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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enz... See more...
Aliases for GSTM3 Gene
Aliases for GSTM3 Gene
External Ids for GSTM3 Gene
- HGNC: 4635
- NCBI Entrez Gene: 2947
- Ensembl: ENSG00000134202
- OMIM®: 138390
- UniProtKB/Swiss-Prot: P21266
Previous GeneCards Identifiers for GSTM3 Gene
- GC01M110758
- GC01M109208
- GC01M109381
- GC01M109577
- GC01M109576
- GC01M109988
- GC01M110276
- GC01M108146
Summaries for GSTM3 Gene
-
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
GeneCards Summary for GSTM3 Gene
GSTM3 (Glutathione S-Transferase Mu 3) is a Protein Coding gene. Diseases associated with GSTM3 include Larynx Cancer and Pharynx Cancer. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is GSTM4.
UniProtKB/Swiss-Prot Summary for GSTM3 Gene
-
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
Additional gene information for GSTM3 Gene
- HGNC (4635)
- NCBI Entrez Gene (2947)
- Ensembl (ENSG00000134202)
- OMIM® (138390)
- UniProtKB/Swiss-Prot (P21266)
- Open Targets Platform(ENSG00000134202)
- Search for GSTM3 at DataMed
- Search for GSTM3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTM3 Gene
Genomics for GSTM3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GSTM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSTM3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTM3
- Top Transcription factor binding sites by QIAGEN in the GSTM3 gene promoter:
-
- AREB6
- LUN-1
- NF-AT
- NF-AT1
- NF-AT2
- NF-AT3
- NF-AT4
- NF-kappaB
- NF-kappaB1
- STAT5A
Genomic Locations for GSTM3 Gene
Latest Assembly
- chr1:109,733,932-109,741,038
- (GRCh38/hg38)
- Size:
- 7,107 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:110,276,559-110,283,660
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 7,102 bases
- Orientation:
- Minus strand
- chr1:110,276,554-110,284,384
- (GRCh37/hg19 by Ensembl)
- Size:
- 7,831 bases
- Orientation:
- Minus strand
Genomic View for GSTM3 Gene
Genes around GSTM3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
GSTM3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSTM3 Gene
Proteins for GSTM3 Gene
-
Protein details for GSTM3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P21266-GSTM3_HUMAN
- Recommended name:
- Glutathione S-transferase Mu 3
- Protein Accession:
- P21266
- O60550
- Q96HA3
Protein attributes for GSTM3 Gene
- Size:
- 225 amino acids
- Molecular mass:
- 26560 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for GSTM3 Gene
Selected DME Specific Peptides for GSTM3 Gene
- P21266:
-
- TEEEKIRVDI
- TQSNAILRY
- LGYWDIRG
- APDYDRSQWL
- RFEALEKI
- LDFPNLPYL
- CGETEEE
- KITQSNAI
Post-translational modifications for GSTM3 Gene
- The N-terminus is blocked.
-
Ubiquitination at Lys128
- NX_P21266 (NX_P21266-1)
- Modification sites at PhosphoSitePlus
Other Protein References for GSTM3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ GSTM3 Antibody
- NSJ Bioreagents GSTM3 Antibody (Protein Microarray-Validated Monoclonal)
- Novus Biologicals Antibodies for GSTM3
-
Abcam antibodies for GSTM3
- Invitrogen Antibodies for GSTM3 (AFLGC-GSTM3)
-
Boster Bio Antibodies for GSTM3
- Sino Biological Antibodies for GSTM3
Protein products for research
-
OriGene Purified Proteins for GSTM3
- Search Origene for MassSpec and Protein Over-expression Lysates for GSTM3
- Origene Custom Protein Services for GSTM3
- antibodies-online: Show 8 available GSTM3 Proteins ranked by validation data
- Compare Top GSTM3 Proteins
-
Quality Products:
-
Abcam proteins for GSTM3
Assay products for research
- antibodies-online: Show 5 available GSTM3 Elisa Kits ranked by validation data
- Compare Top GSTM3 Elisa Kits
-
Quality Products:
Domains & Families for GSTM3 Gene
Gene Families for GSTM3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for GSTM3 Gene
- InterPro:
- Blocks:
-
- Glutathione S-transferase, N-terminal
- Mu-class glutathione S-transferase signature
- ProtoNet:
Suggested Antigen Peptide Sequences for GSTM3 Gene
- GenScript: Design optimal peptide antigens:
-
- Brain type mu-glutathione S-transferase (A4UJ43_HUMAN)
- GSTM3-3 (GSTM3_HUMAN)
- cDNA, FLJ93985, Homo sapiens glutathione S-transferase M3 (brain) (GSTM3), mRNA (Q6FGJ9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P21266- Family:
-
- Belongs to the GST superfamily. Mu family.
Function for GSTM3 Gene
Molecular function for GSTM3 Gene
- UniProtKB/Swiss-Prot Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:10587441};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1.1 mM for 1-chloro-2,4-dinitrobenzene {ECO:0000269|PubMed:10587441}; KM=0.084 mM for glutathione {ECO:0000269|PubMed:10587441};
- GENATLAS Biochemistry:
- glutathione-S-transferase 3,mu class,expressed in brain
Enzyme Numbers (IUBMB) for GSTM3 Gene
Phenotypes From GWAS Catalog for GSTM3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | IEA,IDA | 8373352 |
| GO:0005515 | protein binding | IEA,IPI | 23355646 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0019899 | enzyme binding | IPI | 8373352 |
| GO:0042802 | identical protein binding | IPI | 16189514 |
Phenotypes for GSTM3 Gene
- MGI mutant phenotypes for GSTM3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GSTM3:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GSTM3 - Starting at $85 >
- * GSTM3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GSTM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTM3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTM3
miRNA for GSTM3 Gene
- miRTarBase miRNAs that target GSTM3
-
- hsa-miR-122-5p (MIRT023377)
- hsa-miR-92b-3p (MIRT040526)
- hsa-miR-5698 (MIRT676184)
- hsa-miR-6836-3p (MIRT676185)
- hsa-miR-7641 (MIRT676186)
- hsa-miR-5001-3p (MIRT676187)
- hsa-miR-143-5p (MIRT676188)
- hsa-miR-4284 (MIRT676189)
- hsa-miR-6829-3p (MIRT676190)
- hsa-miR-6791-3p (MIRT676191)
- hsa-miR-6778-3p (MIRT676192)
- hsa-miR-6499-3p (MIRT676193)
- hsa-miR-4695-3p (MIRT676194)
- hsa-miR-4772-3p (MIRT676195)
- hsa-miR-4638-5p (MIRT676196)
- hsa-miR-1307-3p (MIRT676197)
- hsa-miR-1304-3p (MIRT676198)
- hsa-miR-6741-3p (MIRT676199)
- hsa-miR-5693 (MIRT676200)
- hsa-miR-6890-3p (MIRT676201)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTM3
- Browse OriGene Inhibitory RNA Products For GSTM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTM3
Clone products for research
- Applied Biological Materials (abm): Clones for GSTM3 - Starting at $45 >
- * GSTM3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for GSTM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTM3
Cell Lines for research
-
Horizon Cell Lines for GSTM3
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTM3 Gene
Localization for GSTM3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTM3 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005737 | cytoplasm | IEA,IDA | 8373352 |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0035686 | sperm fibrous sheath | IEA | -- |
| GO:0045171 | intercellular bridge | IDA | -- |
Pathways & Interactions for GSTM3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Glutathione metabolism |
Glutathione metabolism
.60
|
|
| 3 | Cytochrome P450 - arranged by substrate type | ||
| 4 | Metabolism |
.40
|
|
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for GSTM3 Gene
4 BioSystems pathways for GSTM3 Gene
4 Reactome pathways for GSTM3 Gene
10 KEGG pathways for GSTM3 Gene
1 GeneGo (Thomson Reuters) pathway for GSTM3 Gene
- Glutathione metabolism
Interacting Proteins for GSTM3 Gene
Selected Interacting proteins:
P21266-GSTM3_HUMAN
ENSP00000256594
for GSTM3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GSTM3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | IEA,IDA | 8373352 |
| GO:0008065 | establishment of blood-nerve barrier | TAS | 2345169 |
| GO:0018916 | nitrobenzene metabolic process | IDA | 8373352 |
| GO:0042178 | xenobiotic catabolic process | IDA | 8373352 |
| GO:0043627 | response to estrogen | IEP | 10037815 |
No data available for SIGNOR curated interactions for GSTM3 Gene
Drugs & Compounds for GSTM3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutathione | Approved, Investigational | Nutra | Target | 0 | ||
| Vitamin E | Approved, Vet_approved | Nutra | Enzyme, inducer | 549,557 | ||
| Oxidized glutathione | Approved, Experimental, Investigational | Pharma | Target, activator | 0 | ||
| alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Enzyme, inducer | 0 | ||
| alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Enzyme, inducer | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S,2R)-Naphthalene 1,2-oxide |
|
|
||||
| 1,1-Dichloroethylene epoxide |
|
|
Transcripts for GSTM3 Gene
mRNA/cDNA for GSTM3 Gene
- 1 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000256594 4046 nts (view in UCSC)
- ENST00000361066 4122 nts (view in UCSC)
- ENST00000476321 742 nts (view in UCSC)
- ENST00000486823 783 nts (view in UCSC)
- ENST00000488824 1118 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GSTM3 - Starting at $85 >
- * GSTM3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GSTM3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTM3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTM3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GSTM3
- Browse OriGene Inhibitory RNA Products For GSTM3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTM3
Clone products for research
- Applied Biological Materials (abm): Clones for GSTM3 - Starting at $45 >
- * GSTM3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for GSTM3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTM3
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: |
Relevant External Links for GSTM3 Gene
- GeneLoc Exon Structure for
- GSTM3
Expression for GSTM3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- XY Germ Cells Testis Cord
- Seminiferous Tubules
- Testis Interstitium
- Brain (Nervous System)
-
Eye (Sensory Organs)
- Mature Horizontal Cells Inner Nuclear Layer
- Mature Rod Bipolar Cells Inner Nuclear Layer
- Trabecular meshwork-derived mesenchymal stem cells
- Neural Tube (Nervous System)
-
Neurons
- Mature Horizontal Cells Inner Nuclear Layer
- Mature Rod Bipolar Cells Inner Nuclear Layer
-
Primitive Streak (Early Embryonic Tissues)
- Primitive Node Cells Primitive Node
- Primitive Node
-
Gonad
- XY Germ Cells Testis Cord
-
Epiblast (Early Embryo)
- Primitive Node Cells Primitive Node
- Mesenchymal Stem Cells
- Neural Ectoderm (Nervous System)
-
Kidney (Urinary System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for GSTM3 Gene
This gene is overexpressed in Testis (x5.7).
This gene is overexpressed in Testis (10.1) and Ovary (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTM3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTM3
SOURCE GeneReport for Unigene cluster for GSTM3 Gene:
Hs.2006mRNA Expression by UniProt/SwissProt for GSTM3 Gene:
P21266-GSTM3_HUMAN
Tissue specificity:
Testis and brain.
Evidence on tissue expression from TISSUES for GSTM3 Gene
- Nervous system(4.8)
- Blood(4.1)
- Kidney(2.7)
- Liver(2.6)
- Skin(2.5)
- Heart(2.4)
- Lung(2.4)
- Intestine(2.3)
- Muscle(2.3)
- Eye(2.2)
- Stomach(2.1)
- Pancreas(2.1)
Primer products for research
-
OriGene qPCR primer pairs for GSTM3
-
OriGene qPCR primer pairs and template standards for GSTM3
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTM3 Gene
Orthologs for GSTM3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GSTM3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GSTM3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gstm5 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GSTM3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gstm5 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GSTM3 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:173994 30 31 |
|
ManyToMany | |
| gstm 31 |
|
ManyToMany | |||
| gstm3 31 |
|
ManyToMany | |||
| wufc26g06 30 |
|
||||
| Worm (Caenorhabditis elegans) |
Secernentea | gst-1 31 |
|
ManyToMany | |
| gst-23 31 |
|
ManyToMany | |||
| gst-25 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for GSTM3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for GSTM3 Gene
- ENSEMBL:
- Gene Tree for GSTM3 (if available)
- TreeFam:
- Gene Tree for GSTM3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSTM3: view image
Paralogs for GSTM3 Gene
Paralogs for GSTM3 Gene
(6) SIMAP similar genes for GSTM3 Gene using alignment to 3 proteins:
- GSTM3_HUMAN
- A4UJ43_HUMAN
- Q6FGJ9_HUMAN
Pseudogenes.org Pseudogenes for GSTM3 Gene
Variants for GSTM3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTM3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs7483 | - |
p.Val224Ile |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1003914 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.07;
60.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSTM3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTM3 Gene
Disorders for GSTM3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| larynx cancer |
|
|
| pharynx cancer |
|
|
| laryngeal squamous cell carcinoma |
|
|
| oral cancer |
|
|
| barrett's adenocarcinoma |
|
|
Search GSTM3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GSTM3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GSTM3 Gene
Publications for GSTM3 Gene
- An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PMID: 17372252) Schwartzbaum JA … Feychting M (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 23 26 41
- Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 23 41
- A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. (PMID: 18423940) Maes OC … Wang E (Neurobiology of aging 2010) 3 23 41
- Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1. (PMID: 19856098) Yu KD … Shao ZM (Breast cancer research and treatment 2010) 3 23 41
- GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population. (PMID: 19922706) Chatzimichalis M … Bibas A (The Journal of laryngology and otology 2010) 3 23 41
ExternalLinks
Products for GSTM3 Gene
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Sources for GSTM3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
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- (30) HomoloGene
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- (35) WormBase
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- (67) Reactome
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- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (78) RefSeq
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- (83) Illumina
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- (86) PaxDb
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- (88) Addgene
- (89) antibodies-online
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (100) DGIdb
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- (102) RVIS
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- (104) diseasecard
- (105) NIH Rare Diseases
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- (136) Human Protein Atlas
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- (139) DataMed
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- (177) MirGeneDB