrous sheath | IEA | -- |
GO:0045171 | intercellular bridge | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 | ||
2 | Glutathione metabolism |
Glutathione metabolism
.60
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3 | Cytochrome P450 - arranged by substrate type | ||
4 | Metabolism |
.40
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5 | Fluid shear stress and atherosclerosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006749 | glutathione metabolic process | IEA,IDA | 8373352 |
GO:0008065 | establishment of blood-nerve barrier | TAS | 2345169 |
GO:0018916 | nitrobenzene metabolic process | IDA | 8373352 |
GO:0042178 | xenobiotic catabolic process | IDA | 8373352 |
GO:0043627 | response to estrogen | IEP | 10037815 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Glutathione | Approved, Investigational | Nutra | Target | 0 | ||
Vitamin E | Approved, Vet_approved | Nutra | Enzyme, inducer | 549,557 | ||
Oxidized glutathione | Approved, Experimental, Investigational | Pharma | Target, activator | 0 | ||
alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Enzyme, inducer | 0 | ||
alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Enzyme, inducer | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
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(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
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(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
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(1S,2R)-Naphthalene 1,2-oxide |
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1,1-Dichloroethylene epoxide |
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ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GSTM3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GSTM3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gstm5 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GSTM3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gstm5 30 |
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Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | GSTM3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:173994 30 31 |
|
ManyToMany | |
gstm 31 |
|
ManyToMany | |||
gstm3 31 |
|
ManyToMany | |||
wufc26g06 30 |
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Worm (Caenorhabditis elegans) |
Secernentea | gst-1 31 |
|
ManyToMany | |
gst-23 31 |
|
ManyToMany | |||
gst-25 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs7483 | - |
p.Val224Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1003914 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
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larynx cancer |
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pharynx cancer |
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laryngeal squamous cell carcinoma |
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oral cancer |
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barrett's adenocarcinoma |
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