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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
GSTM2 (Glutathione S-Transferase Mu 2) is a Protein Coding gene. Diseases associated with GSTM2 include Barrett's Adenocarcinoma and Hepatocellular Carcinoma. Among its related pathways are Drug metabolism - cytochrome P450 and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is GSTM1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004364 | glutathione transferase activity | IEA,IDA | 2034681 |
GO:0004602 | glutathione peroxidase activity | IDA | 16624487 |
GO:0005102 | signaling receptor binding | IPI | 22406107 |
GO:0005504 | fatty acid binding | IPI | 16624487 |
GO:0005515 | protein binding | IEA,IPI | 24965446 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 2034681 |
GO:0005829 | cytosol | IDA,TAS | -- |
GO:0016529 | sarcoplasmic reticulum | IDA | 22406107 |
GO:0045171 | intercellular bridge | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 | ||
2 | Glutathione metabolism |
Glutathione metabolism
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3 | Cytochrome P450 - arranged by substrate type | ||
4 | Metabolism |
.40
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5 | Fluid shear stress and atherosclerosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006749 | glutathione metabolic process | IDA | 2034681 |
GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | IDA | 17023043 |
GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | IC | 17023043 |
GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | IC | 17023043 |
GO:0018916 | nitrobenzene metabolic process | IDA | 2034681 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Glutathione | Approved, Investigational | Nutra | Target | 0 | ||
Oxidized glutathione | Approved, Experimental, Investigational | Pharma | Target, Target, activator | 0 | ||
Trichloroethylene | Approved | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
S-(2,4-dinitrophenyl)glutathione | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene |
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(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene |
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(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene |
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(1S,2R)-Naphthalene 1,2-oxide |
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1,1-Dichloroethylene epoxide |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Rat (Rattus norvegicus) |
Mammalia | Gstm7 30 |
|
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Mouse (Mus musculus) |
Mammalia | Gstm7 30 17 31 |
|
ManyToMany | |
Gm6665 31 |
|
ManyToMany | |||
Gstm2 31 |
|
ManyToMany | |||
Gstm4 31 |
|
ManyToMany | |||
Gstm3 31 |
|
ManyToMany | |||
Gstm1 31 |
|
ManyToMany | |||
Gstm6 31 |
|
ManyToMany | |||
Gm4845 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | GSTM4 31 |
|
ManyToMany | |
GSTM1 31 31 |
|
ManyToMany | |||
GSTM2 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:173994 31 |
|
ManyToMany | |
gstm 31 |
|
ManyToMany | |||
gstm3 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | gst-23 31 |
|
ManyToMany | |
gst-1 31 |
|
ManyToMany | |||
gst-25 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
barrett's adenocarcinoma |
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hepatocellular carcinoma |
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