Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enz... See more...
Aliases for GSTM2 Gene
Aliases for GSTM2 Gene
External Ids for GSTM2 Gene
- HGNC: 4634
- Entrez Gene: 2946
- Ensembl: ENSG00000213366
- OMIM: 138380
- UniProtKB: P28161
Previous GeneCards Identifiers for GSTM2 Gene
- GC01P110689
- GC01P109140
- GC01P109312
- GC01P109509
- GC01P109922
- GC01P110013
- GC01P110210
- GC01P108098
Summaries for GSTM2 Gene
-
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
GeneCards Summary for GSTM2 Gene
GSTM2 (Glutathione S-Transferase Mu 2) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Platinum drug resistance. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is GSTM1.
UniProtKB/Swiss-Prot Summary for GSTM2 Gene
-
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Additional gene information for GSTM2 Gene
- Monarch Initiative
- Search for GSTM2 at DataMed
- Search for GSTM2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTM2 Gene
Genomics for GSTM2 Gene
GeneHancer (GH) Regulatory Elements for GSTM2 Gene
Promoters and enhancers for GSTM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GSTM2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GSTM2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- FOXO4
- HNF-3beta
- NF-kappaB
- NF-kappaB1
Genomic Locations for GSTM2 Gene
Genomic Locations for GSTM2 Gene
- chr1:109,668,022-109,709,551
- (GRCh38/hg38)
- Size:
- 41,530 bases
- Orientation:
- Plus strand
- chr1:110,210,644-110,252,171
- (GRCh37/hg19)
- Size:
- 41,528 bases
- Orientation:
- Plus strand
Genomic View for GSTM2 Gene
Genes around GSTM2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
GSTM2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GSTM2 Gene
Proteins for GSTM2 Gene
-
Protein details for GSTM2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28161-GSTM2_HUMAN
- Recommended name:
- Glutathione S-transferase Mu 2
- Protein Accession:
- P28161
- B4DRY4
- E9PEM9
- Q2M318
- Q5TZY5
- Q8WWE1
Protein attributes for GSTM2 Gene
- Size:
- 218 amino acids
- Molecular mass:
- 25745 Da
- Quaternary structure:
-
- Homodimer.
Three dimensional structures from OCA and Proteopedia for GSTM2 Gene
Protein Expression for GSTM2 Gene
Selected DME Specific Peptides for GSTM2 Gene
- P28161:
-
- WLNEKFK
- KISAYMK
- IRLLLEYT
- SRFLPRP
- TQSNAILRY
- GDKITFVDFIAYDVLERNQVFE
- FPNLKDF
- APDYDRSQWL
- LDFPNLPYL
- FLGKQPWF
- KITQSNAI
- CLDAFPNL
- NLKDFISRFEGL
Post-translational modifications for GSTM2 Gene
Other Protein References for GSTM2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GSTM2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for GSTM2
- Novus Biologicals Antibodies for GSTM2
-
Abcam antibodies for GSTM2
- Invitrogen Antibodies for GSTM2 (AFLGC-GSTM2)
-
Biorbyt antibodies for GSTM2
-
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Protein Products
-
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-
Abcam proteins for GSTM2
Domains & Families for GSTM2 Gene
Gene Families for GSTM2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for GSTM2 Gene
Suggested Antigen Peptide Sequences for GSTM2 Gene
- GenScript: Design optimal peptide antigens:
-
- Glutathione S-transferase M2 (Muscle) (A8HT81_HUMAN)
- GSTM2-2 (GSTM2_HUMAN)
- Glutathione S-transferase mu 2 (Muscle) (Q0D2I8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P28161- Family:
-
- Belongs to the GST superfamily. Mu family.
Function for GSTM2 Gene
Molecular function for GSTM2 Gene
- UniProtKB/Swiss-Prot Function:
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence=. ;.
- GENATLAS Biochemistry:
- glutathione-S-transferase 2 ,mu class,expressed in muscle
Enzyme Numbers (IUBMB) for GSTM2 Gene
Phenotypes From GWAS Catalog for GSTM2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004364 | glutathione transferase activity | IDA | 2034681 |
| GO:0004602 | glutathione peroxidase activity | IDA | 16624487 |
| GO:0005102 | signaling receptor binding | IPI | 22406107 |
| GO:0005515 | protein binding | IPI,IEA | 24965446 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for GSTM2 Gene
- GenomeRNAi human phenotypes for GSTM2:
-
- Strongly decreased NFAT1-GFP nuclear translocation
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased viability
- Increased transferrin (TF) endocytosis
- Increased viability with MLN4924 (a NAE inhibitor)
- Lamellipodia cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTM2
miRNA for GSTM2 Gene
- miRTarBase miRNAs that target GSTM2
miRNA Products
Inhibitory RNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for GSTM2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTM2 Gene
Localization for GSTM2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GSTM2 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| endoplasmic reticulum | 4 |
| nucleus | 3 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 2034681 |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0016529 | sarcoplasmic reticulum | IDA | 22406107 |
| GO:0045171 | intercellular bridge | IDA | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for GSTM2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Glutathione metabolism | ||
| 3 | Cytochrome P450 - arranged by substrate type | ||
| 4 | Metabolism |
.40
|
|
| 5 | Fluid shear stress and atherosclerosis | ||
Pathways by source for GSTM2 Gene
3 BioSystems pathways for GSTM2 Gene
4 Reactome pathways for GSTM2 Gene
10 KEGG pathways for GSTM2 Gene
1 GeneGo (Thomson Reuters) pathway for GSTM2 Gene
Interacting Proteins for GSTM2 Gene
GPS-Prot Interaction Network for GSTM2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006749 | glutathione metabolic process | IDA | 2034681 |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | IDA | 17023043 |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | IC | 17023043 |
| GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | IC | 17023043 |
| GO:0018916 | nitrobenzene metabolic process | IDA | 2034681 |
No data available for SIGNOR curated interactions for GSTM2 Gene
Drugs & Compounds for GSTM2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Oxidized glutathione | Approved, Experimental, Investigational | Pharma | Target | 0 | ||
| Trichloroethylene | Approved | Pharma | 5 | |||
| Water | Approved | Pharma | 0 | |||
| S-(2,4-dinitrophenyl)glutathione | Experimental | Pharma | Target | 0 | ||
| S-METHYL-GLUTATHIONE | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
|
|
||||
| (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
|
|
||||
| (1S,2R)-Naphthalene 1,2-oxide |
|
|
||||
| 1,1-Dichloroethylene epoxide |
|
|
Transcripts for GSTM2 Gene
mRNA/cDNA for GSTM2 Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (28) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369831 1730 bps (ENST00000369831.6)
- ENST00000460717 1449 bps (ENST00000460717.7)
- ENST00000464206 709 bps (ENST00000464206.5)
- ENST00000481656 519 bps (ENST00000481656.2)
- ENST00000476040 943 bps (ENST00000476040.6)
CRISPR Products
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GSTM2
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-
Santa Cruz Biotechnology (SCBT) CRISPR for GSTM2
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for GSTM2 - Select products 50% OFF >
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- * GSTM2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for GSTM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GSTM2
- genomics-online: cdna clones - Search results for available GSTM2 gene related products
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Expression for GSTM2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Thymus (Hematopoietic System)
- NULL (Uncategorized)
This gene is overexpressed in Ovary (9.2) and Retina (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTM2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GSTM2 Gene:
GSTM2SOURCE GeneReport for Unigene cluster for GSTM2 Gene:
Hs.279837mRNA Expression by UniProt/SwissProt for GSTM2 Gene:
P28161-GSTM2_HUMAN
Tissue specificity:
Muscle.
Evidence on tissue expression from TISSUES for GSTM2 Gene
- Nervous system(4.7)
- Muscle(4.6)
- Liver(2.6)
- Skin(2.5)
- Blood(2.3)
- Kidney(2.3)
- Lung(2.3)
- Heart(2.2)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for GSTM2
-
OriGene qPCR primer pairs and template standards for GSTM2
- genomics-online: primer clones - Search results for available GSTM2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTM2 Gene
Orthologs for GSTM2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| rat (Rattus norvegicus) |
Mammalia | Gstm7 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Gstm7 17 33 32 |
|
||
| Gm6665 33 |
|
ManyToMany | |||
| Gstm2 33 |
|
ManyToMany | |||
| Gstm4 33 |
|
ManyToMany | |||
| Gstm3 33 |
|
ManyToMany | |||
| Gstm1 33 |
|
ManyToMany | |||
| Gstm6 33 |
|
ManyToMany | |||
| Gm4845 33 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | GSTM4 33 |
|
ManyToMany | |
| GSTM1 33 33 |
|
ManyToMany | |||
| GSTM2 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:173994 33 |
|
ManyToMany | |
| gstm 33 |
|
ManyToMany | |||
| gstm3 33 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | gst-23 33 |
|
ManyToMany | |
| gst-1 33 |
|
ManyToMany | |||
| gst-25 33 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
ManyToMany | |
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany | |||
| -- 33 |
|
ManyToMany |
- Species where no ortholog for GSTM2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for GSTM2 Gene
- ENSEMBL:
- Gene Tree for GSTM2 (if available)
- TreeFam:
- Gene Tree for GSTM2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GSTM2: view image
Paralogs for GSTM2 Gene
Paralogs for GSTM2 Gene
(6) SIMAP similar genes for GSTM2 Gene using alignment to 8 proteins:
- GSTM2_HUMAN
- A8HT81_HUMAN
- E9PGV1_HUMAN
- E9PHN6_HUMAN
- E9PHN7_HUMAN
- E9PLF1_HUMAN
- F6XZQ7_HUMAN
- Q0D2I8_HUMAN
Pseudogenes.org Pseudogenes for GSTM2 Gene
Variants for GSTM2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000072383 | -- | 109,677,533(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000866694 | -- | 109,676,430(+) | C/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000933050 | -- | 109,669,444(+) | GAGAG/GAG | intron_variant | |
| rs1001479157 | -- | 109,679,190(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1001652092 | -- | 109,673,371(+) | G/C | intron_variant |
Residual Variation Intolerance Score:
53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.10;
22.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GSTM2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GSTM2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTM2 Gene
Disorders for GSTM2 Gene
Additional Disease Information for GSTM2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GSTM2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GSTM2 Gene
Publications for GSTM2 Gene
- Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus. (PMID: 2034681) Vorachek WR … Rule GS (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23 56
- No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova IE … Brauch H (Breast cancer research and treatment 2010) 3 23 43 56
- Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1. (PMID: 19856098) Yu KD … Shao ZM (Breast cancer research and treatment 2010) 3 23 43 56
- Glutathione S-transferase variants and hypertension. (PMID: 18551009) Delles C … Dominiczak AF (Journal of hypertension 2008) 3 23 43 56
- Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 43 56
ExternalLinks
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- Biorbyt antibodies for GSTM2
Sources for GSTM2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource