Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enz... See more...

Aliases for GSTM1 Gene

Aliases for GSTM1 Gene

  • Glutathione S-Transferase Mu 1 2 3 3 4 5
  • Glutathione S-Transferase M1 2 3
  • GST HB Subunit 4 3 4
  • GST Class-Mu 1 3 4
  • EC 2.5.1.18 4 50
  • GSTM1a-1a 3 4
  • GSTM1b-1b 3 4
  • GSTM1-1 3 4
  • GST1 3 4
  • GTH4 3 4
  • H-B 2 3
  • MU 2 3
  • S-(Hydroxyalkyl)Glutathione Lyase 3
  • Glutathione S-Aralkyltransferase 3
  • Glutathione S-Alkyltransferase 3
  • Glutathione S-Aryltransferase 3
  • HB Subunit 4 3
  • GSTM1 5
  • GTM1 3
  • MU-1 3

External Ids for GSTM1 Gene

Previous HGNC Symbols for GSTM1 Gene

  • GST1

Previous GeneCards Identifiers for GSTM1 Gene

  • GC01P110709
  • GC01P109159
  • GC01P109332
  • GC01P109529
  • GC01P109942
  • GC01P110031
  • GC01P110231
  • GC01P110232

Summaries for GSTM1 Gene

Entrez Gene Summary for GSTM1 Gene

  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GSTM1 Gene

GSTM1 (Glutathione S-Transferase Mu 1) is a Protein Coding gene. Diseases associated with GSTM1 include Asbestosis and Oral Leukoplakia. Among its related pathways are Naphthalene metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is GSTM5.

UniProtKB/Swiss-Prot Summary for GSTM1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).

Gene Wiki entry for GSTM1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GSTM1 Gene

Genomics for GSTM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GSTM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J109655 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 255 -31.4 -31422 2.4 MYC IKZF1 ZNF592 POLR2A ZIC2 YY1 MXD4 NONO KLF11 SMAD5 GSTM4 GSTM1 M99422 GSTM2 HSALNG0005910
GH01J109687 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 263.1 +0.2 173 1.6 POLR2A YY1 CTCF ELF1 TAF1 RB1 RAD21 REST IKZF1 TRIM22 GSTM1 ENSG00000241720 lnc-GSTM3-5 GSTM5 ENSG00000260246 GSTM2
GH01J109711 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 8.2 +24.5 24510 1.5 POLR2A SCRT2 GSTM5 GSTM3 GSTM1 SORT1 HSALNG0005918 ENSG00000241720
GH01J109482 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 4.7 -203.8 -203790 2.4 BCLAF1 SP1 ZNF207 NCOR1 MYC ZNF600 SIX5 ZNF580 ZMYM3 ATF2 ATXN7L2 HSALNG0005891 ENSG00000258634 PRPF38B STRIP1 RPL17P7 SYPL2 ENSG00000273373 RBM15 ENSG00000228665
GH01J109640 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 -46.0 -46013 5.6 BCLAF1 ZNF654 MYC ZMYM3 ZNF223 ZIC2 ZBTB10 NONO CTCF REST GSTM4 GSTM3 GNAT2 AMPD2 GNAI3 MIR197 ENSG00000225113 RNU6V GSTM2 GSTM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GSTM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GSTM1

Top Transcription factor binding sites by QIAGEN in the GSTM1 gene promoter:
  • AP-1
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for GSTM1 Gene

Latest Assembly
chr1:109,687,814-109,709,039
(GRCh38/hg38)
Size:
21,226 bases
Orientation:
Plus strand

Previous Assembly
chr1:110,230,439-110,236,367
(GRCh37/hg19 by Entrez Gene)
Size:
5,929 bases
Orientation:
Plus strand

chr1:110,230,436-110,251,661
(GRCh37/hg19 by Ensembl)
Size:
21,226 bases
Orientation:
Plus strand

Genomic View for GSTM1 Gene

Genes around GSTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTM1 Gene

Proteins for GSTM1 Gene

  • Protein details for GSTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09488-GSTM1_HUMAN
    Recommended name:
    Glutathione S-transferase Mu 1
    Protein Accession:
    P09488
    Secondary Accessions:
    • Q5GHG0
    • Q6FH88
    • Q8TC98
    • Q9UC96

    Protein attributes for GSTM1 Gene

    Size:
    218 amino acids
    Molecular mass:
    25712 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for GSTM1 Gene

    Alternative splice isoforms for GSTM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTM1 Gene

Selected DME Specific Peptides for GSTM1 Gene

P09488:
  • WLNEKFK
  • KISAYMK
  • IRLLLEYT
  • TEEEKIRVDI
  • SRFLPRP
  • FLGKRPWF
  • IRVDILENQ
  • LGYWDIRG
  • FPNLKDF
  • APDYDRSQWL
  • LDFPNLPYL
  • CGETEEE
  • KITQSNAI
  • CLDAFPNL
  • NLKDFISRFEGL

Post-translational modifications for GSTM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

Domains & Families for GSTM1 Gene

Gene Families for GSTM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GSTM1 Gene

InterPro:
Blocks:
  • Glutathione S-transferase, N-terminal
  • Mu-class glutathione S-transferase signature

Suggested Antigen Peptide Sequences for GSTM1 Gene

GenScript: Design optimal peptide antigens:
  • GTH4 (GSTM1_HUMAN)
  • GSTM1 protein (Q16041_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09488

UniProtKB/Swiss-Prot:

GSTM1_HUMAN :
  • Belongs to the GST superfamily. Mu family.
Family:
  • Belongs to the GST superfamily. Mu family.
genes like me logo Genes that share domains with GSTM1: view

Function for GSTM1 Gene

Molecular function for GSTM1 Gene

UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:16548513};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + prostaglandin A2 = prostaglandin A2-S-(R)-glutathione; Xref=Rhea:RHEA:50796, ChEBI:CHEBI:57925, ChEBI:CHEBI:133370, ChEBI:CHEBI:133768; Evidence={ECO:0000269|PubMed:9084911};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione; Xref=Rhea:RHEA:50804, ChEBI:CHEBI:57925, ChEBI:CHEBI:133396, ChEBI:CHEBI:133771; Evidence={ECO:0000269|PubMed:9084911};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + prostaglandin J2 = prostaglandin J2-S-(S)-glutathione; Xref=Rhea:RHEA:50808, ChEBI:CHEBI:57925, ChEBI:CHEBI:133396, ChEBI:CHEBI:133772; Evidence={ECO:0000269|PubMed:9084911};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione; Xref=Rhea:RHEA:50800, ChEBI:CHEBI:57925, ChEBI:CHEBI:133370, ChEBI:CHEBI:133769; Evidence={ECO:0000269|PubMed:9084911};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate; Xref=Rhea:RHEA:50260, ChEBI:CHEBI:57925, ChEBI:CHEBI:132200, ChEBI:CHEBI:132201; Evidence={ECO:0000269|PubMed:21046276};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=26 uM for prostaglandin A2 (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:9084911}; KM=95 uM for prostaglandin J2 (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:9084911}; Vmax=27 nmol/min/mg enzyme for the formation of the glutathione-S-conjugate of prostaglandin A2 (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:9084911}; Vmax=72 nmol/min/mg enzyme for the formation of the glutathione-S-conjugate of prostaglandin J2 (at pH 7.0 and 37 degrees Celsius) {ECO:0000269|PubMed:9084911};
GENATLAS Biochemistry:
glutathione-S-transferase 1 ,mu class,deleted in lung and urinary bladder cancer (in dependance on the exposure to carcinogens as cigarette) and in childhood acute leukemia (null allele) in association with CYP1A1*2A

Enzyme Numbers (IUBMB) for GSTM1 Gene

Phenotypes From GWAS Catalog for GSTM1 Gene

Gene Ontology (GO) - Molecular Function for GSTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA,IDA 8373352
GO:0005515 protein binding IEA --
GO:0016740 transferase activity IEA --
GO:0019899 enzyme binding IPI 8373352
GO:0042803 protein homodimerization activity IPI 8373352
genes like me logo Genes that share ontologies with GSTM1: view
genes like me logo Genes that share phenotypes with GSTM1: view

miRNA for GSTM1 Gene

miRTarBase miRNAs that target GSTM1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTM1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTM1 Gene

Localization for GSTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTM1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTM1 gene
Compartment Confidence
cytosol 5
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GSTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 8373352
GO:0005829 cytosol IDA,TAS --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with GSTM1: view

Pathways & Interactions for GSTM1 Gene

genes like me logo Genes that share pathways with GSTM1: view

SIGNOR curated interactions for GSTM1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GSTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006693 prostaglandin metabolic process IDA 9084911
GO:0006749 glutathione metabolic process IEA,IDA 8373352
GO:0018916 nitrobenzene metabolic process IDA 8373352
GO:0042178 xenobiotic catabolic process IDA 8373352
GO:0051122 hepoxilin biosynthetic process IDA 21046276
genes like me logo Genes that share ontologies with GSTM1: view

Drugs & Compounds for GSTM1 Gene

(63) Drugs for GSTM1 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Busulfan Approved, Investigational Pharma Enzyme, substrate 636
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 2071
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3624
Glutathione Approved, Investigational Nutra Target 0
Bleomycin Approved, Investigational Pharma 178

(92) Additional Compounds for GSTM1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane
genes like me logo Genes that share compounds with GSTM1: view

Transcripts for GSTM1 Gene

mRNA/cDNA for GSTM1 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GSTM1

Alternative Splicing Database (ASD) splice patterns (SP) for GSTM1 Gene

No ASD Table

Relevant External Links for GSTM1 Gene

GeneLoc Exon Structure for
GSTM1

Expression for GSTM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GSTM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GSTM1 Gene

This gene is overexpressed in Liver, secretome (11.0), Tonsil (10.0), Ovary (7.2), Skin (6.9), and Gallbladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GSTM1 Gene



Protein tissue co-expression partners for GSTM1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GSTM1

SOURCE GeneReport for Unigene cluster for GSTM1 Gene:

Hs.301961

mRNA Expression by UniProt/SwissProt for GSTM1 Gene:

P09488-GSTM1_HUMAN
Tissue specificity: Liver (at protein level).

Evidence on tissue expression from TISSUES for GSTM1 Gene

  • Liver(4.7)
  • Intestine(4.5)
  • Heart(4.5)
  • Nervous system(3.3)
  • Skin(3.2)
  • Muscle(3)
  • Blood(3)
  • Kidney(2.7)
  • Lung(2.4)
  • Adrenal gland(2.4)
  • Eye(2.3)
  • Stomach(2.3)
  • Pancreas(2.3)
  • Thyroid gland(2.2)
  • Urine(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with GSTM1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTM1 Gene

Orthologs for GSTM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GSTM1 29 30
  • 99.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GSTM1 29 30 30
  • 86.7 (n)
ManyToMany
GSTM4 30
  • 86 (a)
ManyToMany
GSTM2 30
  • 83 (a)
ManyToMany
-- 30
  • 75 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gstm2 29 16 30
  • 85.78 (n)
ManyToMany
Gstm7 30
  • 81 (a)
ManyToMany
Gstm4 30
  • 80 (a)
ManyToMany
Gm6665 30
  • 78 (a)
ManyToMany
Gstm1 30
  • 78 (a)
ManyToMany
Gstm6 30
  • 78 (a)
ManyToMany
Gstm3 30
  • 76 (a)
ManyToMany
Gm4845 30
  • 73 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Gstm2 29
  • 83.64 (n)
Dog
(Canis familiaris)
Mammalia -- 30
  • 79 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 73 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gstm1 29
  • 65.12 (n)
Str.5827 29
African clawed frog
(Xenopus laevis)
Amphibia gstm2-prov 29
Zebrafish
(Danio rerio)
Actinopterygii zgc:173994 30
  • 66 (a)
ManyToMany
gstm 30
  • 65 (a)
ManyToMany
gstm3 30
  • 63 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea gst-1 30
  • 31 (a)
ManyToMany
gst-23 30
  • 30 (a)
ManyToMany
gst-25 30
  • 28 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
ManyToMany
-- 30
  • 43 (a)
ManyToMany
-- 30
  • 40 (a)
ManyToMany
-- 30
  • 29 (a)
ManyToMany
Species where no ortholog for GSTM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GSTM1 Gene

ENSEMBL:
Gene Tree for GSTM1 (if available)
TreeFam:
Gene Tree for GSTM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GSTM1: view image
Alliance of Genome Resources:
Additional Orthologs for GSTM1

Paralogs for GSTM1 Gene

Paralogs for GSTM1 Gene

(6) SIMAP similar genes for GSTM1 Gene using alignment to 6 proteins:

  • GSTM1_HUMAN
  • B9ZVX7_HUMAN
  • E7EWW9_HUMAN
  • H3BQT3_HUMAN
  • H3BRM6_HUMAN
  • Q16041_HUMAN
genes like me logo Genes that share paralogs with GSTM1: view

Variants for GSTM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GSTM1 Gene

GSTM1_HUMAN-P09488
There are two alleles; GSTM1A and GSTM1B which differ in position 173. The sequence shown is that of allele GSTM1A.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GSTM1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs138440339 Likely Benign: not provided 109,690,472(+) C/G
NM_000561.4(GSTM1):c.475C>G (p.Leu159Val)
MISSENSE_VARIANT,INTRON
rs199816990 Benign: not provided 109,689,252(+) G/T
NM_000561.4(GSTM1):c.287G>T (p.Arg96Leu)
MISSENSE
rs202002774 Benign: not provided 109,689,279(+) T/C
NM_000561.4(GSTM1):c.314T>C (p.Met105Thr)
MISSENSE
rs567320393 Likely Benign: not provided 109,688,178(+) C/A
NM_000561.4(GSTM1):c.45C>A (p.His15Gln)
MISSENSE
rs1065411 -- p.Lys173Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GSTM1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GSTM1 Gene

Variant ID Type Subtype PubMed ID
dgv142n106 CNV deletion 24896259
dgv15n111 CNV deletion 26073780
dgv16n111 CNV deletion 26073780
dgv1e213 CNV gain 24956385
dgv253n100 CNV gain 25217958
dgv254n100 CNV gain+loss 25217958
dgv255n100 CNV gain 25217958
dgv256n100 CNV loss 25217958
dgv257n100 CNV gain 25217958
dgv258n100 CNV gain 25217958
dgv259n100 CNV gain+loss 25217958
dgv260n100 CNV loss 25217958
dgv261n100 CNV gain 25217958
dgv262n100 CNV gain+loss 25217958
dgv263n100 CNV gain+loss 25217958
dgv264n100 CNV gain 25217958
dgv265n100 CNV gain 25217958
dgv266n100 CNV gain+loss 25217958
dgv267n100 CNV gain+loss 25217958
dgv268n100 CNV loss 25217958
dgv269n100 CNV gain+loss 25217958
dgv270n100 CNV gain 25217958
dgv271n100 CNV loss 25217958
dgv272n100 CNV gain+loss 25217958
dgv273n100 CNV loss 25217958
dgv274n100 CNV loss 25217958
dgv275n100 CNV gain+loss 25217958
dgv276n100 CNV loss 25217958
dgv3e203 CNV gain+loss 21179565
dgv3n47 CNV loss 21111241
dgv500n54 CNV gain 21841781
dgv61e199 CNV deletion 23128226
dgv66n67 CNV gain 20364138
dgv6e180 CNV gain 20482838
dgv77e212 CNV loss 25503493
esv1003982 CNV deletion 20482838
esv2421364 OTHER complex 20811451
esv25172 CNV gain+loss 19812545
esv2530591 CNV loss 19546169
esv2716040 CNV deletion 23290073
esv3257828 CNV deletion 24192839
esv33243 CNV gain 17666407
esv3378880 CNV duplication 20981092
esv3381843 CNV duplication 20981092
esv3584594 CNV loss 24956385
esv3584928 CNV gain 24956385
esv3587154 CNV loss 21293372
esv3587155 CNV loss 21293372
esv3587156 CNV gain 21293372
esv998761 CNV gain 20482838
nsv1000726 CNV gain+loss 25217958
nsv1001758 CNV gain 25217958
nsv1003510 CNV loss 25217958
nsv1003898 CNV gain 25217958
nsv1003914 CNV gain 25217958
nsv1007399 CNV loss 25217958
nsv1009692 CNV gain 25217958
nsv1009967 CNV loss 25217958
nsv10617 CNV gain 18304495
nsv1077552 CNV deletion 25765185
nsv2310 CNV deletion 18451855
nsv2332 CNV insertion 18451855
nsv276 CNV deletion 15895083
nsv435675 CNV deletion 17901297
nsv437937 CNV loss 16468122
nsv442967 CNV loss 18776908
nsv482092 CNV gain 20164927
nsv508471 CNV deletion 20534489
nsv510951 OTHER complex 20534489
nsv514002 CNV gain 21397061
nsv547486 CNV loss 21841781
nsv547487 CNV gain 21841781
nsv820548 CNV deletion 20802225
nsv824076 CNV loss 20364138
nsv824087 CNV loss 20364138
nsv946134 CNV duplication 23825009
nsv951392 CNV deletion 24416366

Variation tolerance for GSTM1 Gene

Gene Damage Index Score: 5.09; 69.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTM1 Gene

Human Gene Mutation Database (HGMD)
GSTM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTM1
Leiden Open Variation Database (LOVD)
GSTM1

SNP Genotyping and Copy Number Assays for research

Disorders for GSTM1 Gene

MalaCards: The human disease database

(90) MalaCards diseases for GSTM1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
asbestosis
  • idiopathic interstitial pneumonitis - from asbestos exposure
oral leukoplakia
  • leukoplakia oral
senile cataract
larynx cancer
  • laryngeal carcinoma
oligoasthenoteratozoospermia
  • oat
- elite association - COSMIC cancer census association via MalaCards
Search GSTM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTM1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GSTM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTM1 Gene

Publications for GSTM1 Gene

  1. Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women. (PMID: 17624589) Sakoda LC … Chen C (Breast cancer research and treatment 2008) 3 22 25 40
  2. An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (PMID: 17372252) Schwartzbaum JA … Feychting M (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007) 3 22 25 40
  3. Influence of class M1 glutathione S-transferase (GST Mu) polymorphism on GST M1 gene expression level and tumor size in oral squamous cell carcinoma. (PMID: 20060357) Koch FP … Brieger J (Oral oncology 2010) 3 22 40
  4. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 22 40
  5. Interaction between GSTM1/GSTT1 polymorphism and blood mercury on birth weight. (PMID: 20194072) Lee BE … Ha EH (Environmental health perspectives 2010) 3 22 40

Products for GSTM1 Gene

Sources for GSTM1 Gene